MOUSE:PTN11

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ptpn11
Protein Name(s)	Tyrosine-protein phosphatase non-receptor type 11 Protein-tyrosine phosphatase SYP SH-PTP2 SHP-2 Shp2
External Links
UniProt	P35235
EMBL	D84372 AK159501 AK159587 AK163809 BC057398 BC059278 L08663
CCDS	CCDS39247.1 CCDS51637.1
PIR	A46209
RefSeq	NP_001103462.1 NP_035332.1
UniGene	Mm.8681
PDB	1AYA 1AYB 1AYC 1AYD
PDBsum	1AYA 1AYB 1AYC 1AYD
ProteinModelPortal	P35235
SMR	P35235
BioGrid	202477
DIP	DIP-29669N
IntAct	P35235
MINT	MINT-4110032
ChEMBL	CHEMBL2620
PhosphoSite	P35235
MaxQB	P35235
PaxDb	P35235
PRIDE	P35235
Ensembl	ENSMUST00000054547 ENSMUST00000100770
GeneID	19247
KEGG	mmu:19247
UCSC	uc008zio.2 uc008zip.2
CTD	5781
MGI	MGI:99511
eggNOG	COG5599
GeneTree	ENSGT00770000120452
HOGENOM	HOG000273907
HOVERGEN	HBG000223
InParanoid	P35235
KO	K07293
OMA	KEYGAMR
OrthoDB	EOG7NPFST
PhylomeDB	P35235
TreeFam	TF351632
Reactome	REACT_169390 REACT_188529 REACT_188578 REACT_196588 REACT_198525 REACT_198526 REACT_198561 REACT_198622 REACT_198627 REACT_199118 REACT_206286 REACT_211860 REACT_223993 REACT_225463 REACT_225477 REACT_225836 REACT_226341 REACT_230639 REACT_234357 REACT_240139 REACT_247448 REACT_253341 REACT_261568 REACT_263321 REACT_263643
SABIO-RK	P35235
ChiTaRS	Ptpn11
EvolutionaryTrace	P35235
NextBio	296074
PRO	PR:P35235
Proteomes	UP000000589
Bgee	P35235
ExpressionAtlas	P35235
Genevestigator	P35235
GO	GO:0005829 GO:0005739 GO:0005634 GO:0043234 GO:0004726 GO:0051428 GO:0004721 GO:0004725 GO:0030971 GO:0033277 GO:0000187 GO:0036302 GO:0007409 GO:0007420 GO:0000077 GO:0048013 GO:0007173 GO:0060325 GO:0048806 GO:0042593 GO:0042445 GO:0009755 GO:0048839 GO:0007229 GO:0006629 GO:0035855 GO:0048609 GO:0033629 GO:0051463 GO:0060125 GO:0046888 GO:0046676 GO:0048011 GO:0035265 GO:0035335 GO:0030220 GO:0048008 GO:0070374 GO:2001275 GO:0046887 GO:0045931 GO:0009967 GO:0033628 GO:0040014 GO:0046825 GO:0006641
Gene3D	3.30.505.10 3.90.190.10
InterPro	IPR029021 IPR000980 IPR000387 IPR016130 IPR012152 IPR000242
Pfam	PF00017 PF00102
PIRSF	PIRSF000929
PRINTS	PR00700 PR00401
SMART	SM00194 SM00252
SUPFAM	SSF52799 SSF55550
PROSITE	PS50001 PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0019901	protein kinase binding	PMID:17954568^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9WUN2	F	occurs_in:(CL:0000235) part_of:(GO:0071222)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:17954568^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88351	F	occurs_in:(CL:0000235) part_of:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	PMID:17954568^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000235) regulates_o_occurs_in:(CL:0000235) part_of:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:17954568^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P97797	P	occurs_in:(CL:0000235) regulates_o_occurs_in:(CL:0000235) part_of:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:17954568^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P97797	P	occurs_in:(CL:0000235) regulates_o_occurs_in:(CL:0000235) part_of:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06124	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06124	C		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	PMID:19948503^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16573	F		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
involved_in	GO:0033628	regulation of cell adhesion mediated by integrin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	PMID:16885344^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08922	F		Seeded From UniProt	complete
enables	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06124	F		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:24431450^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99604	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:18827006^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061582	intestinal epithelial cell migration	PMID:24675817^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060325	face morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060125	negative regulation of growth hormone secretion	PMID:15520383^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522021	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060020	Bergmann glial cell differentiation	PMID:24431450^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1346866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060020	Bergmann glial cell differentiation	PMID:24431450^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4868451	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051463	negative regulation of cortisol secretion	PMID:15520383^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522021	P		Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	PMID:15520383^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P48356	F	occurs_in:(EMAPA:17536)	Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048873	homeostasis of number of cells within a tissue	PMID:24675817^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96680	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048873	homeostasis of number of cells within a tissue	PMID:24675817^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048839	inner ear development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048806	genitalia development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048609	multicellular organismal reproductive process	PMID:15520383^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522021	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048013	ephrin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048011	neurotrophin TRK receptor signaling pathway	PMID:12482708^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048008	platelet-derived growth factor receptor signaling pathway	PMID:18827006^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046888	negative regulation of hormone secretion	PMID:15520383^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522021	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046887	positive regulation of hormone secretion	PMID:15520383^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522021	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046825	regulation of protein export from nucleus	PMID:12937170^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046676	negative regulation of insulin secretion	PMID:15520383^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522021	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046326	positive regulation of glucose import	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045931	positive regulation of mitotic cell cycle	PMID:18827006^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87859 MGI:MGI:97528	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	F		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043254	regulation of protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:15520383^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522021	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042445	hormone metabolic process	PMID:15520383^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522021	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038127	ERBB signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036302	atrioventricular canal development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035855	megakaryocyte development	PMID:23509158^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035265	organ growth	PMID:15520383^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522021	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:24675817^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:15520383^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522021	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033629	negative regulation of cell adhesion mediated by integrin	PMID:23509158^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690333	P	regulates_o_has_participant:(CL:0000233)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033628	regulation of cell adhesion mediated by integrin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033277	abortive mitotic cell cycle	PMID:23509158^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690333	P	occurs_in:(CL:0000556)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032528	microvillus organization	PMID:24675817^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690333	P		Seeded From UniProt	complete
enables	GO:0031748	D1 dopamine receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	F		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030220	platelet formation	PMID:23509158^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2146995 MGI:MGI:96055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021697	cerebellar cortex formation	PMID:24431450^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1346866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021697	cerebellar cortex formation	PMID:24431450^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4868451	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009967	positive regulation of signal transduction	PMID:15520383^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522021	P	regulates_o_occurs_in:(EMAPA:17536)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009755	hormone-mediated signaling pathway	PMID:15520383^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17536)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:12482708^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007229	integrin-mediated signaling pathway	PMID:23509158^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690333	P	occurs_in:(CL:0000556)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:18827006^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87859 MGI:MGI:87860 MGI:MGI:95290 MGI:MGI:95294	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006641	triglyceride metabolic process	PMID:15520383^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522021	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006629	lipid metabolic process	PMID:15520383^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522021	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006470	protein dephosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	C		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	F		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	F		Seeded From UniProt	complete
enables	GO:0005070	SH3/SH2 adaptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	F		Seeded From UniProt	complete
enables	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:18827006^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3447	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	PMID:15273746^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3050284	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06124	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	PMID:15273746^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3050284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	PMID:12937170^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000077	DNA damage checkpoint	PMID:12937170^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176524	P		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	C		Seeded From UniProt	complete
enables	GO:0031748	D1 dopamine receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	C		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
involved_in	GO:0048806	genitalia development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
involved_in	GO:0043254	regulation of protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
involved_in	GO:0038127	ERBB signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
involved_in	GO:0033628	regulation of cell adhesion mediated by integrin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	C		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	C		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	F		Seeded From UniProt	complete
enables	GO:0005070	SH3/SH2 adaptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	F		Seeded From UniProt	complete
enables	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR012152 InterPro:IPR016130	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR012152	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-914067 Reactome:R-MMU-418862 Reactome:R-MMU-2671740 Reactome:R-MMU-2671739	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Kong, XN et al. (2007) LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages. J. Exp. Med. 204 2719-31 PubMed GONUTS page
↑ Müller, MM et al. (2009) Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. J. Cell Biol. 187 569-81 PubMed GONUTS page
↑ Charest, A et al. (2006) ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res. 66 7473-81 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Li, K et al. (2014) Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum. J. Neurosci. 34 922-31 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Mitra, S et al. (2008) SHP-2 is a novel target of Abl kinases during cell proliferation. J. Cell. Sci. 121 3335-46 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Yamashita, H et al. (2014) Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium. PLoS ONE 9 e92904 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 Zhang, EE et al. (2004) Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc. Natl. Acad. Sci. U.S.A. 101 16064-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Chen, B et al. (2002) SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons. Dev. Biol. 252 170-87 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Yuan, L et al. (2003) DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase. J. Biol. Chem. 278 42812-20 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Mazharian, A et al. (2013) Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function. Blood 121 4205-20 PubMed GONUTS page
↑ ^11.0 ^11.1 Araki, T et al. (2004) Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat. Med. 10 849-57 PubMed GONUTS page

[PMID:17954568-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Kong, XN et al. (2007) LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages. J. Exp. Med. 204 2719-31 PubMed GONUTS page

[PMID:19948503-2] Müller, MM et al. (2009) Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. J. Cell Biol. 187 569-81 PubMed GONUTS page

[PMID:16885344-3] Charest, A et al. (2006) ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res. 66 7473-81 PubMed GONUTS page

[PMID:24431450-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Li, K et al. (2014) Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum. J. Neurosci. 34 922-31 PubMed GONUTS page

[PMID:18827006-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Mitra, S et al. (2008) SHP-2 is a novel target of Abl kinases during cell proliferation. J. Cell. Sci. 121 3335-46 PubMed GONUTS page

[PMID:24675817-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Yamashita, H et al. (2014) Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium. PLoS ONE 9 e92904 PubMed GONUTS page

[PMID:15520383-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 Zhang, EE et al. (2004) Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc. Natl. Acad. Sci. U.S.A. 101 16064-9 PubMed GONUTS page

[PMID:12482708-8] 8.0 ^8.1 Chen, B et al. (2002) SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons. Dev. Biol. 252 170-87 PubMed GONUTS page

[PMID:12937170-9] 9.0 ^9.1 ^9.2 Yuan, L et al. (2003) DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase. J. Biol. Chem. 278 42812-20 PubMed GONUTS page

[PMID:23509158-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Mazharian, A et al. (2013) Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function. Blood 121 4205-20 PubMed GONUTS page

[PMID:15273746-11] 11.0 ^11.1 Araki, T et al. (2004) Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat. Med. 10 849-57 PubMed GONUTS page

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