MOUSE:SNAI1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Snai1 (synonyms: Sna)
Protein Name(s)	Zinc finger protein SNAI1 Protein snail homolog 1 Protein sna
External Links
UniProt	Q02085
EMBL	M95604 X67253 BC034857 U95961
CCDS	CCDS17102.1
PIR	A49149
RefSeq	NP_035557.1
UniGene	Mm.2093
ProteinModelPortal	Q02085
SMR	Q02085
BioGrid	203361
IntAct	Q02085
STRING	10090.ENSMUSP00000050581
PhosphoSite	Q02085
PRIDE	Q02085
Ensembl	ENSMUST00000052631
GeneID	20613
KEGG	mmu:20613
UCSC	uc008nzy.1
CTD	6615
MGI	MGI:98330
eggNOG	COG5048
HOGENOM	HOG000261665
HOVERGEN	HBG007477
InParanoid	Q02085
KO	K05707
OMA	CNKEYLS
OrthoDB	EOG7P2XSG
PhylomeDB	Q02085
TreeFam	TF315515
NextBio	298979
PRO	PR:Q02085
Proteomes	UP000000589
Bgee	Q02085
CleanEx	MM_SNAI1
ExpressionAtlas	Q02085
Genevestigator	Q02085
GO	GO:0005737 GO:0005634 GO:0046872 GO:0001078 GO:0000977 GO:0001227 GO:0043565 GO:0060536 GO:0016477 GO:0001837 GO:0003198 GO:0031069 GO:0060972 GO:0007498 GO:0001707 GO:0060806 GO:0043518 GO:1902230 GO:0000122 GO:0045892 GO:0010957 GO:0061314 GO:0001649 GO:0060021 GO:0030335 GO:0010718 GO:0045893 GO:2000810 GO:0006357 GO:0060707
Gene3D	3.30.160.60
InterPro	IPR029795 IPR007087 IPR015880 IPR013087
PANTHER	PTHR11389:SF430
Pfam	PF00096
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:24239292^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005721	pericentric heterochromatin	PMID:24239292^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070828	heterochromatin organization	PMID:24239292^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:12917416^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:12917416^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12917416^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:25412)	Seeded From UniProt	complete
involved_in	GO:0061314	Notch signaling involved in heart development	PMID:20890042^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q01705	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:20890042^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:20890042^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20890042^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	PMID:18663143^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q3UZ96	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12832491^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12832491^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:10655586^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12832491^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12832491^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:18832382^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:11689706^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:10655586^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	PMID:11689706^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12832491^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10655586^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037618 MGI:MGI:1353563 PANTHER:PTN001227002 ZFIN:ZDB-GENE-100318-5	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000286 FB:FBgn0000289 FB:FBgn0003448 MGI:MGI:1096393 MGI:MGI:1353563 MGI:MGI:2139287 MGI:MGI:2176606 MGI:MGI:98330 PANTHER:PTN001227002 RGD:1310136 SGD:S000004972 UniProtKB:O43623 UniProtKB:Q2M1K9 UniProtKB:Q4WJ81 UniProtKB:Q8NAP3 UniProtKB:Q9P1Z0 UniProtKB:Q9Y2X9 WB:WBGene00001324	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037618 MGI:MGI:1353563 PANTHER:PTN001227002 RGD:1310136 UniProtKB:Q9Y2X9	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003448 FB:FBgn0037617 FB:FBgn0039860 PANTHER:PTN001227002	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000810	regulation of bicellular tight junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060972	left/right pattern formation	PMID:16801545^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183156	P	occurs_in:(EMAPA:16039)\|occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060806	negative regulation of cell differentiation involved in embryonic placenta development	PMID:9676199^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060707	trophoblast giant cell differentiation	PMID:9676199^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060536	cartilage morphogenesis	PMID:17376812^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096393	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060021	roof of mouth development	PMID:17376812^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096393	P	results_in_development_of:(EMAPA:17930)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:9676199^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031069	hair follicle morphogenesis	PMID:15630473^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:17376812^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096393	P	occurs_in:(EMAPA:17931) results_in_movement_of:(CL:0000078)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010957	negative regulation of vitamin D biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007498	mesoderm development	PMID:16801545^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183156	P	results_in_development_of:(EMAPA:16097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:9676199^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96920 MGI:MGI:98510	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	C		Seeded From UniProt	complete
part_of	GO:0005721	pericentric heterochromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15630473^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18771) part_of:(CL:0000362)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:17093497^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:98505)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9676199^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95863	P		Seeded From UniProt	complete
involved_in	GO:2000810	regulation of bicellular tight junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	P		Seeded From UniProt	complete
involved_in	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	P		Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	F		Seeded From UniProt	complete
involved_in	GO:0010957	negative regulation of vitamin D biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	C		Seeded From UniProt	complete
part_of	GO:0005721	pericentric heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	C		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95863 ensembl:ENSP00000244050	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Millanes-Romero, A et al. (2013) Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition. Mol. Cell 52 746-57 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Seki, K et al. (2003) Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. J. Biol. Chem. 278 41862-70 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Luna-Zurita, L et al. (2010) Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J. Clin. Invest. 120 3493-507 PubMed GONUTS page
↑ Niessen, K et al. (2008) Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J. Cell Biol. 182 315-25 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Domínguez, D et al. (2003) Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor. Mol. Cell. Biol. 23 5078-89 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Cano, A et al. (2000) The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2 76-83 PubMed GONUTS page
↑ Thuault, S et al. (2008) HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J. Biol. Chem. 283 33437-46 PubMed GONUTS page
↑ ^8.0 ^8.1 Carver, EA et al. (2001) The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol. Cell. Biol. 21 8184-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 Murray, SA & Gridley, T (2006) Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc. Natl. Acad. Sci. U.S.A. 103 10300-4 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Nakayama, H et al. (1998) The transition to endoreduplication in trophoblast giant cells is regulated by the mSNA zinc finger transcription factor. Dev. Biol. 199 150-63 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Murray, SA et al. (2007) Multiple functions of Snail family genes during palate development in mice. Development 134 1789-97 PubMed GONUTS page
↑ ^13.0 ^13.1 Jamora, C et al. (2005) A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol. 3 e11 PubMed GONUTS page
↑ Boutet, A et al. (2006) Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J. 25 5603-13 PubMed GONUTS page

[PMID:24239292-1] 1.0 ^1.1 ^1.2 Millanes-Romero, A et al. (2013) Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition. Mol. Cell 52 746-57 PubMed GONUTS page

[PMID:12917416-2] 2.0 ^2.1 ^2.2 Seki, K et al. (2003) Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. J. Biol. Chem. 278 41862-70 PubMed GONUTS page

[PMID:20890042-3] 3.0 ^3.1 ^3.2 ^3.3 Luna-Zurita, L et al. (2010) Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J. Clin. Invest. 120 3493-507 PubMed GONUTS page

[PMID:18663143-4] Niessen, K et al. (2008) Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J. Cell Biol. 182 315-25 PubMed GONUTS page

[PMID:12832491-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Domínguez, D et al. (2003) Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor. Mol. Cell. Biol. 23 5078-89 PubMed GONUTS page

[PMID:10655586-6] 6.0 ^6.1 ^6.2 Cano, A et al. (2000) The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2 76-83 PubMed GONUTS page

[PMID:18832382-7] Thuault, S et al. (2008) HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J. Biol. Chem. 283 33437-46 PubMed GONUTS page

[PMID:11689706-8] 8.0 ^8.1 Carver, EA et al. (2001) The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol. Cell. Biol. 21 8184-8 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16801545-10] 10.0 ^10.1 Murray, SA & Gridley, T (2006) Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc. Natl. Acad. Sci. U.S.A. 103 10300-4 PubMed GONUTS page

[PMID:9676199-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Nakayama, H et al. (1998) The transition to endoreduplication in trophoblast giant cells is regulated by the mSNA zinc finger transcription factor. Dev. Biol. 199 150-63 PubMed GONUTS page

[PMID:17376812-12] 12.0 ^12.1 ^12.2 Murray, SA et al. (2007) Multiple functions of Snail family genes during palate development in mice. Development 134 1789-97 PubMed GONUTS page

[PMID:15630473-13] 13.0 ^13.1 Jamora, C et al. (2005) A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol. 3 e11 PubMed GONUTS page

[PMID:17093497-14] Boutet, A et al. (2006) Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J. 25 5603-13 PubMed GONUTS page

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MOUSE:SNAI1

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