GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

MOUSE:RO52

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Trim21 (synonyms: Ro52, Ssa1)
Protein Name(s) E3 ubiquitin-protein ligase TRIM21

52 kDa Ro protein 52 kDa ribonucleoprotein autoantigen Ro/SS-A Ro(SS-A) Sjoegren syndrome type A antigen SS-A Tripartite motif-containing protein 21

External Links
UniProt Q62191
EMBL L27990
UniGene Mm.321227
PDB 2VOK
3ZO0
PDBsum 2VOK
3ZO0
ProteinModelPortal Q62191
SMR Q62191
IntAct Q62191
PhosphoSite Q62191
MaxQB Q62191
PaxDb Q62191
PRIDE Q62191
MGI MGI:106657
eggNOG NOG276395
HOGENOM HOG000234134
HOVERGEN HBG001357
InParanoid Q62191
PhylomeDB Q62191
UniPathway UPA00143
EvolutionaryTrace Q62191
PRO PR:Q62191
Proteomes UP000000589
CleanEx MM_TRIM21
Genevestigator Q62191
GO GO:0005737
GO:0000932
GO:0005634
GO:0003677
GO:0016874
GO:0003723
GO:0004842
GO:0008270
GO:0007049
GO:0032088
GO:0090086
GO:0045787
GO:0051865
GO:0031648
GO:0006513
GO:0000209
GO:0016567
Gene3D 3.30.40.10
4.10.45.10
InterPro IPR001870
IPR003879
IPR013320
IPR006574
IPR003877
IPR000315
IPR020457
IPR018957
IPR001841
IPR013083
IPR017907
Pfam PF13765
PF00622
PF00643
PF00097
PRINTS PR01406
PR01407
SMART SM00336
SM00589
SM00184
SM00449
SUPFAM SSF49899
PROSITE PS50188
PS50119
PS00518
PS50089

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032088

negative regulation of NF-kappaB transcription factor activity

PMID:19494276[1]

ECO:0000269

P

Fig 8A: Analyses using a NF-κB-driven luciferase reporter for cells stimulated with LPS or poly(I:C). LPS- and poly(I:C)-induced luciferase activity was significantly higher in Trim21−/− cells than in Trim21+/+ cells

complete

GO:0032088

negative regulation of NF-kappaB transcription factor activity

PMID:19494276[1]

ECO:0000269

P

Anaylses using a NF-kB driven luciferase reporter for cells stimulated with LPS or Poly (I:C) . As shown in Fig 8A, the LPS and Poly (I:C) - induced luciferase activity was significantly higher in Trim -/- than in Trim +/-

complete

involved_in

GO:0034341

response to interferon-gamma

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

involved_in

GO:0010508

positive regulation of autophagy

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

involved_in

GO:0090086

negative regulation of protein deubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

involved_in

GO:0051865

protein autoubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

involved_in

GO:0045787

positive regulation of cell cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

involved_in

GO:0031648

protein destabilization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

colocalizes_with

GO:0019005

SCF ubiquitin ligase complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

involved_in

GO:0006513

protein monoubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P51965

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

F

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902187

negative regulation of viral release from host cell

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090086

negative regulation of protein deubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070206

protein trimerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051865

protein autoubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045787

positive regulation of cell cycle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045087

innate immune response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034341

response to interferon-gamma

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032897

negative regulation of viral transcription

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031648

protein destabilization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

colocalizes_with

GO:0019005

SCF ubiquitin ligase complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016567

protein ubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010508

positive regulation of autophagy

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006513

protein monoubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11331580[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000209

protein polyubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000315
InterPro:IPR020457

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018957

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0000932

P-body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0230

C

Seeded From UniProt

complete

part_of

GO:0005776

autophagosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0023

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Yoshimi, R et al. (2009) Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. J. Immunol. 182 7527-38 PubMed GONUTS page
  2. Reymond, A et al. (2001) The tripartite motif family identifies cell compartments. EMBO J. 20 2140-51 PubMed GONUTS page