MOUSE:PTC1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ptch1 (synonyms: Ptch)
Protein Name(s)	Protein patched homolog 1 PTC PTC1
External Links
UniProt	Q61115
EMBL	U46155
CCDS	CCDS26592.1
PIR	T30172
RefSeq	NP_032983.1 XP_006517222.1
UniGene	Mm.228798 Mm.488634
ProteinModelPortal	Q61115
DIP	DIP-60268N
PhosphoSite	Q61115
PRIDE	Q61115
Ensembl	ENSMUST00000021921
GeneID	19206
KEGG	mmu:19206
UCSC	uc007qxv.1
CTD	5727
MGI	MGI:105373
eggNOG	NOG313603
GeneTree	ENSGT00760000119174
HOGENOM	HOG000231331
HOVERGEN	HBG003801
InParanoid	Q61115
KO	K06225
OMA	LQRPSYC
OrthoDB	EOG7HMS06
PhylomeDB	Q61115
TreeFam	TF106489
Reactome	REACT_250061 REACT_269412
ChiTaRS	Ptch1
NextBio	295938
PRO	PR:Q61115
Proteomes	UP000000589
Bgee	Q61115
CleanEx	MM_PTCH1
ExpressionAtlas	Q61115
Genevestigator	Q61115
GO	GO:0044295 GO:0005901 GO:0044294 GO:0005576 GO:0005794 GO:0005887 GO:0030496 GO:0048471 GO:0005886 GO:0014069 GO:0072372 GO:0015485 GO:0030332 GO:0008158 GO:0008201 GO:0005113 GO:0032403 GO:0008270 GO:0007420 GO:0001658 GO:0061005 GO:0072203 GO:0071397 GO:0021904 GO:0009953 GO:0030326 GO:0048568 GO:0008544 GO:0042593 GO:0003007 GO:0035137 GO:0001701 GO:0043616 GO:0030879 GO:0060603 GO:0060644 GO:0051782 GO:0008285 GO:0050680 GO:0040015 GO:0045668 GO:0043433 GO:0045879 GO:0000122 GO:0021997 GO:0001843 GO:0001841 GO:0009887 GO:0007389 GO:0060037 GO:0010875 GO:0016485 GO:0072661 GO:0042127 GO:0040008 GO:0007346 GO:0032880 GO:0008589 GO:0010157 GO:0042493 GO:0032355 GO:0009612 GO:0032526 GO:0007165 GO:0007224 GO:0060831 GO:0061053 GO:0021522
InterPro	IPR003392 IPR000731 IPR004766
Pfam	PF02460
TIGRFAMs	TIGR00918
PROSITE	PS50156

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0035085	cilium axoneme	PMID:21209331^[1]	ECO:0000314			C		Fig S9D shows mouse Ptch1 has cilia tip localisation in MEF	complete CACAO 2882
	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24548465^[2]	ECO:0000315			P		When Patched1 is knocked down by siRNA, this lead to a decrease in mRNA production of IGFBP-1 72 hours after transfection of the siRNA as shown in Fig 5B graph 2.	complete CACAO 9967
	GO:0045892	negative regulation of transcription, DNA-templated	PMID:24548465^[2]	ECO:0000315			P		When Patched1 was knocked down with siRNA there was an increase in IGF1 and Gli3 mRNA production shown in Figure 5B	complete CACAO 9968
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:24548465^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24548465^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071397	cellular response to cholesterol	PMID:21931618^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061053	somite development	PMID:11517919^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051782	negative regulation of cell division	PMID:11331587^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045879	negative regulation of smoothened signaling pathway	PMID:21931618^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0045879	negative regulation of smoothened signaling pathway	PMID:11517919^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	PMID:11331587^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P13350)	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:11331587^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(GO:0031387)	Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	PMID:11331587^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13350	F		Seeded From UniProt	complete
involved_in	GO:0021997	neural plate axis specification	PMID:11517919^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:11331587^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:11517919^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21931618^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11331587^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:10500113^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:10500113^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10500113^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005113	patched binding	PMID:10500113^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001841	neural tube formation	PMID:10500113^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:15166316^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097108	hedgehog family protein binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000847539 UniProtKB:Q13635 UniProtKB:Q9Y6C5	F		Seeded From UniProt	complete
enables	GO:0008158	hedgehog receptor activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003892 PANTHER:PTN000847539	F		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003892 MGI:MGI:105373 PANTHER:PTN000847539 UniProtKB:Q13635	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003892 MGI:MGI:105373 PANTHER:PTN002916954 UniProtKB:Q13635	C		Seeded From UniProt	complete
enables	GO:0005119	smoothened binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000847539 UniProtKB:Q13635 UniProtKB:Q9Y6C5	F		Seeded From UniProt	complete
enables	GO:0097108	hedgehog family protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072659	protein localization to plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072203	cell proliferation involved in metanephros development	PMID:19809516^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P	occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071679	commissural neuron axon guidance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621425	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071397	cellular response to cholesterol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061053	somite development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061005	cell differentiation involved in kidney development	PMID:19809516^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P	occurs_in:(EMAPA:28477)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	PMID:19684112^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P	occurs_in:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060644	mammary gland epithelial cell differentiation	PMID:10529434^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P	occurs_in:(EMAPA:17760) results_in_acquisition_of_features_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060603	mammary gland duct morphogenesis	PMID:10529434^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060037	pharyngeal system development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:17631878^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856954	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048568	embryonic organ development	PMID:24302887^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2144467	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045668	negative regulation of osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045606	positive regulation of epidermal cell differentiation	PMID:24492243^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1095405	P		Seeded From UniProt	complete
part_of	GO:0044295	axonal growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621425	C		Seeded From UniProt	complete
part_of	GO:0044294	dendritic growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621425	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043616	keratinocyte proliferation	PMID:17631878^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856954	P	occurs_in:(EMAPA:32779) acts_on_population_of:(CL:0000312)\|occurs_in(EMAPA:32779) acts_on_population_of:(CL:0000646)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:11044404^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:19809516^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P	occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040015	negative regulation of multicellular organism growth	PMID:11784021^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856954	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040008	regulation of growth	PMID:9262482^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P	regulates_o_has_participant:(EMAPA:16142)\|regulates_o_has_participant:(EMAPA:16162)\|regulates_o_has_participant:(EMAPA:16146)\|regulates_o_has_participant:(EMAPA:16151)\|regulates_o_has_participant:(EMAPA:16288)\|regulates_o_has_participant:(EMAPA:16159)\|regulates_o_has_participant:(EMAPA:16292)\|regulates_o_has_participant:(EMAPA:16295)\|regulates_o_has_participant:(EMAPA:16299)\|regulates_o_has_participant:(EMAPA:16303)\|regulates_o_has_participant:(EMAPA:16307)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035137	hindlimb morphogenesis	PMID:9262482^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P	has_participant:(EMAPA:17459)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035108	limb morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032880	regulation of protein localization	PMID:16489008^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675356	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030879	mammary gland development	PMID:10529434^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:11389830^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P	has_participant:(EMAPA:17428)\|has_participant:(EMAPA:17459)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:11784021^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856954	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021904	dorsal/ventral neural tube patterning	PMID:9262482^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021532	neural tube patterning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021522	spinal cord motor neuron differentiation	PMID:21552265^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107736	P	occurs_in:(EMAPA:16530) results_in_acquisition_of_features_of:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	PMID:16061793^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P	occurs_in:(EMAPA:16039) has_participant:(MGI:MGI:95729)	Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621425	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010875	positive regulation of cholesterol efflux	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010157	response to chlorate	PMID:11476578^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009957	epidermal cell fate specification	PMID:24492243^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1095405	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:15576403^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1341847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:12917290^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P	has_participant:(EMAPA:17503)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008544	epidermis development	PMID:17631878^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856954	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:16489008^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675356	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:9262482^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P	occurs_in:(EMAPA:17459)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007346	regulation of mitotic cell cycle	PMID:16489008^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675356	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:19004860^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2142166	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:19809516^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P	regulates_o_occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:11784021^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153143	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:9006067^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:11493558^[27]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:19684112^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:19654211^[28]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:24062445^[29]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000644)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	C		Seeded From UniProt	complete
colocalizes_with	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621425	C		Seeded From UniProt	complete
enables	GO:0005119	smoothened binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003007	heart morphogenesis	PMID:9262482^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P	has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001843	neural tube closure	PMID:9262482^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P	has_participant:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001709	cell fate determination	PMID:24492243^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1095405	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:21406566^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2384818	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:19809516^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857447	P	has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13635	P		Seeded From UniProt	complete
enables	GO:0097108	hedgehog family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	F		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	P		Seeded From UniProt	complete
involved_in	GO:0072001	renal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	P		Seeded From UniProt	complete
involved_in	GO:0071397	cellular response to cholesterol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	P		Seeded From UniProt	complete
involved_in	GO:0061053	somite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	C		Seeded From UniProt	complete
involved_in	GO:0045668	negative regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	C		Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	P		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	F		Seeded From UniProt	complete
involved_in	GO:0021532	neural tube patterning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	P		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	F		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	C		Seeded From UniProt	complete
enables	GO:0005119	smoothened binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13635 ensembl:ENSP00000332353	P		Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
involved_in	GO:0071679	commissural neuron axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
part_of	GO:0044295	axonal growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	C		Seeded From UniProt	complete
part_of	GO:0044294	dendritic growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	C		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	C		Seeded From UniProt	complete
enables	GO:0008158	hedgehog receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004766	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003392 InterPro:IPR004766	C		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:10500113^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:10500113^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-517521 Reactome:R-MMU-5632654 Reactome:R-MMU-5632644 Reactome:R-MMU-5632642	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008158	hedgehog receptor activity	PMID:11784021^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:11784021^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Matz-Soja, M et al. (2014) Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels. Cell Commun. Signal 12 11 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Bidet, M et al. (2011) The hedgehog receptor patched is involved in cholesterol transport. PLoS ONE 6 e23834 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Zhang, XM et al. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106 781-92 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Barnes, EA et al. (2001) Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J. 20 2214-23 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Fuse, N et al. (1999) Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proc. Natl. Acad. Sci. U.S.A. 96 10992-9 PubMed GONUTS page
↑ Skop, AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305 61-6 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Cain, JE et al. (2009) GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells. PLoS ONE 4 e7313 PubMed GONUTS page
↑ ^10.0 ^10.1 Chen, MH et al. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23 1910-28 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Lewis, MT et al. (1999) Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1. Development 126 5181-93 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Nieuwenhuis, E et al. (2007) Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1. Dev. Biol. 308 547-60 PubMed GONUTS page
↑ Cui, C et al. (2013) Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 11 e1001720 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Adolphe, C et al. (2014) Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation. J. Invest. Dermatol. 134 1981-90 PubMed GONUTS page
↑ Hebrok, M et al. (2000) Regulation of pancreas development by hedgehog signaling. Development 127 4905-13 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Makino, S et al. (2001) A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc). Dev. Biol. 239 95-106 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Goodrich, LV et al. (1997) Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277 1109-13 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Adolphe, C et al. (2006) Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res. 66 2081-8 PubMed GONUTS page
↑ Lewis, PM et al. (2001) Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 105 599-612 PubMed GONUTS page
↑ Ocbina, PJ et al. (2011) Complex interactions between genes controlling trafficking in primary cilia. Nat. Genet. 43 547-53 PubMed GONUTS page
↑ Huangfu, D & Anderson, KV (2005) Cilia and Hedgehog responsiveness in the mouse. Proc. Natl. Acad. Sci. U.S.A. 102 11325-30 PubMed GONUTS page
↑ Gritli-Linde, A et al. (2001) The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev. Biol. 236 364-86 PubMed GONUTS page
↑ Jeong, J & McMahon, AP (2005) Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development 132 143-54 PubMed GONUTS page
↑ Kawahira, H et al. (2003) Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development 130 4871-9 PubMed GONUTS page
↑ Hoover, AN et al. (2008) C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development 135 4049-58 PubMed GONUTS page
↑ Bellusci, S et al. (1997) Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development 124 53-63 PubMed GONUTS page
↑ Mahlapuu, M et al. (2001) Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development 128 2397-406 PubMed GONUTS page
↑ Clement, CA et al. (2009) The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J. Cell. Sci. 122 3070-82 PubMed GONUTS page
↑ Marazziti, D et al. (2013) Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor. Proc. Natl. Acad. Sci. U.S.A. 110 16486-91 PubMed GONUTS page
↑ Saarikangas, J et al. (2011) Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J. Cell. Sci. 124 1245-55 PubMed GONUTS page

[PMID:21209331-1] Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page

[PMID:24548465-2] 2.0 ^2.1 ^2.2 ^2.3 Matz-Soja, M et al. (2014) Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels. Cell Commun. Signal 12 11 PubMed GONUTS page

[PMID:21931618-3] 3.0 ^3.1 ^3.2 Bidet, M et al. (2011) The hedgehog receptor patched is involved in cholesterol transport. PLoS ONE 6 e23834 PubMed GONUTS page

[PMID:11517919-4] 4.0 ^4.1 ^4.2 ^4.3 Zhang, XM et al. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106 781-92 PubMed GONUTS page

[PMID:11331587-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Barnes, EA et al. (2001) Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J. 20 2214-23 PubMed GONUTS page

[PMID:10500113-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Fuse, N et al. (1999) Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proc. Natl. Acad. Sci. U.S.A. 96 10992-9 PubMed GONUTS page

[PMID:15166316-7] Skop, AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305 61-6 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19809516-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Cain, JE et al. (2009) GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells. PLoS ONE 4 e7313 PubMed GONUTS page

[PMID:19684112-10] 10.0 ^10.1 Chen, MH et al. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23 1910-28 PubMed GONUTS page

[PMID:10529434-11] 11.0 ^11.1 ^11.2 Lewis, MT et al. (1999) Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1. Development 126 5181-93 PubMed GONUTS page

[PMID:17631878-12] 12.0 ^12.1 ^12.2 Nieuwenhuis, E et al. (2007) Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1. Dev. Biol. 308 547-60 PubMed GONUTS page

[PMID:24302887-13] Cui, C et al. (2013) Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 11 e1001720 PubMed GONUTS page

[PMID:24492243-14] 14.0 ^14.1 ^14.2 Adolphe, C et al. (2014) Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation. J. Invest. Dermatol. 134 1981-90 PubMed GONUTS page

[PMID:11044404-15] Hebrok, M et al. (2000) Regulation of pancreas development by hedgehog signaling. Development 127 4905-13 PubMed GONUTS page

[PMID:11784021-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Makino, S et al. (2001) A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc). Dev. Biol. 239 95-106 PubMed GONUTS page

[PMID:9262482-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Goodrich, LV et al. (1997) Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277 1109-13 PubMed GONUTS page

[PMID:16489008-18] 18.0 ^18.1 ^18.2 Adolphe, C et al. (2006) Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res. 66 2081-8 PubMed GONUTS page

[PMID:11389830-19] Lewis, PM et al. (2001) Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 105 599-612 PubMed GONUTS page

[PMID:21552265-20] Ocbina, PJ et al. (2011) Complex interactions between genes controlling trafficking in primary cilia. Nat. Genet. 43 547-53 PubMed GONUTS page

[PMID:16061793-21] Huangfu, D & Anderson, KV (2005) Cilia and Hedgehog responsiveness in the mouse. Proc. Natl. Acad. Sci. U.S.A. 102 11325-30 PubMed GONUTS page

[PMID:11476578-22] Gritli-Linde, A et al. (2001) The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev. Biol. 236 364-86 PubMed GONUTS page

[PMID:15576403-23] Jeong, J & McMahon, AP (2005) Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development 132 143-54 PubMed GONUTS page

[PMID:12917290-24] Kawahira, H et al. (2003) Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development 130 4871-9 PubMed GONUTS page

[PMID:19004860-25] Hoover, AN et al. (2008) C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development 135 4049-58 PubMed GONUTS page

[PMID:9006067-26] Bellusci, S et al. (1997) Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development 124 53-63 PubMed GONUTS page

[PMID:11493558-27] Mahlapuu, M et al. (2001) Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development 128 2397-406 PubMed GONUTS page

[PMID:19654211-28] Clement, CA et al. (2009) The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J. Cell. Sci. 122 3070-82 PubMed GONUTS page

[PMID:24062445-29] Marazziti, D et al. (2013) Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor. Proc. Natl. Acad. Sci. U.S.A. 110 16486-91 PubMed GONUTS page

[PMID:21406566-30] Saarikangas, J et al. (2011) Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J. Cell. Sci. 124 1245-55 PubMed GONUTS page

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