PMID:8673128

Citation	Larsson, NG, Garman, JD, Oldfors, A, Barsh, GS and Clayton, DA (1996) A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein. Nat. Genet. 13:296-302
Abstract	Mitochondrial transcription factor A (mtTFA) is a key regulator of mammalian mitochondrial DNA transcription. We report here that a testis-specific isoform of mouse mtTFA lacks the mitochondrial targeting sequence and is present in the nucleus of spermatocytes and elongating spermatids, thus representing the first reported mammalian gene encoding protein isoforms targeted for the mitochondria or the nucleus. The presence of the mitochondrial transcriptional activator in the nucleus raises the possibility of a role for this protein in both genetic systems. Mutations in the nuclear mtTFA gene may therefore exhibit phenotypic consequences due to altered function in either or both genetic compartments.
Links	PubMed Online version:10.1038/ng0796-296
Keywords	Amino Acid Sequence; Animals; Base Sequence; Cell Nucleus/chemistry; Cell Nucleus/genetics; Cloning, Molecular; DNA-Binding Proteins/biosynthesis; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/genetics; High Mobility Group Proteins/genetics; Male; Mice; Mice, Inbred Strains; Mitochondria/chemistry; Mitochondrial Proteins; Molecular Sequence Data; Nuclear Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Spermatocytes/chemistry; Testis/chemistry; Testis/metabolism; Transcription Factors/biosynthesis; Transcription Factors/chemistry; Transcription Factors/genetics; Transcription, Genetic
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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