MOUSE:ZBT20

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Zbtb20 (synonyms: Zfp288)
Protein Name(s)	Zinc finger and BTB domain-containing protein 20 BTB/POZ domain zinc finger factor HOF Zinc finger protein 288
External Links
UniProt	Q8K0L9
EMBL	AF194030 AK005028 CT010512 CT010512 BC031114 BC056446
CCDS	CCDS28178.1 CCDS49851.1
RefSeq	NP_001272734.1 NP_062752.2 NP_851401.1 XP_006522475.1 XP_006522476.1 XP_006522477.1 XP_006522478.1 XP_006522479.1 XP_006522480.1 XP_006522481.1 XP_006522482.1 XP_006522483.1 XP_006522484.1 XP_006522485.1 XP_006522486.1 XP_006522487.1
UniGene	Mm.136238 Mm.441121 Mm.441972 Mm.460947 Mm.491236
ProteinModelPortal	Q8K0L9
SMR	Q8K0L9
IntAct	Q8K0L9
MaxQB	Q8K0L9
PaxDb	Q8K0L9
PRIDE	Q8K0L9
Ensembl	ENSMUST00000079441 ENSMUST00000114690 ENSMUST00000114691 ENSMUST00000114694 ENSMUST00000114695
GeneID	56490
KEGG	mmu:56490
UCSC	uc007zga.2
CTD	26137
MGI	MGI:1929213
eggNOG	COG5048
GeneTree	ENSGT00760000119063
HOGENOM	HOG000136747
HOVERGEN	HBG060183
InParanoid	Q8K0L9
KO	K10501
OMA	VRIQTLM
OrthoDB	EOG7GQXV7
PhylomeDB	Q8K0L9
TreeFam	TF335684
ChiTaRS	Zbtb20
NextBio	312770
PRO	PR:Q8K0L9
Proteomes	UP000000589
Bgee	Q8K0L9
CleanEx	MM_ZBTB20
ExpressionAtlas	Q8K0L9
Genevestigator	Q8K0L9
GO	GO:0005634 GO:0003677 GO:0046872 GO:0001078 GO:0000122
Gene3D	3.30.160.60
InterPro	IPR000210 IPR011333 IPR013069 IPR007087 IPR015880 IPR013087
Pfam	PF00651 PF00096
SMART	SM00225 SM00355
SUPFAM	SSF54695
PROSITE	PS50097 PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0032728	positive regulation of interferon-beta production	PMID:23776228^[1]	ECO:0000315			P		Figure 1A the third graph with the knockout of the protein zbt20 shows IFN beta in significantly lowered quanities. This is also shown in figure 3A third graph and figure 3c graph 3 with siRNA interference of ZBT20 resulting in similar effects.	complete CACAO 8626
	GO:0032760	positive regulation of tumor necrosis factor production	PMID:23776228^[1]	ECO:0000315			P		Figure 1A the first graph with the knockout of the protein shows Zbt20 shows that TNF is present in significantly lowered quantities. This is also shown in figure 3A first graph and figure 3c graph 1 with RNA interference of zbt20 production resulting in lowered amount of TNF.	complete CACAO 8627
	GO:0032755	positive regulation of interleukin-6 production	PMID:23776228^[1]	ECO:0000315			P		Figure 1A the third graph with the knockout of the protein Zbt20 shows a lowered amount of interleukin 6 (IL-6) being produced. This is also shown in figure 3A second graph and figure 3c graph 2 with siRNA with zbt20 resulting in lowered quantities of IL-6.	complete CACAO 8631
	GO:0032728	positive regulation of interferon-beta production	PMID:23776228^[1]	ECO:0000314			P		Overexpression of Zbt20 results in figure 3E graph 3, with excess zbt20 expression there is an increased production of interferon beta.	complete CACAO 8634
	GO:0032760	positive regulation of tumor necrosis factor production	PMID:23776228^[1]	ECO:0000314			P		Figure 3E graph 1 demonstrates when zbt20 is overexpressed there is an increased amount of TNF (tumor necrosis factor) produced when compared to the control.	complete CACAO 8636
	GO:0032755	positive regulation of interleukin-6 production	PMID:23776228^[1]	ECO:0000314			P		Figure 3E graph 2 demonstrates that when Zbt20 is overexpressed there is an increased production of interleukin-6 (IL-6) in response when compared to the control.	complete CACAO 8637
	GO:0010629	negative regulation of gene expression	PMID:23776228^[1]	ECO:0000315			P		In fig. 4A and S6 when the control is compared to knockout ZBT20 in immunoblot analysis, the IkB alpha gene shows increased expression of IkBalpha so when Zbt20 is present IkB alph gene transcription is repressed.	complete CACAO 8641
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:23776228^[1]	ECO:0000314			P		In fig. 6A HEK293 cells were cotransfected with ZBTB20 expressing plasmids while maintaining a constant amount of DNA transfected versus mock normal DNA shows that in this repression fold graph that when the cotransfected plasmid is at its largest the amount of transcription is decreased 10 fold of expression. This amount transcription is decreased is in correlation to the amount of ZBT20 plasmid present.	complete CACAO 8800
involved_in	GO:0055088	lipid homeostasis	PMID:28327662^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:28327662^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000182)	Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:28327662^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045821	positive regulation of glycolytic process	PMID:28327662^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046889	positive regulation of lipid biosynthetic process	PMID:28327662^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:28327662^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000182) exists_during:(GO:0071333)	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:28327662^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000182) has_direct_input:(UniProtKB:P13516) has_direct_input:(UniProtKB:Q99MZ3)	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:23776228^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23776228^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:23776228^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:23776228^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	PMID:23776228^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:23776228^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:23776228^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	PMID:23776228^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC78	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC78	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17301088^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32845) part_of:(CL:0000598)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11744704^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC78	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:11744704^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:18669658^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18669658^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3812013	P	occurs_in:(EMAPA:16846) has_regulation_target:(MGI:MGI:87951)	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HC78 ensembl:ENSP00000419153	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HC78 ensembl:ENSP00000419153	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HC78 ensembl:ENSP00000419153	C		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 Liu, X et al. (2013) Zinc finger protein ZBTB20 promotes Toll-like receptor-triggered innate immune responses by repressing IκBα gene transcription. Proc. Natl. Acad. Sci. U.S.A. 110 11097-102 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Liu, G et al. (2017) Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20. Nat Commun 8 14824 PubMed GONUTS page
↑ Nielsen, JV et al. (2007) Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger gene Zbtb20 in mice. Development 134 1133-40 PubMed GONUTS page
↑ ^4.0 ^4.1 Mitchelmore, C et al. (2002) Characterization of two novel nuclear BTB/POZ domain zinc finger isoforms. Association with differentiation of hippocampal neurons, cerebellar granule cells, and macroglia. J. Biol. Chem. 277 7598-609 PubMed GONUTS page
↑ ^5.0 ^5.1 Xie, Z et al. (2008) Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc. Natl. Acad. Sci. U.S.A. 105 10859-64 PubMed GONUTS page

[PMID:23776228-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 Liu, X et al. (2013) Zinc finger protein ZBTB20 promotes Toll-like receptor-triggered innate immune responses by repressing IκBα gene transcription. Proc. Natl. Acad. Sci. U.S.A. 110 11097-102 PubMed GONUTS page

[PMID:28327662-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Liu, G et al. (2017) Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20. Nat Commun 8 14824 PubMed GONUTS page

[PMID:17301088-3] Nielsen, JV et al. (2007) Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger gene Zbtb20 in mice. Development 134 1133-40 PubMed GONUTS page

[PMID:11744704-4] 4.0 ^4.1 Mitchelmore, C et al. (2002) Characterization of two novel nuclear BTB/POZ domain zinc finger isoforms. Association with differentiation of hippocampal neurons, cerebellar granule cells, and macroglia. J. Biol. Chem. 277 7598-609 PubMed GONUTS page

[PMID:18669658-5] 5.0 ^5.1 Xie, Z et al. (2008) Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc. Natl. Acad. Sci. U.S.A. 105 10859-64 PubMed GONUTS page

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MOUSE:ZBT20

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