MOUSE:TFAM

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tfam (synonyms: Hmgts)
Protein Name(s)	Transcription factor A, mitochondrial mtTFA Testis-specific high mobility group protein TS-HMG
External Links
UniProt	P40630
EMBL	U57939 U63858 BC001987 BC083084 AK004857 AK050446 AK167348 AK167777 AK169808 U63712 L07107
CCDS	CCDS23916.1
PIR	I49745
RefSeq	NP_033386.1
UniGene	Mm.229292
ProteinModelPortal	P40630
SMR	P40630
BioGrid	204137
IntAct	P40630
MINT	MINT-1861500
STRING	10090.ENSMUSP00000090086
iPTMnet	P40630
PhosphoSitePlus	P40630
MaxQB	P40630
PaxDb	P40630
PeptideAtlas	P40630
PRIDE	P40630
Ensembl	ENSMUST00000092430 ENSMUST00000105432
GeneID	21780
KEGG	mmu:21780
UCSC	uc007fol.1 uc007fom.1
CTD	7019
MGI	MGI:107810
eggNOG	KOG0381 COG5648
GeneTree	ENSGT00440000039001
HOGENOM	HOG000139423
HOVERGEN	HBG106674
InParanoid	P40630
KO	K11830
OMA	SEKEVYM
OrthoDB	EOG091G0SA8
PhylomeDB	P40630
TreeFam	TF318343
Reactome	[www.reactome.org/content/detail/R-MMU-163282 R-MMU-163282] [www.reactome.org/content/detail/R-MMU-2151201 R-MMU-2151201]
ChiTaRS	Tfam
PRO	PR:P40630
Proteomes	UP000000589
Bgee	ENSMUSG00000003923
CleanEx	MM_TFAM
ExpressionAtlas	P40630
Genevisible	P40630
GO	GO:0042645 GO:0005739 GO:0005634 GO:0005667 GO:0003682 GO:0008301 GO:0070363 GO:0003723 GO:0000978 GO:0003700 GO:0033108 GO:0045944 GO:0045893 GO:0006390 GO:0006391
Gene3D	1.10.30.10
InterPro	IPR009071
Pfam	PF00505 PF09011
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005759	mitochondrial matrix	PMID:21245132^[1]	ECO:0000314			C		As seen on figure 6, Tfam is localized to the mitochondrial matrix. Transcription factor A, mitochondrial Mouse	complete CACAO 12797
enables	GO:0001018	mitochondrial promoter sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00059	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00059	P		Seeded From UniProt	complete
part_of	GO:0042645	mitochondrial nucleoid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00059	C		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00059	F		Seeded From UniProt	complete
involved_in	GO:0006391	transcription initiation from mitochondrial promoter	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00059	P		Seeded From UniProt	complete
involved_in	GO:0006390	mitochondrial transcription	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00059	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00059	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00059	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00059	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00059	F		Seeded From UniProt	complete
part_of	GO:0042645	mitochondrial nucleoid	PMID:24703694^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042645	mitochondrial nucleoid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00059	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033108	mitochondrial respiratory chain complex assembly	PMID:11259653^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860962,MGI:MGI:2177173	P	occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00059	C		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620682	F		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00059	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006391	transcription initiation from mitochondrial promoter	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00059	P		Seeded From UniProt	complete
involved_in	GO:0006390	mitochondrial transcription	PMID:2628167^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006390	mitochondrial transcription	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00059	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006390	mitochondrial transcription	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620682	P		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00059	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)\|part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:8673128^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:2628167^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00059	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620682	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00059	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620682	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00059	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620682	F		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620682	F		Seeded From UniProt	complete
enables	GO:0001018	mitochondrial promoter sequence-specific DNA binding	PMID:2628167^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0005739) occurs_in:(UBERON:0000061) part_of:(GO:0006390) part_of:(GO:0034246)	Seeded From UniProt	complete
enables	GO:0001018	mitochondrial promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00059	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E5KSU5 ensembl:ENSP00000420588	C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00059 ensembl:ENSP00000420588	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00059 ensembl:ENSP00000420588	F		Seeded From UniProt	complete
part_of	GO:0042645	mitochondrial nucleoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00059 ensembl:ENSP00000420588	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00059 ensembl:ENSP00000420588	C		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00059 ensembl:ENSP00000420588	F		Seeded From UniProt	complete
involved_in	GO:0006391	transcription initiation from mitochondrial promoter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00059 ensembl:ENSP00000420588	P		Seeded From UniProt	complete
involved_in	GO:0006390	mitochondrial transcription	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00059 ensembl:ENSP00000420588	P		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00059 ensembl:ENSP00000420588	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00059 ensembl:ENSP00000420588	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00059 ensembl:ENSP00000420588	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00059 ensembl:ENSP00000420588	F		Seeded From UniProt	complete
enables	GO:0001018	mitochondrial promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00059 ensembl:ENSP00000420588	F		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZW1 ensembl:ENSRNOP00000000753	F		Seeded From UniProt	complete
involved_in	GO:0006390	mitochondrial transcription	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZW1 ensembl:ENSRNOP00000000753	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZW1 ensembl:ENSRNOP00000000753	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZW1 ensembl:ENSRNOP00000000753	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZW1 ensembl:ENSRNOP00000000753	F		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZW1 ensembl:ENSRNOP00000000753	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0042645	mitochondrial nucleoid	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1135 UniProtKB-SubCell:SL-0269	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Safdar, A et al. (2011) Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis. J. Biol. Chem. 286 10605-17 PubMed GONUTS page
↑ Bogenhagen, DF et al. (2014) Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids. Cell Metab. 19 618-29 PubMed GONUTS page
↑ Wang, J et al. (2001) Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression. Proc. Natl. Acad. Sci. U.S.A. 98 4038-43 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Fisher, RP et al. (1989) Flexible recognition of rapidly evolving promoter sequences by mitochondrial transcription factor 1. Genes Dev. 3 2202-17 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
↑ Larsson, NG et al. (1996) A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein. Nat. Genet. 13 296-302 PubMed GONUTS page

[PMID:21245132-1] Safdar, A et al. (2011) Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis. J. Biol. Chem. 286 10605-17 PubMed GONUTS page

[PMID:24703694-2] Bogenhagen, DF et al. (2014) Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids. Cell Metab. 19 618-29 PubMed GONUTS page

[PMID:11259653-3] Wang, J et al. (2001) Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression. Proc. Natl. Acad. Sci. U.S.A. 98 4038-43 PubMed GONUTS page

[PMID:2628167-4] 4.0 ^4.1 ^4.2 Fisher, RP et al. (1989) Flexible recognition of rapidly evolving promoter sequences by mitochondrial transcription factor 1. Genes Dev. 3 2202-17 PubMed GONUTS page

[PMID:18614015-5] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:14651853-6] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:8673128-7] Larsson, NG et al. (1996) A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein. Nat. Genet. 13 296-302 PubMed GONUTS page

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MOUSE:TFAM

Contents

Annotations

Notes

References

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