MOUSE:VLDLR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Vldlr
Protein Name(s)	Very low-density lipoprotein receptor VLDL receptor VLDL-R
External Links
UniProt	P98156
EMBL	L33417 U06670 S73732
CCDS	CCDS29721.1
PIR	I48952
RefSeq	NP_001154892.1 NP_038731.2 XP_006526980.1 XP_006526981.1
UniGene	Mm.4141
ProteinModelPortal	P98156
SMR	P98156
BioGrid	204529
DIP	DIP-33283N
IntAct	P98156
MINT	MINT-4140012
MaxQB	P98156
PaxDb	P98156
PRIDE	P98156
Ensembl	ENSMUST00000167487
GeneID	22359
KEGG	mmu:22359
UCSC	uc008hbt.2
CTD	7436
MGI	MGI:98935
eggNOG	NOG255913
GeneTree	ENSGT00760000118968
HOGENOM	HOG000115656
HOVERGEN	HBG006250
InParanoid	P98156
OMA	MGTSARW
PhylomeDB	P98156
TreeFam	TF351700
NextBio	302661
PRO	PR:P98156
Proteomes	UP000000589
Bgee	P98156
CleanEx	MM_VLDLR
ExpressionAtlas	P98156
Genevestigator	P98156
GO	GO:0005905 GO:0005615 GO:0016021 GO:0016020 GO:0043235 GO:0034361 GO:0005509 GO:0034437 GO:0038025 GO:0030229 GO:0008203 GO:0006869 GO:0000122 GO:1900006 GO:0045860 GO:0038026 GO:0021517 GO:0034447
Gene3D	2.120.10.30 4.10.400.10
InterPro	IPR011042 IPR000742 IPR001881 IPR013032 IPR000152 IPR018097 IPR009030 IPR023415 IPR000033 IPR002172
Pfam	PF07645 PF00057 PF00058
PRINTS	PR00261
SMART	SM00181 SM00179 SM00192 SM00135
SUPFAM	SSF57184 SSF57424
PROSITE	PS00010 PS01186 PS50026 PS01187 PS01209 PS50068 PS51120

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0038025	reelin receptor activity	PMID:18778775^[1]	ECO:0000315			F		Reelin signal was measured in Vldlr knockout mice by measuring Dab1 expression to examine neuron’s ability to transmit Reelin signal across plasma membrane. Quantitative immunofluorescence microscopy was used to determine levels of Dab1 expression. If neurons respond to Reelin, Dab1 expression is decreased whereas neurons that do not respond to Reelin, Dab1 expression is increased. Therefore knockout mice showed higher expression of Dab1 than wild type (five times)when mice reached maturity, meaning knockout mice did not respond to Reelin signaling. (supplemental figure 2)	complete CACAO 2140
	GO:0048813	dendrite morphogenesis	PMID:18778775^[1]	ECO:0000315			P		Supplemental figure 3B: significant difference in primary and secondary dendritic branch length at early development of 4 DIV knockout Vldlr mice. Also figure 2C shows shorter dendrites in knockout than wild type	complete CACAO 2141
involved_in	GO:0048813	dendrite morphogenesis	PMID:18778775^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0038025	reelin receptor activity	PMID:18778775^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1900006	positive regulation of dendrite development	PMID:18778775^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q924X6	P		Seeded From UniProt	complete
involved_in	GO:0038026	reelin-mediated signaling pathway	PMID:18778775^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q924X6	P		Seeded From UniProt	complete
enables	GO:0038025	reelin receptor activity	PMID:18778775^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q924X6	F		Seeded From UniProt	complete
involved_in	GO:0034447	very-low-density lipoprotein particle clearance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P98155	P		Seeded From UniProt	complete
enables	GO:0030229	very-low-density lipoprotein particle receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P98155	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15950758^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18778775^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021517	ventral spinal cord development	PMID:20711475^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3963	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3963	C		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98155	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045860	positive regulation of protein kinase activity	PMID:12526740^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103022 MGI:MGI:1340044	P	regulates_o_occurs_in:(EMAPA:17544) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3963	C		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98155	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034447	very-low-density lipoprotein particle clearance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98155	P		Seeded From UniProt	complete
enables	GO:0034437	glycoprotein transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98155	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034436	glycoprotein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98155	P		Seeded From UniProt	complete
enables	GO:0034189	very-low-density lipoprotein particle binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98155	F		Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98155	F		Seeded From UniProt	complete
enables	GO:0030229	very-low-density lipoprotein particle receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98155	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15082773^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98155	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3963	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006898	receptor-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98155	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3963	C		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98155 ensembl:ENSP00000371532	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98155 ensembl:ENSP00000371532	C		Seeded From UniProt	complete
involved_in	GO:0034447	very-low-density lipoprotein particle clearance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98155 ensembl:ENSP00000371532	P		Seeded From UniProt	complete
enables	GO:0034437	glycoprotein transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98155 ensembl:ENSP00000371532	F		Seeded From UniProt	complete
involved_in	GO:0034436	glycoprotein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98155 ensembl:ENSP00000371532	P		Seeded From UniProt	complete
enables	GO:0034189	very-low-density lipoprotein particle binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98155 ensembl:ENSP00000371532	F		Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98155 ensembl:ENSP00000371532	F		Seeded From UniProt	complete
enables	GO:0030229	very-low-density lipoprotein particle receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98155 ensembl:ENSP00000371532	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98155 ensembl:ENSP00000371532	C		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98155 ensembl:ENSP00000371532	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001881 InterPro:IPR018097	F		Seeded From UniProt	complete
enables	GO:0030229	very-low-density lipoprotein particle receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032931	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0850	C		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Fish, KN & Krucker, T (2008) Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse. Neurobiol. Dis. 32 391-401 PubMed GONUTS page
↑ Hoe, HS & Rebeck, GW (2005) Regulation of ApoE receptor proteolysis by ligand binding. Brain Res. Mol. Brain Res. 137 31-9 PubMed GONUTS page
↑ Palmesino, E et al. (2010) Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 8 e1000446 PubMed GONUTS page
↑ Bock, HH & Herz, J (2003) Reelin activates SRC family tyrosine kinases in neurons. Curr. Biol. 13 18-26 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ Marschang, P et al. (2004) Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol. Cell. Biol. 24 3782-93 PubMed GONUTS page

[PMID:18778775-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Fish, KN & Krucker, T (2008) Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse. Neurobiol. Dis. 32 391-401 PubMed GONUTS page

[PMID:15950758-2] Hoe, HS & Rebeck, GW (2005) Regulation of ApoE receptor proteolysis by ligand binding. Brain Res. Mol. Brain Res. 137 31-9 PubMed GONUTS page

[PMID:20711475-3] Palmesino, E et al. (2010) Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 8 e1000446 PubMed GONUTS page

[PMID:12526740-4] Bock, HH & Herz, J (2003) Reelin activates SRC family tyrosine kinases in neurons. Curr. Biol. 13 18-26 PubMed GONUTS page

[PMID:23382219-5] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

[PMID:15082773-6] Marschang, P et al. (2004) Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol. Cell. Biol. 24 3782-93 PubMed GONUTS page

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MOUSE:VLDLR

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