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PMID:7596437

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Citation

Sato, TN, Tozawa, Y, Deutsch, U, Wolburg-Buchholz, K, Fujiwara, Y, Gendron-Maguire, M, Gridley, T, Wolburg, H, Risau, W and Qin, Y (1995) Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376:70-4

Abstract

Tie-1 and Tie-2 define a new class of receptor tyrosine kinases that are specifically expressed in developing vascular endothelial cells. To study the functions of Tie-1 and Tie-2 during vascular endothelial cell growth and differentiation in vivo, targeted mutations of the genes in mice were introduced by homologous recombination. Embryos deficient in Tie-1 failed to establish structural integrity of vascular endothelial cells, resulting in oedema and subsequently localized haemorrhage. However, analyses of embryos deficient in Tie-2 showed that it is important in angiogenesis, particularly for vascular network formation in endothelial cells. This result contrasts with previous reports on Tie-2 function in vasculogenesis and/or endothelial cell survival. Our in vivo analyses indicate that the structurally related receptor tyrosine kinases Tie-1 and Tie-2 have important but distinct roles in the formation of blood vessels.

Links

PubMed Online version:10.1038/376070a0

Keywords

Animals; Base Sequence; Blood Vessels/embryology; Blood Vessels/growth & development; Cell Differentiation/physiology; Cell Division/physiology; Cell Line; DNA Primers; Edema/embryology; Endothelium, Vascular/cytology; Endothelium, Vascular/embryology; Hemorrhage/embryology; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutagenesis; Phenotype; Receptor Protein-Tyrosine Kinases/genetics; Receptor Protein-Tyrosine Kinases/physiology; Receptor, TIE-1; Receptor, TIE-2; Receptors, TIE

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:TIE1

involved_in

GO:0007498: mesoderm development

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:TIE2

involved_in

GO:0001525: angiogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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