MOUSE:ROCK2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rock2
Protein Name(s)	Rho-associated protein kinase 2 Rho-associated, coiled-coil-containing protein kinase 2 Rho-associated, coiled-coil-containing protein kinase II ROCK-II p164 ROCK-2
External Links
UniProt	P70336
EMBL	U58513 DQ864977 AK045517 AK035509
CCDS	CCDS36410.1
PIR	S74245
RefSeq	NP_033098.2
UniGene	Mm.276024
ProteinModelPortal	P70336
SMR	P70336
BioGrid	202951
IntAct	P70336
MINT	MINT-4132887
PhosphoSite	P70336
MaxQB	P70336
PaxDb	P70336
PRIDE	P70336
GeneID	19878
KEGG	mmu:19878
CTD	9475
MGI	MGI:107926
eggNOG	COG0515
HOGENOM	HOG000017259
HOVERGEN	HBG053111
InParanoid	P70336
KO	K17388
PhylomeDB	P70336
NextBio	297370
PRO	PR:P70336
Proteomes	UP000000589
Genevestigator	P70336
GO	GO:0005813 GO:0005737 GO:0005634 GO:0005886 GO:0031616 GO:0005524 GO:0046872 GO:0004674 GO:0030036 GO:0048813 GO:0008625 GO:0001843 GO:0010825 GO:0042752 GO:0007266 GO:0048511
Gene3D	2.30.29.30
InterPro	IPR000961 IPR011009 IPR002219 IPR001849 IPR011993 IPR000719 IPR017441 IPR015008 IPR020684 IPR029878 IPR002290 IPR008271
PANTHER	PTHR22988:SF24
Pfam	PF00169 PF00069 PF08912
PIRSF	PIRSF037568
SMART	SM00109 SM00233 SM00133 SM00220
SUPFAM	SSF56112
PROSITE	PS51285 PS50003 PS00107 PS50011 PS00108 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1990776	response to angiotensin	PMID:28679962^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70335	P	occurs_in:(CL:2000042) regulates:(GO:0004672)	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:28679962^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	PMID:24305806^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P12023-2) has_output:(UniProtKB:P12023:PRO_0000000119) regulates_o_occurs_in:(CL:0002609)\|has_regulation_target(UniProtKB:P12023-2) has_output:(UniProtKB:P12023:PRO_0000000118) regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:24305806^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P51667) occurs_in:(CL:0002609)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:24305806^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_input:(UniProtKB:P51667) occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:1902993	positive regulation of amyloid precursor protein catabolic process	PMID:24305806^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P12023-2) has_output:(UniProtKB:P12023:PRO_0000000119) regulates_o_occurs_in:(CL:0002609) positively_regulates:(GO:0034205)\|has_regulation_target(UniProtKB:P12023-2) has_output:(UniProtKB:P12023:PRO_0000000118) regulates_o_occurs_in:(CL:0002609) positively_regulates:(GO:0034205)	Seeded From UniProt	complete
involved_in	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	PMID:24305806^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0004679) has_regulation_target:(UniProtKB:P56818)\|regulates_o_occurs_in(UBERON:0016530) has_regulation_target:(UniProtKB:P56818)	Seeded From UniProt	complete
involved_in	GO:0071559	response to transforming growth factor beta	PMID:28679962^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70335	P	occurs_in:(CL:2000042) regulates:(GO:0004672)	Seeded From UniProt	complete
involved_in	GO:0051246	regulation of protein metabolic process	PMID:24305806^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0004679) regulates:(GO:0034205) has_output:(UniProtKB:P12023:PRO_0000000118)\|regulates_o_occurs_in(UBERON:0016530) regulates:(GO:0034205) has_output:(UniProtKB:P12023:PRO_0000000118)\|regulates_o_occurs_in(UBERON:0004679) regulates:(GO:0034205) has_output:(UniProtKB:P12023:PRO_0000000119)\|regulates_o_occurs_in(UBERON:0016530) regulates:(GO:0034205) has_output:(UniProtKB:P12023:PRO_0000000119)	Seeded From UniProt	complete
involved_in	GO:0010613	positive regulation of cardiac muscle hypertrophy	PMID:28679962^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0000948) occurs_in:(CL:0002548) part_of:(GO:0110061)	Seeded From UniProt	complete
involved_in	GO:1905205	positive regulation of connective tissue replacement	PMID:28679962^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0000948) occurs_in:(CL:0002548) part_of:(GO:0110061)	Seeded From UniProt	complete
involved_in	GO:0110061	regulation of angiotensin-activated signaling pathway	PMID:28679962^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002548)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:28679962^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000035783) regulates_o_occurs_in:(CL:0002548) occurs_in:(CL:0002548) part_of:(GO:0110061)\|regulates_expression_of(ENSEMBL:ENSMUSG00000037225) regulates_o_occurs_in:(CL:0002548) occurs_in:(CL:0002548) part_of:(GO:0110061)\|regulates_expression_of(ENSEMBL:ENSMUSG00000019997) regulates_o_occurs_in:(CL:0002548) occurs_in:(CL:0002548) part_of:(GO:0110061)\|regulates_expression_of(ENSEMBL:ENSMUSG00000041616) regulates_o_occurs_in:(CL:0002548) occurs_in:(CL:0002548) part_of:(GO:0110061)\|regulates_expression_of(ENSEMBL:ENSMUSG00000031972) regulates_o_occurs_in:(CL:0002548) occurs_in:(CL:0002548) part_of:(GO:0110061)\|regulates_expression_of(ENSEMBL:ENSMUSG00000001506) regulates_o_occurs_in:(CL:0002548) occurs_in:(CL:0002548) part_of:(GO:0110061)\|regulates_expression_of(ENSEMBL:ENSMUSG00000026193) regulates_o_occurs_in:(CL:0002548) occurs_in:(CL:0002548) part_of:(GO:0110061)\|regulates_expression_of(ENSEMBL:ENSMUSG00000002603) regulates_o_occurs_in:(CL:0002548) occurs_in:(CL:0002548) part_of:(GO:0110061)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:29353861^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_input:(UniProtKB:P10126) occurs_in:(CL:2000044) part_of:(GO:0061157)\|causally_upstream_of(GO:0050115) occurs_in:(CL:2000044)	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:29353861^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P10126) occurs_in:(CL:2000044) part_of:(GO:0061157)	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:29353861^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	causally_upstream_of:(GO:0050115) occurs_in:(CL:2000044)\|causally_upstream_of(GO:0050115) occurs_in:(CL:0010008)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:29353861^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000028978) occurs_in:(CL:2000044) part_of:(GO:0002931) occurs_in:(UBERON:0000956)\|regulates_expression_of(ENSEMBL:ENSMUSG00000028978) occurs_in:(CL:0010008)	Seeded From UniProt	complete
involved_in	GO:0045019	negative regulation of nitric oxide biosynthetic process	PMID:29353861^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0002931) occurs_in:(CL:2000044) occurs_in:(UBERON:0000956)\|occurs_in:(CL:0010008)	Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	PMID:29353861^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000044) occurs_in:(UBERON:0000956)\|occurs_in:(CL:0002544)	Seeded From UniProt	complete
involved_in	GO:1905145	cellular response to acetylcholine	PMID:29353861^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002544)	Seeded From UniProt	complete
involved_in	GO:0097746	regulation of blood vessel diameter	PMID:29353861^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002544) regulates_o_occurs_in:(UBERON:0001981) part_of:(GO:1905145)\|occurs_in(CL:0002544) regulates_o_occurs_in:(UBERON:0001981) part_of:(GO:0071732)	Seeded From UniProt	complete
involved_in	GO:0061157	mRNA destabilization	PMID:29353861^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates:(GO:0010467) has_regulation_target:(ENSEMBL:ENSMUSG00000028978) occurs_in:(CL:0010008)	Seeded From UniProt	complete
involved_in	GO:0031644	regulation of neurological system process	PMID:29353861^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002544) part_of:(GO:1900037)	Seeded From UniProt	complete
involved_in	GO:1900037	regulation of cellular response to hypoxia	PMID:29353861^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002544)	Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:23172836^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:18718479^[5]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:18718479^[5]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:18718479^[5]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	PMID:18718479^[5]	ECO:0006003	electron microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	PMID:18718479^[5]	ECO:0006003	electron microscopy evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	PMID:18718479^[5]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	PMID:18718479^[5]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	PMID:18718479^[5]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	PMID:18718479^[5]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:18718479^[5]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:18718479^[5]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:18718479^[5]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905205	positive regulation of connective tissue replacement	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903347	negative regulation of bicellular tight junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903140	regulation of establishment of endothelial barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902993	positive regulation of amyloid precursor protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902966	positive regulation of protein localization to early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902004	positive regulation of amyloid-beta formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0150033	negative regulation of protein localization to lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090271	positive regulation of fibroblast growth factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072659	protein localization to plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
enables	GO:0072518	Rho-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071559	response to transforming growth factor beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071394	cellular response to testosterone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051298	centrosome duplication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048813	dendrite morphogenesis	PMID:23365224^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045616	regulation of keratinocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045019	negative regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0039694	viral RNA genome replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032723	positive regulation of connective tissue growth factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3590	P		Seeded From UniProt	complete
part_of	GO:0031616	spindle pole centrosome	PMID:17015463^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030866	cortical actin cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030036	actin cytoskeleton organization	PMID:16249236^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107927 MGI:MGI:1351655 MGI:MGI:1930780	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016525	negative regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010825	positive regulation of centrosome duplication	PMID:17015463^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000007)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010613	positive regulation of cardiac muscle hypertrophy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:16365167^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95484 MGI:MGI:97847	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007266	Rho protein signal transduction	PMID:18332105^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q62868	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007249	I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:18524939^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:17015463^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:25959411^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q28021	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001843	neural tube closure	PMID:17229766^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1100883 MGI:MGI:2135272	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961 InterPro:IPR020684 InterPro:IPR029878 InterPro:IPR037311	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0006939	smooth muscle contraction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029878 InterPro:IPR037311	P		Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029878 InterPro:IPR037311	P		Seeded From UniProt	complete
involved_in	GO:0010825	positive regulation of centrosome duplication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029878 InterPro:IPR037311	P		Seeded From UniProt	complete
enables	GO:0017048	Rho GTPase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015008	F		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020684	P		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029878 InterPro:IPR037311	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002219	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Shimizu, T et al. (2017) Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. JCI Insight 2 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Herskowitz, JH et al. (2013) Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model. J. Neurosci. 33 19086-98 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 Hiroi, Y et al. (2018) Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice. Circ. J. 82 1195-1204 PubMed GONUTS page
↑ Saito, T et al. (2013) Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility. Circulation 127 104-14 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 Zhou, Z et al. (2009) A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function. Neuropharmacology 56 81-9 PubMed GONUTS page
↑ Lin, YC et al. (2013) Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways. J. Neurosci. 33 1846-57 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Ma, Z et al. (2006) Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol. Cell. Biol. 26 9016-34 PubMed GONUTS page
↑ Hildebrand, JD (2005) Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network. J. Cell. Sci. 118 5191-203 PubMed GONUTS page
↑ Piazzolla, D et al. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling. J. Cell Biol. 171 1013-22 PubMed GONUTS page
↑ Ogata, T et al. (2008) MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Mol. Cell. Biol. 28 3424-36 PubMed GONUTS page
↑ Mizuno, Y et al. (2008) Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo. Am. J. Physiol., Cell Physiol. 295 C358-64 PubMed GONUTS page
↑ Li, J et al. (2015) MiR-154-5p regulates osteogenic differentiation of adipose-derived mesenchymal stem cells under tensile stress through the Wnt/PCP pathway by targeting Wnt11. Bone 78 130-41 PubMed GONUTS page
↑ Ybot-Gonzalez, P et al. (2007) Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development 134 789-99 PubMed GONUTS page

[PMID:28679962-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Shimizu, T et al. (2017) Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. JCI Insight 2 PubMed GONUTS page

[PMID:24305806-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Herskowitz, JH et al. (2013) Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model. J. Neurosci. 33 19086-98 PubMed GONUTS page

[PMID:29353861-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 Hiroi, Y et al. (2018) Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice. Circ. J. 82 1195-1204 PubMed GONUTS page

[PMID:23172836-4] Saito, T et al. (2013) Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility. Circulation 127 104-14 PubMed GONUTS page

[PMID:18718479-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 Zhou, Z et al. (2009) A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function. Neuropharmacology 56 81-9 PubMed GONUTS page

[PMID:23365224-6] Lin, YC et al. (2013) Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways. J. Neurosci. 33 1846-57 PubMed GONUTS page

[PMID:17015463-7] 7.0 ^7.1 ^7.2 Ma, Z et al. (2006) Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol. Cell. Biol. 26 9016-34 PubMed GONUTS page

[PMID:16249236-8] Hildebrand, JD (2005) Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network. J. Cell. Sci. 118 5191-203 PubMed GONUTS page

[PMID:16365167-9] Piazzolla, D et al. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling. J. Cell Biol. 171 1013-22 PubMed GONUTS page

[PMID:18332105-10] Ogata, T et al. (2008) MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Mol. Cell. Biol. 28 3424-36 PubMed GONUTS page

[PMID:18524939-11] Mizuno, Y et al. (2008) Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo. Am. J. Physiol., Cell Physiol. 295 C358-64 PubMed GONUTS page

[PMID:25959411-12] Li, J et al. (2015) MiR-154-5p regulates osteogenic differentiation of adipose-derived mesenchymal stem cells under tensile stress through the Wnt/PCP pathway by targeting Wnt11. Bone 78 130-41 PubMed GONUTS page

[PMID:17229766-13] Ybot-Gonzalez, P et al. (2007) Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development 134 789-99 PubMed GONUTS page

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