MOUSE:TIE2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tek (synonyms: Hyk, Tie-2, Tie2)
Protein Name(s)	Angiopoietin-1 receptor Endothelial tyrosine kinase HYK STK1 Tunica interna endothelial cell kinase Tyrosine kinase with Ig and EGF homology domains-2 Tyrosine-protein kinase receptor TEK Tyrosine-protein kinase receptor TIE-2 mTIE2 p140 TEK
External Links
UniProt	Q02858
EMBL	X71426 X67553 D13738 S67051
CCDS	CCDS71421.1
PIR	I54237 JH0771 JN0712
RefSeq	NP_001277478.1
UniGene	Mm.14313
ProteinModelPortal	Q02858
SMR	Q02858
DIP	DIP-6050N
IntAct	Q02858
MINT	MINT-4137861
BindingDB	Q02858
ChEMBL	CHEMBL5199
PhosphoSite	Q02858
PaxDb	Q02858
PRIDE	Q02858
Ensembl	ENSMUST00000071168
GeneID	21687
KEGG	mmu:21687
UCSC	uc008tsk.1
CTD	7010
MGI	MGI:98664
eggNOG	COG0515
GeneTree	ENSGT00770000120533
HOGENOM	HOG000049232
HOVERGEN	HBG007316
InParanoid	Q02858
KO	K05121
BRENDA	2.7.10.1
Reactome	REACT_211860
PRO	PR:Q02858
Proteomes	UP000000589
Bgee	Q02858
CleanEx	MM_TEK
ExpressionAtlas	Q02858
Genevestigator	Q02858
GO	GO:0005856 GO:0005576 GO:0005925 GO:0016021 GO:0005887 GO:0048471 GO:0005886 GO:0005524 GO:0004713 GO:0004872 GO:0004714 GO:0001525 GO:0007160 GO:0001935 GO:0007507 GO:0060347 GO:0030097 GO:0016525 GO:0043066 GO:2000352 GO:0001569 GO:0018108 GO:0045766 GO:0045785 GO:0002741 GO:0010595 GO:0070374 GO:0051894 GO:1902533 GO:0033138 GO:0043552 GO:0014068 GO:0042307 GO:0051897 GO:0001934 GO:0030949 GO:0046777 GO:0045765 GO:0030334 GO:0001936 GO:0032878 GO:1901222 GO:0032526 GO:0016337 GO:0002040 GO:0034446 GO:0048014 GO:0007169 GO:0001570
Gene3D	2.60.40.10
InterPro	IPR000742 IPR013032 IPR002049 IPR003961 IPR007110 IPR013783 IPR011009 IPR000719 IPR017441 IPR001245 IPR018941 IPR008266 IPR020635
Pfam	PF00041 PF10430 PF07714
PRINTS	PR00109
SMART	SM00181 SM00180 SM00060 SM00219
SUPFAM	SSF49265 SSF56112
PROSITE	PS00022 PS01186 PS50026 PS50853 PS50835 PS00107 PS50011 PS00109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
incorrect (CACAO)	GO:0035162	embryonic hemopoiesis	PMID:16219799^[1]	ECO:0000304			P	intro 'Tie2 is dispensable for embryonic hematopoiesis using ES cell mouse chimeras'	complete
incorrect (CACAO)	GO:0007507	heart development	PMID:16219799^[1]	ECO:0000304			P	intro 'Tie2-deficient mice exhibit severe defects in vascular and heart development and die by E9.5'	complete
NOT	GO:0060218	hemopoietic stem cell differentiation	PMID:16219799^[1]	ECO:0000315			P	Fig.3A-D; Fig.4G	complete
	GO:0060837	blood vessel endothelial cell differentiation	PMID:16219799^[1]	ECO:0000315			P	Fig.4	complete
	GO:0060836	lymphatic endothelial cell differentiation	PMID:16219799^[1]	ECO:0000315			P	Fig.4	complete
	GO:0006916	anti-apoptosis	PMID:16219799^[1]	ECO:0000315			P	Fig.5	complete
	GO:0010468	regulation of gene expression	PMID:16219799^[1]	ECO:0000315			P	Fig.1	complete
involved_in	GO:0032526	response to retinoic acid	PMID:18439490^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	PMID:11375937^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902533	positive regulation of intracellular signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0060347	heart trabecula formation	PMID:7958865^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0048014	Tie signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0032878	regulation of establishment or maintenance of cell polarity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:7958865^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:7958865^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:7958865^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0001935	endothelial cell proliferation	PMID:7958865^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	PMID:7958865^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:7596437^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814572 UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001562412 RGD:620980 UniProtKB:Q02763	P	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814572 UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814572 UniProtKB:Q02763	P	Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C	Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F	Seeded From UniProt	complete
involved_in	GO:0001935	endothelial cell proliferation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98664 PANTHER:PTN002814572	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98664 PANTHER:PTN001562412 UniProtKB:Q02763 ZFIN:ZDB-GENE-990415-56	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000251	positive regulation of actin cytoskeleton reorganization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902533	positive regulation of intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901222	regulation of NIK/NF-kappaB signaling	PMID:20060382^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108448	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098609	cell-cell adhesion	PMID:9683559^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2159358	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072012	glomerulus vasculature development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620980	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051259	protein complex oligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:20060382^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048014	Tie signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045785	positive regulation of cell adhesion	PMID:15260986^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620980	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045765	regulation of angiogenesis	PMID:9683559^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2159358	P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043627	response to estrogen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620980	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:19409199^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108448	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042307	positive regulation of protein import into nucleus	PMID:20060382^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:8980223^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O08538	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:19409199^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108448	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032878	regulation of establishment or maintenance of cell polarity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	PMID:9683559^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2159358	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	PMID:20060382^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030097	hemopoiesis	PMID:9846489^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2159357	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030097	hemopoiesis	PMID:15260986^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620980	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016525	negative regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:8415706^[13]	ECO:0000255	match to sequence model evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
acts_upstream_of_or_within	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	C	Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007160	cell-matrix adhesion	PMID:9683559^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2159358	P	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	C	Seeded From UniProt	complete
part_of	GO:0005902	microvillus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	C	Seeded From UniProt	complete
colocalizes_with	GO:0005884	actin filament	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	C	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002741	positive regulation of cytokine secretion involved in immune response	PMID:20060382^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002040	sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:20060382^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	P	Seeded From UniProt	complete
colocalizes_with	GO:0001725	stress fiber	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02763	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620980	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:9846489^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2159357	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F	Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018941	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441 InterPro:IPR018941	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018941	C	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR018941 InterPro:IPR020635	P	Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018941	P	Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F	Seeded From UniProt	complete
involved_in	GO:0048014	Tie signaling pathway	PMID:20299672^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:20406889^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:20406889^[15] PMID:20299672^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001936	regulation of endothelial cell proliferation	PMID:20406889^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	PMID:20299672^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:20299672^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-211119	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0118	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Hamaguchi, I et al. (2006) Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival. Blood 107 1207-13 PubMed GONUTS page
↑ Su, D & Gudas, LJ (2008) Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp. Hematol. 36 624-41 PubMed GONUTS page
↑ Jones, N et al. (2001) Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function. EMBO Rep. 2 438-45 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Dumont, DJ et al. (1994) Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev. 8 1897-909 PubMed GONUTS page
↑ Sato, TN et al. (1995) Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376 70-4 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gu, H et al. (2010) Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells. Biochem. Biophys. Res. Commun. 392 178-82 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Patan, S (1998) TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth. Microvasc. Res. 56 1-21 PubMed GONUTS page
↑ ^9.0 ^9.1 Arai, F et al. (2004) Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118 149-61 PubMed GONUTS page
↑ ^10.0 ^10.1 Bai, Y et al. (2009) An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation. Neuroscience 160 371-81 PubMed GONUTS page
↑ Davis, S et al. (1996) Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87 1161-9 PubMed GONUTS page
↑ ^12.0 ^12.1 Takakura, N et al. (1998) Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Immunity 9 677-86 PubMed GONUTS page
↑ Sato, TN et al. (1993) Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc. Natl. Acad. Sci. U.S.A. 90 9355-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Suzuki, Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J. Cell. Sci. 123 1684-92 PubMed GONUTS page

[PMID:16219799-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Hamaguchi, I et al. (2006) Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival. Blood 107 1207-13 PubMed GONUTS page

[PMID:18439490-2] Su, D & Gudas, LJ (2008) Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp. Hematol. 36 624-41 PubMed GONUTS page

[PMID:11375937-3] Jones, N et al. (2001) Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function. EMBO Rep. 2 438-45 PubMed GONUTS page

[PMID:7958865-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Dumont, DJ et al. (1994) Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev. 8 1897-909 PubMed GONUTS page

[PMID:7596437-5] Sato, TN et al. (1995) Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376 70-4 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20060382-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gu, H et al. (2010) Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells. Biochem. Biophys. Res. Commun. 392 178-82 PubMed GONUTS page

[PMID:9683559-8] 8.0 ^8.1 ^8.2 ^8.3 Patan, S (1998) TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth. Microvasc. Res. 56 1-21 PubMed GONUTS page

[PMID:15260986-9] 9.0 ^9.1 Arai, F et al. (2004) Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118 149-61 PubMed GONUTS page

[PMID:19409199-10] 10.0 ^10.1 Bai, Y et al. (2009) An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation. Neuroscience 160 371-81 PubMed GONUTS page

[PMID:8980223-11] Davis, S et al. (1996) Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87 1161-9 PubMed GONUTS page

[PMID:9846489-12] 12.0 ^12.1 Takakura, N et al. (1998) Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Immunity 9 677-86 PubMed GONUTS page

[PMID:8415706-13] Sato, TN et al. (1993) Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc. Natl. Acad. Sci. U.S.A. 90 9355-8 PubMed GONUTS page

[PMID:20299672-14] 14.0 ^14.1 ^14.2 ^14.3 Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page

[PMID:20406889-15] 15.0 ^15.1 ^15.2 Suzuki, Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J. Cell. Sci. 123 1684-92 PubMed GONUTS page

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