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MOUSE:ROCK2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Rock2
Protein Name(s) Rho-associated protein kinase 2

Rho-associated, coiled-coil-containing protein kinase 2 Rho-associated, coiled-coil-containing protein kinase II ROCK-II p164 ROCK-2

External Links
UniProt P70336
EMBL U58513
DQ864977
AK045517
AK035509
CCDS CCDS36410.1
PIR S74245
RefSeq NP_033098.2
UniGene Mm.276024
ProteinModelPortal P70336
SMR P70336
BioGrid 202951
IntAct P70336
MINT MINT-4132887
PhosphoSite P70336
MaxQB P70336
PaxDb P70336
PRIDE P70336
GeneID 19878
KEGG mmu:19878
CTD 9475
MGI MGI:107926
eggNOG COG0515
HOGENOM HOG000017259
HOVERGEN HBG053111
InParanoid P70336
KO K17388
PhylomeDB P70336
NextBio 297370
PRO PR:P70336
Proteomes UP000000589
Genevestigator P70336
GO GO:0005813
GO:0005737
GO:0005634
GO:0005886
GO:0031616
GO:0005524
GO:0046872
GO:0004674
GO:0030036
GO:0048813
GO:0008625
GO:0001843
GO:0010825
GO:0042752
GO:0007266
GO:0048511
Gene3D 2.30.29.30
InterPro IPR000961
IPR011009
IPR002219
IPR001849
IPR011993
IPR000719
IPR017441
IPR015008
IPR020684
IPR029878
IPR002290
IPR008271
PANTHER PTHR22988:SF24
Pfam PF00169
PF00069
PF08912
PIRSF PIRSF037568
SMART SM00109
SM00233
SM00133
SM00220
SUPFAM SSF56112
PROSITE PS51285
PS50003
PS00107
PS50011
PS00108
PS50081

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1990776

response to angiotensin

PMID:28679962[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P70335

P

Seeded From UniProt

complete

involved_in

GO:0043410

positive regulation of MAPK cascade

PMID:28679962[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1902004

positive regulation of amyloid-beta formation

PMID:24305806[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:24305806[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:24305806[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1902993

positive regulation of amyloid precursor protein catabolic process

PMID:24305806[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1902961

positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

PMID:24305806[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071559

response to transforming growth factor beta

PMID:28679962[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P70335

P

Seeded From UniProt

complete

involved_in

GO:0051246

regulation of protein metabolic process

PMID:24305806[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010613

positive regulation of cardiac muscle hypertrophy

PMID:28679962[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates_o_occurs_in:(UBERON:0000948)
  • occurs_in:(CL:0002548)
  • part_of:(GO:0110061)

Seeded From UniProt

complete

involved_in

GO:1905205

positive regulation of connective tissue replacement

PMID:28679962[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates_o_occurs_in:(UBERON:0000948)
  • occurs_in:(CL:0002548)
  • part_of:(GO:0110061)

Seeded From UniProt

complete

involved_in

GO:0110061

regulation of angiotensin-activated signaling pathway

PMID:28679962[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002548)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:28679962[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSMUSG00000035783)
  • regulates_o_occurs_in:(CL:0002548)
  • occurs_in:(CL:0002548)
  • part_of:(GO:0110061)|regulates_expression_of(ENSEMBL:ENSMUSG00000037225)
  • regulates_o_occurs_in:(CL:0002548)
  • occurs_in:(CL:0002548)
  • part_of:(GO:0110061)|regulates_expression_of(ENSEMBL:ENSMUSG00000019997)
  • regulates_o_occurs_in:(CL:0002548)
  • occurs_in:(CL:0002548)
  • part_of:(GO:0110061)|regulates_expression_of(ENSEMBL:ENSMUSG00000041616)
  • regulates_o_occurs_in:(CL:0002548)
  • occurs_in:(CL:0002548)
  • part_of:(GO:0110061)|regulates_expression_of(ENSEMBL:ENSMUSG00000031972)
  • regulates_o_occurs_in:(CL:0002548)
  • occurs_in:(CL:0002548)
  • part_of:(GO:0110061)|regulates_expression_of(ENSEMBL:ENSMUSG00000001506)
  • regulates_o_occurs_in:(CL:0002548)
  • occurs_in:(CL:0002548)
  • part_of:(GO:0110061)|regulates_expression_of(ENSEMBL:ENSMUSG00000026193)
  • regulates_o_occurs_in:(CL:0002548)
  • occurs_in:(CL:0002548)
  • part_of:(GO:0110061)|regulates_expression_of(ENSEMBL:ENSMUSG00000002603)
  • regulates_o_occurs_in:(CL:0002548)
  • occurs_in:(CL:0002548)
  • part_of:(GO:0110061)

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:29353861[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0018107

peptidyl-threonine phosphorylation

PMID:29353861[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018107

peptidyl-threonine phosphorylation

PMID:29353861[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • causally_upstream_of:(GO:0050115)
  • occurs_in:(CL:2000044)|causally_upstream_of(GO:0050115)
  • occurs_in:(CL:0010008)

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:29353861[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSMUSG00000028978)
  • occurs_in:(CL:2000044)
  • part_of:(GO:0002931)
  • occurs_in:(UBERON:0000956)|regulates_expression_of(ENSEMBL:ENSMUSG00000028978)
  • occurs_in:(CL:0010008)

Seeded From UniProt

complete

involved_in

GO:0045019

negative regulation of nitric oxide biosynthetic process

PMID:29353861[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • part_of:(GO:0002931)
  • occurs_in:(CL:2000044)
  • occurs_in:(UBERON:0000956)|occurs_in:(CL:0010008)

Seeded From UniProt

complete

involved_in

GO:0002931

response to ischemia

PMID:29353861[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(CL:2000044)
  • occurs_in:(UBERON:0000956)|occurs_in:(CL:0002544)

Seeded From UniProt

complete

involved_in

GO:1905145

cellular response to acetylcholine

PMID:29353861[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002544)

Seeded From UniProt

complete

involved_in

GO:0097746

regulation of blood vessel diameter

PMID:29353861[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(CL:0002544)
  • regulates_o_occurs_in:(UBERON:0001981)
  • part_of:(GO:1905145)|occurs_in(CL:0002544)
  • regulates_o_occurs_in:(UBERON:0001981)
  • part_of:(GO:0071732)

Seeded From UniProt

complete

involved_in

GO:0061157

mRNA destabilization

PMID:29353861[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates:(GO:0010467)
  • has_regulation_target:(ENSEMBL:ENSMUSG00000028978)
  • occurs_in:(CL:0010008)

Seeded From UniProt

complete

involved_in

GO:0031644

regulation of neurological system process

PMID:29353861[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900037

regulation of cellular response to hypoxia

PMID:29353861[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002544)

Seeded From UniProt

complete

involved_in

GO:0042752

regulation of circadian rhythm

PMID:23172836[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:18718479[5]

ECO:0006003

electron microscopy evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:18718479[5]

ECO:0005589

confocal microscopy evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:18718479[5]

ECO:0001225

knockout evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0098974

postsynaptic actin cytoskeleton organization

PMID:18718479[5]

ECO:0006003

electron microscopy evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0098974

postsynaptic actin cytoskeleton organization

PMID:18718479[5]

ECO:0006003

electron microscopy evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0098974

postsynaptic actin cytoskeleton organization

PMID:18718479[5]

ECO:0005589

confocal microscopy evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0098974

postsynaptic actin cytoskeleton organization

PMID:18718479[5]

ECO:0005589

confocal microscopy evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0098974

postsynaptic actin cytoskeleton organization

PMID:18718479[5]

ECO:0001225

knockout evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0098974

postsynaptic actin cytoskeleton organization

PMID:18718479[5]

ECO:0001225

knockout evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

PMID:18718479[5]

ECO:0006003

electron microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

PMID:18718479[5]

ECO:0005589

confocal microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

PMID:18718479[5]

ECO:0001225

knockout evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1905205

positive regulation of connective tissue replacement

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3590

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903347

negative regulation of bicellular tight junction assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903140

regulation of establishment of endothelial barrier

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902993

positive regulation of amyloid precursor protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902966

positive regulation of protein localization to early endosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902961

positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902004

positive regulation of amyloid-beta formation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0150033

negative regulation of protein localization to lysosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090271

positive regulation of fibroblast growth factor production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3590

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072659

protein localization to plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

enables

GO:0072518

Rho-dependent protein serine/threonine kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071559

response to transforming growth factor beta

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3590

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071394

cellular response to testosterone stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051496

positive regulation of stress fiber assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051298

centrosome duplication

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048813

dendrite morphogenesis

PMID:23365224[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:87860

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045616

regulation of keratinocyte differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045019

negative regulation of nitric oxide biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0039694

viral RNA genome replication

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

part_of

GO:0036464

cytoplasmic ribonucleoprotein granule

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035509

negative regulation of myosin-light-chain-phosphatase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032723

positive regulation of connective tissue growth factor production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3590

P

Seeded From UniProt

complete

part_of

GO:0031616

spindle pole centrosome

PMID:17015463[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030866

cortical actin cytoskeleton organization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030335

positive regulation of cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030036

actin cytoskeleton organization

PMID:16249236[8]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:107927
MGI:MGI:1351655
MGI:MGI:1930780

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0018107

peptidyl-threonine phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0018105

peptidyl-serine phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016525

negative regulation of angiogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010825

positive regulation of centrosome duplication

PMID:17015463[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000007)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3590

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010613

positive regulation of cardiac muscle hypertrophy

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3590

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010595

positive regulation of endothelial cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

PMID:16365167[9]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95484
MGI:MGI:97847

P

regulates_o_occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007266

Rho protein signal transduction

PMID:18332105[10]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q62868

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007249

I-kappaB kinase/NF-kappaB signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

PMID:18524939[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:17015463[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:25959411[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q28021

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001843

neural tube closure

PMID:17229766[13]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1100883
MGI:MGI:2135272

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000961
InterPro:IPR020684
InterPro:IPR029878
InterPro:IPR037311

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR008271

P

Seeded From UniProt

complete

involved_in

GO:0006939

smooth muscle contraction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029878
InterPro:IPR037311

P

Seeded From UniProt

complete

involved_in

GO:0007266

Rho protein signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029878
InterPro:IPR037311

P

Seeded From UniProt

complete

involved_in

GO:0010825

positive regulation of centrosome duplication

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029878
InterPro:IPR037311

P

Seeded From UniProt

complete

enables

GO:0017048

Rho GTPase binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015008

F

Seeded From UniProt

complete

involved_in

GO:0030036

actin cytoskeleton organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020684

P

Seeded From UniProt

complete

involved_in

GO:0032956

regulation of actin cytoskeleton organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029878
InterPro:IPR037311

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002219

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Shimizu, T et al. (2017) Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. JCI Insight 2 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Herskowitz, JH et al. (2013) Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model. J. Neurosci. 33 19086-98 PubMed GONUTS page
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 Hiroi, Y et al. (2018) Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice. Circ. J. 82 1195-1204 PubMed GONUTS page
  4. Saito, T et al. (2013) Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility. Circulation 127 104-14 PubMed GONUTS page
  5. 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 Zhou, Z et al. (2009) A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function. Neuropharmacology 56 81-9 PubMed GONUTS page
  6. Lin, YC et al. (2013) Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways. J. Neurosci. 33 1846-57 PubMed GONUTS page
  7. 7.0 7.1 7.2 Ma, Z et al. (2006) Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol. Cell. Biol. 26 9016-34 PubMed GONUTS page
  8. Hildebrand, JD (2005) Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network. J. Cell. Sci. 118 5191-203 PubMed GONUTS page
  9. Piazzolla, D et al. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling. J. Cell Biol. 171 1013-22 PubMed GONUTS page
  10. Ogata, T et al. (2008) MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Mol. Cell. Biol. 28 3424-36 PubMed GONUTS page
  11. Mizuno, Y et al. (2008) Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo. Am. J. Physiol., Cell Physiol. 295 C358-64 PubMed GONUTS page
  12. Li, J et al. (2015) MiR-154-5p regulates osteogenic differentiation of adipose-derived mesenchymal stem cells under tensile stress through the Wnt/PCP pathway by targeting Wnt11. Bone 78 130-41 PubMed GONUTS page
  13. Ybot-Gonzalez, P et al. (2007) Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development 134 789-99 PubMed GONUTS page