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PMID:11331580

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Citation

Reymond, A, Meroni, G, Fantozzi, A, Merla, G, Cairo, S, Luzi, L, Riganelli, D, Zanaria, E, Messali, S, Cainarca, S, Guffanti, A, Minucci, S, Pelicci, PG and Ballabio, A (2001) The tripartite motif family identifies cell compartments. EMBO J. 20:2140-51

Abstract

A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.

Links

PubMed PMC125245 Online version:10.1093/emboj/20.9.2140

Keywords

Amino Acid Motifs/physiology; Animals; Blotting, Northern; Carrier Proteins; Cell Compartmentation/physiology; Cell Line; Chromosome Mapping; Cloning, Molecular; Databases, Factual; Embryo, Mammalian; Humans; In Situ Hybridization; Mice; Molecular Sequence Data; Multigene Family/genetics; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Organ Specificity; Protein Binding/physiology; Protein Structure, Tertiary/physiology; Proteins/physiology; Sequence Homology, Amino Acid; Subcellular Fractions/metabolism; Two-Hybrid System Techniques

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

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