MOUSE:SPI1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Spi1 (synonyms: Sfpi-1, Sfpi1)
Protein Name(s)	Transcription factor PU.1 31 kDa-transforming protein SFFV proviral integration 1 protein
External Links
UniProt	P17433
EMBL	X17463 L03215 M32370 M38252 BC003815
CCDS	CCDS16425.1
PIR	A34693
RefSeq	NP_035485.1
UniGene	Mm.1302
PDB	1PUE
PDBsum	1PUE
ProteinModelPortal	P17433
SMR	P17433
BioGrid	203184
IntAct	P17433
MINT	MINT-94708
PhosphoSite	P17433
PRIDE	P17433
Ensembl	ENSMUST00000002180
GeneID	20375
KEGG	mmu:20375
UCSC	uc008kuj.1
CTD	6688
MGI	MGI:98282
eggNOG	NOG237824
HOGENOM	HOG000095520
HOVERGEN	HBG002474
InParanoid	P17433
KO	K09438
OMA	PRMCLPY
PhylomeDB	P17433
TreeFam	TF352494
EvolutionaryTrace	P17433
NextBio	298282
PRO	PR:P17433
Proteomes	UP000000589
Bgee	P17433
CleanEx	MM_SFPI1
ExpressionAtlas	P17433
Genevestigator	P17433
GO	GO:0000790 GO:0005634 GO:0005667 GO:0003677 GO:0051525 GO:0003723 GO:0000978 GO:0001078 GO:0001077 GO:0000979 GO:0000980 GO:0003705 GO:0001205 GO:0001085 GO:0043565 GO:0003700 GO:0060033 GO:1902262 GO:0030218 GO:0030851 GO:0043966 GO:0044027 GO:0030098 GO:0002320 GO:0030225 GO:0043011 GO:0002573 GO:0045814 GO:0090241 GO:0045347 GO:0000122 GO:0045944 GO:0045893 GO:0045646 GO:0006357 GO:0006355 GO:0035019 GO:0006366 GO:0001944
Gene3D	1.10.10.10
InterPro	IPR000418 IPR011991
Pfam	PF00178
PRINTS	PR00454
SMART	SM00413
PROSITE	PS00345 PS00346 PS50061

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:18384814^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15304486^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:1513)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:16002702^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:15304486^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:16002702^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:15304486^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16002702^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:12479)	Seeded From UniProt	complete
enables	GO:0051525	NFAT protein binding	PMID:15304486^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88942	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15304486^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045347	negative regulation of MHC class II biosynthetic process	PMID:7592651^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P14483)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15304486^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:15304486^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:7592651^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P14483)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:15304486^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:18063754^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17679	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:15304486^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88942	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:15304486^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:15187136^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109336 PANTHER:PTN000218930	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95455 MGI:MGI:95610 MGI:MGI:98282 PANTHER:PTN000218930 UniProtKB:Q15723	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000097 FB:FBgn0000567 FB:FBgn0003118 MGI:MGI:101762 MGI:MGI:107180 MGI:MGI:109637 MGI:MGI:1335079 MGI:MGI:1353422 MGI:MGI:2449712 MGI:MGI:95455 MGI:MGI:95554 MGI:MGI:95610 MGI:MGI:98282 MGI:MGI:99423 PANTHER:PTN000218930 RGD:1359607 RGD:1598663 RGD:2583 UniProtKB:P14921 UniProtKB:P17947 UniProtKB:P19419 UniProtKB:P32519 UniProtKB:P41161 UniProtKB:Q01543 UniProtKB:Q06546 WB:WBGene00002990 WB:WBGene00017687	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218930 UniProtKB:Q15723	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902262	apoptotic process involved in blood vessel morphogenesis	PMID:16163358^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927876	P	occurs_in:(EMAPA:16198)\|occurs_in:(EMAPA:35198)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090241	negative regulation of histone H4 acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070102	interleukin-6-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061614	pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060033	anatomical structure regression	PMID:16163358^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927876	P	has_participant:(EMAPA:16198)\|has_participant:(EMAPA:35198)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15100295^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359607	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359607	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045814	negative regulation of gene expression, epigenetic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045646	regulation of erythrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044027	hypermethylation of CpG island	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043966	histone H3 acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23775123^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:96607)\|has_direct_input:(MGI:MGI:1339758)\|has_direct_input:(MGI:MGI:95499)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:1409581^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359607	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043011	myeloid dendritic cell differentiation	PMID:10648399^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930970	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035019	somatic stem cell population maintenance	PMID:19379700^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030851	granulocyte differentiation	PMID:11980719^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030225	macrophage differentiation	PMID:11980719^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030218	erythrocyte differentiation	PMID:9133423^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930970	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030098	lymphocyte differentiation	PMID:11980719^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:19796622^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:16735694^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P11835) has_regulation_target:(UniProtKB:Q3UV74)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:14962908^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:11980719^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:11980719^[14]	ECO:0000305	curator inference used in manual assertion	GO:0003700	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19796622^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16735694^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15361867^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359607	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14962908^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11980719^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359607	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15361867^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002573	myeloid leukocyte differentiation	PMID:9133423^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930970	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002320	lymphoid progenitor cell differentiation	PMID:9133423^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930970	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001944	vasculature development	PMID:16163358^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927876	P	results_in_development_of:(EMAPA:16198)\|results_in_development_of:(EMAPA:35198)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:16735694^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(UniProtKB:Q3UV74) occurs_at:(SO:0001668)\|has_regulation_target(UniProtKB:P11835) occurs_at:(SO:0001668)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:23980096^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:16735694^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17947	C		Seeded From UniProt	complete
involved_in	GO:0090241	negative regulation of histone H4 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	P		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	P		Seeded From UniProt	complete
involved_in	GO:0061614	pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	P		Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	P		Seeded From UniProt	complete
involved_in	GO:0045646	regulation of erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	P		Seeded From UniProt	complete
involved_in	GO:0044027	hypermethylation of CpG island	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	P		Seeded From UniProt	complete
involved_in	GO:0043966	histone H3 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17947 ensembl:ENSP00000227163	C		Seeded From UniProt	complete
involved_in	GO:0071361	cellular response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6BDS1 ensembl:ENSRNOP00000016306	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6BDS1 ensembl:ENSRNOP00000016306	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6BDS1 ensembl:ENSRNOP00000016306	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6BDS1 ensembl:ENSRNOP00000016306	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6BDS1 ensembl:ENSRNOP00000016306	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6BDS1 ensembl:ENSRNOP00000016306	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000418	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000418	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000418	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-8865529	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Fujita, S et al. (2008) miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J. Mol. Biol. 378 492-504 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Matsumoto, M et al. (2004) Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J. Biol. Chem. 279 45969-79 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Geng, Y et al. (2005) Transcriptional regulation of CD1D1 by Ets family transcription factors. J. Immunol. 175 1022-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Borràs, FE et al. (1995) Repression of I-A beta gene expression by the transcription factor PU.1. J. Biol. Chem. 270 24385-91 PubMed GONUTS page
↑ Sugiyama, D et al. (2008) Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation. Blood 111 1924-32 PubMed GONUTS page
↑ Pauleau, AL et al. (2004) Enhancer-mediated control of macrophage-specific arginase I expression. J. Immunol. 172 7565-73 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Lobov, IB et al. (2005) WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437 417-21 PubMed GONUTS page
↑ Yee, CS et al. (2004) Cathepsin E: a novel target for regulation by class II transactivator. J. Immunol. 172 5528-34 PubMed GONUTS page
↑ Dispirito, JR et al. (2013) Pruning of the adipocyte peroxisome proliferator-activated receptor γ cistrome by hematopoietic master regulator PU.1. Mol. Cell. Biol. 33 3354-64 PubMed GONUTS page
↑ Hagman, J & Grosschedl, R (1992) An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene. Proc. Natl. Acad. Sci. U.S.A. 89 8889-93 PubMed GONUTS page
↑ Guerriero, A et al. (2000) PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. Blood 95 879-85 PubMed GONUTS page
↑ Deneault, E et al. (2009) A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell 137 369-79 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Dahl, R et al. (2002) Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. EMBO J. 21 2220-30 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Scott, EW et al. (1997) PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity 6 437-47 PubMed GONUTS page
↑ ^16.0 ^16.1 Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Hale, JS et al. (2006) Transcriptional control of Pactolus: evidence of a negative control region and comparison with its evolutionary paralogue, CD18 (beta2 integrin). J. Leukoc. Biol. 80 383-98 PubMed GONUTS page
↑ ^18.0 ^18.1 Rosenbauer, F et al. (2004) pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1. Blood 103 4294-301 PubMed GONUTS page
↑ ^19.0 ^19.1 Xue, HH et al. (2004) GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells. Nat. Immunol. 5 1036-44 PubMed GONUTS page
↑ Maruyama, K et al. (2013) Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J. Exp. Med. 210 1947-60 PubMed GONUTS page

[PMID:18384814-1] Fujita, S et al. (2008) miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J. Mol. Biol. 378 492-504 PubMed GONUTS page

[PMID:15304486-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Matsumoto, M et al. (2004) Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J. Biol. Chem. 279 45969-79 PubMed GONUTS page

[PMID:16002702-3] 3.0 ^3.1 ^3.2 Geng, Y et al. (2005) Transcriptional regulation of CD1D1 by Ets family transcription factors. J. Immunol. 175 1022-9 PubMed GONUTS page

[PMID:7592651-4] 4.0 ^4.1 Borràs, FE et al. (1995) Repression of I-A beta gene expression by the transcription factor PU.1. J. Biol. Chem. 270 24385-91 PubMed GONUTS page

[PMID:18063754-5] Sugiyama, D et al. (2008) Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation. Blood 111 1924-32 PubMed GONUTS page

[PMID:15187136-6] Pauleau, AL et al. (2004) Enhancer-mediated control of macrophage-specific arginase I expression. J. Immunol. 172 7565-73 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16163358-8] 8.0 ^8.1 ^8.2 Lobov, IB et al. (2005) WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437 417-21 PubMed GONUTS page

[PMID:15100295-9] Yee, CS et al. (2004) Cathepsin E: a novel target for regulation by class II transactivator. J. Immunol. 172 5528-34 PubMed GONUTS page

[PMID:23775123-10] Dispirito, JR et al. (2013) Pruning of the adipocyte peroxisome proliferator-activated receptor γ cistrome by hematopoietic master regulator PU.1. Mol. Cell. Biol. 33 3354-64 PubMed GONUTS page

[PMID:1409581-11] Hagman, J & Grosschedl, R (1992) An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene. Proc. Natl. Acad. Sci. U.S.A. 89 8889-93 PubMed GONUTS page

[PMID:10648399-12] Guerriero, A et al. (2000) PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. Blood 95 879-85 PubMed GONUTS page

[PMID:19379700-13] Deneault, E et al. (2009) A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell 137 369-79 PubMed GONUTS page

[PMID:11980719-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Dahl, R et al. (2002) Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. EMBO J. 21 2220-30 PubMed GONUTS page

[PMID:9133423-15] 15.0 ^15.1 ^15.2 Scott, EW et al. (1997) PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity 6 437-47 PubMed GONUTS page

[PMID:19796622-16] 16.0 ^16.1 Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:16735694-17] 17.0 ^17.1 ^17.2 ^17.3 Hale, JS et al. (2006) Transcriptional control of Pactolus: evidence of a negative control region and comparison with its evolutionary paralogue, CD18 (beta2 integrin). J. Leukoc. Biol. 80 383-98 PubMed GONUTS page

[PMID:14962908-18] 18.0 ^18.1 Rosenbauer, F et al. (2004) pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1. Blood 103 4294-301 PubMed GONUTS page

[PMID:15361867-19] 19.0 ^19.1 Xue, HH et al. (2004) GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells. Nat. Immunol. 5 1036-44 PubMed GONUTS page

[PMID:23980096-20] Maruyama, K et al. (2013) Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J. Exp. Med. 210 1947-60 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

MOUSE:SPI1

Contents

Annotations

Notes

References

a

c

d

e

g

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools