MOUSE:PGH1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ptgs1 (synonyms: Cox-1, Cox1)
Protein Name(s)	Prostaglandin G/H synthase 1 Cyclooxygenase-1 COX-1 Prostaglandin H2 synthase 1 PGH synthase 1 PGHS-1 PHS 1 Prostaglandin-endoperoxide synthase 1
External Links
UniProt	P22437
EMBL	M34141 BC005573
CCDS	CCDS15970.1
PIR	A35564
RefSeq	NP_032995.1 XP_006497853.1 XP_006497854.1 XP_006497855.1 XP_006497856.1
UniGene	Mm.275434
ProteinModelPortal	P22437
SMR	P22437
BioGrid	202462
IntAct	P22437
MINT	MINT-4107353
BindingDB	P22437
ChEMBL	CHEMBL2649
PeroxiBase	3361
PhosphoSite	P22437
MaxQB	P22437
PaxDb	P22437
PRIDE	P22437
Ensembl	ENSMUST00000062069
GeneID	19224
KEGG	mmu:19224
UCSC	uc008jll.1
CTD	5742
MGI	MGI:97797
eggNOG	NOG39991
HOGENOM	HOG000013149
HOVERGEN	HBG000366
InParanoid	P22437
KO	K00509
OMA	FKTSGKM
OrthoDB	EOG7RFTHC
PhylomeDB	P22437
TreeFam	TF329675
Reactome	REACT_188623 REACT_263041
UniPathway	UPA00662
ChiTaRS	Ptgs1
NextBio	296008
PRO	PR:P22437
Proteomes	UP000000589
Bgee	P22437
CleanEx	MM_PTGS1
ExpressionAtlas	P22437
Genevestigator	P22437
GO	GO:0005737 GO:0005789 GO:0001750 GO:0051213 GO:0020037 GO:0046872 GO:0004601 GO:0004666 GO:0019371 GO:0006954 GO:0030216 GO:0001516 GO:0006693 GO:0008217 GO:0042127 GO:0006979
Gene3D	1.10.640.10
InterPro	IPR029580 IPR000742 IPR010255 IPR019791
PANTHER	PTHR11903:SF6
Pfam	PF03098
PRINTS	PR00457
SMART	SM00181
SUPFAM	SSF48113
PROSITE	PS50026 PS50292

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0030216	keratinocyte differentiation	PMID:12067981^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097756	negative regulation of blood vessel diameter	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3439	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045987	positive regulation of smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3439	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3439	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23219	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:10987272^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035633	maintenance of permeability of blood-brain barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3439	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032811	negative regulation of epinephrine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3439	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019371	cyclooxygenase pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23219	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019233	sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3439	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010700	negative regulation of norepinephrine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3439	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008217	regulation of blood pressure	PMID:12093889^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857238	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3439	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3439	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006693	prostaglandin metabolic process	PMID:10987272^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857238	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23219	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12355421^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17168) part_of:(CL:0000287)\|part_of:(EMAPA:17168) part_of:(CL:0000745)\|part_of:(EMAPA:17168) part_of:(CL:0000129)\|part_of:(EMAPA:17168) part_of:(CL:0000127)\|part_of:(EMAPA:17168) part_of:(CL:0000740)\|part_of:(EMAPA:17168) part_of:(CL:0000561)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12021206^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18681) part_of:(CL:0000362)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12355421^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23219	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3439	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3439	C		Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23219	F		Seeded From UniProt	complete
part_of	GO:0001750	photoreceptor outer segment	PMID:12355421^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17168) part_of:(CL:0000287)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001516	prostaglandin biosynthetic process	PMID:12093889^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857238	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3439	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004601	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004601	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23219 ensembl:ENSP00000354612	C		Seeded From UniProt	complete
involved_in	GO:0019371	cyclooxygenase pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23219 ensembl:ENSP00000354612	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23219 ensembl:ENSP00000354612	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23219 ensembl:ENSP00000354612	C		Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23219 ensembl:ENSP00000354612	F		Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029580	P		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	F		Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029580	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029580	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	P		Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029580	P		Seeded From UniProt	complete
involved_in	GO:0019371	cyclooxygenase pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029580	P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	P		Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.99.1	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0051213	dioxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0223	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492	C		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0575	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
involved_in	GO:0006693	prostaglandin metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0644	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0643 UniPathway:UPA00662	P		Seeded From UniProt	complete
part_of	GO:0031090	organelle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0165	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Tiano, HF et al. (2002) Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res. 62 3395-401 PubMed GONUTS page
↑ ^2.0 ^2.1 Chulada, PC et al. (2000) Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res. 60 4705-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Qi, Z et al. (2002) Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. J. Clin. Invest. 110 61-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Ju, WK & Neufeld, AH (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J. Comp. Neurol. 452 392-9 PubMed GONUTS page
↑ Lazarus, M et al. (2002) Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs. Endocrinology 143 2410-9 PubMed GONUTS page

[PMID:12067981-1] Tiano, HF et al. (2002) Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res. 62 3395-401 PubMed GONUTS page

[PMID:10987272-2] 2.0 ^2.1 Chulada, PC et al. (2000) Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res. 60 4705-8 PubMed GONUTS page

[PMID:12093889-3] 3.0 ^3.1 Qi, Z et al. (2002) Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. J. Clin. Invest. 110 61-9 PubMed GONUTS page

[PMID:12355421-4] 4.0 ^4.1 ^4.2 Ju, WK & Neufeld, AH (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J. Comp. Neurol. 452 392-9 PubMed GONUTS page

[PMID:12021206-5] Lazarus, M et al. (2002) Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs. Endocrinology 143 2410-9 PubMed GONUTS page

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MOUSE:PGH1

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