MOUSE:S10A8

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	S100a8 (synonyms: Caga, Mrp8)
Protein Name(s)	Protein S100-A8 Calgranulin-A Chemotactic cytokine CP-10 Leukocyte L1 complex light chain Migration inhibitory factor-related protein 8 MRP-8 p8 Pro-inflammatory S100 cytokine S100 calcium-binding protein A8
External Links
UniProt	P27005
EMBL	M83218 S57123 X87966 BC078629
CCDS	CCDS38507.1
PIR	I56163
RefSeq	NP_038678.1
UniGene	Mm.21567
ProteinModelPortal	P27005
SMR	P27005
IntAct	P27005
MINT	MINT-4133571
PhosphoSite	P27005
MaxQB	P27005
PaxDb	P27005
PRIDE	P27005
Ensembl	ENSMUST00000069927
GeneID	20201
KEGG	mmu:20201
UCSC	uc008qdd.1
CTD	6279
MGI	MGI:88244
eggNOG	NOG39611
HOGENOM	HOG000246968
HOVERGEN	HBG001479
InParanoid	P27005
OMA	DTWFKEL
OrthoDB	EOG76HQ48
PhylomeDB	P27005
TreeFam	TF332727
NextBio	297779
PRO	PR:P27005
Proteomes	UP000000589
Bgee	P27005
CleanEx	MM_S100A8
ExpressionAtlas	P27005
Genevestigator	P27005
GO	GO:0005737 GO:0005856 GO:0005615 GO:0070062 GO:0005634 GO:0005886 GO:0016209 GO:0050544 GO:0005509 GO:0008270 GO:0006919 GO:0002526 GO:0006914 GO:0002544 GO:0045087 GO:0002523 GO:0070488 GO:0030593 GO:0050729 GO:2001244 GO:0002793 GO:0045471 GO:0032496 GO:0010043 GO:0042060
Gene3D	1.10.238.10
InterPro	IPR011992 IPR018247 IPR002048 IPR001751 IPR013787 IPR028474
PANTHER	PTHR11639:SF5
Pfam	PF00036 PF01023
PROSITE	PS00018 PS50222 PS00303

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0010543	regulation of platelet activation	PMID:24935259^[1]	ECO:0000314			P	As seen in Figure 1D, WT mice had platelet accumulation after 30 seconds of being previously injured by a laser.	complete CACAO 10667
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
involved_in	GO:0070488	neutrophil aggregation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
involved_in	GO:0002523	leukocyte migration involved in inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070488	neutrophil aggregation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050729	positive regulation of inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
part_of	GO:0045111	intermediate filament cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05109	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035425	autocrine signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620265	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030593	neutrophil chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018119	peptidyl-cysteine S-nitrosylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014002	astrocyte development	PMID:22577135^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1338947	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006914	autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05109	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05109	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620265	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002793	positive regulation of peptide secretion	PMID:18820689^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002793	positive regulation of peptide secretion	PMID:18820689^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002523	leukocyte migration involved in inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05109	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016209	P	Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05109 ensembl:ENSP00000357721	P	Seeded From UniProt	complete
involved_in	GO:0070488	neutrophil aggregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05109 ensembl:ENSP00000357721	P	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05109 ensembl:ENSP00000357721	P	Seeded From UniProt	complete
part_of	GO:0045111	intermediate filament cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05109 ensembl:ENSP00000357721	C	Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05109 ensembl:ENSP00000357721	P	Seeded From UniProt	complete
involved_in	GO:0018119	peptidyl-cysteine S-nitrosylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05109 ensembl:ENSP00000357721	P	Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05109 ensembl:ENSP00000357721	P	Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05109 ensembl:ENSP00000357721	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05109 ensembl:ENSP00000357721	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05109 ensembl:ENSP00000357721	C	Seeded From UniProt	complete
involved_in	GO:0002523	leukocyte migration involved in inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05109 ensembl:ENSP00000357721	P	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001751 InterPro:IPR002048 InterPro:IPR028474	F	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028474	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028474	F	Seeded From UniProt	complete
enables	GO:0035662	Toll-like receptor 4 binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028474	F	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028474	P	Seeded From UniProt	complete
enables	GO:0050544	arachidonic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028474	F	Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028474	P	Seeded From UniProt	complete
enables	GO:0050786	RAGE receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028474	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
enables	GO:0016209	antioxidant activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0049	F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ García-Vallejo, JJ et al. (2014) CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG. J. Exp. Med. 211 1465-83 PubMed GONUTS page
↑ Ryu, MJ et al. (2012) Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis. J. Biol. Chem. 287 22948-58 PubMed GONUTS page
↑ ^3.0 ^3.1 Hiratsuka, S et al. (2008) The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat. Cell Biol. 10 1349-55 PubMed GONUTS page

[PMID:24935259-1] García-Vallejo, JJ et al. (2014) CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG. J. Exp. Med. 211 1465-83 PubMed GONUTS page

[PMID:22577135-2] Ryu, MJ et al. (2012) Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis. J. Biol. Chem. 287 22948-58 PubMed GONUTS page

[PMID:18820689-3] 3.0 ^3.1 Hiratsuka, S et al. (2008) The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat. Cell Biol. 10 1349-55 PubMed GONUTS page

[1]

[2]

[3]

MOUSE:S10A8

Contents

Annotations

Notes

References

a

c

e

g

i

l

m

n

o

p

r

s

t

v

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools