MOUSE:PAR2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	F2rl1 (synonyms: Gpcr11, Gpr11, Par2)
Protein Name(s)	Proteinase-activated receptor 2 PAR-2 Coagulation factor II receptor-like 1 G-protein coupled receptor 11 Thrombin receptor-like 1
External Links
UniProt	P55086
EMBL	Z48043
CCDS	CCDS26700.1
PIR	I48705
RefSeq	NP_032000.3
UniGene	Mm.1614
ProteinModelPortal	P55086
SMR	P55086
PhosphoSite	P55086
PRIDE	P55086
Ensembl	ENSMUST00000022185
GeneID	14063
KEGG	mmu:14063
UCSC	uc011zda.2
CTD	2150
MGI	MGI:101910
eggNOG	NOG145128
HOGENOM	HOG000116291
HOVERGEN	HBG105658
InParanoid	P55086
KO	K04234
OMA	LAMYLIC
OrthoDB	EOG7DNNVR
PhylomeDB	P55086
TreeFam	TF330775
Reactome	REACT_207651 REACT_235286
ChiTaRS	F2rl1
NextBio	285036
PRO	PR:P55086
Proteomes	UP000000589
Bgee	P55086
CleanEx	MM_F2RL1
ExpressionAtlas	P55086
Genevestigator	P55086
GO	GO:0005769 GO:0005887 GO:0005886 GO:0031143 GO:0001965 GO:0031681 GO:0004930 GO:0032795 GO:0015057 GO:0007596 GO:0035926 GO:0090195 GO:0051607 GO:0061028 GO:0006954 GO:0045087 GO:0072643 GO:0050702 GO:0072608 GO:0050900 GO:0070661 GO:0097029 GO:0090198 GO:0046329 GO:0034140 GO:0010804 GO:0042119 GO:0030836 GO:0030335 GO:0050921 GO:0002741 GO:0007204 GO:0043311 GO:0070374 GO:0003104 GO:0043123 GO:2000778 GO:2000484 GO:0046330 GO:0002690 GO:0070963 GO:0060100 GO:0014068 GO:0050927 GO:0031274 GO:1900135 GO:0035025 GO:0032930 GO:0034137 GO:0034141 GO:0034145 GO:0045944 GO:0045909 GO:0030193 GO:0043122 GO:0046328 GO:0002286
InterPro	IPR000276 IPR017452 IPR002281 IPR003912
Pfam	PF00001
PRINTS	PR00237 PR01428 PR01152
PROSITE	PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	PMID:25216639^[1]	ECO:0000314			C		Figure 2A	complete CACAO 10849
	GO:0005886	plasma membrane	PMID:25216639^[1]	ECO:0000314			C		Figure 2A	complete CACAO 10850
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
involved_in	GO:2000484	positive regulation of interleukin-8 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
involved_in	GO:1900135	positive regulation of renin secretion into blood stream	PMID:21859963^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097029	mature conventional dendritic cell differentiation	PMID:19845798^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090195	chemokine secretion	PMID:19494303^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072643	interferon-gamma secretion	PMID:19494303^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072608	interleukin-10 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
involved_in	GO:0070661	leukocyte proliferation	PMID:19494303^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:20215560^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:19494303^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050921	positive regulation of chemotaxis	PMID:12821670^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
involved_in	GO:0046328	regulation of JNK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	PMID:9918574^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	PMID:21859963^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0006544)	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
involved_in	GO:0042119	neutrophil activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
involved_in	GO:0035926	chemokine (C-C motif) ligand 2 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
involved_in	GO:0035025	positive regulation of Rho protein signal transduction	PMID:20215560^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032930	positive regulation of superoxide anion generation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
enables	GO:0031681	G-protein beta-subunit binding	PMID:20215560^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031274	positive regulation of pseudopodium assembly	PMID:12821670^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031143	pseudopodium	PMID:12821670^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:20215560^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:20215560^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:20215560^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:20215560^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003104	positive regulation of glomerular filtration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63645	P		Seeded From UniProt	complete
involved_in	GO:0002741	positive regulation of cytokine secretion involved in immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
involved_in	GO:0002286	T cell activation involved in immune response	PMID:19845798^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	PMID:20215560^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000660850 RGD:2586	P		Seeded From UniProt	complete
involved_in	GO:0035025	positive regulation of Rho protein signal transduction	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101802 MGI:MGI:101910 PANTHER:PTN000660850 UniProtKB:P55085 UniProtKB:Q9Y2T6	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1929509 PANTHER:PTN000660850 UniProtKB:P55085 UniProtKB:Q99678 UniProtKB:Q9HC97 UniProtKB:Q9Y2T6	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101802 MGI:MGI:101910 MGI:MGI:2441992 PANTHER:PTN000660850 UniProtKB:P55085 UniProtKB:Q8IYL9 UniProtKB:Q99678 UniProtKB:Q9HC97	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000484	positive regulation of interleukin-8 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097029	mature conventional dendritic cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090198	negative regulation of chemokine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090195	chemokine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072608	interleukin-10 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070963	positive regulation of neutrophil mediated killing of gram-negative bacterium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061028	establishment of endothelial barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060100	positive regulation of phagocytosis, engulfment	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051607	defense response to virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050927	positive regulation of positive chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050900	leukocyte migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050702	interleukin-1 beta secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046329	negative regulation of JNK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046328	regulation of JNK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045217	cell-cell junction maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043547	positive regulation of GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043311	positive regulation of eosinophil degranulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042119	neutrophil activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035926	chemokine (C-C motif) ligand 2 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035025	positive regulation of Rho protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032930	positive regulation of superoxide anion generation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030836	positive regulation of actin filament depolymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030193	regulation of blood coagulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003104	positive regulation of glomerular filtration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002741	positive regulation of cytokine secretion involved in immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002690	positive regulation of leukocyte chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55085	P		Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:2000484	positive regulation of interleukin-8 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0097029	mature conventional dendritic cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0090198	negative regulation of chemokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0090195	chemokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0072608	interleukin-10 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0070963	positive regulation of neutrophil mediated killing of gram-negative bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0061028	establishment of endothelial barrier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0060100	positive regulation of phagocytosis, engulfment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0050927	positive regulation of positive chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0046329	negative regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0046328	regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0045217	cell-cell junction maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0043311	positive regulation of eosinophil degranulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0042119	neutrophil activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0035926	chemokine (C-C motif) ligand 2 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0035025	positive regulation of Rho protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0032930	positive regulation of superoxide anion generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0030836	positive regulation of actin filament depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0030193	regulation of blood coagulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	F		Seeded From UniProt	complete
involved_in	GO:0002741	positive regulation of cytokine secretion involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0002690	positive regulation of leukocyte chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55085 ensembl:ENSP00000296677	P		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63645 ensembl:ENSRNOP00000058298	P		Seeded From UniProt	complete
involved_in	GO:0003104	positive regulation of glomerular filtration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63645 ensembl:ENSRNOP00000058298	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003912	P		Seeded From UniProt	complete
enables	GO:0015057	thrombin-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002281 InterPro:IPR003912	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR002281 InterPro:IPR003912 InterPro:IPR017452	C		Seeded From UniProt	complete
involved_in	GO:0070493	thrombin-activated receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002281 InterPro:IPR003912	P		Seeded From UniProt	complete
enables	GO:0032795	heterotrimeric G-protein binding	PMID:20215560^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Joyal, JS et al. (2014) Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nat. Med. 20 1165-73 PubMed GONUTS page
↑ ^2.0 ^2.1 Höcherl, K et al. (2011) Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release. Hypertension 58 611-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Ramelli, G et al. (2010) Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo. Immunology 129 20-7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Khoufache, K et al. (2009) Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway. J. Immunol. 182 7795-802 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 McCoy, KL et al. (2010) PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Mol. Pharmacol. 77 1005-15 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Ge, L et al. (2003) A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J. Biol. Chem. 278 34418-26 PubMed GONUTS page
↑ Damiano, BP et al. (1999) Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. J. Pharmacol. Exp. Ther. 288 671-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25216639-1] 1.0 ^1.1 Joyal, JS et al. (2014) Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nat. Med. 20 1165-73 PubMed GONUTS page

[PMID:21859963-2] 2.0 ^2.1 Höcherl, K et al. (2011) Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release. Hypertension 58 611-8 PubMed GONUTS page

[PMID:19845798-3] 3.0 ^3.1 Ramelli, G et al. (2010) Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo. Immunology 129 20-7 PubMed GONUTS page

[PMID:19494303-4] 4.0 ^4.1 ^4.2 ^4.3 Khoufache, K et al. (2009) Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway. J. Immunol. 182 7795-802 PubMed GONUTS page

[PMID:20215560-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 McCoy, KL et al. (2010) PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Mol. Pharmacol. 77 1005-15 PubMed GONUTS page

[PMID:12821670-6] 6.0 ^6.1 ^6.2 Ge, L et al. (2003) A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J. Biol. Chem. 278 34418-26 PubMed GONUTS page

[PMID:9918574-7] Damiano, BP et al. (1999) Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. J. Pharmacol. Exp. Ther. 288 671-8 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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