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MOUSE:PGH1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ptgs1 (synonyms: Cox-1, Cox1)
Protein Name(s) Prostaglandin G/H synthase 1

Cyclooxygenase-1 COX-1 Prostaglandin H2 synthase 1 PGH synthase 1 PGHS-1 PHS 1 Prostaglandin-endoperoxide synthase 1

External Links
UniProt P22437
EMBL M34141
BC005573
CCDS CCDS15970.1
PIR A35564
RefSeq NP_032995.1
XP_006497853.1
XP_006497854.1
XP_006497855.1
XP_006497856.1
UniGene Mm.275434
ProteinModelPortal P22437
SMR P22437
BioGrid 202462
IntAct P22437
MINT MINT-4107353
BindingDB P22437
ChEMBL CHEMBL2649
PeroxiBase 3361
PhosphoSite P22437
MaxQB P22437
PaxDb P22437
PRIDE P22437
Ensembl ENSMUST00000062069
GeneID 19224
KEGG mmu:19224
UCSC uc008jll.1
CTD 5742
MGI MGI:97797
eggNOG NOG39991
HOGENOM HOG000013149
HOVERGEN HBG000366
InParanoid P22437
KO K00509
OMA FKTSGKM
OrthoDB EOG7RFTHC
PhylomeDB P22437
TreeFam TF329675
Reactome REACT_188623
REACT_263041
UniPathway UPA00662
ChiTaRS Ptgs1
NextBio 296008
PRO PR:P22437
Proteomes UP000000589
Bgee P22437
CleanEx MM_PTGS1
ExpressionAtlas P22437
Genevestigator P22437
GO GO:0005737
GO:0005789
GO:0001750
GO:0051213
GO:0020037
GO:0046872
GO:0004601
GO:0004666
GO:0019371
GO:0006954
GO:0030216
GO:0001516
GO:0006693
GO:0008217
GO:0042127
GO:0006979
Gene3D 1.10.640.10
InterPro IPR029580
IPR000742
IPR010255
IPR019791
PANTHER PTHR11903:SF6
Pfam PF03098
PRINTS PR00457
SMART SM00181
SUPFAM SSF48113
PROSITE PS50026
PS50292

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0030216

keratinocyte differentiation

PMID:12067981[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097756

negative regulation of blood vessel diameter

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3439

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045987

positive regulation of smooth muscle contraction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3439

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045907

positive regulation of vasoconstriction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3439

P

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P23219

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042127

regulation of cell population proliferation

PMID:10987272[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88039

P

occurs_in:(EMAPA:32874)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035633

maintenance of permeability of blood-brain barrier

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3439

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032811

negative regulation of epinephrine secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3439

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019371

cyclooxygenase pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P23219

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019233

sensory perception of pain

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3439

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010700

negative regulation of norepinephrine secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3439

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008217

regulation of blood pressure

PMID:12093889[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857238

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007613

memory

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3439

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007612

learning

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3439

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006693

prostaglandin metabolic process

PMID:10987272[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857238

P

occurs_in:(EMAPA:32874)

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P23219

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12355421[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17168)
  • part_of:(CL:0000287)|part_of:(EMAPA:17168)
  • part_of:(CL:0000745)|part_of:(EMAPA:17168)
  • part_of:(CL:0000129)|part_of:(EMAPA:17168)
  • part_of:(CL:0000127)|part_of:(EMAPA:17168)
  • part_of:(CL:0000740)|part_of:(EMAPA:17168)
  • part_of:(CL:0000561)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12021206[5]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:18681)
  • part_of:(CL:0000362)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12355421[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P23219

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3439

C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3439

C

Seeded From UniProt

complete

enables

GO:0004666

prostaglandin-endoperoxide synthase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P23219

F

Seeded From UniProt

complete

part_of

GO:0001750

photoreceptor outer segment

PMID:12355421[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17168)
  • part_of:(CL:0000287)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001516

prostaglandin biosynthetic process

PMID:12093889[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857238

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001516

prostaglandin biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3439

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004601

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004601

P

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23219
ensembl:ENSP00000354612

C

Seeded From UniProt

complete

involved_in

GO:0019371

cyclooxygenase pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23219
ensembl:ENSP00000354612

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23219
ensembl:ENSP00000354612

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23219
ensembl:ENSP00000354612

C

Seeded From UniProt

complete

enables

GO:0004666

prostaglandin-endoperoxide synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23219
ensembl:ENSP00000354612

F

Seeded From UniProt

complete

involved_in

GO:0001516

prostaglandin biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029580

P

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010255

F

Seeded From UniProt

complete

enables

GO:0004666

prostaglandin-endoperoxide synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029580

F

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029580

P

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010255

P

Seeded From UniProt

complete

involved_in

GO:0008217

regulation of blood pressure

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029580

P

Seeded From UniProt

complete

involved_in

GO:0019371

cyclooxygenase pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029580

P

Seeded From UniProt

complete

enables

GO:0020037

heme binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010255

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010255

P

Seeded From UniProt

complete

enables

GO:0004666

prostaglandin-endoperoxide synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.14.99.1

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0051213

dioxygenase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0223

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0492

C

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0275

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0575

F

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

involved_in

GO:0006693

prostaglandin metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0644

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0001516

prostaglandin biosynthetic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0643
UniPathway:UPA00662

P

Seeded From UniProt

complete

part_of

GO:0031090

organelle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0165

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Tiano, HF et al. (2002) Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res. 62 3395-401 PubMed GONUTS page
  2. 2.0 2.1 Chulada, PC et al. (2000) Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res. 60 4705-8 PubMed GONUTS page
  3. 3.0 3.1 Qi, Z et al. (2002) Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. J. Clin. Invest. 110 61-9 PubMed GONUTS page
  4. 4.0 4.1 4.2 Ju, WK & Neufeld, AH (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J. Comp. Neurol. 452 392-9 PubMed GONUTS page
  5. Lazarus, M et al. (2002) Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs. Endocrinology 143 2410-9 PubMed GONUTS page