MOUSE:SRC

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Src
Protein Name(s)	Neuronal proto-oncogene tyrosine-protein kinase Src Proto-oncogene c-Src pp60c-src p60-Src
External Links
UniProt	P05480
EMBL	M17031 AY902331 AL672259 CH466551
CCDS	CCDS38305.1
PIR	A43610
RefSeq	NP_001020566.1 NP_033297.2
UniGene	Mm.22845
ProteinModelPortal	P05480
SMR	P05480
BioGrid	203491
DIP	DIP-31071N
IntAct	P05480
MINT	MINT-85032
STRING	10090.ENSMUSP00000105155
BindingDB	P05480
ChEMBL	CHEMBL3074
PhosphoSite	P05480
MaxQB	P05480
PaxDb	P05480
PRIDE	P05480
Ensembl	ENSMUST00000092576 ENSMUST00000109529
GeneID	20779
KEGG	mmu:20779
UCSC	uc008npa.1
CTD	6714
MGI	MGI:98397
eggNOG	COG0515
GeneTree	ENSGT00760000118938
HOGENOM	HOG000233858
HOVERGEN	HBG008761
InParanoid	P05480
KO	K05704
OMA	CHRLTNV
OrthoDB	EOG7GTT2V
BRENDA	2.7.10.2
Reactome	REACT_188191 REACT_188578 REACT_196487 REACT_198526 REACT_204081 REACT_206286 REACT_207601 REACT_220322 REACT_224600 REACT_227425 REACT_230639 REACT_237796 REACT_240371 REACT_241951 REACT_242976 REACT_243212 REACT_243590 REACT_243939 REACT_245086 REACT_245546 REACT_246176 REACT_248291 REACT_253341 REACT_257088 REACT_257656 REACT_257923 REACT_258158 REACT_259068 REACT_261568
ChiTaRS	Src
NextBio	299503
PRO	PR:P05480
Proteomes	UP000000589
Bgee	P05480
CleanEx	MM_SRC
ExpressionAtlas	P05480
Genevestigator	P05480
GO	GO:0005884 GO:0005829 GO:0005743 GO:0005634 GO:0048471 GO:0005886 GO:0032587 GO:0005524 GO:0046875 GO:0020037 GO:0016301 GO:0004715 GO:0019904 GO:0004672 GO:0004713 GO:0045453 GO:0060444 GO:0007049 GO:0016477 GO:0036120 GO:0071560 GO:0030900 GO:0035556 GO:0048477 GO:0036035 GO:0018108 GO:0090263 GO:0070374 GO:0071803 GO:0006468 GO:0060491 GO:0033146 GO:0043393 GO:0034446 GO:0060065
Gene3D	3.30.505.10
InterPro	IPR011009 IPR000719 IPR017441 IPR001245 IPR000980 IPR001452 IPR008266 IPR020635
Pfam	PF07714 PF00017 PF00018
PRINTS	PR00401 PR00452 PR00109
SMART	SM00252 SM00326 SM00219
SUPFAM	SSF50044 SSF55550 SSF56112
PROSITE	PS00107 PS50011 PS00109 PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0031648	protein destabilization	PMID:25259869^[1]	ECO:0000315			P		Figure 6 shows Tks5-beta levels decrease in cells with increased Src levels because Src destabilizes Tks5-beta	complete CACAO 10521
part_of	GO:0005737	cytoplasm	PMID:14699011^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0071253	connexin binding	PMID:14699011^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23242	F		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	PMID:25259869^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:12091389^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q9WVC3) occurs_in:(UBERON:0002048)	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	PMID:12091389^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q9WVC3) occurs_in:(UBERON:0002048)	Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:12091389^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:12091389^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9WVC3	F	occurs_in:(UBERON:0002048)	Seeded From UniProt	complete
involved_in	GO:0086098	angiotensin-activated signaling pathway involved in heart process	PMID:25017399^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09470 UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	PMID:25017399^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09470	P	occurs_in:(UBERON:0002084) occurs_in:(CL:0000746)	Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:25017399^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49817	F	occurs_in:(UBERON:0002084) occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:17045821^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	PMID:12925710^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8CBF3	F		Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	PMID:14739300^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 UniProtKB:P12931	P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 UniProtKB:P12931	P		Seeded From UniProt	complete
enables	GO:0070851	growth factor receptor binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 UniProtKB:P12931	F		Seeded From UniProt	complete
involved_in	GO:0050847	progesterone receptor signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 RGD:620795	P		Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98397 PANTHER:PTN000701142	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:Q9H3Y6 WB:WBGene00005077	P		Seeded From UniProt	complete
involved_in	GO:0036035	osteoclast development	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98397 PANTHER:PTN000701142	P		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:P08631	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 RGD:621423	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 RGD:620795	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:P07948	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262733 PANTHER:PTN002521528 RGD:2641 RGD:620795 RGD:621017 UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95527 PANTHER:PTN002521528 UniProtKB:P09769 UniProtKB:P51451 UniProtKB:Q13882 WB:WBGene00005077	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:22759635^[9]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001286	regulation of caveolin-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000811	negative regulation of anoikis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000641	regulation of early endosome to late endosome transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000588	positive regulation of platelet-derived growth factor receptor-beta signaling pathway	PMID:23651497^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000394	positive regulation of lamellipodium morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000386	positive regulation of ovarian follicle development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902533	positive regulation of intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900182	positive regulation of protein localization to nucleus	PMID:17344476^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1932535	P	has_direct_input:(UniProtKB:P30999)	Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098962	regulation of postsynaptic neurotransmitter receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:19920076^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956 UniProtKB:Q08463	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071803	positive regulation of podosome assembly	PMID:21525037^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096342 MGI:MGI:1858952	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071803	positive regulation of podosome assembly	PMID:24127566^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071803	positive regulation of podosome assembly	PMID:21525037^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:21829547^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95602 MGI:MGI:99147	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071498	cellular response to fluid shear stress	PMID:24841674^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071393	cellular response to progesterone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
enables	GO:0070851	growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070555	response to interleukin-1	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	PMID:23651497^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060491	regulation of cell projection assembly	PMID:11864995^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87859	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060444	branching involved in mammary gland duct morphogenesis	PMID:16007215^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857247	P	has_participant:(EMAPA:35538)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060065	uterus development	PMID:16007215^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857247	P	results_in_development_of:(EMAPA:29915)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051974	negative regulation of telomerase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051902	negative regulation of mitochondrial depolarization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051895	negative regulation of focal adhesion assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051222	positive regulation of protein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051057	positive regulation of small GTPase mediated signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050847	progesterone receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:17344476^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:105100	P	has_direct_input:(PR:P30999)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048477	oogenesis	PMID:16007215^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857247	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:24841674^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:17623777^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048011	neurotrophin TRK receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045785	positive regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045453	bone resorption	PMID:19448635^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857247	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045056	transcytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	F		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043393	regulation of protein binding	PMID:22027834^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043149	stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042476	odontogenesis	PMID:23174213^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857247	P		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036120	cellular response to platelet-derived growth factor stimulus	PMID:17623777^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036035	osteoclast development	PMID:23526378^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2142227	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	PMID:23526378^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2142227	P	occurs_in:(CL:0000092)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034614	cellular response to reactive oxygen species	PMID:24190966^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034446	substrate adhesion-dependent cell spreading	PMID:11864995^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034332	adherens junction organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033146	regulation of intracellular estrogen receptor signaling pathway	PMID:16007215^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857247	P	regulates_o_occurs_in:(EMAPA:17760) regulates_o_occurs_in:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	PMID:17623777^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032463	negative regulation of protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032211	negative regulation of telomere maintenance via telomerase	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032148	activation of protein kinase B activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031954	positive regulation of protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:16162939^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95602	P	results_in_development_of:(EMAPA:17544)	Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022407	regulation of cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:8438166^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q06649	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	F		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:12526740^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:22732588^[28]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:15292044^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:28281)\|occurs_in:(EMAPA:28407)	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:12808090^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010954	positive regulation of protein processing	PMID:17344476^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:105100	P	has_direct_input:(PR:Q8VDL9-1)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010907	positive regulation of glucose metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010632	regulation of epithelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:27994061^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:15937334^[32]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:11274221^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21525037^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	C		Seeded From UniProt	complete
part_of	GO:0005884	actin filament	PMID:17623777^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24841674^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	F		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:14636584^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:23100514^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000235) has_direct_input:(MGI:MGI:95499)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:27994061^[31]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:24190966^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:19920076^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:106613)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:11274221^[33]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
part_of	GO:0002102	podosome	PMID:17893324^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001545	primary ovarian follicle growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620795	P		Seeded From UniProt	complete
involved_in	GO:2001286	regulation of caveolin-mediated endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:2000641	regulation of early endosome to late endosome transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:2000394	positive regulation of lamellipodium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
enables	GO:0070851	growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:0051974	negative regulation of telomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:0051902	negative regulation of mitochondrial depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
involved_in	GO:0051057	positive regulation of small GTPase mediated signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:0043149	stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:0032463	negative regulation of protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:0032211	negative regulation of telomere maintenance via telomerase	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:0022407	regulation of cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:0010632	regulation of epithelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12931 ensembl:ENSP00000362680	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
involved_in	GO:0001545	primary ovarian follicle growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:2000386	positive regulation of ovarian follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:1902533	positive regulation of intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
involved_in	GO:0098962	regulation of postsynaptic neurotransmitter receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0071393	cellular response to progesterone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0051895	negative regulation of focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0051385	response to mineralocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0051222	positive regulation of protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0050847	progesterone receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0048011	neurotrophin TRK receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0045056	transcytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0034332	adherens junction organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0031954	positive regulation of protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
involved_in	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
involved_in	GO:0010907	positive regulation of glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0010447	response to acidic pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-9011252	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-5218834 Reactome:R-MMU-420382 Reactome:R-MMU-418870 Reactome:R-MMU-3928622 Reactome:R-MMU-1433273	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-8937738 Reactome:R-MMU-8937703	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	Reactome:R-MMU-9011252 Reactome:R-MMU-420382 Reactome:R-MMU-418870 Reactome:R-MMU-3928622	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Cejudo-Martin, P et al. (2014) Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5. PLoS ONE 9 e107674 PubMed GONUTS page
↑ ^2.0 ^2.1 Duffy, HS et al. (2004) Regulation of connexin43 protein complexes by intracellular acidification. Circ. Res. 94 215-22 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Lee, H et al. (2002) Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. J. Biol. Chem. 277 34556-67 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Yang, KC et al. (2014) Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase. Circ Arrhythm Electrophysiol 7 701-10 PubMed GONUTS page
↑ Shi, X et al. (2006) CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity 25 595-606 PubMed GONUTS page
↑ Vindis, C et al. (2003) EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J. Cell Biol. 162 661-71 PubMed GONUTS page
↑ Miyazaki, T et al. (2004) Src kinase activity is essential for osteoclast function. J. Biol. Chem. 279 17660-6 PubMed GONUTS page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Huang, H et al. (2012) A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev. 26 1587-601 PubMed GONUTS page
↑ ^10.0 ^10.1 Cinq-Frais, C et al. (2013) A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochim. Biophys. Acta 1831 1344-56 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Hosking, CR et al. (2007) The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol. Biol. Cell 18 1918-27 PubMed GONUTS page
↑ ^12.0 ^12.1 Yokoyama, N & Malbon, CC (2009) Dishevelled-2 docks and activates Src in a Wnt-dependent manner. J. Cell. Sci. 122 4439-51 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Kuroiwa, M et al. (2011) The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation. J. Cell. Sci. 124 1726-38 PubMed GONUTS page
↑ Pan, YR et al. (2013) Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts. J. Cell. Sci. 126 5670-80 PubMed GONUTS page
↑ Samarakoon, R et al. (2011) Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression. PLoS ONE 6 e22896 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Hum, JM et al. (2014) Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression. PLoS ONE 9 e97942 PubMed GONUTS page
↑ ^17.0 ^17.1 Woodring, PJ et al. (2002) Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J. Cell Biol. 156 879-92 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Kim, H et al. (2005) c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling. Oncogene 24 5629-36 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Sandilands, E et al. (2007) The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. J. Cell. Sci. 120 2555-64 PubMed GONUTS page
↑ Schinke, T et al. (2009) Impaired gastric acidification negatively affects calcium homeostasis and bone mass. Nat. Med. 15 674-81 PubMed GONUTS page
↑ Fukumoto, Y et al. (2011) Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein. J. Biol. Chem. 286 43537-48 PubMed GONUTS page
↑ Koehne, T et al. (2013) Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization. Bone 53 25-33 PubMed GONUTS page
↑ ^23.0 ^23.1 Xing, W et al. (2013) Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis. J. Bone Miner. Res. 28 1962-74 PubMed GONUTS page
↑ ^24.0 ^24.1 Lei, H & Kazlauskas, A (2014) A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α. Mol. Cell. Biol. 34 110-22 PubMed GONUTS page
↑ Kuo, G et al. (2005) Absence of Fyn and Src causes a reeler-like phenotype. J. Neurosci. 25 8578-86 PubMed GONUTS page
↑ Ren, R et al. (1993) Identification of a ten-amino acid proline-rich SH3 binding site. Science 259 1157-61 PubMed GONUTS page
↑ Bock, HH & Herz, J (2003) Reelin activates SRC family tyrosine kinases in neurons. Curr. Biol. 13 18-26 PubMed GONUTS page
↑ Lesourne, R et al. (2012) Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. J. Immunol. 189 1154-61 PubMed GONUTS page
↑ Ziehr, J et al. (2004) Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice. Am. J. Physiol. Renal Physiol. 287 F1154-63 PubMed GONUTS page
↑ Holgado-Madruga, M & Wong, AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol. Cell. Biol. 23 4471-84 PubMed GONUTS page
↑ ^31.0 ^31.1 Cheng, Z et al. (2017) Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth. J. Biol. Chem. 292 2065-2079 PubMed GONUTS page
↑ Auger, R et al. (2005) A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death. J. Biol. Chem. 280 28142-51 PubMed GONUTS page
↑ ^33.0 ^33.1 Andreev, J et al. (2001) Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J. Biol. Chem. 276 20130-5 PubMed GONUTS page
↑ Ishibe, S et al. (2003) Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis. Mol. Cell 12 1275-85 PubMed GONUTS page
↑ Greuber, EK & Pendergast, AM (2012) Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages. J. Immunol. 189 5382-92 PubMed GONUTS page
↑ Bharti, S et al. (2007) Src-dependent phosphorylation of ASAP1 regulates podosomes. Mol. Cell. Biol. 27 8271-83 PubMed GONUTS page

[PMID:25259869-1] 1.0 ^1.1 Cejudo-Martin, P et al. (2014) Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5. PLoS ONE 9 e107674 PubMed GONUTS page

[PMID:14699011-2] 2.0 ^2.1 Duffy, HS et al. (2004) Regulation of connexin43 protein complexes by intracellular acidification. Circ. Res. 94 215-22 PubMed GONUTS page

[PMID:12091389-3] 3.0 ^3.1 ^3.2 ^3.3 Lee, H et al. (2002) Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. J. Biol. Chem. 277 34556-67 PubMed GONUTS page

[PMID:25017399-4] 4.0 ^4.1 ^4.2 Yang, KC et al. (2014) Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase. Circ Arrhythm Electrophysiol 7 701-10 PubMed GONUTS page

[PMID:17045821-5] Shi, X et al. (2006) CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity 25 595-606 PubMed GONUTS page

[PMID:12925710-6] Vindis, C et al. (2003) EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J. Cell Biol. 162 661-71 PubMed GONUTS page

[PMID:14739300-7] Miyazaki, T et al. (2004) Src kinase activity is essential for osteoclast function. J. Biol. Chem. 279 17660-6 PubMed GONUTS page

[PMID:21873635-8] 8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22759635-9] Huang, H et al. (2012) A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev. 26 1587-601 PubMed GONUTS page

[PMID:23651497-10] 10.0 ^10.1 Cinq-Frais, C et al. (2013) A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochim. Biophys. Acta 1831 1344-56 PubMed GONUTS page

[PMID:17344476-11] 11.0 ^11.1 ^11.2 Hosking, CR et al. (2007) The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol. Biol. Cell 18 1918-27 PubMed GONUTS page

[PMID:19920076-12] 12.0 ^12.1 Yokoyama, N & Malbon, CC (2009) Dishevelled-2 docks and activates Src in a Wnt-dependent manner. J. Cell. Sci. 122 4439-51 PubMed GONUTS page

[PMID:21525037-13] 13.0 ^13.1 ^13.2 Kuroiwa, M et al. (2011) The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation. J. Cell. Sci. 124 1726-38 PubMed GONUTS page

[PMID:24127566-14] Pan, YR et al. (2013) Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts. J. Cell. Sci. 126 5670-80 PubMed GONUTS page

[PMID:21829547-15] Samarakoon, R et al. (2011) Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression. PLoS ONE 6 e22896 PubMed GONUTS page

[PMID:24841674-16] 16.0 ^16.1 ^16.2 Hum, JM et al. (2014) Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression. PLoS ONE 9 e97942 PubMed GONUTS page

[PMID:11864995-17] 17.0 ^17.1 Woodring, PJ et al. (2002) Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J. Cell Biol. 156 879-92 PubMed GONUTS page

[PMID:16007215-18] 18.0 ^18.1 ^18.2 ^18.3 Kim, H et al. (2005) c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling. Oncogene 24 5629-36 PubMed GONUTS page

[PMID:17623777-19] 19.0 ^19.1 ^19.2 ^19.3 Sandilands, E et al. (2007) The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. J. Cell. Sci. 120 2555-64 PubMed GONUTS page

[PMID:19448635-20] Schinke, T et al. (2009) Impaired gastric acidification negatively affects calcium homeostasis and bone mass. Nat. Med. 15 674-81 PubMed GONUTS page

[PMID:22027834-21] Fukumoto, Y et al. (2011) Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein. J. Biol. Chem. 286 43537-48 PubMed GONUTS page

[PMID:23174213-22] Koehne, T et al. (2013) Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization. Bone 53 25-33 PubMed GONUTS page

[PMID:23526378-23] 23.0 ^23.1 Xing, W et al. (2013) Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis. J. Bone Miner. Res. 28 1962-74 PubMed GONUTS page

[PMID:24190966-24] 24.0 ^24.1 Lei, H & Kazlauskas, A (2014) A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α. Mol. Cell. Biol. 34 110-22 PubMed GONUTS page

[PMID:16162939-25] Kuo, G et al. (2005) Absence of Fyn and Src causes a reeler-like phenotype. J. Neurosci. 25 8578-86 PubMed GONUTS page

[PMID:8438166-26] Ren, R et al. (1993) Identification of a ten-amino acid proline-rich SH3 binding site. Science 259 1157-61 PubMed GONUTS page

[PMID:12526740-27] Bock, HH & Herz, J (2003) Reelin activates SRC family tyrosine kinases in neurons. Curr. Biol. 13 18-26 PubMed GONUTS page

[PMID:22732588-28] Lesourne, R et al. (2012) Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. J. Immunol. 189 1154-61 PubMed GONUTS page

[PMID:15292044-29] Ziehr, J et al. (2004) Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice. Am. J. Physiol. Renal Physiol. 287 F1154-63 PubMed GONUTS page

[PMID:12808090-30] Holgado-Madruga, M & Wong, AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol. Cell. Biol. 23 4471-84 PubMed GONUTS page

[PMID:27994061-31] 31.0 ^31.1 Cheng, Z et al. (2017) Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth. J. Biol. Chem. 292 2065-2079 PubMed GONUTS page

[PMID:15937334-32] Auger, R et al. (2005) A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death. J. Biol. Chem. 280 28142-51 PubMed GONUTS page

[PMID:11274221-33] 33.0 ^33.1 Andreev, J et al. (2001) Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J. Biol. Chem. 276 20130-5 PubMed GONUTS page

[PMID:14636584-34] Ishibe, S et al. (2003) Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis. Mol. Cell 12 1275-85 PubMed GONUTS page

[PMID:23100514-35] Greuber, EK & Pendergast, AM (2012) Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages. J. Immunol. 189 5382-92 PubMed GONUTS page

[PMID:17893324-36] Bharti, S et al. (2007) Src-dependent phosphorylation of ASAP1 regulates podosomes. Mol. Cell. Biol. 27 8271-83 PubMed GONUTS page

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