MOUSE:SOX2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sox2 (synonyms: Sox-2)
Protein Name(s)	Transcription factor SOX-2
External Links
UniProt	P48432
EMBL	U31967 X94127
CCDS	CCDS38413.1
PIR	S10949
RefSeq	NP_035573.3
UniGene	Mm.65396
PDB	1GT0
PDBsum	1GT0
ProteinModelPortal	P48432
SMR	P48432
BioGrid	203406
DIP	DIP-54522N
IntAct	P48432
PhosphoSite	P48432
MaxQB	P48432
PRIDE	P48432
GeneID	20674
KEGG	mmu:20674
CTD	6657
MGI	MGI:98364
eggNOG	NOG321816
HOGENOM	HOG000231647
HOVERGEN	HBG105663
InParanoid	P48432
KO	K16796
PhylomeDB	P48432
EvolutionaryTrace	P48432
NextBio	299161
PRO	PR:P48432
Proteomes	UP000000589
CleanEx	MM_SOX2
Genevestigator	P48432
GO	GO:0005737 GO:0044798 GO:0005634 GO:0005667 GO:0003682 GO:0003677 GO:0046982 GO:0043565 GO:0000981 GO:0003700 GO:0008134 GO:0044212 GO:0021984 GO:0048646 GO:0045165 GO:0001708 GO:0021987 GO:0050973 GO:0050910 GO:0048852 GO:0048568 GO:0001714 GO:0060441 GO:0021879 GO:0042472 GO:0060235 GO:0048286 GO:0030539 GO:0090090 GO:0045596 GO:0045665 GO:0045668 GO:0000122 GO:0030178 GO:0048663 GO:0097150 GO:0030910 GO:0046148 GO:0030858 GO:0002052 GO:0045666 GO:0045747 GO:0045944 GO:0050767 GO:0006357 GO:0006355 GO:0010033 GO:0032526 GO:0060042 GO:0007605 GO:0048863 GO:0019827 GO:0043586 GO:0006366
Gene3D	1.10.30.10
InterPro	IPR009071 IPR022097
Pfam	PF00505 PF12336
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:26691508^[1]	ECO:0000314			P		Protein Name: Transcription factor SOX-2; Sox2 Organism: Mus musculus (Mouse) Notes: In Figure 1, more specifically 1C, it is shown how Transcription factor SOX-2/Sox2 in Mus musculus upregulates Wdr5 and Dpy30 expression at the RNA level	complete CACAO 13345
	GO:0036207	positive regulation of histone gene expression	PMID:26691508^[1]	ECO:0000314			P		Fig. 1C and D shows that Mouse cells treated with Sox2 exhibit increased mRNA levels of histone related genes Wdr5 and Actb relative to the control.	complete CACAO 13354
enables	GO:0043565	sequence-specific DNA binding	PMID:23169531^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	PMID:23169531^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:23169531^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21076177^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20263	F		Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	PMID:22198669^[4]	ECO:0000316	genetic interaction evidence used in manual assertion		P		Seeded From UniProt	Missing: with/from
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:17875931^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19328208^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19816951^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q60793	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19490090^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030807 UniProtKB:P48431	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98364 PANTHER:PTN000030807 RGD:1565646 UniProtKB:P48430 UniProtKB:P48431	P		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98364 PANTHER:PTN000030807	P		Seeded From UniProt	complete
part_of	GO:0044798	nuclear transcription factor complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98362 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98660 PANTHER:PTN000030384	C		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030807 UniProtKB:P48431	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030745 ZFIN:ZDB-GENE-980526-333	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98363 PANTHER:PTN000030384	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030745 ZFIN:ZDB-GENE-980526-333	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:2654070 MGI:MGI:98364 PANTHER:PTN000030384 UniProtKB:P48431 UniProtKB:Q06945	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000411 FB:FBgn0005612 FB:FBgn0005613 FB:FBgn0029123 FB:FBgn0036411 MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98357 MGI:MGI:98359 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98369 MGI:MGI:98660 PANTHER:PTN000030384 RGD:1565646 RGD:3759 RGD:69351 UniProtKB:P35713 UniProtKB:P35716 UniProtKB:P48430 UniProtKB:P48431 UniProtKB:Q05066 UniProtKB:Q06945 UniProtKB:Q9BT81 UniProtKB:Q9H6I2 WB:WBGene00004771	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98362 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98660 PANTHER:PTN000030384 ZFIN:ZDB-GENE-990715-6	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98364 PANTHER:PTN000030807	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070848	response to growth factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:18374910^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060235	lens induction in camera-type eye	PMID:17140559^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101898	P	has_participant:(EMAPA:16672)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060042	retina morphogenesis in camera-type eye	PMID:16651659^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3625176	P	has_participant:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050973	detection of mechanical stimulus involved in equilibrioception	PMID:15846349^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	PMID:15846349^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447995	P	occurs_in:(EMAPA:19151) occurs_in:(CL:0000202)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050767	regulation of neurogenesis	PMID:22513373^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102780 MGI:MGI:109344 MGI:MGI:1915344 MGI:MGI:88192	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048863	stem cell differentiation	PMID:20123909^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_acquisition_of_features_of:(CL:0002322)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048852	diencephalon morphogenesis	PMID:15240551^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181440 MGI:MGI:3052123	P	has_participant:(EMAPA:17540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048663	neuron fate commitment	PMID:17015430^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3589809	P	has_participant:(EMAPA:18875) results_in_commitment_to:(CL:0000006)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:9851841^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2135304	P	results_in_formation_of:(EMAPA:16072)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:17522155^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3589809 MGI:MGI:3625175	P	results_in_formation_of:(EMAPA:16833)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048568	embryonic organ development	PMID:17522155^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3589809 MGI:MGI:3625175	P	results_in_development_of:(EMAPA:18889)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048286	lung alveolus development	PMID:18374910^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:22344693^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046148	pigment biosynthetic process	PMID:12036291^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447996	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:7590241^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101893	P	has_regulation_target:(MGI:MGI:95518)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17507372^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101893	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17140559^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101898	P	has_regulation_target:(MGI:MGI:97490)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17097055^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101893	P	has_regulation_target:(MGI:MGI:95518)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15863505^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101893	P	has_regulation_target:(MGI:MGI:95518)\|has_regulation_target:(MGI:MGI:1354755)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15988017^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:98364)\|has_regulation_target:(MGI:MGI:101893)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:7628452^[27]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:88526)\|has_regulation_target:(MGI:MGI:95518)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17507372^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17097055^[24]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:95518)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16932809^[28]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:96071)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21245162^[29]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1565646	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045747	positive regulation of Notch signaling pathway	PMID:16631155^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000031)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045668	negative regulation of osteoblast differentiation	PMID:15781477^[31]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	PMID:16651659^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3625176	P	regulates_o_occurs_in:(EMAPA:17168) regulates_o_results_in_acquisition_of_features_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	PMID:16631155^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045597	positive regulation of cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1565646	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045596	negative regulation of cell differentiation	PMID:17507372^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:1000274)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:18374910^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0044798	nuclear transcription factor complex	PMID:22344693^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:20123909^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043586	tongue development	PMID:17015430^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3589809	P	results_in_development_of:(EMAPA:18875)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:9669521^[32]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:95518)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:9649510^[33]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:98389)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:7628452^[27]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:88526)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:18400104^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21245162^[29]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:15846349^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447995	P	has_participant:(EMAPA:17293)\|has_participant:(EMAPA:17290)	Seeded From UniProt	complete
enables	GO:0035198	miRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035019	somatic stem cell population maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032526	response to retinoic acid	PMID:18400104^[34]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16039) occurs_in:(CL:0000034)	Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:24268575^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030910	olfactory placode formation	PMID:17140559^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101898	P	results_in_formation_of:(EMAPA:16800)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030858	positive regulation of epithelial cell differentiation	PMID:18374910^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030539	male genitalia development	PMID:16932809^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449045	P	results_in_development_of:(EMAPA:17972)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:15781477^[31]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88276	P	regulates_o_occurs_in:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022409	positive regulation of cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1565646	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021987	cerebral cortex development	PMID:15240551^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181440 MGI:MGI:3052123	P	results_in_development_of:(EMAPA:17544)\|results_in_development_of:(EMAPA:17549)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021984	adenohypophysis development	PMID:16932809^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449045	P	results_in_development_of:(EMAPA:17514)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021879	forebrain neuron differentiation	PMID:15240551^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181440 MGI:MGI:3052123	P	occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:20720539^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:16767105^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010033	response to organic substance	PMID:18400104^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:12036291^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447996	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:19796622^[38]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12665572^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12514105^[40]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16046)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:17507372^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9512512^[41]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16198) part_of:(CL:0000306)\|part_of:(EMAPA:16799)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25535395^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25335925^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24191021^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24036311^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23447615^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23284756^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23056351^[48]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16910)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22992956^[49]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16069)\|part_of:(EMAPA:16095)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22232070^[50]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21300049^[51]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20531390^[52]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20123909^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19796622^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18448678^[53]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18287078^[54]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17522155^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18862) part_of:(CL:0000646)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17507372^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16932809^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16631155^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000031)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12514105^[40]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16041)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12665572^[39]	ECO:0000305	curator inference used in manual assertion	GO:0003700	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1565646	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48430	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9669521^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:7628452^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17097055^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:16932809^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12665572^[39]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:15988017^[26]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:98364)\|has_participant:(MGI:MGI:101893)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15863505^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101893	F	has_participant:(MGI:MGI:95518)\|has_participant:(MGI:MGI:1354755)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8625802^[55]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15082719^[56]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12665572^[39]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002052	positive regulation of neuroblast proliferation	PMID:16651659^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3625176	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002052	positive regulation of neuroblast proliferation	PMID:15240551^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181440 MGI:MGI:3052123	P	regulates_o_occurs_in:(EMAPA:32845)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001714	endodermal cell fate specification	PMID:21245162^[29]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001708	cell fate specification	PMID:12514105^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449045	P	has_participant:(EMAPA:16050)\|has_participant:(EMAPA:16041)\|has_participant:(EMAPA:16065)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48431	P		Seeded From UniProt	complete
contributes_to	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1565646	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:22344693^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1565646	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9649510^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101893	P	has_regulation_target:(MGI:MGI:98389)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032643	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032643	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022097 InterPro:IPR032643	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9615549	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Hutchins, AP et al. (2013) Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells. Stem Cells 31 269-81 PubMed GONUTS page
↑ Johansson, H & Simonsson, S (2010) Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY) 2 815-22 PubMed GONUTS page
↑ Andreu-Agullo, C et al. (2012) Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Nature 481 195-8 PubMed GONUTS page
↑ Sinner, D et al. (2007) Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol. Cell. Biol. 27 7802-15 PubMed GONUTS page
↑ Palasingam, P et al. (2009) The structure of Sox17 bound to DNA reveals a conserved bending topology but selective protein interaction platforms. J. Mol. Biol. 388 619-30 PubMed GONUTS page
↑ Wei, Z et al. (2009) Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells 27 2969-78 PubMed GONUTS page
↑ Haslinger, A et al. (2009) Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis. Eur. J. Neurosci. 29 2103-14 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Gontan, C et al. (2008) Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev. Biol. 317 296-309 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Donner, AL et al. (2007) Sox2 and Pou2f1 interact to control lens and olfactory placode development. Dev. Biol. 303 784-99 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Taranova, OV et al. (2006) SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev. 20 1187-202 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Kiernan, AE et al. (2005) Sox2 is required for sensory organ development in the mammalian inner ear. Nature 434 1031-5 PubMed GONUTS page
↑ Ahmed, M et al. (2012) EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development 139 1965-77 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Niakan, KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 24 312-26 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Ferri, AL et al. (2004) Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development 131 3805-19 PubMed GONUTS page
↑ ^17.0 ^17.1 Okubo, T et al. (2006) Sox2 is required for development of taste bud sensory cells. Genes Dev. 20 2654-9 PubMed GONUTS page
↑ Tomihara-Newberger, C et al. (1998) The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives. Dev. Biol. 204 34-54 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Que, J et al. (2007) Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development 134 2521-31 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Ng, CK et al. (2012) Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 40 4933-41 PubMed GONUTS page
↑ ^21.0 ^21.1 Dong, S et al. (2002) Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3. Genomics 79 777-84 PubMed GONUTS page
↑ Yuan, H et al. (1995) Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev. 9 2635-45 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 Li, J et al. (2007) A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells. J. Biol. Chem. 282 19481-92 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Tsuruzoe, S et al. (2006) Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem. Biophys. Res. Commun. 351 920-6 PubMed GONUTS page
↑ ^25.0 ^25.1 Maruyama, M et al. (2005) Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J. Biol. Chem. 280 24371-9 PubMed GONUTS page
↑ ^26.0 ^26.1 Chew, JL et al. (2005) Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol. Cell. Biol. 25 6031-46 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Kamachi, Y et al. (1995) Involvement of SOX proteins in lens-specific activation of crystallin genes. EMBO J. 14 3510-9 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 ^28.4 Kelberman, D et al. (2006) Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans. J. Clin. Invest. 116 2442-55 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Teo, AK et al. (2011) Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 25 238-50 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Bani-Yaghoub, M et al. (2006) Role of Sox2 in the development of the mouse neocortex. Dev. Biol. 295 52-66 PubMed GONUTS page
↑ ^31.0 ^31.1 Mansukhani, A et al. (2005) Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J. Cell Biol. 168 1065-76 PubMed GONUTS page
↑ ^32.0 ^32.1 Johnson, LR et al. (1998) Role of the transcription factor Sox-2 in the expression of the FGF-4 gene in embryonal carcinoma cells. Mol. Reprod. Dev. 50 377-86 PubMed GONUTS page
↑ ^33.0 ^33.1 Botquin, V et al. (1998) New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev. 12 2073-90 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 Kunarso, G et al. (2008) Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics 9 155 PubMed GONUTS page
↑ Payer, B et al. (2013) Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Mol. Cell 52 805-18 PubMed GONUTS page
↑ Kagey, MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature 467 430-5 PubMed GONUTS page
↑ Ivanova, N et al. (2006) Dissecting self-renewal in stem cells with RNA interference. Nature 442 533-8 PubMed GONUTS page
↑ ^38.0 ^38.1 Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 ^39.3 Tokuzawa, Y et al. (2003) Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol. Cell. Biol. 23 2699-708 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 Avilion, AA et al. (2003) Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 17 126-40 PubMed GONUTS page
↑ Nishiguchi, S et al. (1998) Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev. 12 776-81 PubMed GONUTS page
↑ Li, W et al. (2015) Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc. Natl. Acad. Sci. U.S.A. 112 166-71 PubMed GONUTS page
↑ Shen, J et al. (2015) Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling. Stem Cells 33 661-73 PubMed GONUTS page
↑ Rockich, BE et al. (2013) Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 110 E4456-64 PubMed GONUTS page
↑ Zhang, K et al. (2013) CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev. Biol. 383 15-27 PubMed GONUTS page
↑ Shimozaki, K et al. (2013) Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J. Neurosci. 33 4066-75 PubMed GONUTS page
↑ Krolewski, RC et al. (2012) Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS ONE 7 e51737 PubMed GONUTS page
↑ Konno, D et al. (2012) The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex. PLoS ONE 7 e46577 PubMed GONUTS page
↑ Iwafuchi-Doi, M et al. (2012) Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development 139 3926-37 PubMed GONUTS page
↑ Li, Y et al. (2012) Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1. Stem Cells 30 741-52 PubMed GONUTS page
↑ Tateya, T et al. (2011) Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. Dev. Biol. 352 329-40 PubMed GONUTS page
↑ Shiwaku, H et al. (2010) Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J. 29 2446-60 PubMed GONUTS page
↑ Gao, X et al. (2008) ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc. Natl. Acad. Sci. U.S.A. 105 6656-61 PubMed GONUTS page
↑ Fauquier, T et al. (2008) SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland. Proc. Natl. Acad. Sci. U.S.A. 105 2907-12 PubMed GONUTS page
↑ Collignon, J et al. (1996) A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development 122 509-20 PubMed GONUTS page
↑ Murakami, A et al. (2004) SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. J. Biol. Chem. 279 28564-73 PubMed GONUTS page

[PMID:26691508-1] 1.0 ^1.1 Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page

[PMID:23169531-2] 2.0 ^2.1 ^2.2 Hutchins, AP et al. (2013) Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells. Stem Cells 31 269-81 PubMed GONUTS page

[PMID:21076177-3] Johansson, H & Simonsson, S (2010) Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY) 2 815-22 PubMed GONUTS page

[PMID:22198669-4] Andreu-Agullo, C et al. (2012) Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Nature 481 195-8 PubMed GONUTS page

[PMID:17875931-5] Sinner, D et al. (2007) Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol. Cell. Biol. 27 7802-15 PubMed GONUTS page

[PMID:19328208-6] Palasingam, P et al. (2009) The structure of Sox17 bound to DNA reveals a conserved bending topology but selective protein interaction platforms. J. Mol. Biol. 388 619-30 PubMed GONUTS page

[PMID:19816951-7] Wei, Z et al. (2009) Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells 27 2969-78 PubMed GONUTS page

[PMID:19490090-8] Haslinger, A et al. (2009) Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis. Eur. J. Neurosci. 29 2103-14 PubMed GONUTS page

[PMID:21873635-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18374910-10] 10.0 ^10.1 ^10.2 ^10.3 Gontan, C et al. (2008) Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev. Biol. 317 296-309 PubMed GONUTS page

[PMID:17140559-11] 11.0 ^11.1 ^11.2 Donner, AL et al. (2007) Sox2 and Pou2f1 interact to control lens and olfactory placode development. Dev. Biol. 303 784-99 PubMed GONUTS page

[PMID:16651659-12] 12.0 ^12.1 ^12.2 Taranova, OV et al. (2006) SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev. 20 1187-202 PubMed GONUTS page

[PMID:15846349-13] 13.0 ^13.1 ^13.2 Kiernan, AE et al. (2005) Sox2 is required for sensory organ development in the mammalian inner ear. Nature 434 1031-5 PubMed GONUTS page

[PMID:22513373-14] Ahmed, M et al. (2012) EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development 139 1965-77 PubMed GONUTS page

[PMID:20123909-15] 15.0 ^15.1 ^15.2 Niakan, KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 24 312-26 PubMed GONUTS page

[PMID:15240551-16] 16.0 ^16.1 ^16.2 ^16.3 Ferri, AL et al. (2004) Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development 131 3805-19 PubMed GONUTS page

[PMID:17015430-17] 17.0 ^17.1 Okubo, T et al. (2006) Sox2 is required for development of taste bud sensory cells. Genes Dev. 20 2654-9 PubMed GONUTS page

[PMID:9851841-18] Tomihara-Newberger, C et al. (1998) The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives. Dev. Biol. 204 34-54 PubMed GONUTS page

[PMID:17522155-19] 19.0 ^19.1 ^19.2 Que, J et al. (2007) Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development 134 2521-31 PubMed GONUTS page

[PMID:22344693-20] 20.0 ^20.1 ^20.2 Ng, CK et al. (2012) Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 40 4933-41 PubMed GONUTS page

[PMID:12036291-21] 21.0 ^21.1 Dong, S et al. (2002) Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3. Genomics 79 777-84 PubMed GONUTS page

[PMID:7590241-22] Yuan, H et al. (1995) Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev. 9 2635-45 PubMed GONUTS page

[PMID:17507372-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 Li, J et al. (2007) A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells. J. Biol. Chem. 282 19481-92 PubMed GONUTS page

[PMID:17097055-24] 24.0 ^24.1 ^24.2 Tsuruzoe, S et al. (2006) Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem. Biophys. Res. Commun. 351 920-6 PubMed GONUTS page

[PMID:15863505-25] 25.0 ^25.1 Maruyama, M et al. (2005) Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J. Biol. Chem. 280 24371-9 PubMed GONUTS page

[PMID:15988017-26] 26.0 ^26.1 Chew, JL et al. (2005) Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol. Cell. Biol. 25 6031-46 PubMed GONUTS page

[PMID:7628452-27] 27.0 ^27.1 ^27.2 Kamachi, Y et al. (1995) Involvement of SOX proteins in lens-specific activation of crystallin genes. EMBO J. 14 3510-9 PubMed GONUTS page

[PMID:16932809-28] 28.0 ^28.1 ^28.2 ^28.3 ^28.4 Kelberman, D et al. (2006) Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans. J. Clin. Invest. 116 2442-55 PubMed GONUTS page

[PMID:21245162-29] 29.0 ^29.1 ^29.2 Teo, AK et al. (2011) Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 25 238-50 PubMed GONUTS page

[PMID:16631155-30] 30.0 ^30.1 ^30.2 Bani-Yaghoub, M et al. (2006) Role of Sox2 in the development of the mouse neocortex. Dev. Biol. 295 52-66 PubMed GONUTS page

[PMID:15781477-31] 31.0 ^31.1 Mansukhani, A et al. (2005) Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J. Cell Biol. 168 1065-76 PubMed GONUTS page

[PMID:9669521-32] 32.0 ^32.1 Johnson, LR et al. (1998) Role of the transcription factor Sox-2 in the expression of the FGF-4 gene in embryonal carcinoma cells. Mol. Reprod. Dev. 50 377-86 PubMed GONUTS page

[PMID:9649510-33] 33.0 ^33.1 Botquin, V et al. (1998) New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev. 12 2073-90 PubMed GONUTS page

[PMID:18400104-34] 34.0 ^34.1 ^34.2 Kunarso, G et al. (2008) Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics 9 155 PubMed GONUTS page

[PMID:24268575-35] Payer, B et al. (2013) Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Mol. Cell 52 805-18 PubMed GONUTS page

[PMID:20720539-36] Kagey, MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature 467 430-5 PubMed GONUTS page

[PMID:16767105-37] Ivanova, N et al. (2006) Dissecting self-renewal in stem cells with RNA interference. Nature 442 533-8 PubMed GONUTS page

[PMID:19796622-38] 38.0 ^38.1 Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:12665572-39] 39.0 ^39.1 ^39.2 ^39.3 Tokuzawa, Y et al. (2003) Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol. Cell. Biol. 23 2699-708 PubMed GONUTS page

[PMID:12514105-40] 40.0 ^40.1 ^40.2 Avilion, AA et al. (2003) Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 17 126-40 PubMed GONUTS page

[PMID:9512512-41] Nishiguchi, S et al. (1998) Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev. 12 776-81 PubMed GONUTS page

[PMID:25535395-42] Li, W et al. (2015) Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc. Natl. Acad. Sci. U.S.A. 112 166-71 PubMed GONUTS page

[PMID:25335925-43] Shen, J et al. (2015) Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling. Stem Cells 33 661-73 PubMed GONUTS page

[PMID:24191021-44] Rockich, BE et al. (2013) Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 110 E4456-64 PubMed GONUTS page

[PMID:24036311-45] Zhang, K et al. (2013) CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev. Biol. 383 15-27 PubMed GONUTS page

[PMID:23447615-46] Shimozaki, K et al. (2013) Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J. Neurosci. 33 4066-75 PubMed GONUTS page

[PMID:23284756-47] Krolewski, RC et al. (2012) Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS ONE 7 e51737 PubMed GONUTS page

[PMID:23056351-48] Konno, D et al. (2012) The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex. PLoS ONE 7 e46577 PubMed GONUTS page

[PMID:22992956-49] Iwafuchi-Doi, M et al. (2012) Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development 139 3926-37 PubMed GONUTS page

[PMID:22232070-50] Li, Y et al. (2012) Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1. Stem Cells 30 741-52 PubMed GONUTS page

[PMID:21300049-51] Tateya, T et al. (2011) Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. Dev. Biol. 352 329-40 PubMed GONUTS page

[PMID:20531390-52] Shiwaku, H et al. (2010) Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J. 29 2446-60 PubMed GONUTS page

[PMID:18448678-53] Gao, X et al. (2008) ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc. Natl. Acad. Sci. U.S.A. 105 6656-61 PubMed GONUTS page

[PMID:18287078-54] Fauquier, T et al. (2008) SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland. Proc. Natl. Acad. Sci. U.S.A. 105 2907-12 PubMed GONUTS page

[PMID:8625802-55] Collignon, J et al. (1996) A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development 122 509-20 PubMed GONUTS page

[PMID:15082719-56] Murakami, A et al. (2004) SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. J. Biol. Chem. 279 28564-73 PubMed GONUTS page

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MOUSE:SOX2

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