MOUSE:TP53B

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tp53bp1 (synonyms: Trp53bp1)
Protein Name(s)	Tumor suppressor p53-binding protein 1 53BP1 p53-binding protein 1 p53BP1
External Links
UniProt	P70399
EMBL	AJ414734 BC035206 BC079906 U67885
RefSeq	NP_001277759.1 NP_038763.3
UniGene	Mm.215389 Mm.383499 Mm.481841
PDB	1SSF
PDBsum	1SSF
ProteinModelPortal	P70399
SMR	P70399
BioGrid	205144
DIP	DIP-31595N
IntAct	P70399
MINT	MINT-136714
PhosphoSite	P70399
MaxQB	P70399
PaxDb	P70399
PRIDE	P70399
GeneID	27223
KEGG	mmu:27223
CTD	27223
MGI	MGI:1351320
eggNOG	NOG264535
HOGENOM	HOG000231961
HOVERGEN	HBG060882
InParanoid	P70399
EvolutionaryTrace	P70399
NextBio	305136
PRO	PR:P70399
Proteomes	UP000000589
Genevestigator	P70399
GO	GO:0000777 GO:0000776 GO:0005634 GO:0005657 GO:0003684 GO:0035064 GO:0043565 GO:0042162 GO:0008134 GO:0006974 GO:0006281 GO:0006355 GO:0006351
Gene3D	2.30.30.30 3.40.50.10190
InterPro	IPR015125 IPR001357 IPR014722
Pfam	PF09038
SMART	SM00292
SUPFAM	SSF52113
PROSITE	PS50172

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0035861	site of double-strand break	PMID:23209566^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	PMID:23209566^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:23333305^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2000042	negative regulation of double-strand break repair via homologous recombination	PMID:23333305^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:23333305^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000042	negative regulation of double-strand break repair via homologous recombination	PMID:20362325^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:20362325^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045830	positive regulation of isotype switching	PMID:15159415^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045830	positive regulation of isotype switching	PMID:15077110^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0061649	ubiquitin modification-dependent histone binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12888	F	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12888	P	Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12888	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001809041 SGD:S000002625 UniProtKB:Q12888	P	Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001809041 SGD:S000002625	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1351320 PANTHER:PTN001809041 PomBase:SPBC342.05 RGD:1308039 UniProtKB:Q12888	C	Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001809041 SGD:S000002625 UniProtKB:A0A1D8PNH8	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000042	negative regulation of double-strand break repair via homologous recombination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	P	Seeded From UniProt	complete
part_of	GO:1990391	DNA repair complex	PMID:24217620^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0061649	ubiquitin modification-dependent histone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045830	positive regulation of isotype switching	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23241889^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	PMID:17053789^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	C	Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	F	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	PMID:21746928^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:17500065^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006303	double-strand break repair via nonhomologous end joining	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006281	DNA repair	PMID:15364958^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	C	Seeded From UniProt	complete
part_of	GO:0005657	replication fork	PMID:15364958^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24001775^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308039	C	Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	F	Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:11934988^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	F	Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	F	Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:19001091^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:0000781	chromosome, telomeric region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12888	C	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:11801725^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0071481	cellular response to X-ray	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M842 ensembl:ENSRNOP00000019025	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M842 ensembl:ENSRNOP00000019025	C	Seeded From UniProt	complete
involved_in	GO:2000042	negative regulation of double-strand break repair via homologous recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	P	Seeded From UniProt	complete
enables	GO:0061649	ubiquitin modification-dependent histone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	F	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	P	Seeded From UniProt	complete
involved_in	GO:0045830	positive regulation of isotype switching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	P	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	C	Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	F	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	P	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	C	Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	F	Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	F	Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	F	Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12888 ensembl:ENSP00000371475	C	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:8910340^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:8910340^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0995	C	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0149	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hartlerode, AJ et al. (2012) Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. PLoS ONE 7 e49211 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Chapman, JR et al. (2013) RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol. Cell 49 858-71 PubMed GONUTS page
↑ ^3.0 ^3.1 Bunting, SF et al. (2010) 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 141 243-54 PubMed GONUTS page
↑ Ward, IM et al. (2004) 53BP1 is required for class switch recombination. J. Cell Biol. 165 459-64 PubMed GONUTS page
↑ Manis, JP et al. (2004) 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat. Immunol. 5 481-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Mosammaparast, N et al. (2013) The histone demethylase LSD1/KDM1A promotes the DNA damage response. J. Cell Biol. 203 457-70 PubMed GONUTS page
↑ Pei, H et al. (2013) The histone methyltransferase MMSET regulates class switch recombination. J. Immunol. 190 756-63 PubMed GONUTS page
↑ He, H et al. (2006) POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J. 25 5180-90 PubMed GONUTS page
↑ Krishnan, V et al. (2011) Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 108 12325-30 PubMed GONUTS page
↑ Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page
↑ ^12.0 ^12.1 Sengupta, S et al. (2004) Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J. Cell Biol. 166 801-13 PubMed GONUTS page
↑ Park, E et al. (2013) Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice. Mol. Cell. Biol. 33 4360-70 PubMed GONUTS page
↑ Celeste, A et al. (2002) Genomic instability in mice lacking histone H2AX. Science 296 922-7 PubMed GONUTS page
↑ Adelman, CA et al. (2009) Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol. Cell. Biol. 29 483-92 PubMed GONUTS page
↑ Jullien, D et al. (2002) Kinetochore localisation of the DNA damage response component 53BP1 during mitosis. J. Cell. Sci. 115 71-9 PubMed GONUTS page
↑ ^17.0 ^17.1 Datta, B et al. (1996) p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition. J. Biol. Chem. 271 27544-55 PubMed GONUTS page

[PMID:23209566-1] 1.0 ^1.1 Hartlerode, AJ et al. (2012) Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. PLoS ONE 7 e49211 PubMed GONUTS page

[PMID:23333305-2] 2.0 ^2.1 ^2.2 Chapman, JR et al. (2013) RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol. Cell 49 858-71 PubMed GONUTS page

[PMID:20362325-3] 3.0 ^3.1 Bunting, SF et al. (2010) 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 141 243-54 PubMed GONUTS page

[PMID:15159415-4] Ward, IM et al. (2004) 53BP1 is required for class switch recombination. J. Cell Biol. 165 459-64 PubMed GONUTS page

[PMID:15077110-5] Manis, JP et al. (2004) 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat. Immunol. 5 481-7 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24217620-7] Mosammaparast, N et al. (2013) The histone demethylase LSD1/KDM1A promotes the DNA damage response. J. Cell Biol. 203 457-70 PubMed GONUTS page

[PMID:23241889-8] Pei, H et al. (2013) The histone methyltransferase MMSET regulates class switch recombination. J. Immunol. 190 756-63 PubMed GONUTS page

[PMID:17053789-9] He, H et al. (2006) POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J. 25 5180-90 PubMed GONUTS page

[PMID:21746928-10] Krishnan, V et al. (2011) Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 108 12325-30 PubMed GONUTS page

[PMID:17500065-11] Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page

[PMID:15364958-12] 12.0 ^12.1 Sengupta, S et al. (2004) Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J. Cell Biol. 166 801-13 PubMed GONUTS page

[PMID:24001775-13] Park, E et al. (2013) Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice. Mol. Cell. Biol. 33 4360-70 PubMed GONUTS page

[PMID:11934988-14] Celeste, A et al. (2002) Genomic instability in mice lacking histone H2AX. Science 296 922-7 PubMed GONUTS page

[PMID:19001091-15] Adelman, CA et al. (2009) Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol. Cell. Biol. 29 483-92 PubMed GONUTS page

[PMID:11801725-16] Jullien, D et al. (2002) Kinetochore localisation of the DNA damage response component 53BP1 during mitosis. J. Cell. Sci. 115 71-9 PubMed GONUTS page

[PMID:8910340-17] 17.0 ^17.1 Datta, B et al. (1996) p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition. J. Biol. Chem. 271 27544-55 PubMed GONUTS page

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MOUSE:TP53B

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