GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:ROCK2
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Rock2 | |
Protein Name(s) | Rho-associated protein kinase 2
Rho-associated, coiled-coil-containing protein kinase 2 Rho-associated, coiled-coil-containing protein kinase II ROCK-II p164 ROCK-2 | |
External Links | ||
UniProt | P70336 | |
EMBL | U58513 DQ864977 AK045517 AK035509 | |
CCDS | CCDS36410.1 | |
PIR | S74245 | |
RefSeq | NP_033098.2 | |
UniGene | Mm.276024 | |
ProteinModelPortal | P70336 | |
SMR | P70336 | |
BioGrid | 202951 | |
IntAct | P70336 | |
MINT | MINT-4132887 | |
PhosphoSite | P70336 | |
MaxQB | P70336 | |
PaxDb | P70336 | |
PRIDE | P70336 | |
GeneID | 19878 | |
KEGG | mmu:19878 | |
CTD | 9475 | |
MGI | MGI:107926 | |
eggNOG | COG0515 | |
HOGENOM | HOG000017259 | |
HOVERGEN | HBG053111 | |
InParanoid | P70336 | |
KO | K17388 | |
PhylomeDB | P70336 | |
NextBio | 297370 | |
PRO | PR:P70336 | |
Proteomes | UP000000589 | |
Genevestigator | P70336 | |
GO | GO:0005813 GO:0005737 GO:0005634 GO:0005886 GO:0031616 GO:0005524 GO:0046872 GO:0004674 GO:0030036 GO:0048813 GO:0008625 GO:0001843 GO:0010825 GO:0042752 GO:0007266 GO:0048511 | |
Gene3D | 2.30.29.30 | |
InterPro | IPR000961 IPR011009 IPR002219 IPR001849 IPR011993 IPR000719 IPR017441 IPR015008 IPR020684 IPR029878 IPR002290 IPR008271 | |
PANTHER | PTHR22988:SF24 | |
Pfam | PF00169 PF00069 PF08912 | |
PIRSF | PIRSF037568 | |
SMART | SM00109 SM00233 SM00133 SM00220 | |
SUPFAM | SSF56112 | |
PROSITE | PS51285 PS50003 PS00107 PS50011 PS00108 PS50081 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:1990776 |
response to angiotensin |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0043410 |
positive regulation of MAPK cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1902004 |
positive regulation of amyloid-beta formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:1902993 |
positive regulation of amyloid precursor protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:1902961 |
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0071559 |
response to transforming growth factor beta |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0051246 |
regulation of protein metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0010613 |
positive regulation of cardiac muscle hypertrophy |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:1905205 |
positive regulation of connective tissue replacement |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0110061 |
regulation of angiotensin-activated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002548) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0018107 |
peptidyl-threonine phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0018107 |
peptidyl-threonine phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0045019 |
negative regulation of nitric oxide biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0002931 |
response to ischemia |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:1905145 |
cellular response to acetylcholine |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002544) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097746 |
regulation of blood vessel diameter |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0061157 |
mRNA destabilization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0031644 |
regulation of neurological system process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:1900037 |
regulation of cellular response to hypoxia |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002544) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042752 |
regulation of circadian rhythm |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0005589 |
confocal microscopy evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0001225 |
knockout evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0098974 |
postsynaptic actin cytoskeleton organization |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0098974 |
postsynaptic actin cytoskeleton organization |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0098974 |
postsynaptic actin cytoskeleton organization |
ECO:0005589 |
confocal microscopy evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0098974 |
postsynaptic actin cytoskeleton organization |
ECO:0005589 |
confocal microscopy evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0098974 |
postsynaptic actin cytoskeleton organization |
ECO:0001225 |
knockout evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0098974 |
postsynaptic actin cytoskeleton organization |
ECO:0001225 |
knockout evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0098685 |
Schaffer collateral - CA1 synapse |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0098685 |
Schaffer collateral - CA1 synapse |
ECO:0005589 |
confocal microscopy evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0098685 |
Schaffer collateral - CA1 synapse |
ECO:0001225 |
knockout evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1905205 |
positive regulation of connective tissue replacement |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3590 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1903347 |
negative regulation of bicellular tight junction assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903140 |
regulation of establishment of endothelial barrier |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902993 |
positive regulation of amyloid precursor protein catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902966 |
positive regulation of protein localization to early endosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902961 |
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902004 |
positive regulation of amyloid-beta formation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0150033 |
negative regulation of protein localization to lysosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0090271 |
positive regulation of fibroblast growth factor production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3590 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0072659 |
protein localization to plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0072518 |
Rho-dependent protein serine/threonine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071559 |
response to transforming growth factor beta |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3590 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0071394 |
cellular response to testosterone stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051496 |
positive regulation of stress fiber assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051298 |
centrosome duplication |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0048813 |
dendrite morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:87860 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045616 |
regulation of keratinocyte differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045019 |
negative regulation of nitric oxide biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0039694 |
viral RNA genome replication |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0036464 |
cytoplasmic ribonucleoprotein granule |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0035509 |
negative regulation of myosin-light-chain-phosphatase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0032723 |
positive regulation of connective tissue growth factor production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3590 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0031616 |
spindle pole centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030866 |
cortical actin cytoskeleton organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030335 |
positive regulation of cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030036 |
actin cytoskeleton organization |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:107927 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0018107 |
peptidyl-threonine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0016525 |
negative regulation of angiogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010825 |
positive regulation of centrosome duplication |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:0000007) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0010628 |
positive regulation of gene expression |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010628 |
positive regulation of gene expression |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3590 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0010613 |
positive regulation of cardiac muscle hypertrophy |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3590 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0010595 |
positive regulation of endothelial cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008625 |
extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:95484 |
P |
regulates_o_occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0007266 |
Rho protein signal transduction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007249 |
I-kappaB kinase/NF-kappaB signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001843 |
neural tube closure |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1100883 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000961 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006939 |
smooth muscle contraction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007266 |
Rho protein signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010825 |
positive regulation of centrosome duplication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0017048 |
Rho GTPase binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030036 |
actin cytoskeleton organization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032956 |
regulation of actin cytoskeleton organization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048511 |
rhythmic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Shimizu, T et al. (2017) Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. JCI Insight 2 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Herskowitz, JH et al. (2013) Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model. J. Neurosci. 33 19086-98 PubMed GONUTS page
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 Hiroi, Y et al. (2018) Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice. Circ. J. 82 1195-1204 PubMed GONUTS page
- ↑ Saito, T et al. (2013) Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility. Circulation 127 104-14 PubMed GONUTS page
- ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 Zhou, Z et al. (2009) A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function. Neuropharmacology 56 81-9 PubMed GONUTS page
- ↑ Lin, YC et al. (2013) Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways. J. Neurosci. 33 1846-57 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Ma, Z et al. (2006) Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol. Cell. Biol. 26 9016-34 PubMed GONUTS page
- ↑ Hildebrand, JD (2005) Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network. J. Cell. Sci. 118 5191-203 PubMed GONUTS page
- ↑ Piazzolla, D et al. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling. J. Cell Biol. 171 1013-22 PubMed GONUTS page
- ↑ Ogata, T et al. (2008) MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Mol. Cell. Biol. 28 3424-36 PubMed GONUTS page
- ↑ Mizuno, Y et al. (2008) Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo. Am. J. Physiol., Cell Physiol. 295 C358-64 PubMed GONUTS page
- ↑ Li, J et al. (2015) MiR-154-5p regulates osteogenic differentiation of adipose-derived mesenchymal stem cells under tensile stress through the Wnt/PCP pathway by targeting Wnt11. Bone 78 130-41 PubMed GONUTS page
- ↑ Ybot-Gonzalez, P et al. (2007) Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development 134 789-99 PubMed GONUTS page
a
c
- GO:0007249 ! canonical NF-kappaB signal transduction
- GO:0071732 ! cellular response to nitric oxide
- GO:1905145 ! cellular response to acetylcholine
- GO:0071394 ! cellular response to testosterone stimulus
- GO:0005813 ! centrosome
- GO:0051298 ! centrosome duplication
- Chordata
- GO:0030866 ! cortical actin cytoskeleton organization
- Craniata
- GO:0005737 ! cytoplasm
- GO:0036464 ! cytoplasmic ribonucleoprotein granule
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
e
m
n
- GO:0010629 ! negative regulation of gene expression
- GO:0045019 ! negative regulation of nitric oxide biosynthetic process
- GO:0016525 ! negative regulation of angiogenesis
- GO:0150033 ! negative regulation of protein localization to lysosome
- GO:1903347 ! negative regulation of bicellular tight junction assembly
- GO:0001843 ! neural tube closure
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
p
- GO:0018105 ! peptidyl-serine phosphorylation
- GO:0018107 ! peptidyl-threonine phosphorylation
- GO:0016310 ! phosphorylation
- GO:0005886 ! plasma membrane
- GO:0010628 ! positive regulation of gene expression
- GO:1905205 ! positive regulation of connective tissue replacement
- GO:0010613 ! positive regulation of cardiac muscle hypertrophy
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:1902961 ! positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
- GO:0051496 ! positive regulation of stress fiber assembly
- GO:1902993 ! positive regulation of amyloid precursor protein catabolic process
- GO:1902966 ! positive regulation of protein localization to early endosome
- GO:0010595 ! positive regulation of endothelial cell migration
- GO:0010825 ! positive regulation of centrosome duplication
- GO:0030335 ! positive regulation of cell migration
- GO:0032723 ! positive regulation of connective tissue growth factor production
- GO:0090271 ! positive regulation of fibroblast growth factor production
- GO:1902004 ! positive regulation of amyloid-beta formation
- GO:0043410 ! positive regulation of MAPK cascade
- GO:0098974 ! postsynaptic actin cytoskeleton organization
- GO:0004672 ! protein kinase activity
- GO:0072659 ! protein localization to plasma membrane
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
r
- GO:0051246 ! regulation of protein metabolic process
- GO:0110061 ! regulation of angiotensin-activated signaling pathway
- GO:1900037 ! regulation of cellular response to hypoxia
- GO:0032956 ! regulation of actin cytoskeleton organization
- GO:0045616 ! regulation of keratinocyte differentiation
- GO:0031644 ! regulation of nervous system process
- GO:1903140 ! regulation of establishment of endothelial barrier
- GO:0042752 ! regulation of circadian rhythm
- GO:0002931 ! response to ischemia
- GO:0071559 ! response to transforming growth factor beta
- GO:1990776 ! response to angiotensin
- GO:0072518 ! Rho-dependent protein serine/threonine kinase activity
- GO:0017048 ! Rho GTPase binding
- GO:0007266 ! Rho protein signal transduction
- GO:0048511 ! rhythmic process
- Rodentia
s