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MOUSE:RO52
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Trim21 (synonyms: Ro52, Ssa1) | |
| Protein Name(s) | E3 ubiquitin-protein ligase TRIM21
52 kDa Ro protein 52 kDa ribonucleoprotein autoantigen Ro/SS-A Ro(SS-A) Sjoegren syndrome type A antigen SS-A Tripartite motif-containing protein 21 | |
| External Links | ||
| UniProt | Q62191 | |
| EMBL | L27990 | |
| UniGene | Mm.321227 | |
| PDB | 2VOK 3ZO0 | |
| PDBsum | 2VOK 3ZO0 | |
| ProteinModelPortal | Q62191 | |
| SMR | Q62191 | |
| IntAct | Q62191 | |
| PhosphoSite | Q62191 | |
| MaxQB | Q62191 | |
| PaxDb | Q62191 | |
| PRIDE | Q62191 | |
| MGI | MGI:106657 | |
| eggNOG | NOG276395 | |
| HOGENOM | HOG000234134 | |
| HOVERGEN | HBG001357 | |
| InParanoid | Q62191 | |
| PhylomeDB | Q62191 | |
| UniPathway | UPA00143 | |
| EvolutionaryTrace | Q62191 | |
| PRO | PR:Q62191 | |
| Proteomes | UP000000589 | |
| CleanEx | MM_TRIM21 | |
| Genevestigator | Q62191 | |
| GO | GO:0005737 GO:0000932 GO:0005634 GO:0003677 GO:0016874 GO:0003723 GO:0004842 GO:0008270 GO:0007049 GO:0032088 GO:0090086 GO:0045787 GO:0051865 GO:0031648 GO:0006513 GO:0000209 GO:0016567 | |
| Gene3D | 3.30.40.10 4.10.45.10 | |
| InterPro | IPR001870 IPR003879 IPR013320 IPR006574 IPR003877 IPR000315 IPR020457 IPR018957 IPR001841 IPR013083 IPR017907 | |
| Pfam | PF13765 PF00622 PF00643 PF00097 | |
| PRINTS | PR01406 PR01407 | |
| SMART | SM00336 SM00589 SM00184 SM00449 | |
| SUPFAM | SSF49899 | |
| PROSITE | PS50188 PS50119 PS00518 PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000269 |
P |
Fig 8A: Analyses using a NF-κB-driven luciferase reporter for cells stimulated with LPS or poly(I:C). LPS- and poly(I:C)-induced luciferase activity was significantly higher in Trim21−/− cells than in Trim21+/+ cells |
complete | |||||
| GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000269 |
P |
Anaylses using a NF-kB driven luciferase reporter for cells stimulated with LPS or Poly (I:C) . As shown in Fig 8A, the LPS and Poly (I:C) - induced luciferase activity was significantly higher in Trim -/- than in Trim +/- |
complete | |||||
|
involved_in |
GO:0034341 |
response to interferon-gamma |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010508 |
positive regulation of autophagy |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090086 |
negative regulation of protein deubiquitination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051865 |
protein autoubiquitination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045787 |
positive regulation of cell cycle |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031648 |
protein destabilization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0019005 |
SCF ubiquitin ligase complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006513 |
protein monoubiquitination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1902187 |
negative regulation of viral release from host cell |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0090086 |
negative regulation of protein deubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070206 |
protein trimerization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051865 |
protein autoubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045787 |
positive regulation of cell cycle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045087 |
innate immune response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0034341 |
response to interferon-gamma |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032897 |
negative regulation of viral transcription |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031648 |
protein destabilization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0019005 |
SCF ubiquitin ligase complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016567 |
protein ubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010508 |
positive regulation of autophagy |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006513 |
protein monoubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000209 |
protein polyubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000932 |
P-body |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005776 |
autophagosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Yoshimi, R et al. (2009) Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. J. Immunol. 182 7527-38 PubMed GONUTS page
- ↑ Reymond, A et al. (2001) The tripartite motif family identifies cell compartments. EMBO J. 20 2140-51 PubMed GONUTS page
g
n
- GO:0032088 ! negative regulation of NF-kappaB transcription factor activity
- GO:1902187 ! negative regulation of viral release from host cell
- GO:0032897 ! negative regulation of viral transcription
- GO:0090086 ! negative regulation of protein deubiquitination
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
p
- GO:0000932 ! P-body
- GO:0010508 ! positive regulation of autophagy
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0045787 ! positive regulation of cell cycle
- GO:0051865 ! protein autoubiquitination
- GO:0031648 ! protein destabilization
- GO:0006513 ! protein monoubiquitination
- GO:0000209 ! protein polyubiquitination
- GO:0070206 ! protein trimerization
- GO:0016567 ! protein ubiquitination
