MOUSE:STAT1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Stat1
Protein Name(s)	Signal transducer and activator of transcription 1
External Links
UniProt	P42225
EMBL	U06924
CCDS	CCDS56628.1
UniGene	Mm.277406 Mm.487336
ProteinModelPortal	P42225
SMR	P42225
DIP	DIP-38739N
IntAct	P42225
BindingDB	P42225
ChEMBL	CHEMBL1667670
PhosphoSite	P42225
MaxQB	P42225
PaxDb	P42225
PRIDE	P42225
MGI	MGI:103063
eggNOG	NOG310130
HOVERGEN	HBG055669
InParanoid	P42225
PhylomeDB	P42225
Reactome	REACT_198614
SABIO-RK	P42225
ChiTaRS	Stat1
PRO	PR:P42225
Proteomes	UP000000589
Genevestigator	P42225
GO	GO:0030424 GO:0005737 GO:0005829 GO:0030425 GO:0005634 GO:0005509 GO:0003677 GO:0003700 GO:0004871 GO:0006919 GO:0006915 GO:0008015 GO:0071222 GO:0019221 GO:0060333 GO:0031663 GO:0072162 GO:0072136 GO:0034240 GO:0003340 GO:0072308 GO:0000122 GO:0002053 GO:0048661 GO:0061326 GO:0009617 GO:0051591 GO:0034097 GO:0043330 GO:0032496 GO:0043434 GO:0006351 GO:0060337
Gene3D	1.10.238.10 1.10.532.10 1.20.1050.20 2.60.40.630 3.30.505.10
InterPro	IPR011992 IPR008967 IPR000980 IPR001217 IPR022752 IPR013800 IPR015988 IPR013801 IPR012345 IPR013799
PANTHER	PTHR11801
Pfam	PF00017 PF12162 PF01017 PF02864 PF02865
SMART	SM00252 SM00964
SUPFAM	SSF47655 SSF48092 SSF49417 SSF55550
PROSITE	PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060337	type I interferon signaling pathway	PMID:24598055^[1]	ECO:0000315			P		This protein forms a heterodimer with STAT2 which then functions to increase expression of Trex1 (three prime repair exonuclease 1) STAT knockout resulted in no increase in transcription while also knockout of Stat2 did not increase transcription. WT with both did show increased transcription of Trex1. Figure 2D and C along with figure 4 D graph and E.	complete CACAO 9649
involved_in	GO:0010742	macrophage derived foam cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
involved_in	GO:0032727	positive regulation of interferon-alpha production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
involved_in	GO:0034340	response to type I interferon	PMID:24882218^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002048)	Seeded From UniProt	complete
involved_in	GO:0060337	type I interferon signaling pathway	PMID:24598055^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072308	negative regulation of metanephric nephron tubule epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QXK0	P		Seeded From UniProt	complete
involved_in	GO:0072162	metanephric mesenchymal cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QXK0	P		Seeded From UniProt	complete
involved_in	GO:0072136	metanephric mesenchymal cell proliferation involved in metanephros development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QXK0	P		Seeded From UniProt	complete
involved_in	GO:0061326	renal tubule development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E2RLW2	P		Seeded From UniProt	complete
involved_in	GO:0060337	type I interferon signaling pathway	PMID:12138178^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	PMID:12138178^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QXK0	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QXK0	P		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QXK0	P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QXK0	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QXK0	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QXK0	C		Seeded From UniProt	complete
involved_in	GO:0008015	blood circulation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QXK0	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:10692450^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QXK0	P		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QXK0	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QXK0	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	PMID:19414010^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:A0A0G2JX93	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071346	cellular response to interferon-gamma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071345	cellular response to cytokine stimulus	PMID:19414010^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:A0A0G2JX93	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:21606371^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861949	P		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061326	renal tubule development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060337	type I interferon signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060333	interferon-gamma-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	P		Seeded From UniProt	complete
enables	GO:0051721	protein phosphatase 2A binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051607	defense response to virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051591	response to cAMP	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046725	negative regulation by virus of viral protein levels in host cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
enables	GO:0044389	ubiquitin-like protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043434	response to peptide hormone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043330	response to exogenous dsRNA	PMID:12872135^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035458	cellular response to interferon-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035456	response to interferon-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034240	negative regulation of macrophage fusion	PMID:22865856^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034097	response to cytokine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032869	cellular response to insulin stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032727	positive regulation of interferon-alpha production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:12872135^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
enables	GO:0031730	CCR5 chemokine receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:12872135^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019221	cytokine-mediated signaling pathway	PMID:12872135^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016525	negative regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010742	macrophage derived foam cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009617	response to bacterium	PMID:15661922^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009612	response to mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008015	blood circulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007584	response to nutrient	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007259	receptor signaling pathway via JAK-STAT	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007259	receptor signaling pathway via JAK-STAT	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006351	transcription, DNA-templated	PMID:15485925^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15661922^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14522949^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12634107^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12957148^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	C		Seeded From UniProt	complete
colocalizes_with	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15485925^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002230	positive regulation of defense response to virus by host	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42224	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013801	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR008967 InterPro:IPR022752	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR008967 InterPro:IPR013799 InterPro:IPR013800 InterPro:IPR015988	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR013799 InterPro:IPR013800 InterPro:IPR015988	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-9008004 Reactome:R-MMU-1169206 Reactome:R-MMU-1169142	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Xu, J et al. (2014) TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways. J. Leukoc. Biol. 96 93-103 PubMed GONUTS page
↑ Rajsbaum, R et al. (2014) Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response. Immunity 40 880-95 PubMed GONUTS page
↑ ^3.0 ^3.1 ten Hoeve, J et al. (2002) Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 22 5662-8 PubMed GONUTS page
↑ Huang, YQ et al. (2000) Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway. J. Biol. Chem. 275 6462-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Lv, N et al. (2009) JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp. Cell Res. 315 2064-71 PubMed GONUTS page
↑ Bhattacharyya, S et al. (2011) Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc. Natl. Acad. Sci. U.S.A. 108 9554-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Hoebe, K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424 743-8 PubMed GONUTS page
↑ Miyamoto, H et al. (2012) An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion. J. Biol. Chem. 287 32479-84 PubMed GONUTS page
↑ ^9.0 ^9.1 O'Connell, RM et al. (2005) Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1. J. Immunol. 174 1602-7 PubMed GONUTS page
↑ ^10.0 ^10.1 Kim, KI et al. (2004) Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation. Mol. Cell. Biol. 24 9592-600 PubMed GONUTS page
↑ Aszodi, A et al. (2003) Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev. 17 2465-79 PubMed GONUTS page
↑ Zhang, SS et al. (2003) Expression and activation of STAT proteins during mouse retina development. Exp. Eye Res. 76 421-31 PubMed GONUTS page
↑ Tadayoni, R et al. (2003) Erythrocyte and leukocyte dynamics in the retinal capillaries of diabetic mice. Exp. Eye Res. 77 497-504 PubMed GONUTS page

[PMID:24598055-1] 1.0 ^1.1 Xu, J et al. (2014) TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways. J. Leukoc. Biol. 96 93-103 PubMed GONUTS page

[PMID:24882218-2] Rajsbaum, R et al. (2014) Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response. Immunity 40 880-95 PubMed GONUTS page

[PMID:12138178-3] 3.0 ^3.1 ten Hoeve, J et al. (2002) Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 22 5662-8 PubMed GONUTS page

[PMID:10692450-4] Huang, YQ et al. (2000) Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway. J. Biol. Chem. 275 6462-8 PubMed GONUTS page

[PMID:19414010-5] 5.0 ^5.1 Lv, N et al. (2009) JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp. Cell Res. 315 2064-71 PubMed GONUTS page

[PMID:21606371-6] Bhattacharyya, S et al. (2011) Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc. Natl. Acad. Sci. U.S.A. 108 9554-9 PubMed GONUTS page

[PMID:12872135-7] 7.0 ^7.1 ^7.2 ^7.3 Hoebe, K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424 743-8 PubMed GONUTS page

[PMID:22865856-8] Miyamoto, H et al. (2012) An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion. J. Biol. Chem. 287 32479-84 PubMed GONUTS page

[PMID:15661922-9] 9.0 ^9.1 O'Connell, RM et al. (2005) Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1. J. Immunol. 174 1602-7 PubMed GONUTS page

[PMID:15485925-10] 10.0 ^10.1 Kim, KI et al. (2004) Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation. Mol. Cell. Biol. 24 9592-600 PubMed GONUTS page

[PMID:14522949-11] Aszodi, A et al. (2003) Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev. 17 2465-79 PubMed GONUTS page

[PMID:12634107-12] Zhang, SS et al. (2003) Expression and activation of STAT proteins during mouse retina development. Exp. Eye Res. 76 421-31 PubMed GONUTS page

[PMID:12957148-13] Tadayoni, R et al. (2003) Erythrocyte and leukocyte dynamics in the retinal capillaries of diabetic mice. Exp. Eye Res. 77 497-504 PubMed GONUTS page

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