MOUSE:PIWL2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Piwil2 (synonyms: Mili)
Protein Name(s)	Piwi-like protein 2
External Links
UniProt	Q8CDG1
EMBL	AB032605 AK030116 AK163647 CH466535 BC138444 BC145717 AF285586
CCDS	CCDS27252.1
RefSeq	NP_067283.1 XP_006519392.1
UniGene	Mm.85253
PDB	4B9W
PDBsum	4B9W
ProteinModelPortal	Q8CDG1
SMR	Q8CDG1
BioGrid	208309
DIP	DIP-48522N
IntAct	Q8CDG1
MINT	MINT-8174116
STRING	10090.ENSMUSP00000047385
PhosphoSite	Q8CDG1
PaxDb	Q8CDG1
PRIDE	Q8CDG1
Ensembl	ENSMUST00000048129
GeneID	57746
KEGG	mmu:57746
UCSC	uc007unx.1
CTD	55124
MGI	MGI:1930036
eggNOG	NOG286051
GeneTree	ENSGT00760000119148
HOGENOM	HOG000254789
HOVERGEN	HBG049411
InParanoid	Q8CDG1
KO	K02156
OMA	QELNWIK
OrthoDB	EOG712TVQ
PhylomeDB	Q8CDG1
TreeFam	TF354206
NextBio	313885
PRO	PR:Q8CDG1
Proteomes	UP000000589
Bgee	Q8CDG1
CleanEx	MM_PIWIL2
Genevestigator	Q8CDG1
GO	GO:0033391 GO:0005737 GO:0043186 GO:0071546 GO:0003729 GO:0034584 GO:0043046 GO:0031047 GO:0030718 GO:0051321 GO:0007275 GO:0048477 GO:0034587 GO:0060903 GO:0045727 GO:0000966 GO:0007283
Gene3D	3.30.420.10
InterPro	IPR003100 IPR003165 IPR012337
Pfam	PF02170 PF02171
SMART	SM00949 SM00950
SUPFAM	SSF101690 SSF53098
PROSITE	PS50821 PS50822

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:2000617	positive regulation of histone H3-K9 acetylation	PMID:22110608^[1]	ECO:0000314			P	Fig 4C. Western blotting reveals that piwil2 upregulates H3K9 acetylation in mouse embryonic fibroblasts irradiated by UV light.	complete CACAO 6943
	GO:0043971	histone H3-K18 acetylation	PMID:22110608^[1]	ECO:0000314			P	Fig 4C. Western blotting reveals that piwil2 upregulates H3K18 acetylation in mouse embryonic fibroblasts irradiated by UV light.	complete CACAO 6944
	GO:0071442	positive regulation of histone H3-K14 acetylation	PMID:22110608^[1]	ECO:0000315			P	Fig 4C. Western blotting reveals that piwil2 upregulates H3K14 acetylation in mouse embryonic fibroblasts irradiated by UV light.	complete CACAO 7106
involved_in	GO:0042754	negative regulation of circadian rhythm	PMID:28903391^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:28633017^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1990511	piRNA biosynthetic process	PMID:28633017^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010529	negative regulation of transposition	PMID:23706823^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010529	negative regulation of transposition	PMID:22020280^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:23706823^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:22020280^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0034587	piRNA metabolic process	PMID:23706823^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034587	piRNA metabolic process	PMID:22020280^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:23706823^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:22020280^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043186	P granule	PMID:20439430^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0034587	piRNA metabolic process	PMID:26669262^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:1990923	PET complex	PMID:26669262^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0071442	positive regulation of histone H3-K14 acetylation	PMID:22110608^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000617	positive regulation of histone H3-K9 acetylation	PMID:22110608^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0071546	pi-body	PMID:19730684^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0071546	pi-body	PMID:20059948^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0071546	pi-body	PMID:20011505^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	PMID:18404146^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	PMID:19114715^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043186	P granule	PMID:18922463^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043046	DNA methylation involved in gamete generation	PMID:18381894^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043046	DNA methylation involved in gamete generation	PMID:18922463^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034587	piRNA metabolic process	PMID:18381894^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034587	piRNA metabolic process	PMID:18922463^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034587	piRNA metabolic process	PMID:17446352^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034587	piRNA metabolic process	PMID:16751777^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0034584	piRNA binding	PMID:16751777^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0034584	piRNA binding	PMID:18404146^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0034584	piRNA binding	PMID:18922463^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0034584	piRNA binding	PMID:17446352^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0034584	piRNA binding	PMID:18381894^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0033391	chromatoid body	PMID:19114715^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	PMID:18381894^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	PMID:17446352^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	PMID:18922463^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030718	germ-line stem cell population maintenance	PMID:19114715^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:18381894^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:1905538	polysome binding	PMID:19114715^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19114715^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:19114715^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000966	RNA 5'-end processing	PMID:17446352^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0097433	dense body	PMID:21539824^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060903	positive regulation of meiosis I	PMID:14736746^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029596	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042754	negative regulation of circadian rhythm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8TC59	P	Seeded From UniProt	complete
enables	GO:0034584	piRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8TC59	F	Seeded From UniProt	complete
part_of	GO:0033391	chromatoid body	PMID:21539824^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0010370	perinucleolar chromocenter	PMID:21539824^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21539824^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20014101^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8TC59	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:27856912^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8TC59	C	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P	Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P	Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P	Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P	Seeded From UniProt	complete
involved_in	GO:0042754	negative regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8TC59 ensembl:ENSP00000349208	P	Seeded From UniProt	complete
enables	GO:0034584	piRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8TC59 ensembl:ENSP00000349208	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8TC59 ensembl:ENSP00000349208	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8TC59 ensembl:ENSP00000349208	C	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003165 InterPro:IPR036397	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-5629217 Reactome:R-MMU-5606252 Reactome:R-MMU-5606226 Reactome:R-MMU-5605349 Reactome:R-MMU-5605279 Reactome:R-MMU-5605213 Reactome:R-MMU-5605205	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0744	P	Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P	Seeded From UniProt	complete
involved_in	GO:0051321	meiotic cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0469	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0896	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F	Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Yin, DT et al. (2011) Germline stem cell gene PIWIL2 mediates DNA repair through relaxation of chromatin. PLoS ONE 6 e27154 PubMed GONUTS page
↑ Lu, Y et al. (2017) Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK. Oncotarget 8 54913-54924 PubMed GONUTS page
↑ ^3.0 ^3.1 Wenda, JM et al. (2017) Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function. Dev. Cell 41 623-637.e9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Di Giacomo, M et al. (2013) Multiple epigenetic mechanisms and the piRNA pathway enforce LINE1 silencing during adult spermatogenesis. Mol. Cell 50 601-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 De Fazio, S et al. (2011) The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements. Nature 480 259-63 PubMed GONUTS page
↑ Kuramochi-Miyagawa, S et al. (2010) MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev. 24 887-92 PubMed GONUTS page
↑ ^7.0 ^7.1 Yang, Z et al. (2016) PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway. Mol. Cell 61 138-52 PubMed GONUTS page
↑ Ma, L et al. (2009) GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet. 5 e1000635 PubMed GONUTS page
↑ Shoji, M et al. (2009) The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev. Cell 17 775-87 PubMed GONUTS page
↑ Aravin, AA et al. (2009) Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet. 5 e1000764 PubMed GONUTS page
↑ ^11.0 ^11.1 Watanabe, T et al. (2008) Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 453 539-43 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Unhavaithaya, Y et al. (2009) MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J. Biol. Chem. 284 6507-19 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Aravin, AA et al. (2008) A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol. Cell 31 785-99 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Kuramochi-Miyagawa, S et al. (2008) DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev. 22 908-17 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Aravin, AA et al. (2007) Developmentally regulated piRNA clusters implicate MILI in transposon control. Science 316 744-7 PubMed GONUTS page
↑ ^16.0 ^16.1 Aravin, A et al. (2006) A novel class of small RNAs bind to MILI protein in mouse testes. Nature 442 203-7 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Beyret, E & Lin, H (2011) Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Dev. Biol. 355 215-26 PubMed GONUTS page
↑ Kuramochi-Miyagawa, S et al. (2004) Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development 131 839-49 PubMed GONUTS page
↑ Hu, J et al. (2010) Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest. Dev. Dyn. 239 407-24 PubMed GONUTS page
↑ Barau, J et al. (2016) The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science 354 909-912 PubMed GONUTS page

[PMID:22110608-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Yin, DT et al. (2011) Germline stem cell gene PIWIL2 mediates DNA repair through relaxation of chromatin. PLoS ONE 6 e27154 PubMed GONUTS page

[PMID:28903391-2] Lu, Y et al. (2017) Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK. Oncotarget 8 54913-54924 PubMed GONUTS page

[PMID:28633017-3] 3.0 ^3.1 Wenda, JM et al. (2017) Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function. Dev. Cell 41 623-637.e9 PubMed GONUTS page

[PMID:23706823-4] 4.0 ^4.1 ^4.2 ^4.3 Di Giacomo, M et al. (2013) Multiple epigenetic mechanisms and the piRNA pathway enforce LINE1 silencing during adult spermatogenesis. Mol. Cell 50 601-8 PubMed GONUTS page

[PMID:22020280-5] 5.0 ^5.1 ^5.2 ^5.3 De Fazio, S et al. (2011) The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements. Nature 480 259-63 PubMed GONUTS page

[PMID:20439430-6] Kuramochi-Miyagawa, S et al. (2010) MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev. 24 887-92 PubMed GONUTS page

[PMID:26669262-7] 7.0 ^7.1 Yang, Z et al. (2016) PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway. Mol. Cell 61 138-52 PubMed GONUTS page

[PMID:19730684-8] Ma, L et al. (2009) GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet. 5 e1000635 PubMed GONUTS page

[PMID:20059948-9] Shoji, M et al. (2009) The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev. Cell 17 775-87 PubMed GONUTS page

[PMID:20011505-10] Aravin, AA et al. (2009) Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet. 5 e1000764 PubMed GONUTS page

[PMID:18404146-11] 11.0 ^11.1 Watanabe, T et al. (2008) Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 453 539-43 PubMed GONUTS page

[PMID:19114715-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Unhavaithaya, Y et al. (2009) MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J. Biol. Chem. 284 6507-19 PubMed GONUTS page

[PMID:18922463-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Aravin, AA et al. (2008) A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol. Cell 31 785-99 PubMed GONUTS page

[PMID:18381894-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Kuramochi-Miyagawa, S et al. (2008) DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev. 22 908-17 PubMed GONUTS page

[PMID:17446352-15] 15.0 ^15.1 ^15.2 ^15.3 Aravin, AA et al. (2007) Developmentally regulated piRNA clusters implicate MILI in transposon control. Science 316 744-7 PubMed GONUTS page

[PMID:16751777-16] 16.0 ^16.1 Aravin, A et al. (2006) A novel class of small RNAs bind to MILI protein in mouse testes. Nature 442 203-7 PubMed GONUTS page

[PMID:21539824-17] 17.0 ^17.1 ^17.2 ^17.3 Beyret, E & Lin, H (2011) Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Dev. Biol. 355 215-26 PubMed GONUTS page

[PMID:14736746-18] Kuramochi-Miyagawa, S et al. (2004) Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development 131 839-49 PubMed GONUTS page

[PMID:20014101-19] Hu, J et al. (2010) Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest. Dev. Dyn. 239 407-24 PubMed GONUTS page

[PMID:27856912-20] Barau, J et al. (2016) The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science 354 909-912 PubMed GONUTS page

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MOUSE:PIWL2

Contents

Annotations

Notes

References

c

d

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