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MOUSE:S10A9
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | S100a9 (synonyms: Cagb, Mrp14) | |
| Protein Name(s) | Protein S100-A9
Calgranulin-B Leukocyte L1 complex heavy chain Migration inhibitory factor-related protein 14 MRP-14 p14 S100 calcium-binding protein A9 | |
| External Links | ||
| UniProt | P31725 | |
| EMBL | M83219 AJ250496 BC027635 | |
| CCDS | CCDS17543.1 | |
| PIR | S68242 | |
| RefSeq | NP_001268781.1 NP_033140.1 | |
| UniGene | Mm.2128 | |
| ProteinModelPortal | P31725 | |
| SMR | P31725 | |
| IntAct | P31725 | |
| MINT | MINT-4133588 | |
| STRING | 10090.ENSMUSP00000112843 | |
| PhosphoSite | P31725 | |
| MaxQB | P31725 | |
| PaxDb | P31725 | |
| PRIDE | P31725 | |
| Ensembl | ENSMUST00000069960 ENSMUST00000117167 | |
| GeneID | 20202 | |
| KEGG | mmu:20202 | |
| UCSC | uc008qde.1 | |
| CTD | 6280 | |
| MGI | MGI:1338947 | |
| eggNOG | NOG47012 | |
| HOGENOM | HOG000246968 | |
| HOVERGEN | HBG001479 | |
| InParanoid | P31725 | |
| OMA | HEKMHEN | |
| OrthoDB | EOG73807B | |
| PhylomeDB | P31725 | |
| TreeFam | TF332727 | |
| ChiTaRS | S100a9 | |
| NextBio | 297783 | |
| PRO | PR:P31725 | |
| Proteomes | UP000000589 | |
| Bgee | P31725 | |
| CleanEx | MM_S100A9 | |
| ExpressionAtlas | P31725 | |
| Genevestigator | P31725 | |
| GO | GO:0005737 GO:0005856 GO:0005615 GO:0070062 GO:0005634 GO:0005886 GO:0016209 GO:0050544 GO:0005509 GO:0008270 GO:0031532 GO:0006919 GO:0006914 GO:0002544 GO:0045087 GO:0030595 GO:0002523 GO:0070488 GO:0030593 GO:0050729 GO:2001244 GO:0002793 GO:0045113 GO:0045471 GO:0032496 GO:0010043 | |
| Gene3D | 1.10.238.10 | |
| InterPro | IPR011992 IPR002048 IPR028475 IPR001751 IPR013787 | |
| PANTHER | PTHR11639:SF53 | |
| Pfam | PF01023 | |
| PROSITE | PS50222 PS00303 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0030194 |
positive regulation of blood coagulation |
ECO:0000315 |
P |
In figure 3, MRP-14 deficiency reduces thrombus formation and size under flow, as well as collagen formation factors expressed. |
complete | |||||
| GO:0002543 |
activation of blood coagulation via clotting cascade |
ECO:0000315 |
P |
In Figure 1D, the Mrp -/- phenotype shows stunted thrombus formation. Inferably, the protein Mrp +/+, or +/- where + is dominant, or its byproducts, cause thrombus formation. |
complete | |||||
|
involved_in |
GO:0006417 |
regulation of translation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018119 |
peptidyl-cysteine S-nitrosylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030194 |
positive regulation of blood coagulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001244 |
positive regulation of intrinsic apoptotic signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070488 |
neutrophil aggregation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030593 |
neutrophil chemotaxis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006914 |
autophagy |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002523 |
leukocyte migration involved in inflammatory response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2001244 |
positive regulation of intrinsic apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070488 |
neutrophil aggregation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045113 |
regulation of integrin biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2450165 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0035821 |
modification of morphology or physiology of other organism |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035606 |
peptidyl-cysteine S-trans-nitrosylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035425 |
autocrine signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620267 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0031532 |
actin cytoskeleton reorganization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2450165 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030595 |
leukocyte chemotaxis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2450165 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030593 |
neutrophil chemotaxis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0014002 |
astrocyte development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88244 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010976 |
positive regulation of neuron projection development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620267 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006914 |
autophagy |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620267 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0002793 |
positive regulation of peptide secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0002793 |
positive regulation of peptide secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0002523 |
leukocyte migration involved in inflammatory response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0098869 |
cellular oxidant detoxification |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0016209 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008017 |
microtubule binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035662 |
Toll-like receptor 4 binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050544 |
arachidonic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050727 |
regulation of inflammatory response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050786 |
RAGE receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006935 |
chemotaxis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016209 |
antioxidant activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006914 |
autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Wang, Y et al. (2014) Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis. J. Clin. Invest. 124 2160-71 PubMed GONUTS page
- ↑ 2.0 2.1 Jia, J et al. (2014) Target-selective protein S-nitrosylation by sequence motif recognition. Cell 159 623-34 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Manitz, MP et al. (2003) Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro. Mol. Cell. Biol. 23 1034-43 PubMed GONUTS page
- ↑ Ryu, MJ et al. (2012) Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis. J. Biol. Chem. 287 22948-58 PubMed GONUTS page
- ↑ 5.0 5.1 Hiratsuka, S et al. (2008) The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat. Cell Biol. 10 1349-55 PubMed GONUTS page
a
- GO:0002543 ! activation of blood coagulation via clotting cascade
- GO:0061844 ! antimicrobial humoral immune response mediated by antimicrobial peptide
- GO:0016209 ! antioxidant activity
- GO:0006915 ! apoptotic process
- GO:0050544 ! arachidonate binding
- GO:0014002 ! astrocyte development
- GO:0035425 ! autocrine signaling
- GO:0006914 ! autophagy
c
e
g
i
l
m
o
p
- GO:0018119 ! peptidyl-cysteine S-nitrosylation
- GO:0035606 ! peptidyl-cysteine S-trans-nitrosylation
- GO:0005886 ! plasma membrane
- GO:0030194 ! positive regulation of blood coagulation
- GO:0002793 ! positive regulation of peptide secretion
- GO:0010976 ! positive regulation of neuron projection development
- GO:0050729 ! positive regulation of inflammatory response
- GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway
r
