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MOUSE:SULF1
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Sulf1 (synonyms: Kiaa1077) | |
Protein Name(s) | Extracellular sulfatase Sulf-1
mSulf-1 | |
External Links | ||
UniProt | Q8K007 | |
EMBL | AY101178 AK129278 AK028285 AK045002 BC034547 BC049276 | |
CCDS | CCDS14820.1 | |
RefSeq | NP_001185494.1 NP_001185495.1 NP_758498.1 | |
UniGene | Mm.45563 | |
ProteinModelPortal | Q8K007 | |
SMR | Q8K007 | |
PhosphoSite | Q8K007 | |
MaxQB | Q8K007 | |
PaxDb | Q8K007 | |
PRIDE | Q8K007 | |
Ensembl | ENSMUST00000088585 ENSMUST00000177608 ENSMUST00000180062 ENSMUST00000186051 | |
GeneID | 240725 | |
KEGG | mmu:240725 | |
UCSC | uc007aia.2 | |
CTD | 23213 | |
MGI | MGI:2138563 | |
eggNOG | COG3119 | |
GeneTree | ENSGT00400000022041 | |
HOGENOM | HOG000290161 | |
HOVERGEN | HBG056431 | |
InParanoid | Q8K007 | |
KO | K14607 | |
OMA | HCEREIY | |
OrthoDB | EOG7FR7H6 | |
PhylomeDB | Q8K007 | |
TreeFam | TF313545 | |
NextBio | 384701 | |
PRO | PR:Q8K007 | |
Proteomes | UP000000589 | |
Bgee | Q8K007 | |
CleanEx | MM_SULF1 | |
Genevestigator | Q8K007 | |
GO | GO:0009986 GO:0005783 GO:0005615 GO:0005794 GO:0005795 GO:0045121 GO:0005886 GO:0004065 GO:0005509 GO:0008449 GO:0006915 GO:0060348 GO:0001502 GO:0051216 GO:0007155 GO:0002063 GO:0048706 GO:0014846 GO:0035860 GO:0032836 GO:0003094 GO:0030201 GO:0060384 GO:0001822 GO:0036022 GO:0016525 GO:0030336 GO:0001937 GO:0040037 GO:0060686 GO:0030513 GO:0048661 GO:0030177 GO:0010575 GO:0006790 GO:0048010 | |
Gene3D | 3.40.720.10 | |
InterPro | IPR017849 IPR017850 IPR014615 IPR024609 IPR000917 IPR024607 | |
Pfam | PF12548 PF00884 | |
PIRSF | PIRSF036665 | |
SUPFAM | SSF53649 | |
PROSITE | PS00523 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0060348 |
bone development |
17593974 |
ECO:0000315 |
P |
Fig 4: Embryos deficient for both Sulf1 and Sulf2 had distinct bone development defects, such as sternabrae asymmetry/fusion. Table 1 shows that mice deficient for either Sulf1 or Sulf2 alone were viable, fertile and normal so the genes are redundant/overlap in function. |
Missing: reference | ||||
GO:0008543 |
fibroblast growth factor receptor signaling pathway |
17593974 |
ECO:0000315 |
P |
Fig 5: sulfatase-deficient mouse embryonic fibroblasts were hypersensitive to both FGF1 and FGF2, demonstrating sulfatases are involved with modulation of FGF signalling. |
Missing: reference | ||||
GO:0072001 |
renal system development |
17593974 |
ECO:0000315 |
P |
Fig 3: Embryos deficient for both Sulf1 and Sulf2 had kidney hypoplasia. Table 1 shows that mice deficient for either Sulf1 or Sulf2 alone were viable, fertile and normal so the genes are redundant/overlap in function. |
Missing: reference | ||||
involved_in |
GO:0060348 |
bone development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0040037 |
negative regulation of fibroblast growth factor receptor signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001822 |
kidney development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060686 |
negative regulation of prostatic bud formation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060384 |
innervation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051216 |
cartilage development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048706 |
embryonic skeletal system development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048010 |
vascular endothelial growth factor receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0045121 |
membrane raft |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0040037 |
negative regulation of fibroblast growth factor receptor signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
occurs_in:(CL:0000653) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0040037 |
negative regulation of fibroblast growth factor receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0036022 |
limb joint morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035860 |
glial cell-derived neurotrophic factor receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032836 |
glomerular basement membrane development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030513 |
positive regulation of BMP signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030336 |
negative regulation of cell migration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030201 |
heparan sulfate proteoglycan metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030177 |
positive regulation of Wnt signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016525 |
negative regulation of angiogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0014846 |
esophagus smooth muscle contraction |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010575 |
positive regulation of vascular endothelial growth factor production |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
occurs_in:(CL:0000653) |
Seeded From UniProt |
complete | ||
part_of |
GO:0009986 |
cell surface |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008449 |
N-acetylglucosamine-6-sulfatase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000653) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004065 |
arylsulfatase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003094 |
glomerular filtration |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002063 |
chondrocyte development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001937 |
negative regulation of endothelial cell proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001502 |
cartilage condensation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0040037 |
negative regulation of fibroblast growth factor receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919293 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032836 |
glomerular basement membrane development |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919293 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030201 |
heparan sulfate proteoglycan metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919293 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030177 |
positive regulation of Wnt signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919293 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010575 |
positive regulation of vascular endothelial growth factor production |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919293 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0009986 |
cell surface |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000038172 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0008449 |
N-acetylglucosamine-6-sulfatase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919293 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919293 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000038172 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005539 |
glycosaminoglycan binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000038170 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048010 |
vascular endothelial growth factor receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0045121 |
membrane raft |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0040037 |
negative regulation of fibroblast growth factor receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0040036 |
regulation of fibroblast growth factor receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030513 |
positive regulation of BMP signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030336 |
negative regulation of cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030201 |
heparan sulfate proteoglycan metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030177 |
positive regulation of Wnt signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0016525 |
negative regulation of angiogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:708554 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0008449 |
N-acetylglucosamine-6-sulfatase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:AY101175 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008449 |
N-acetylglucosamine-6-sulfatase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006790 |
sulfur compound metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:AY101175 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:708554 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:708554 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:AY101175 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004065 |
arylsulfatase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:AY101175 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004065 |
arylsulfatase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001937 |
negative regulation of endothelial cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048010 |
vascular endothelial growth factor receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0045121 |
membrane raft |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0040037 |
negative regulation of fibroblast growth factor receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0040036 |
regulation of fibroblast growth factor receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030513 |
positive regulation of BMP signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030336 |
negative regulation of cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030201 |
heparan sulfate proteoglycan metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030177 |
positive regulation of Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016525 |
negative regulation of angiogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0009986 |
cell surface |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0008449 |
N-acetylglucosamine-6-sulfatase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004065 |
arylsulfatase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001937 |
negative regulation of endothelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IWU6 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005509 |
calcium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008484 |
sulfuric ester hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005795 |
Golgi stack |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Holst, CR et al. (2007) Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival. PLoS ONE 2 e575 PubMed GONUTS page
- ↑ 2.0 2.1 Buresh, RA et al. (2010) Sulfatase 1 is an inhibitor of ductal morphogenesis with sexually dimorphic expression in the urogenital sinus. Endocrinology 151 3420-31 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Ai, X et al. (2007) SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development 134 3327-38 PubMed GONUTS page
- ↑ 4.0 4.1 Otsuki, S et al. (2010) Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 107 10202-7 PubMed GONUTS page
- ↑ Ratzka, A et al. (2008) Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development. Dev. Dyn. 237 339-53 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Schumacher, VA et al. (2011) WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J. Am. Soc. Nephrol. 22 1286-96 PubMed GONUTS page
- ↑ 7.0 7.1 Lamanna, WC et al. (2008) Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling. J. Biol. Chem. 283 27724-35 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Morimoto-Tomita, M et al. (2002) Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J. Biol. Chem. 277 49175-85 PubMed GONUTS page
c
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- GO:0008449 ! N-acetylglucosamine-6-sulfatase activity
- GO:0001937 ! negative regulation of endothelial cell proliferation
- GO:0060686 ! negative regulation of prostatic bud formation
- GO:0016525 ! negative regulation of angiogenesis
- GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway
- GO:0030336 ! negative regulation of cell migration
p
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s