MOUSE:SESN2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sesn2 (synonyms: Sest2)
Protein Name(s)	Sestrin-2
External Links
UniProt	P58043
EMBL	BC005672
CCDS	CCDS18726.1
RefSeq	NP_659156.1
UniGene	Mm.23608
ProteinModelPortal	P58043
BioGrid	231026
IntAct	P58043
STRING	10090.ENSMUSP00000030724
PhosphoSite	P58043
MaxQB	P58043
PRIDE	P58043
Ensembl	ENSMUST00000030724
GeneID	230784
KEGG	mmu:230784
UCSC	uc008vbj.1
CTD	83667
MGI	MGI:2651874
eggNOG	NOG312456
GeneTree	ENSGT00440000040103
HOGENOM	HOG000232949
HOVERGEN	HBG054648
InParanoid	P58043
KO	K10141
OMA	MENRFEL
OrthoDB	EOG7SBNNF
PhylomeDB	P58043
TreeFam	TF314230
NextBio	380152
PRO	PR:P58043
Proteomes	UP000000589
Bgee	P58043
CleanEx	MM_SESN2
Genevestigator	P58043
GO	GO:0005737 GO:0005634 GO:0006914 GO:0006635 GO:0042593 GO:0046323 GO:0032042 GO:0007005 GO:0043491 GO:2000479 GO:0090526 GO:0001932 GO:1901031 GO:0009749 GO:0032868 GO:0070328
Gene3D	1.20.1290.10
InterPro	IPR029032 IPR006730
Pfam	PF04636
SUPFAM	SSF69118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0010255	glucose mediated signaling pathway	PMID:22958918^[1]	ECO:0000314			P	Figure 1A and 1B show that a deficiency in SESN2 had a great effect on the activation and production of Glucose.	complete CACAO 5082
	GO:0000723	telomere maintenance	PMID:22958918^[1]	ECO:0000021		UniProtKB:Q9Y478	P	From the graphical abstract one can see that SESN2 would be used as an activating and maintainer of AMPK. This is also seen in figure one where the concentration of SESN2 effects the activation of AMPK	complete CACAO 5083
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:25259925^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0031932	TORC2 complex	PMID:25377878^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:23274085^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0031588	nucleotide-activated protein kinase complex	PMID:18692468^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:24947615^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	PMID:24947615^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1990253	cellular response to leucine starvation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
colocalizes_with	GO:1990316	Atg1/ULK1 kinase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P58004	C	Seeded From UniProt	complete
colocalizes_with	GO:0061700	GATOR2 complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P58004	C	Seeded From UniProt	complete
enables	GO:0070728	leucine binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P58004	F	Seeded From UniProt	complete
enables	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P58004	F	Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
involved_in	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:20203043^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030330	DNA damage response, signal transduction by p53 class mediator	PMID:18692468^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005092	GDP-dissociation inhibitor activity	PMID:25259925^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	PMID:25259925^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1990253	cellular response to leucine starvation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004	P	Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1922997 MGI:MGI:2155278 MGI:MGI:2651874 PANTHER:PTN000280005 UniProtKB:P58004 UniProtKB:P58005 UniProtKB:Q9Y6P5	P	Seeded From UniProt	complete
involved_in	GO:0071233	cellular response to leucine	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004	P	Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1922997 MGI:MGI:2155278 MGI:MGI:2651874 PANTHER:PTN000280005 UniProtKB:P58004	P	Seeded From UniProt	complete
enables	GO:0070728	leucine binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004 UniProtKB:Q9Y6P5	F	Seeded From UniProt	complete
colocalizes_with	GO:0061700	GATOR2 complex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004 UniProtKB:P58005 UniProtKB:Q9Y6P5	C	Seeded From UniProt	complete
colocalizes_with	GO:0031932	TORC2 complex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1922997 MGI:MGI:2651874 PANTHER:PTN000280005	C	Seeded From UniProt	complete
enables	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004	F	Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004	P	Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004 UniProtKB:P58005 UniProtKB:Q9Y6P5	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000479	regulation of cAMP-dependent protein kinase activity	PMID:22958918^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3587950	P	Seeded From UniProt	complete
colocalizes_with	GO:1990316	Atg1/ULK1 kinase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990253	cellular response to leucine starvation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904504	positive regulation of lipophagy	PMID:22958918^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3587950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904262	negative regulation of TORC1 signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900182	positive regulation of protein localization to nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071233	cellular response to leucine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
enables	GO:0070728	leucine binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070328	triglyceride homeostasis	PMID:22958918^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3587950	P	Seeded From UniProt	complete
colocalizes_with	GO:0061700	GATOR2 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046323	glucose import	PMID:22958918^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3587950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043491	protein kinase B signaling	PMID:22958918^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3587950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:22958918^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104663	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042149	cellular response to glucose starvation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034198	cellular response to amino acid starvation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032868	response to insulin	PMID:22958918^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104663 MGI:MGI:1922997	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032868	response to insulin	PMID:22958918^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3587950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032042	mitochondrial DNA metabolic process	PMID:22958918^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3587950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030330	DNA damage response, signal transduction by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
enables	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016239	positive regulation of macroautophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009749	response to glucose	PMID:22958918^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104663 MGI:MGI:1922997	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009749	response to glucose	PMID:22958918^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3587950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	PMID:22958918^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3587950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006635	fatty acid beta-oxidation	PMID:22958918^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104663	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006111	regulation of gluconeogenesis	PMID:22958918^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3587950	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001932	regulation of protein phosphorylation	PMID:22958918^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3587950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001932	regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P58004	P	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0032042	C	Seeded From UniProt	complete
part_of	GO:1990316	Atg1/ULK1 kinase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	C	Seeded From UniProt	complete
involved_in	GO:1990253	cellular response to leucine starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
involved_in	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
involved_in	GO:0071233	cellular response to leucine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
enables	GO:0070728	leucine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	F	Seeded From UniProt	complete
part_of	GO:0061700	GATOR2 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	C	Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
involved_in	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
enables	GO:0032542	sulfiredoxin activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	F	Seeded From UniProt	complete
involved_in	GO:0030330	DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
enables	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	F	Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	C	Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58004 ensembl:ENSP00000253063	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006730	C	Seeded From UniProt	complete
involved_in	GO:1901031	regulation of response to reactive oxygen species	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006730	P	Seeded From UniProt	complete
enables	GO:0051920	peroxiredoxin activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.11.1.15	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 Lee, JH et al. (2012) Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 16 311-21 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Peng, M et al. (2014) Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell 159 122-133 PubMed GONUTS page
↑ Tao, R et al. (2015) Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling. Diabetes 64 1211-23 PubMed GONUTS page
↑ Bae, SH et al. (2013) Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab. 17 73-84 PubMed GONUTS page
↑ ^5.0 ^5.1 Budanov, AV & Karin, M (2008) p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134 451-60 PubMed GONUTS page
↑ ^6.0 ^6.1 Park, HW et al. (2014) Hepatoprotective role of Sestrin2 against chronic ER stress. Nat Commun 5 4233 PubMed GONUTS page
↑ Lee, JH et al. (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327 1223-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22958918-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 Lee, JH et al. (2012) Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 16 311-21 PubMed GONUTS page

[PMID:25259925-2] 2.0 ^2.1 ^2.2 Peng, M et al. (2014) Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell 159 122-133 PubMed GONUTS page

[PMID:25377878-3] Tao, R et al. (2015) Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling. Diabetes 64 1211-23 PubMed GONUTS page

[PMID:23274085-4] Bae, SH et al. (2013) Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab. 17 73-84 PubMed GONUTS page

[PMID:18692468-5] 5.0 ^5.1 Budanov, AV & Karin, M (2008) p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134 451-60 PubMed GONUTS page

[PMID:24947615-6] 6.0 ^6.1 Park, HW et al. (2014) Hepatoprotective role of Sestrin2 against chronic ER stress. Nat Commun 5 4233 PubMed GONUTS page

[PMID:20203043-7] Lee, JH et al. (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327 1223-8 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:SESN2

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