MOUSE:RB

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rb1 (synonyms: Rb-1)
Protein Name(s)	Retinoblastoma-associated protein pRb Rb pp105
External Links
UniProt	P13405
EMBL	M26391 DQ400415 BC096525
CCDS	CCDS27267.1
PIR	A33718
RefSeq	NP_033055.2
UniGene	Mm.273862
ProteinModelPortal	P13405
SMR	P13405
BioGrid	202815
DIP	DIP-37637N
IntAct	P13405
MINT	MINT-225292
PhosphoSite	P13405
MaxQB	P13405
PaxDb	P13405
PRIDE	P13405
Ensembl	ENSMUST00000022701
GeneID	19645
KEGG	mmu:19645
UCSC	uc007upp.2
CTD	5925
MGI	MGI:97874
eggNOG	NOG296920
GeneTree	ENSGT00530000063235
HOGENOM	HOG000136539
HOVERGEN	HBG008967
InParanoid	P13405
KO	K06618
OMA	RTCELIY
OrthoDB	EOG7P5T04
TreeFam	TF105568
Reactome	REACT_196580 REACT_208887 REACT_209428 REACT_219010 REACT_223647 REACT_245230 REACT_258573
NextBio	296890
PRO	PR:P13405
Proteomes	UP000000589
Bgee	P13405
CleanEx	MM_RB1
ExpressionAtlas	P13405
Genevestigator	P13405
GO	GO:0005634 GO:0016605 GO:0035189 GO:0005819 GO:0005667 GO:0001047 GO:0019899 GO:0019900 GO:0001102 GO:0008134 GO:0007050 GO:0051301 GO:0048667 GO:0016568 GO:0048565 GO:0043353 GO:0000082 GO:0034349 GO:0097284 GO:0034088 GO:0045445 GO:0045786 GO:0008285 GO:0050680 GO:2000134 GO:0045930 GO:0006469 GO:0045879 GO:0000122 GO:0071930 GO:0045892 GO:0051402 GO:0030182 GO:0042551 GO:0031175 GO:0045651 GO:0045842 GO:0045944 GO:0071459 GO:0007265 GO:0051726 GO:0071922 GO:0043550 GO:0031134 GO:0035914 GO:0051146 GO:0006351
Gene3D	1.10.472.10
InterPro	IPR013763 IPR002720 IPR002719 IPR015030 IPR028309 IPR024599
PANTHER	PTHR13742
Pfam	PF11934 PF01858 PF01857 PF08934
SMART	SM00385
SUPFAM	SSF47954

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:19417128^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:29304157^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903055	positive regulation of extracellular matrix organization	PMID:29304157^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0011742) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:1904028	positive regulation of collagen fibril organization	PMID:29304157^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0011742) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:1904761	negative regulation of myofibroblast differentiation	PMID:29304157^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0011742) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	PMID:29304157^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0008024	cyclin/CDK positive transcription elongation factor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06400	C		Seeded From UniProt	complete
involved_in	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	PMID:20224733^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q01094	P		Seeded From UniProt	complete
part_of	GO:0035189	Rb-E2F complex	PMID:20224733^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	PMID:20224733^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01094	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20224733^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q01094	P		Seeded From UniProt	complete
involved_in	GO:0045445	myoblast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
involved_in	GO:0043550	regulation of lipid kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06400	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:16616919^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9R144	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06400	C		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:9178770^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8R316	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06400	F		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06400	C		Seeded From UniProt	complete
involved_in	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015799 FB:FBgn0038390 MGI:MGI:97874 PANTHER:PTN000348425	P		Seeded From UniProt	complete
involved_in	GO:0048667	cell morphogenesis involved in neuron differentiation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97874 PANTHER:PTN000348429	P		Seeded From UniProt	complete
part_of	GO:0035189	Rb-E2F complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97874 PANTHER:PTN000348429 UniProtKB:P06400	C		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97874 PANTHER:PTN000348429	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97874 PANTHER:PTN000348429	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000348425 UniProtKB:Q9LKZ3	P		Seeded From UniProt	complete
involved_in	GO:0007346	regulation of mitotic cell cycle	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000348425 UniProtKB:P06400	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103300 MGI:MGI:105085 MGI:MGI:97874 PANTHER:PTN000348425	C		Seeded From UniProt	complete
colocalizes_with	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015799 MGI:MGI:103300 MGI:MGI:105085 MGI:MGI:97874 PANTHER:PTN000348425 RGD:3540 UniProtKB:P06400 UniProtKB:Q08999 UniProtKB:Q9LKZ3 WB:WBGene00003020	C		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97874 PANTHER:PTN000348425	F		Seeded From UniProt	complete
enables	GO:0001012	RNA polymerase II regulatory region DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015799 PANTHER:PTN000348425	F		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015799 PANTHER:PTN000348425 RGD:3541	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000679	positive regulation of transcription regulatory region DNA binding	PMID:25100735^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	PMID:7958874^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857339	P	regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903944	negative regulation of hepatocyte apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3540	P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097284	hepatocyte apoptotic process	PMID:11549719^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857242	P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071922	regulation of cohesin loading	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071466	cellular response to xenobiotic stimulus	PMID:24726645^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931018	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071459	protein localization to chromosome, centromeric region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
enables	GO:0061676	importin-alpha family protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051726	regulation of cell cycle	PMID:15898111^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857242	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:7958874^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857339	P	occurs_in:(EMAPA:36596) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:11549719^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857242	P	occurs_in:(EMAPA:16470)\|occurs_in:(EMAPA:16665)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051301	cell division	PMID:15843406^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857242	P	occurs_in:(EMAPA:17286) results_in_division_of:(CL:0000202)\|occurs_in(EMAPA:17597) results_in_division_of:(CL:0000202)	Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051146	striated muscle cell differentiation	PMID:15542848^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96680	P	occurs_in:(EMAPA:18167) results_in_acquisition_of_features_of:(CL:0000188)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:17257418^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931018,MGI:MGI:3574761	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048667	cell morphogenesis involved in neuron differentiation	PMID:7958874^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857339	P	occurs_in:(EMAPA:36596) results_in_morphogenesis_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048565	digestive tract development	PMID:17257418^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931018,MGI:MGI:3574761	P	results_in_development_of:(EMAPA:18852)\|results_in_development_of:(EMAPA:18932)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23487765^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2137512 MGI:MGI:2444354	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15701640^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1339708 MGI:MGI:1352454	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15701640^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15701640^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045930	negative regulation of mitotic cell cycle	PMID:8612582^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87859	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:11331592^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045879	negative regulation of smoothened signaling pathway	PMID:17257418^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931018,MGI:MGI:3574761	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045842	positive regulation of mitotic metaphase/anaphase transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045786	negative regulation of cell cycle	PMID:12853964^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045651	positive regulation of macrophage differentiation	PMID:15616565^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1857242 MGI:MGI:2384134	P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045445	myoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043550	regulation of lipid kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043353	enucleate erythrocyte differentiation	PMID:15616565^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1857242 MGI:MGI:2384134	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042551	neuron maturation	PMID:7958874^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857339	P	occurs_in:(EMAPA:36596) results_in_maturation_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035914	skeletal muscle cell differentiation	PMID:22147266^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035189	Rb-E2F complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034349	glial cell apoptotic process	PMID:11549719^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857242	P	occurs_in:(EMAPA:16665)\|occurs_in:(EMAPA:16470)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034088	maintenance of mitotic sister chromatid cohesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	PMID:7958874^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857339	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031134	sister chromatid biorientation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:7958874^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857339	P	occurs_in:(EMAPA:36596) results_in_acquisition_of_features_of:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:25100735^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:2669254)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:25100735^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11246230^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97306	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:15843406^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857242	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3540	F		Seeded From UniProt	complete
colocalizes_with	GO:0008024	cyclin/CDK positive transcription elongation factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007346	regulation of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	PMID:15831459^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	P		Seeded From UniProt	complete
part_of	GO:0005819	spindle	PMID:15509711^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:10082561^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16513252^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000448)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15701640^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16898) part_of:(CL:0000467)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15616565^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846) part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10082561^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3540	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001894	tissue homeostasis	PMID:25100735^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2669254	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001558	regulation of cell growth	PMID:25100735^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2669254	P		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06400	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15870077^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104813	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:7797074^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12200151^[29]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:1343102)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000082	G1/S transition of mitotic cell cycle	PMID:15831459^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	F		Seeded From UniProt	complete
involved_in	GO:0071922	regulation of cohesin loading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	P		Seeded From UniProt	complete
involved_in	GO:0071459	protein localization to chromosome, centromeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	P		Seeded From UniProt	complete
enables	GO:0061676	importin-alpha family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	F		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	P		Seeded From UniProt	complete
involved_in	GO:0045842	positive regulation of mitotic metaphase/anaphase transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	P		Seeded From UniProt	complete
involved_in	GO:0045445	myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	P		Seeded From UniProt	complete
involved_in	GO:0043550	regulation of lipid kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	F		Seeded From UniProt	complete
part_of	GO:0035189	Rb-E2F complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	C		Seeded From UniProt	complete
involved_in	GO:0034088	maintenance of mitotic sister chromatid cohesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	F		Seeded From UniProt	complete
involved_in	GO:0031134	sister chromatid biorientation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	C		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	F		Seeded From UniProt	complete
part_of	GO:0008024	cyclin/CDK positive transcription elongation factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	C		Seeded From UniProt	complete
involved_in	GO:0007346	regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	P		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	P		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	C		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06400 ensembl:ENSP00000267163	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002719 InterPro:IPR002720	C		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028309	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033057	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033057	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033057	P		Seeded From UniProt	complete
part_of	GO:0035189	Rb-E2F complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033057	C		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033057	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002719 InterPro:IPR002720 InterPro:IPR028309	P		Seeded From UniProt	complete
involved_in	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033057	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-8985623	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Mercader, J et al. (2009) Haploinsufficiency of the retinoblastoma protein gene reduces diet-induced obesity, insulin resistance, and hepatosteatosis in mice. Am. J. Physiol. Endocrinol. Metab. 297 E184-93 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Freytsis, M et al. (2018) Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation. PLoS ONE 13 e0190623 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Sahin, F & Sladek, TL (2010) E2F-1 has dual roles depending on the cell cycle. Int. J. Biol. Sci. 6 116-28 PubMed GONUTS page
↑ Yoshimoto, T et al. (2006) The arginine methyltransferase PRMT2 binds RB and regulates E2F function. Exp. Cell Res. 312 2040-53 PubMed GONUTS page
↑ Lavender, P et al. (1997) The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A. Oncogene 14 2721-8 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Miles, WO et al. (2014) Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells. EMBO J. 33 2201-15 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Lee, EY et al. (1994) Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 8 2008-21 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Simpson, MT et al. (2001) Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice. J. Neurosci. 21 7089-98 PubMed GONUTS page
↑ Reed, C et al. (2014) RB tumor suppressive function in response to xenobiotic hepatocarcinogens. Am. J. Pathol. 184 1853-9 PubMed GONUTS page
↑ Kalitsis, P et al. (2005) Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice. Genes Chromosomes Cancer 44 29-36 PubMed GONUTS page
↑ ^12.0 ^12.1 Mantela, J et al. (2005) The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear. Development 132 2377-88 PubMed GONUTS page
↑ Takahashi, C et al. (2004) Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression. Mol. Cell. Biol. 24 10406-15 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Yang, HS & Hinds, PW (2007) pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development. BMC Dev. Biol. 7 6 PubMed GONUTS page
↑ Wu, RC et al. (2013) ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways. Proc. Natl. Acad. Sci. U.S.A. 110 4616-21 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Batsché, E et al. (2005) Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription. J. Biol. Chem. 280 16088-95 PubMed GONUTS page
↑ Wen, ST et al. (1996) The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products. EMBO J. 15 1583-95 PubMed GONUTS page
↑ Hsu, SI et al. (2001) TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. EMBO J. 20 2273-85 PubMed GONUTS page
↑ Sage, J et al. (2003) Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424 223-8 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Iavarone, A et al. (2004) Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature 432 1040-5 PubMed GONUTS page
↑ Rajan, S et al. (2012) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol. Genomics 44 183-97 PubMed GONUTS page
↑ Bajenaru, ML et al. (2001) Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes. Glia 33 314-23 PubMed GONUTS page
↑ ^23.0 ^23.1 Chen, PL et al. (2005) Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Mol. Cell. Biol. 25 3535-42 PubMed GONUTS page
↑ Liu, J et al. (2004) Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction 128 643-54 PubMed GONUTS page
↑ ^25.0 ^25.1 Timchenko, NA et al. (1999) C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol. Cell. Biol. 19 2936-45 PubMed GONUTS page
↑ Konishi, M et al. (2006) Role of Fgf10 in cell proliferation in white adipose tissue. Mol. Cell. Endocrinol. 249 71-7 PubMed GONUTS page
↑ Jung, J et al. (2005) Jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein. J. Biol. Chem. 280 30916-23 PubMed GONUTS page
↑ Beijersbergen, RL et al. (1995) Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev. 9 1340-53 PubMed GONUTS page
↑ Yuan, SS et al. (2002) Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member. Biochem. Biophys. Res. Commun. 296 1019-25 PubMed GONUTS page

[PMID:19417128-1] Mercader, J et al. (2009) Haploinsufficiency of the retinoblastoma protein gene reduces diet-induced obesity, insulin resistance, and hepatosteatosis in mice. Am. J. Physiol. Endocrinol. Metab. 297 E184-93 PubMed GONUTS page

[PMID:29304157-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Freytsis, M et al. (2018) Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation. PLoS ONE 13 e0190623 PubMed GONUTS page

[PMID:20224733-3] 3.0 ^3.1 ^3.2 ^3.3 Sahin, F & Sladek, TL (2010) E2F-1 has dual roles depending on the cell cycle. Int. J. Biol. Sci. 6 116-28 PubMed GONUTS page

[PMID:16616919-4] Yoshimoto, T et al. (2006) The arginine methyltransferase PRMT2 binds RB and regulates E2F function. Exp. Cell Res. 312 2040-53 PubMed GONUTS page

[PMID:9178770-5] Lavender, P et al. (1997) The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A. Oncogene 14 2721-8 PubMed GONUTS page

[PMID:21873635-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25100735-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Miles, WO et al. (2014) Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells. EMBO J. 33 2201-15 PubMed GONUTS page

[PMID:7958874-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Lee, EY et al. (1994) Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 8 2008-21 PubMed GONUTS page

[PMID:11549719-9] 9.0 ^9.1 ^9.2 Simpson, MT et al. (2001) Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice. J. Neurosci. 21 7089-98 PubMed GONUTS page

[PMID:24726645-10] Reed, C et al. (2014) RB tumor suppressive function in response to xenobiotic hepatocarcinogens. Am. J. Pathol. 184 1853-9 PubMed GONUTS page

[PMID:15898111-11] Kalitsis, P et al. (2005) Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice. Genes Chromosomes Cancer 44 29-36 PubMed GONUTS page

[PMID:15843406-12] 12.0 ^12.1 Mantela, J et al. (2005) The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear. Development 132 2377-88 PubMed GONUTS page

[PMID:15542848-13] Takahashi, C et al. (2004) Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression. Mol. Cell. Biol. 24 10406-15 PubMed GONUTS page

[PMID:17257418-14] 14.0 ^14.1 ^14.2 Yang, HS & Hinds, PW (2007) pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development. BMC Dev. Biol. 7 6 PubMed GONUTS page

[PMID:23487765-15] Wu, RC et al. (2013) ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways. Proc. Natl. Acad. Sci. U.S.A. 110 4616-21 PubMed GONUTS page

[PMID:15701640-16] 16.0 ^16.1 ^16.2 ^16.3 Batsché, E et al. (2005) Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription. J. Biol. Chem. 280 16088-95 PubMed GONUTS page

[PMID:8612582-17] Wen, ST et al. (1996) The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products. EMBO J. 15 1583-95 PubMed GONUTS page

[PMID:11331592-18] Hsu, SI et al. (2001) TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. EMBO J. 20 2273-85 PubMed GONUTS page

[PMID:12853964-19] Sage, J et al. (2003) Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424 223-8 PubMed GONUTS page

[PMID:15616565-20] 20.0 ^20.1 ^20.2 Iavarone, A et al. (2004) Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature 432 1040-5 PubMed GONUTS page

[PMID:22147266-21] Rajan, S et al. (2012) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol. Genomics 44 183-97 PubMed GONUTS page

[PMID:11246230-22] Bajenaru, ML et al. (2001) Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes. Glia 33 314-23 PubMed GONUTS page

[PMID:15831459-23] 23.0 ^23.1 Chen, PL et al. (2005) Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Mol. Cell. Biol. 25 3535-42 PubMed GONUTS page

[PMID:15509711-24] Liu, J et al. (2004) Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction 128 643-54 PubMed GONUTS page

[PMID:10082561-25] 25.0 ^25.1 Timchenko, NA et al. (1999) C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol. Cell. Biol. 19 2936-45 PubMed GONUTS page

[PMID:16513252-26] Konishi, M et al. (2006) Role of Fgf10 in cell proliferation in white adipose tissue. Mol. Cell. Endocrinol. 249 71-7 PubMed GONUTS page

[PMID:15870077-27] Jung, J et al. (2005) Jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein. J. Biol. Chem. 280 30916-23 PubMed GONUTS page

[PMID:7797074-28] Beijersbergen, RL et al. (1995) Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev. 9 1340-53 PubMed GONUTS page

[PMID:12200151-29] Yuan, SS et al. (2002) Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member. Biochem. Biophys. Res. Commun. 296 1019-25 PubMed GONUTS page

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