MOUSE:WASF1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Wasf1 (synonyms: Wave1)
Protein Name(s)	Wiskott-Aldrich syndrome protein family member 1 WASP family protein member 1 Protein WAVE-1
External Links
UniProt	Q8R5H6
EMBL	AF290877 AF467773 BC016896 BC053423
CCDS	CCDS23801.1
RefSeq	NP_114083.1 XP_006512995.1
UniGene	Mm.41353
ProteinModelPortal	Q8R5H6
SMR	Q8R5H6
BioGrid	219971
IntAct	Q8R5H6
MINT	MINT-4140216
PhosphoSite	Q8R5H6
MaxQB	Q8R5H6
PaxDb	Q8R5H6
PRIDE	Q8R5H6
Ensembl	ENSMUST00000019975 ENSMUST00000105509
GeneID	83767
KEGG	mmu:83767
UCSC	uc007exi.2
CTD	8936
MGI	MGI:1890563
eggNOG	NOG299696
GeneTree	ENSGT00730000110593
HOGENOM	HOG000021456
HOVERGEN	HBG058482
InParanoid	Q8R5H6
KO	K05753
OMA	NILTPYX
OrthoDB	EOG7VHSXK
PhylomeDB	Q8R5H6
TreeFam	TF315031
ChiTaRS	Wasf1
NextBio	350760
PMAP-CutDB	Q8R5H6
PRO	PR:Q8R5H6
Proteomes	UP000000589
Bgee	Q8R5H6
CleanEx	MM_WASF1
Genevestigator	Q8R5H6
GO	GO:0030054 GO:0005737 GO:0005856 GO:0030027 GO:0005741 GO:0005739 GO:0045202 GO:0030036 GO:0072673
InterPro	IPR028288 IPR003124
PANTHER	PTHR12902
Pfam	PF02205
SMART	SM00246
PROSITE	PS51082

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0097484	dendrite extension	PMID:27605705^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway	PMID:27605705^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:27605705^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	PMID:27605705^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	PMID:27605705^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098885	modification of postsynaptic actin cytoskeleton	PMID:16862120^[2]	ECO:0006064	cell-free assay evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098885	modification of postsynaptic actin cytoskeleton	PMID:16862120^[2]	ECO:0006064	cell-free assay evidence used in manual assertion		P	occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0098885	modification of postsynaptic actin cytoskeleton	PMID:16862120^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098885	modification of postsynaptic actin cytoskeleton	PMID:16862120^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0098885	modification of postsynaptic actin cytoskeleton	PMID:16862120^[2]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098885	modification of postsynaptic actin cytoskeleton	PMID:16862120^[2]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0098885	modification of postsynaptic actin cytoskeleton	PMID:16862120^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098885	modification of postsynaptic actin cytoskeleton	PMID:16862120^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0098885	modification of postsynaptic actin cytoskeleton	PMID:16862120^[2]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098885	modification of postsynaptic actin cytoskeleton	PMID:16862120^[2]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:16190876^[3]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:16190876^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92558	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098939	dendritic transport of mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1561954	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072673	lamellipodium morphogenesis	PMID:17664349^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000556)	Seeded From UniProt	complete
enables	GO:0051018	protein kinase A binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92558	F		Seeded From UniProt	complete
contributes_to	GO:0048365	Rac GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92558	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92558	C		Seeded From UniProt	complete
part_of	GO:0031209	SCAR complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92558	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:15148305^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016601	Rac protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92558	P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:12931191^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000182)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:12931191^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000182)\|part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17664349^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000556)	Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0098939	C		Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098939	C		Seeded From UniProt	complete
involved_in	GO:0098939	dendritic transport of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5BJU7 ensembl:ENSRNOP00000064342	P		Seeded From UniProt	complete
involved_in	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92558 ensembl:ENSP00000376367	P		Seeded From UniProt	complete
enables	GO:0051018	protein kinase A binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92558 ensembl:ENSP00000376367	F		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92558 ensembl:ENSP00000376367	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92558 ensembl:ENSP00000376367	C		Seeded From UniProt	complete
part_of	GO:0031209	SCAR complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92558 ensembl:ENSP00000376367	C		Seeded From UniProt	complete
involved_in	GO:0016601	Rac protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92558 ensembl:ENSP00000376367	P		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003124	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028288	C		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028288	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0118	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Xu, C et al. (2016) Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth. Mol. Biol. Cell 27 3342-3356 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Kim, Y et al. (2006) Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature 442 814-7 PubMed GONUTS page
↑ ^3.0 ^3.1 Pilpel, Y & Segal, M (2005) Rapid WAVE dynamics in dendritic spines of cultured hippocampal neurons is mediated by actin polymerization. J. Neurochem. 95 1401-10 PubMed GONUTS page
↑ ^4.0 ^4.1 Eto, K et al. (2007) The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery. Blood 110 3637-47 PubMed GONUTS page
↑ Tanoue, T & Takeichi, M (2004) Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. J. Cell Biol. 165 517-28 PubMed GONUTS page
↑ ^6.0 ^6.1 Danial, NN et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424 952-6 PubMed GONUTS page

[PMID:27605705-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Xu, C et al. (2016) Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth. Mol. Biol. Cell 27 3342-3356 PubMed GONUTS page

[PMID:16862120-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Kim, Y et al. (2006) Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature 442 814-7 PubMed GONUTS page

[PMID:16190876-3] 3.0 ^3.1 Pilpel, Y & Segal, M (2005) Rapid WAVE dynamics in dendritic spines of cultured hippocampal neurons is mediated by actin polymerization. J. Neurochem. 95 1401-10 PubMed GONUTS page

[PMID:17664349-4] 4.0 ^4.1 Eto, K et al. (2007) The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery. Blood 110 3637-47 PubMed GONUTS page

[PMID:15148305-5] Tanoue, T & Takeichi, M (2004) Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. J. Cell Biol. 165 517-28 PubMed GONUTS page

[PMID:12931191-6] 6.0 ^6.1 Danial, NN et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424 952-6 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

MOUSE:WASF1

Contents

Annotations

Notes

References

a

c

d

e

f

g

l

m

n

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools