MOUSE:SULF1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sulf1 (synonyms: Kiaa1077)
Protein Name(s)	Extracellular sulfatase Sulf-1 mSulf-1
External Links
UniProt	Q8K007
EMBL	AY101178 AK129278 AK028285 AK045002 BC034547 BC049276
CCDS	CCDS14820.1
RefSeq	NP_001185494.1 NP_001185495.1 NP_758498.1
UniGene	Mm.45563
ProteinModelPortal	Q8K007
SMR	Q8K007
PhosphoSite	Q8K007
MaxQB	Q8K007
PaxDb	Q8K007
PRIDE	Q8K007
Ensembl	ENSMUST00000088585 ENSMUST00000177608 ENSMUST00000180062 ENSMUST00000186051
GeneID	240725
KEGG	mmu:240725
UCSC	uc007aia.2
CTD	23213
MGI	MGI:2138563
eggNOG	COG3119
GeneTree	ENSGT00400000022041
HOGENOM	HOG000290161
HOVERGEN	HBG056431
InParanoid	Q8K007
KO	K14607
OMA	HCEREIY
OrthoDB	EOG7FR7H6
PhylomeDB	Q8K007
TreeFam	TF313545
NextBio	384701
PRO	PR:Q8K007
Proteomes	UP000000589
Bgee	Q8K007
CleanEx	MM_SULF1
Genevestigator	Q8K007
GO	GO:0009986 GO:0005783 GO:0005615 GO:0005794 GO:0005795 GO:0045121 GO:0005886 GO:0004065 GO:0005509 GO:0008449 GO:0006915 GO:0060348 GO:0001502 GO:0051216 GO:0007155 GO:0002063 GO:0048706 GO:0014846 GO:0035860 GO:0032836 GO:0003094 GO:0030201 GO:0060384 GO:0001822 GO:0036022 GO:0016525 GO:0030336 GO:0001937 GO:0040037 GO:0060686 GO:0030513 GO:0048661 GO:0030177 GO:0010575 GO:0006790 GO:0048010
Gene3D	3.40.720.10
InterPro	IPR017849 IPR017850 IPR014615 IPR024609 IPR000917 IPR024607
Pfam	PF12548 PF00884
PIRSF	PIRSF036665
SUPFAM	SSF53649
PROSITE	PS00523

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060348	bone development	17593974	ECO:0000315			P		Fig 4: Embryos deficient for both Sulf1 and Sulf2 had distinct bone development defects, such as sternabrae asymmetry/fusion. Table 1 shows that mice deficient for either Sulf1 or Sulf2 alone were viable, fertile and normal so the genes are redundant/overlap in function.	Missing: reference
	GO:0008543	fibroblast growth factor receptor signaling pathway	17593974	ECO:0000315			P		Fig 5: sulfatase-deficient mouse embryonic fibroblasts were hypersensitive to both FGF1 and FGF2, demonstrating sulfatases are involved with modulation of FGF signalling.	Missing: reference
	GO:0072001	renal system development	17593974	ECO:0000315			P		Fig 3: Embryos deficient for both Sulf1 and Sulf2 had kidney hypoplasia. Table 1 shows that mice deficient for either Sulf1 or Sulf2 alone were viable, fertile and normal so the genes are redundant/overlap in function.	Missing: reference
involved_in	GO:0060348	bone development	PMID:17593974^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8CFG0	P		Seeded From UniProt	complete
involved_in	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	PMID:17593974^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8CFG0	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:17593974^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8CFG0	P		Seeded From UniProt	complete
involved_in	GO:0060686	negative regulation of prostatic bud formation	PMID:20410206^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060384	innervation	PMID:17720696^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8CFG0	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	PMID:20479257^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048706	embryonic skeletal system development	PMID:18213582^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8CFG0	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q90XB6	P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IWU6	C		Seeded From UniProt	complete
involved_in	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	PMID:21719793^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8CFG0	P	occurs_in:(CL:0000653)	Seeded From UniProt	complete
involved_in	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	PMID:20410206^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036022	limb joint morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q90XB6	P		Seeded From UniProt	complete
involved_in	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	PMID:17720696^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032836	glomerular basement membrane development	PMID:21719793^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8CFG0	P		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
involved_in	GO:0030201	heparan sulfate proteoglycan metabolic process	PMID:18687675^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
involved_in	GO:0014846	esophagus smooth muscle contraction	PMID:17720696^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8CFG0	P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:21719793^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8CFG0	P	occurs_in:(CL:0000653)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IWU6	C		Seeded From UniProt	complete
enables	GO:0008449	N-acetylglucosamine-6-sulfatase activity	PMID:18687675^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q90XB6	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21719793^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000653)	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8VI60	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IWU6	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IWU6	C		Seeded From UniProt	complete
enables	GO:0004065	arylsulfatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IWU6	F		Seeded From UniProt	complete
involved_in	GO:0003094	glomerular filtration	PMID:21719793^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8CFG0	P		Seeded From UniProt	complete
involved_in	GO:0002063	chondrocyte development	PMID:20479257^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
involved_in	GO:0001502	cartilage condensation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q90XB6	P		Seeded From UniProt	complete
involved_in	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919293 MGI:MGI:2138563 PANTHER:PTN001308943 UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
involved_in	GO:0032836	glomerular basement membrane development	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919293 MGI:MGI:2138563 PANTHER:PTN001308943	P		Seeded From UniProt	complete
involved_in	GO:0030201	heparan sulfate proteoglycan metabolic process	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919293 MGI:MGI:2138563 PANTHER:PTN001308943 UniProtKB:Q8IWU5 UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919293 PANTHER:PTN001308943 UniProtKB:Q8IWU5 UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919293 MGI:MGI:2138563 PANTHER:PTN001308943	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000038172 RGD:708554 UniProtKB:Q8IWU5 UniProtKB:Q8IWU6	C		Seeded From UniProt	complete
enables	GO:0008449	N-acetylglucosamine-6-sulfatase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919293 MGI:MGI:2138563 PANTHER:PTN000038170 RGD:1305877 UniProtKB:Q8IWU5 UniProtKB:Q8IWU6 UniProtKB:Q9VEX0	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919293 MGI:MGI:2138563 PANTHER:PTN000038172	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000038172 RGD:708554 UniProtKB:Q8IWU5 UniProtKB:Q8IWU6	C		Seeded From UniProt	complete
enables	GO:0005539	glycosaminoglycan binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000038170 RGD:1305877	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030336	negative regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030201	heparan sulfate proteoglycan metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016525	negative regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708554	C		Seeded From UniProt	complete
enables	GO:0008449	N-acetylglucosamine-6-sulfatase activity	PMID:12368295^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	EMBL:AY101175	F		Seeded From UniProt	complete
enables	GO:0008449	N-acetylglucosamine-6-sulfatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006790	sulfur compound metabolic process	PMID:12368295^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	EMBL:AY101175	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708554	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708554	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12368295^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	EMBL:AY101175	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	C		Seeded From UniProt	complete
enables	GO:0004065	arylsulfatase activity	PMID:12368295^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	EMBL:AY101175	F		Seeded From UniProt	complete
enables	GO:0004065	arylsulfatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IWU6	P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	C		Seeded From UniProt	complete
involved_in	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	P		Seeded From UniProt	complete
involved_in	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	P		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	P		Seeded From UniProt	complete
involved_in	GO:0030201	heparan sulfate proteoglycan metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	P		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	C		Seeded From UniProt	complete
enables	GO:0008449	N-acetylglucosamine-6-sulfatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	C		Seeded From UniProt	complete
enables	GO:0004065	arylsulfatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	F		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IWU6 ensembl:ENSP00000260128	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017849 InterPro:IPR017850	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014615	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014615	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014615	C		Seeded From UniProt	complete
enables	GO:0008484	sulfuric ester hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000917 InterPro:IPR014615	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014615	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C		Seeded From UniProt	complete
part_of	GO:0005795	Golgi stack	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0135	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Holst, CR et al. (2007) Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival. PLoS ONE 2 e575 PubMed GONUTS page
↑ ^2.0 ^2.1 Buresh, RA et al. (2010) Sulfatase 1 is an inhibitor of ductal morphogenesis with sexually dimorphic expression in the urogenital sinus. Endocrinology 151 3420-31 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Ai, X et al. (2007) SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development 134 3327-38 PubMed GONUTS page
↑ ^4.0 ^4.1 Otsuki, S et al. (2010) Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 107 10202-7 PubMed GONUTS page
↑ Ratzka, A et al. (2008) Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development. Dev. Dyn. 237 339-53 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Schumacher, VA et al. (2011) WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J. Am. Soc. Nephrol. 22 1286-96 PubMed GONUTS page
↑ ^7.0 ^7.1 Lamanna, WC et al. (2008) Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling. J. Biol. Chem. 283 27724-35 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Morimoto-Tomita, M et al. (2002) Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J. Biol. Chem. 277 49175-85 PubMed GONUTS page

[PMID:17593974-1] 1.0 ^1.1 ^1.2 Holst, CR et al. (2007) Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival. PLoS ONE 2 e575 PubMed GONUTS page

[PMID:20410206-2] 2.0 ^2.1 Buresh, RA et al. (2010) Sulfatase 1 is an inhibitor of ductal morphogenesis with sexually dimorphic expression in the urogenital sinus. Endocrinology 151 3420-31 PubMed GONUTS page

[PMID:17720696-3] 3.0 ^3.1 ^3.2 Ai, X et al. (2007) SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development 134 3327-38 PubMed GONUTS page

[PMID:20479257-4] 4.0 ^4.1 Otsuki, S et al. (2010) Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 107 10202-7 PubMed GONUTS page

[PMID:18213582-5] Ratzka, A et al. (2008) Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development. Dev. Dyn. 237 339-53 PubMed GONUTS page

[PMID:21719793-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Schumacher, VA et al. (2011) WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J. Am. Soc. Nephrol. 22 1286-96 PubMed GONUTS page

[PMID:18687675-7] 7.0 ^7.1 Lamanna, WC et al. (2008) Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling. J. Biol. Chem. 283 27724-35 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12368295-9] 9.0 ^9.1 ^9.2 ^9.3 Morimoto-Tomita, M et al. (2002) Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J. Biol. Chem. 277 49175-85 PubMed GONUTS page

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