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PMID:12526740
| Citation |
Bock, HH and Herz, J (2003) Reelin activates SRC family tyrosine kinases in neurons. Curr. Biol. 13:18-26 |
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| Abstract |
Reelin is a large signaling molecule that regulates the positioning of neurons in the mammalian brain. Transmission of the Reelin signal to migrating embryonic neurons requires binding to the very-low-density lipoprotein receptor (VLDLR) and the apolipoprotein E receptor-2 (apoER2). This induces tyrosine phosphorylation of the adaptor protein Disabled-1 (Dab1), which interacts with a shared sequence motif in the cytoplasmic tails of both receptors. However, the kinases that mediate Dab1 tyrosine phosphorylation and the intracellular pathways that are triggered by this event remain unknown. |
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| Keywords |
Animals; Cell Adhesion Molecules, Neuronal/genetics; Cell Adhesion Molecules, Neuronal/metabolism; Cell Adhesion Molecules, Neuronal/pharmacology; Cells, Cultured; Cerebral Cortex/cytology; Cerebral Cortex/drug effects; Cerebral Cortex/metabolism; Enzyme Activation/drug effects; Enzyme Inhibitors/pharmacology; Extracellular Matrix Proteins/genetics; Extracellular Matrix Proteins/metabolism; Extracellular Matrix Proteins/pharmacology; Female; LDL-Receptor Related Proteins; Male; Mice; Mice, Mutant Strains; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology; Neurons/cytology; Neurons/drug effects; Neurons/metabolism; Phosphorylation/drug effects; Proto-Oncogene Proteins/deficiency; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-fyn; Receptors, LDL/deficiency; Receptors, LDL/genetics; Receptors, LDL/metabolism; Receptors, Lipoprotein/deficiency; Receptors, Lipoprotein/genetics; Receptors, Lipoprotein/metabolism; Serine Endopeptidases; Signal Transduction; Tyrosine/metabolism; src-Family Kinases/drug effects; src-Family Kinases/genetics; src-Family Kinases/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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