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PMID:17593974

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Citation

Holst, CR, Bou-Reslan, H, Gore, BB, Wong, K, Grant, D, Chalasani, S, Carano, RA, Frantz, GD, Tessier-Lavigne, M, Bolon, B, French, DM and Ashkenazi, A (2007) Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival. PLoS ONE 2:e575

Abstract

Heparan sulfate proteoglycans (HSPGs) use highly sulfated polysaccharide side-chains to interact with several key growth factors and morphogens, thereby regulating their accessibility and biological activity. Various sulfotransferases and sulfatases with differing specificities control the pattern of HSPG sulfation, which is functionally critical. Among these enzymes in the mouse are two secreted 6-O-endosulfatases, Sulf1 and Sulf2, which modify HSPGs in the extracellular matrix and on the cell surface. The roles of Sulf1 and Sulf2 during normal development are not well understood.

Links

PubMed PMC1892809 Online version:10.1371/journal.pone.0000575

Keywords

Animals; Animals, Newborn/growth & development; Cells, Cultured; Embryo, Mammalian/cytology; Embryo, Mammalian/metabolism; Embryonic Development; Female; Fibroblasts/cytology; Fibroblasts/metabolism; Genes, Lethal/physiology; Heparan Sulfate Proteoglycans/metabolism; In Situ Hybridization; Kidney/abnormalities; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal/abnormalities; Pregnancy; Signal Transduction; Sulfatases/physiology; Sulfotransferases/physiology; Survival Rate

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:SULF1

involved_in

GO:0001822: kidney development

ECO:0000316: genetic interaction evidence used in manual assertion

UniProtKB:Q8CFG0

P

Seeded From UniProt

complete

MOUSE:SULF1

involved_in

GO:0040037: negative regulation of fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

UniProtKB:Q8CFG0

P

Seeded From UniProt

complete

MOUSE:SULF1

involved_in

GO:0060348: bone development

ECO:0000316: genetic interaction evidence used in manual assertion

UniProtKB:Q8CFG0

P

Seeded From UniProt

complete

MOUSE:SULF2

involved_in

GO:0001822: kidney development

ECO:0000316: genetic interaction evidence used in manual assertion

UniProtKB:Q8K007

P

Seeded From UniProt

complete

MOUSE:SULF2

involved_in

GO:0040037: negative regulation of fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

UniProtKB:Q8K007

P

Seeded From UniProt

complete

MOUSE:SULF2

involved_in

GO:0060348: bone development

ECO:0000316: genetic interaction evidence used in manual assertion

UniProtKB:Q8K007

P

Seeded From UniProt

complete


See also

References

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