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MOUSE:PAR2

From GONUTS
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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) F2rl1 (synonyms: Gpcr11, Gpr11, Par2)
Protein Name(s) Proteinase-activated receptor 2

PAR-2 Coagulation factor II receptor-like 1 G-protein coupled receptor 11 Thrombin receptor-like 1

External Links
UniProt P55086
EMBL Z48043
CCDS CCDS26700.1
PIR I48705
RefSeq NP_032000.3
UniGene Mm.1614
ProteinModelPortal P55086
SMR P55086
PhosphoSite P55086
PRIDE P55086
Ensembl ENSMUST00000022185
GeneID 14063
KEGG mmu:14063
UCSC uc011zda.2
CTD 2150
MGI MGI:101910
eggNOG NOG145128
HOGENOM HOG000116291
HOVERGEN HBG105658
InParanoid P55086
KO K04234
OMA LAMYLIC
OrthoDB EOG7DNNVR
PhylomeDB P55086
TreeFam TF330775
Reactome REACT_207651
REACT_235286
ChiTaRS F2rl1
NextBio 285036
PRO PR:P55086
Proteomes UP000000589
Bgee P55086
CleanEx MM_F2RL1
ExpressionAtlas P55086
Genevestigator P55086
GO GO:0005769
GO:0005887
GO:0005886
GO:0031143
GO:0001965
GO:0031681
GO:0004930
GO:0032795
GO:0015057
GO:0007596
GO:0035926
GO:0090195
GO:0051607
GO:0061028
GO:0006954
GO:0045087
GO:0072643
GO:0050702
GO:0072608
GO:0050900
GO:0070661
GO:0097029
GO:0090198
GO:0046329
GO:0034140
GO:0010804
GO:0042119
GO:0030836
GO:0030335
GO:0050921
GO:0002741
GO:0007204
GO:0043311
GO:0070374
GO:0003104
GO:0043123
GO:2000778
GO:2000484
GO:0046330
GO:0002690
GO:0070963
GO:0060100
GO:0014068
GO:0050927
GO:0031274
GO:1900135
GO:0035025
GO:0032930
GO:0034137
GO:0034141
GO:0034145
GO:0045944
GO:0045909
GO:0030193
GO:0043122
GO:0046328
GO:0002286
InterPro IPR000276
IPR017452
IPR002281
IPR003912
Pfam PF00001
PRINTS PR00237
PR01428
PR01152
PROSITE PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005634

nucleus

PMID:25216639[1]

ECO:0000314

C

Figure 2A

complete
CACAO 10849

GO:0005886

plasma membrane

PMID:25216639[1]

ECO:0000314

C

Figure 2A

complete
CACAO 10850

involved_in

GO:2000778

positive regulation of interleukin-6 secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

involved_in

GO:2000484

positive regulation of interleukin-8 secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

involved_in

GO:1900135

positive regulation of renin secretion into blood stream

PMID:21859963[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097029

mature conventional dendritic cell differentiation

PMID:19845798[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090195

chemokine secretion

PMID:19494303[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072643

interferon-gamma secretion

PMID:19494303[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072608

interleukin-10 secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

involved_in

GO:0070661

leukocyte proliferation

PMID:19494303[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:20215560[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:19494303[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050921

positive regulation of chemotaxis

PMID:12821670[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050900

leukocyte migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

involved_in

GO:0050702

interleukin-1 beta secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

involved_in

GO:0046328

regulation of JNK cascade

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

involved_in

GO:0097755

positive regulation of blood vessel diameter

PMID:9918574[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097755

positive regulation of blood vessel diameter

PMID:21859963[2]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(UBERON:0006544)

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

involved_in

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

involved_in

GO:0042119

neutrophil activation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

involved_in

GO:0035926

chemokine (C-C motif) ligand 2 secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

involved_in

GO:0035025

positive regulation of Rho protein signal transduction

PMID:20215560[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032930

positive regulation of superoxide anion generation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

enables

GO:0031681

G-protein beta-subunit binding

PMID:20215560[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0031274

positive regulation of pseudopodium assembly

PMID:12821670[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031143

pseudopodium

PMID:12821670[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:20215560[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

PMID:20215560[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:20215560[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:20215560[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0003104

positive regulation of glomerular filtration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63645

P

Seeded From UniProt

complete

involved_in

GO:0002741

positive regulation of cytokine secretion involved in immune response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

involved_in

GO:0002286

T cell activation involved in immune response

PMID:19845798[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001965

G-protein alpha-subunit binding

PMID:20215560[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051482

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000660850
RGD:2586

P

Seeded From UniProt

complete

involved_in

GO:0035025

positive regulation of Rho protein signal transduction

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101802
MGI:MGI:101910
PANTHER:PTN000660850
UniProtKB:P55085
UniProtKB:Q9Y2T6

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1929509
PANTHER:PTN000660850
UniProtKB:P55085
UniProtKB:Q99678
UniProtKB:Q9HC97
UniProtKB:Q9Y2T6

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101802
MGI:MGI:101910
MGI:MGI:2441992
PANTHER:PTN000660850
UniProtKB:P55085
UniProtKB:Q8IYL9
UniProtKB:Q99678
UniProtKB:Q9HC97

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000778

positive regulation of interleukin-6 secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000484

positive regulation of interleukin-8 secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097755

positive regulation of blood vessel diameter

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620866

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097029

mature conventional dendritic cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090198

negative regulation of chemokine secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090195

chemokine secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072608

interleukin-10 secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070963

positive regulation of neutrophil mediated killing of gram-negative bacterium

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061028

establishment of endothelial barrier

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060100

positive regulation of phagocytosis, engulfment

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051607

defense response to virus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050927

positive regulation of positive chemotaxis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050900

leukocyte migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050702

interleukin-1 beta secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046330

positive regulation of JNK cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046329

negative regulation of JNK cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046328

regulation of JNK cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045217

cell-cell junction maintenance

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043547

positive regulation of GTPase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043311

positive regulation of eosinophil degranulation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042119

neutrophil activation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035926

chemokine (C-C motif) ligand 2 secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035025

positive regulation of Rho protein signal transduction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034145

positive regulation of toll-like receptor 4 signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034141

positive regulation of toll-like receptor 3 signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034140

negative regulation of toll-like receptor 3 signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034137

positive regulation of toll-like receptor 2 signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032930

positive regulation of superoxide anion generation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030836

positive regulation of actin filament depolymerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030193

regulation of blood coagulation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010804

negative regulation of tumor necrosis factor-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003104

positive regulation of glomerular filtration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620866

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002741

positive regulation of cytokine secretion involved in immune response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002690

positive regulation of leukocyte chemotaxis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55085

P

Seeded From UniProt

complete

involved_in

GO:2000778

positive regulation of interleukin-6 secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:2000484

positive regulation of interleukin-8 secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0097029

mature conventional dendritic cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0090198

negative regulation of chemokine secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0090195

chemokine secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0072608

interleukin-10 secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0070963

positive regulation of neutrophil mediated killing of gram-negative bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0061028

establishment of endothelial barrier

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0060100

positive regulation of phagocytosis, engulfment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0050927

positive regulation of positive chemotaxis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0050900

leukocyte migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0050702

interleukin-1 beta secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0046330

positive regulation of JNK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0046329

negative regulation of JNK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0046328

regulation of JNK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0045217

cell-cell junction maintenance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0043311

positive regulation of eosinophil degranulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0042119

neutrophil activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0035926

chemokine (C-C motif) ligand 2 secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0035025

positive regulation of Rho protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0034145

positive regulation of toll-like receptor 4 signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0034141

positive regulation of toll-like receptor 3 signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0034140

negative regulation of toll-like receptor 3 signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0034137

positive regulation of toll-like receptor 2 signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0032930

positive regulation of superoxide anion generation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0030836

positive regulation of actin filament depolymerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0030193

regulation of blood coagulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0010804

negative regulation of tumor necrosis factor-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

F

Seeded From UniProt

complete

involved_in

GO:0002741

positive regulation of cytokine secretion involved in immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0002690

positive regulation of leukocyte chemotaxis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55085
ensembl:ENSP00000296677

P

Seeded From UniProt

complete

involved_in

GO:0097755

positive regulation of blood vessel diameter

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63645
ensembl:ENSRNOP00000058298

P

Seeded From UniProt

complete

involved_in

GO:0003104

positive regulation of glomerular filtration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63645
ensembl:ENSRNOP00000058298

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003912

P

Seeded From UniProt

complete

enables

GO:0015057

thrombin-activated receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002281
InterPro:IPR003912

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR002281
InterPro:IPR003912
InterPro:IPR017452

C

Seeded From UniProt

complete

involved_in

GO:0070493

thrombin-activated receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002281
InterPro:IPR003912

P

Seeded From UniProt

complete

enables

GO:0032795

heterotrimeric G-protein binding

PMID:20215560[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Joyal, JS et al. (2014) Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nat. Med. 20 1165-73 PubMed GONUTS page
  2. 2.0 2.1 Höcherl, K et al. (2011) Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release. Hypertension 58 611-8 PubMed GONUTS page
  3. 3.0 3.1 Ramelli, G et al. (2010) Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo. Immunology 129 20-7 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Khoufache, K et al. (2009) Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway. J. Immunol. 182 7795-802 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 McCoy, KL et al. (2010) PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Mol. Pharmacol. 77 1005-15 PubMed GONUTS page
  6. 6.0 6.1 6.2 Ge, L et al. (2003) A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J. Biol. Chem. 278 34418-26 PubMed GONUTS page
  7. Damiano, BP et al. (1999) Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. J. Pharmacol. Exp. Ther. 288 671-8 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page