MOUSE:PDIA3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pdia3 (synonyms: Erp, Erp60, Grp58)
Protein Name(s)	Protein disulfide-isomerase A3 58 kDa glucose-regulated protein 58 kDa microsomal protein p58 Disulfide isomerase ER-60 Endoplasmic reticulum resident protein 57 ER protein 57 ERp57 Endoplasmic reticulum resident protein 60 ER protein 60 ERp60
External Links
UniProt	P27773
EMBL	M73329 DQ000491 AK088721 AK133799 AK167807 AK169611 AL845466 BC003285 BC033439
CCDS	CCDS16643.1
RefSeq	NP_031978.2
UniGene	Mm.263177
ProteinModelPortal	P27773
SMR	P27773
BioGrid	200077
IntAct	P27773
MINT	MINT-4590033
PhosphoSite	P27773
REPRODUCTION-2DPAGE	IPI00230108 P27773 Q3TEI9 Q8C2F4
SWISS-2DPAGE	P27773
MaxQB	P27773
PaxDb	P27773
PRIDE	P27773
Ensembl	ENSMUST00000028683
GeneID	14827
KEGG	mmu:14827
UCSC	uc008lzb.1
CTD	2923
MGI	MGI:95834
eggNOG	COG0526
GeneTree	ENSGT00760000119201
HOGENOM	HOG000162459
HOVERGEN	HBG005920
InParanoid	P27773
KO	K08056
OMA	RFAHTNS
OrthoDB	EOG7VHSX1
PhylomeDB	P27773
TreeFam	TF106382
Reactome	REACT_198616 REACT_199105 REACT_246972
ChiTaRS	Pdia3
NextBio	287035
PRO	PR:P27773
Proteomes	UP000000589
Bgee	P27773
CleanEx	MM_PDIA3
ExpressionAtlas	P27773
Genevestigator	P27773
GO	GO:0009986 GO:0005783 GO:0005788 GO:0070062 GO:0042470 GO:0005634 GO:0005790 GO:0044822 GO:0003756 GO:0045454 GO:2001238 GO:0006457 GO:0034976
Gene3D	3.40.30.10
InterPro	IPR005788 IPR005792 IPR012336 IPR017937 IPR013766
Pfam	PF00085
SUPFAM	SSF52833
TIGRFAMs	TIGR01130 TIGR01126
PROSITE	PS00194 PS51352

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0043209	myelin sheath	PMID:17634366^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000432607 TAIR:locus:2082712 TAIR:locus:2204670 UniProtKB:P07237 UniProtKB:Q9XI01	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95834 PANTHER:PTN001448745 RGD:68430 UniProtKB:P30101	C		Seeded From UniProt	complete
involved_in	GO:0006457	protein folding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000432607 SGD:S000000548 SGD:S000002926 UniProtKB:C0H4Y6	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014002 MGI:MGI:104864 MGI:MGI:95834 MGI:MGI:97464 PANTHER:PTN000432607 RGD:68430 TAIR:locus:2014681 TAIR:locus:2018134 TAIR:locus:2082712 TAIR:locus:2093447 TAIR:locus:2204670 UniProtKB:P07237 UniProtKB:P30101 UniProtKB:Q9FF55 UniProtKB:Q9XI01 WB:WBGene00003963	C		Seeded From UniProt	complete
enables	GO:0003756	protein disulfide isomerase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919080 PANTHER:PTN000432607 RGD:3244 RGD:619835 SGD:S000000548 SGD:S000002926 TAIR:locus:2204670 UniProtKB:C0H4Y6 UniProtKB:O48949 UniProtKB:P07237 UniProtKB:Q4WH99 WB:WBGene00003962 WB:WBGene00003963 WB:WBGene00003964	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	PMID:15858817^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17478) regulates_o_occurs_in:(CL:0000134)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903334	positive regulation of protein folding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098761	cellular response to interleukin-7	PMID:29581031^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071305	cellular response to vitamin D	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	P		Seeded From UniProt	complete
part_of	GO:0042825	TAP complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
part_of	GO:0042824	MHC class I peptide loading complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30101	C		Seeded From UniProt	complete
part_of	GO:0042824	MHC class I peptide loading complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30101	F		Seeded From UniProt	complete
enables	GO:0042288	MHC class I protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	F		Seeded From UniProt	complete
enables	GO:0019153	protein-disulfide reductase (glutathione) activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
enables	GO:0015037	peptide disulfide oxidoreductase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30101	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19995400^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000233)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30101	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:9493907^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30101	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30101	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
part_of	GO:0001669	acrosomal vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68430	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008233	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0015037	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019153	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015037	P		Seeded From UniProt	complete
part_of	GO:0042824	MHC class I peptide loading complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30101 ensembl:ENSP00000300289	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30101 ensembl:ENSP00000300289	F		Seeded From UniProt	complete
enables	GO:0015037	peptide disulfide oxidoreductase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30101 ensembl:ENSP00000300289	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30101 ensembl:ENSP00000300289	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30101 ensembl:ENSP00000300289	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30101 ensembl:ENSP00000300289	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:V9HVY3 ensembl:ENSP00000300289	C		Seeded From UniProt	complete
enables	GO:0003756	protein disulfide isomerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005792	F		Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005788	F		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013766 InterPro:IPR017937	P		Seeded From UniProt	complete
enables	GO:0003756	protein disulfide isomerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:5.3.4.1	F		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-MMU-983160	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0096	C		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0161	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Shan, SW et al. (2005) Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death. Dev. Dyn. 233 266-81 PubMed GONUTS page
↑ Aiello, FB et al. (2018) IL-7-induced phosphorylation of the adaptor Crk-like and other targets. Cell. Signal. 47 131-141 PubMed GONUTS page
↑ Holbrook, LM et al. (2010) Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Br. J. Haematol. 148 627-37 PubMed GONUTS page
↑ Miyaishi, O et al. (1998) Elevated expression of PDI family proteins during differentiation of mouse F9 teratocarcinoma cells. J. Cell. Biochem. 68 436-45 PubMed GONUTS page

[PMID:17634366-1] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15858817-3] Shan, SW et al. (2005) Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death. Dev. Dyn. 233 266-81 PubMed GONUTS page

[PMID:29581031-4] Aiello, FB et al. (2018) IL-7-induced phosphorylation of the adaptor Crk-like and other targets. Cell. Signal. 47 131-141 PubMed GONUTS page

[PMID:19995400-5] Holbrook, LM et al. (2010) Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Br. J. Haematol. 148 627-37 PubMed GONUTS page

[PMID:9493907-6] Miyaishi, O et al. (1998) Elevated expression of PDI family proteins during differentiation of mouse F9 teratocarcinoma cells. J. Cell. Biochem. 68 436-45 PubMed GONUTS page

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MOUSE:PDIA3

Contents

Annotations

Notes

References

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