MOUSE:RFX6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rfx6 (synonyms: Rfxdc1)
Protein Name(s)	DNA-binding protein RFX6 Regulatory factor X 6 Regulatory factor X domain-containing protein 1
External Links
UniProt	Q8C7R7
EMBL	AK029809 AK049380 AC153527 BC132104 BC132294
CCDS	CCDS23835.1 CCDS48558.1
RefSeq	NP_001152861.1 NP_796280.1
UniGene	Mm.109190
ProteinModelPortal	Q8C7R7
SMR	Q8C7R7
STRING	10090.ENSMUSP00000020054
PhosphoSite	Q8C7R7
PaxDb	Q8C7R7
PRIDE	Q8C7R7
Ensembl	ENSMUST00000050455 ENSMUST00000122922
GeneID	320995
KEGG	mmu:320995
UCSC	uc007fax.2 uc007fay.1 uc011xdt.1
CTD	222546
MGI	MGI:2445208
eggNOG	NOG243313
GeneTree	ENSGT00550000074532
HOGENOM	HOG000154105
HOVERGEN	HBG108402
InParanoid	Q8C7R7
OMA	IHDPLNI
OrthoDB	EOG79CXXT
PhylomeDB	Q8C7R7
TreeFam	TF321340
NextBio	397819
PRO	PR:Q8C7R7
Proteomes	UP000000589
Bgee	Q8C7R7
Genevestigator	Q8C7R7
GO	GO:0005634 GO:0044212 GO:0042593 GO:0003310 GO:0003311 GO:0090104 GO:0045893 GO:0050796 GO:0006351 GO:0003309
Gene3D	1.10.10.10
InterPro	IPR003150 IPR011991
Pfam	PF02257
PROSITE	PS51526

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8HWS3	P	Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8HWS3	P	Seeded From UniProt	complete
involved_in	GO:0090104	pancreatic epsilon cell differentiation	PMID:20148032^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	PMID:20148032^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8HWS3	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8HWS3	F	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:20148032^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20148032^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0003311	pancreatic D cell differentiation	PMID:20148032^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003310	pancreatic A cell differentiation	PMID:20148032^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003309	type B pancreatic cell differentiation	PMID:20148032^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090104	pancreatic epsilon cell differentiation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2445208 PANTHER:PTN000289506	P	Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2445208 PANTHER:PTN000289506 UniProtKB:Q8HWS3	P	Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000973231 UniProtKB:Q8HWS3	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106583 MGI:MGI:1918387 PANTHER:PTN000289470 RGD:1588579 WB:WBGene00000914	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1918387 MGI:MGI:2445208 PANTHER:PTN000289470 RGD:1588579 UniProtKB:Q8HWS3 WB:WBGene00000914	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106582 MGI:MGI:106583 PANTHER:PTN000289470 RGD:1588579	F	Seeded From UniProt	complete
involved_in	GO:0003311	pancreatic D cell differentiation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2445208 PANTHER:PTN000289506	P	Seeded From UniProt	complete
involved_in	GO:0003310	pancreatic A cell differentiation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2445208 PANTHER:PTN000289506	P	Seeded From UniProt	complete
involved_in	GO:0003309	type B pancreatic cell differentiation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2445208 PANTHER:PTN000289506	P	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106583 PANTHER:PTN000289470 RGD:1588579 SGD:S000004166 UniProtKB:Q33E94	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050796	regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8HWS3	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8HWS3	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8HWS3	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8HWS3	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8HWS3	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8HWS3	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031018	endocrine pancreas development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8HWS3	P	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8HWS3	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8HWS3	C	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8HWS3	F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8HWS3	F	Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8HWS3 ensembl:ENSP00000332208	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8HWS3 ensembl:ENSP00000332208	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8HWS3 ensembl:ENSP00000332208	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8HWS3 ensembl:ENSP00000332208	F	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8HWS3 ensembl:ENSP00000332208	P	Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8HWS3 ensembl:ENSP00000332208	P	Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8HWS3 ensembl:ENSP00000332208	P	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8HWS3 ensembl:ENSP00000332208	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8HWS3 ensembl:ENSP00000332208	C	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8HWS3 ensembl:ENSP00000332208	F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8HWS3 ensembl:ENSP00000332208	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003150	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039779	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003150	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Smith, SB et al. (2010) Rfx6 directs islet formation and insulin production in mice and humans. Nature 463 775-80 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20148032-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Smith, SB et al. (2010) Rfx6 directs islet formation and insulin production in mice and humans. Nature 463 775-80 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:RFX6

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