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MOUSE:THOC5

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Thoc5 (synonyms: Fmip, Kiaa0983)
Protein Name(s) THO complex subunit 5 homolog

Fms-interacting protein

External Links
UniProt Q8BKT7
EMBL AK050734
BC039758
AK173078
CCDS CCDS24393.1
RefSeq NP_766026.1
UniGene Mm.28969
Mm.446885
BioGrid 223611
IntAct Q8BKT7
MINT MINT-4111331
PhosphoSite Q8BKT7
MaxQB Q8BKT7
PaxDb Q8BKT7
PRIDE Q8BKT7
Ensembl ENSMUST00000038237
GeneID 107829
KEGG mmu:107829
UCSC uc007hvl.1
CTD 8563
MGI MGI:1351333
eggNOG NOG266546
GeneTree ENSGT00390000013777
HOGENOM HOG000007514
HOVERGEN HBG051271
InParanoid Q8BKT7
KO K13174
PhylomeDB Q8BKT7
TreeFam TF314812
NextBio 359543
PRO PR:Q8BKT7
Proteomes UP000000589
Bgee Q8BKT7
CleanEx MM_THOC5
ExpressionAtlas Q8BKT7
Genevestigator Q8BKT7
GO GO:0005737
GO:0016607
GO:0005634
GO:0000445
GO:0003729
GO:0001824
GO:0000902
GO:0030224
GO:0006397
GO:2000002
GO:0045650
GO:0032786
GO:0060215
GO:0010468
GO:0010793
GO:2000035
GO:0008380
GO:0017145
GO:0046784
InterPro IPR019163
Pfam PF09766

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005634

nucleus

PMID:15221008[1]

ECO:0000315

C

Figure 2

complete
CACAO 9013

part_of

GO:0005634

nucleus

PMID:15221008[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:2000002

negative regulation of DNA damage checkpoint

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q13769

P

Seeded From UniProt

complete

involved_in

GO:0060215

primitive hemopoiesis

PMID:20051105[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032786

positive regulation of DNA-templated transcription, elongation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q13769

P

Seeded From UniProt

complete

involved_in

GO:0030224

monocyte differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q13769

P

Seeded From UniProt

complete

involved_in

GO:0032786

positive regulation of DNA-templated transcription, elongation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000332618
UniProtKB:Q13769

P

Seeded From UniProt

complete

involved_in

GO:0006406

mRNA export from nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000332618
UniProtKB:Q13769

P

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1351333
PANTHER:PTN000332618

F

Seeded From UniProt

complete

part_of

GO:0000445

THO complex part of transcription export complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000332618
UniProtKB:Q13769

C

Seeded From UniProt

complete

part_of

GO:0000228

nuclear chromosome

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0034939
PANTHER:PTN000332618

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000035

regulation of stem cell division

PMID:24315442[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000002

negative regulation of DNA damage checkpoint

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13769

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046784

viral mRNA export from host cell nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13769

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045650

negative regulation of macrophage differentiation

PMID:10597251[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032786

positive regulation of DNA-templated transcription, elongation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13769

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030224

monocyte differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13769

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0017145

stem cell division

PMID:24315442[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010793

regulation of mRNA export from nucleus

PMID:24315442[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:24315442[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006406

mRNA export from nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13769

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13769

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24315442[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13769

C

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

PMID:24315442[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001824

blastocyst development

PMID:24315442[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000902

cell morphogenesis

PMID:24315442[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0000784

nuclear chromosome, telomeric region

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13769

C

Seeded From UniProt

complete

part_of

GO:0000445

THO complex part of transcription export complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13769

C

Seeded From UniProt

complete

part_of

GO:0000347

THO complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13769

C

Seeded From UniProt

complete

part_of

GO:0000346

transcription export complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13769

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

involved_in

GO:0051028

mRNA transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0509

P

Seeded From UniProt

complete

involved_in

GO:0008380

RNA splicing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0508

P

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Mancini, A et al. (2004) The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation. Oncogene 23 6581-9 PubMed GONUTS page
  2. ↑ Mancini, A et al. (2010) THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biol. 8 1 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Wang, L et al. (2013) The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Cell Stem Cell 13 676-90 PubMed GONUTS page
  5. ↑ Tamura, T et al. (1999) FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation. Oncogene 18 6488-95 PubMed GONUTS page
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