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MOUSE:SPI1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Spi1 (synonyms: Sfpi-1, Sfpi1)
Protein Name(s) Transcription factor PU.1

31 kDa-transforming protein SFFV proviral integration 1 protein

External Links
UniProt P17433
EMBL X17463
L03215
M32370
M38252
BC003815
CCDS CCDS16425.1
PIR A34693
RefSeq NP_035485.1
UniGene Mm.1302
PDB 1PUE
PDBsum 1PUE
ProteinModelPortal P17433
SMR P17433
BioGrid 203184
IntAct P17433
MINT MINT-94708
PhosphoSite P17433
PRIDE P17433
Ensembl ENSMUST00000002180
GeneID 20375
KEGG mmu:20375
UCSC uc008kuj.1
CTD 6688
MGI MGI:98282
eggNOG NOG237824
HOGENOM HOG000095520
HOVERGEN HBG002474
InParanoid P17433
KO K09438
OMA PRMCLPY
PhylomeDB P17433
TreeFam TF352494
EvolutionaryTrace P17433
NextBio 298282
PRO PR:P17433
Proteomes UP000000589
Bgee P17433
CleanEx MM_SFPI1
ExpressionAtlas P17433
Genevestigator P17433
GO GO:0000790
GO:0005634
GO:0005667
GO:0003677
GO:0051525
GO:0003723
GO:0000978
GO:0001078
GO:0001077
GO:0000979
GO:0000980
GO:0003705
GO:0001205
GO:0001085
GO:0043565
GO:0003700
GO:0060033
GO:1902262
GO:0030218
GO:0030851
GO:0043966
GO:0044027
GO:0030098
GO:0002320
GO:0030225
GO:0043011
GO:0002573
GO:0045814
GO:0090241
GO:0045347
GO:0000122
GO:0045944
GO:0045893
GO:0045646
GO:0006357
GO:0006355
GO:0035019
GO:0006366
GO:0001944
Gene3D 1.10.10.10
InterPro IPR000418
IPR011991
Pfam PF00178
PRINTS PR00454
SMART SM00413
PROSITE PS00345
PS00346
PS50061

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

PMID:18384814[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15304486[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:1513)

Seeded From UniProt

complete

enables

GO:0001227

DNA-binding transcription repressor activity, RNA polymerase II-specific

PMID:16002702[3]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:15304486[2]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:16002702[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:15304486[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:16002702[3]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:12479)

Seeded From UniProt

complete

enables

GO:0051525

NFAT protein binding

PMID:15304486[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O88942

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15304486[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045347

negative regulation of MHC class II biosynthetic process

PMID:7592651[4]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P14483)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15304486[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:15304486[2]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0000165)

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:7592651[4]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:P14483)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:15304486[2]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0000165)

Seeded From UniProt

complete

enables

GO:0001085

RNA polymerase II transcription factor binding

PMID:18063754[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P17679

F

Seeded From UniProt

complete

enables

GO:0001085

RNA polymerase II transcription factor binding

PMID:15304486[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O88942

F

Seeded From UniProt

complete

enables

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

PMID:15304486[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:15187136[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109336
PANTHER:PTN000218930

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95455
MGI:MGI:95610
MGI:MGI:98282
PANTHER:PTN000218930
UniProtKB:Q15723

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000097
FB:FBgn0000567
FB:FBgn0003118
MGI:MGI:101762
MGI:MGI:107180
MGI:MGI:109637
MGI:MGI:1335079
MGI:MGI:1353422
MGI:MGI:2449712
MGI:MGI:95455
MGI:MGI:95554
MGI:MGI:95610
MGI:MGI:98282
MGI:MGI:99423
PANTHER:PTN000218930
RGD:1359607
RGD:1598663
RGD:2583
UniProtKB:P14921
UniProtKB:P17947
UniProtKB:P19419
UniProtKB:P32519
UniProtKB:P41161
UniProtKB:Q01543
UniProtKB:Q06546
WB:WBGene00002990
WB:WBGene00017687

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000218930
UniProtKB:Q15723

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902262

apoptotic process involved in blood vessel morphogenesis

PMID:16163358[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1927876

P

occurs_in:(EMAPA:16198)|occurs_in:(EMAPA:35198)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090241

negative regulation of histone H4 acetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070102

interleukin-6-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061614

pri-miRNA transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060033

anatomical structure regression

PMID:16163358[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1927876

P

has_participant:(EMAPA:16198)|has_participant:(EMAPA:35198)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

PMID:15100295[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1359607

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1359607

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045814

negative regulation of gene expression, epigenetic

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045646

regulation of erythrocyte differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0044027

hypermethylation of CpG island

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043966

histone H3 acetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:23775123[10]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(MGI:MGI:96607)|has_direct_input:(MGI:MGI:1339758)|has_direct_input:(MGI:MGI:95499)

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:1409581[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1359607

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043011

myeloid dendritic cell differentiation

PMID:10648399[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1930970

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035019

somatic stem cell population maintenance

PMID:19379700[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030851

granulocyte differentiation

PMID:11980719[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030225

macrophage differentiation

PMID:11980719[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030218

erythrocyte differentiation

PMID:9133423[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1930970

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030098

lymphocyte differentiation

PMID:11980719[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006357

regulation of transcription by RNA polymerase II

PMID:19796622[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006357

regulation of transcription by RNA polymerase II

PMID:16735694[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006355

regulation of transcription, DNA-templated

PMID:14962908[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006355

regulation of transcription, DNA-templated

PMID:11980719[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

PMID:11980719[14]

ECO:0000305

curator inference used in manual assertion

GO:0003700

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19796622[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16735694[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15361867[19]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1359607

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:14962908[18]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:11980719[14]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1359607

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:15361867[19]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002573

myeloid leukocyte differentiation

PMID:9133423[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1930970

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002320

lymphoid progenitor cell differentiation

PMID:9133423[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1930970

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001944

vasculature development

PMID:16163358[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1927876

P

results_in_development_of:(EMAPA:16198)|results_in_development_of:(EMAPA:35198)

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:16735694[17]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:23980096[20]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:16735694[17]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17947

C

Seeded From UniProt

complete

involved_in

GO:0090241

negative regulation of histone H4 acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

P

Seeded From UniProt

complete

involved_in

GO:0070102

interleukin-6-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

P

Seeded From UniProt

complete

involved_in

GO:0061614

pri-miRNA transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

P

Seeded From UniProt

complete

involved_in

GO:0045814

negative regulation of gene expression, epigenetic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

P

Seeded From UniProt

complete

involved_in

GO:0045646

regulation of erythrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

P

Seeded From UniProt

complete

involved_in

GO:0044027

hypermethylation of CpG island

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

P

Seeded From UniProt

complete

involved_in

GO:0043966

histone H3 acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

F

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17947
ensembl:ENSP00000227163

C

Seeded From UniProt

complete

involved_in

GO:0071361

cellular response to ethanol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6BDS1
ensembl:ENSRNOP00000016306

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6BDS1
ensembl:ENSRNOP00000016306

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6BDS1
ensembl:ENSRNOP00000016306

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6BDS1
ensembl:ENSRNOP00000016306

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6BDS1
ensembl:ENSRNOP00000016306

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6BDS1
ensembl:ENSRNOP00000016306

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000418

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000418

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000418

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-NUL-8865529

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Fujita, S et al. (2008) miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J. Mol. Biol. 378 492-504 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Matsumoto, M et al. (2004) Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J. Biol. Chem. 279 45969-79 PubMed GONUTS page
  3. 3.0 3.1 3.2 Geng, Y et al. (2005) Transcriptional regulation of CD1D1 by Ets family transcription factors. J. Immunol. 175 1022-9 PubMed GONUTS page
  4. 4.0 4.1 Borràs, FE et al. (1995) Repression of I-A beta gene expression by the transcription factor PU.1. J. Biol. Chem. 270 24385-91 PubMed GONUTS page
  5. Sugiyama, D et al. (2008) Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation. Blood 111 1924-32 PubMed GONUTS page
  6. Pauleau, AL et al. (2004) Enhancer-mediated control of macrophage-specific arginase I expression. J. Immunol. 172 7565-73 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. 8.0 8.1 8.2 Lobov, IB et al. (2005) WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437 417-21 PubMed GONUTS page
  9. Yee, CS et al. (2004) Cathepsin E: a novel target for regulation by class II transactivator. J. Immunol. 172 5528-34 PubMed GONUTS page
  10. Dispirito, JR et al. (2013) Pruning of the adipocyte peroxisome proliferator-activated receptor γ cistrome by hematopoietic master regulator PU.1. Mol. Cell. Biol. 33 3354-64 PubMed GONUTS page
  11. Hagman, J & Grosschedl, R (1992) An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene. Proc. Natl. Acad. Sci. U.S.A. 89 8889-93 PubMed GONUTS page
  12. Guerriero, A et al. (2000) PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. Blood 95 879-85 PubMed GONUTS page
  13. Deneault, E et al. (2009) A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell 137 369-79 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 14.5 Dahl, R et al. (2002) Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. EMBO J. 21 2220-30 PubMed GONUTS page
  15. 15.0 15.1 15.2 Scott, EW et al. (1997) PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity 6 437-47 PubMed GONUTS page
  16. 16.0 16.1 Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
  17. 17.0 17.1 17.2 17.3 Hale, JS et al. (2006) Transcriptional control of Pactolus: evidence of a negative control region and comparison with its evolutionary paralogue, CD18 (beta2 integrin). J. Leukoc. Biol. 80 383-98 PubMed GONUTS page
  18. 18.0 18.1 Rosenbauer, F et al. (2004) pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1. Blood 103 4294-301 PubMed GONUTS page
  19. 19.0 19.1 Xue, HH et al. (2004) GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells. Nat. Immunol. 5 1036-44 PubMed GONUTS page
  20. Maruyama, K et al. (2013) Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J. Exp. Med. 210 1947-60 PubMed GONUTS page