MOUSE:TBX2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tbx2
Protein Name(s)	T-box transcription factor TBX2 T-box protein 2
External Links
UniProt	Q60707
EMBL	U15566 AF244917 AL596324 AL662910 AL662910 AL596324 CH466556 BC156393
CCDS	CCDS36266.1
PIR	S46458
RefSeq	NP_033350.2
UniGene	Mm.287052
ProteinModelPortal	Q60707
SMR	Q60707
STRING	10090.ENSMUSP00000000095
PhosphoSite	Q60707
MaxQB	Q60707
PRIDE	Q60707
DNASU	21385
Ensembl	ENSMUST00000000095
GeneID	21385
KEGG	mmu:21385
UCSC	uc007ksb.1
CTD	6909
MGI	MGI:98494
eggNOG	NOG240293
GeneTree	ENSGT00760000118897
HOGENOM	HOG000038046
HOVERGEN	HBG000412
InParanoid	Q60707
KO	K10176
OMA	SPAPEHH
OrthoDB	EOG7W9RV1
TreeFam	TF106341
NextBio	300620
PRO	PR:Q60707
Proteomes	UP000000589
Bgee	Q60707
CleanEx	MM_TBX2
ExpressionAtlas	Q60707
Genevestigator	Q60707
GO	GO:0005634 GO:0005667 GO:0003677 GO:0043565 GO:0003700 GO:0035909 GO:0036302 GO:0048738 GO:0007569 GO:0090398 GO:0060560 GO:0048596 GO:0042733 GO:0003203 GO:0003007 GO:0060596 GO:0007521 GO:1901211 GO:1901208 GO:0000122 GO:0045892 GO:0003151 GO:0003148 GO:0060021 GO:0060465 GO:0060045 GO:0003256 GO:0006351
Gene3D	2.60.40.820
InterPro	IPR008967 IPR022582 IPR002070 IPR001699 IPR018186
PANTHER	PTHR11267
Pfam	PF00907 PF12598
PRINTS	PR00938 PR00937
SMART	SM00425
SUPFAM	SSF49417
PROSITE	PS01283 PS01264 PS50252

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1901211	negative regulation of cardiac chamber formation	PMID:15042700^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901208	negative regulation of heart looping	PMID:15042700^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060465	pharynx development	PMID:15459098^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	PMID:15042700^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048596	embryonic camera-type eye morphogenesis	PMID:15459098^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	PMID:15459098^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	PMID:15459098^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035909	aorta morphogenesis	PMID:15459098^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003256	regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation	PMID:15459098^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P05125)\|has_input:(UniProtKB:Q01231)	Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	PMID:15459098^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	PMID:15042700^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	PMID:15459098^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	PMID:15459098^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7ZTU9	P		Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7ZTU9	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7ZTU9	P		Seeded From UniProt	complete
involved_in	GO:0090398	cellular senescence	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13207	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090398	cellular senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13207	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060596	mammary placode formation	PMID:16222716^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98495	P	results_in_formation_of:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060560	developmental growth involved in morphogenesis	PMID:19769959^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4415614	P	occurs_in:(EMAPA:17932)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060021	roof of mouth development	PMID:19769959^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98495	P	results_in_development_of:(EMAPA:18948)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060021	roof of mouth development	PMID:19769959^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4415614	P	results_in_development_of:(EMAPA:17932)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048738	cardiac muscle tissue development	PMID:15459098^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3505715	P	results_in_development_of:(EMAPA:16546)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:15843407^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:11748239^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13207	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13207	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13207	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007569	cell aging	PMID:11748239^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007569	cell aging	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13207	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007521	muscle cell fate determination	PMID:15459098^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3505715	P	occurs_in:(EMAPA:16546)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	PMID:23117660^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:12023302^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15042700^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13207	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15843407^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15843407^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003007	heart morphogenesis	PMID:15459098^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3505715	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13207	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13207	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18285513^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97168 MGI:MGI:97169	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15042700^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12023302^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13207	P		Seeded From UniProt	complete
involved_in	GO:0090398	cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13207 ensembl:ENSP00000240328	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13207 ensembl:ENSP00000240328	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13207 ensembl:ENSP00000240328	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13207 ensembl:ENSP00000240328	P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13207 ensembl:ENSP00000240328	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13207 ensembl:ENSP00000240328	C		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13207 ensembl:ENSP00000240328	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13207 ensembl:ENSP00000240328	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13207 ensembl:ENSP00000240328	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001699 InterPro:IPR002070 InterPro:IPR008967 InterPro:IPR018186 InterPro:IPR036960	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001699 InterPro:IPR002070 InterPro:IPR018186 InterPro:IPR036960	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001699 InterPro:IPR002070 InterPro:IPR008967 InterPro:IPR018186 InterPro:IPR036960	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Christoffels, VM et al. (2004) T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev. Dyn. 229 763-70 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Harrelson, Z et al. (2004) Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development 131 5041-52 PubMed GONUTS page
↑ Jerome-Majewska, LA et al. (2005) Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway. Dev. Dyn. 234 922-33 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Zirzow, S et al. (2009) Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Dev. Biol. 336 145-55 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Cai, CL et al. (2005) T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development 132 2475-87 PubMed GONUTS page
↑ ^6.0 ^6.1 Brummelkamp, TR et al. (2002) TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. J. Biol. Chem. 277 6567-72 PubMed GONUTS page
↑ Fouillade, C et al. (2013) Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler. Thromb. Vasc. Biol. 33 76-86 PubMed GONUTS page
↑ ^8.0 ^8.1 Habets, PE et al. (2002) Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev. 16 1234-46 PubMed GONUTS page
↑ Boogerd, KJ et al. (2008) Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43. Cardiovasc. Res. 78 485-93 PubMed GONUTS page

[PMID:15042700-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Christoffels, VM et al. (2004) T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev. Dyn. 229 763-70 PubMed GONUTS page

[PMID:15459098-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Harrelson, Z et al. (2004) Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development 131 5041-52 PubMed GONUTS page

[PMID:16222716-3] Jerome-Majewska, LA et al. (2005) Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway. Dev. Dyn. 234 922-33 PubMed GONUTS page

[PMID:19769959-4] 4.0 ^4.1 ^4.2 Zirzow, S et al. (2009) Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Dev. Biol. 336 145-55 PubMed GONUTS page

[PMID:15843407-5] 5.0 ^5.1 ^5.2 Cai, CL et al. (2005) T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development 132 2475-87 PubMed GONUTS page

[PMID:11748239-6] 6.0 ^6.1 Brummelkamp, TR et al. (2002) TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. J. Biol. Chem. 277 6567-72 PubMed GONUTS page

[PMID:23117660-7] Fouillade, C et al. (2013) Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler. Thromb. Vasc. Biol. 33 76-86 PubMed GONUTS page

[PMID:12023302-8] 8.0 ^8.1 Habets, PE et al. (2002) Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev. 16 1234-46 PubMed GONUTS page

[PMID:18285513-9] Boogerd, KJ et al. (2008) Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43. Cardiovasc. Res. 78 485-93 PubMed GONUTS page

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MOUSE:TBX2

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