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MOUSE:PAR2
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | F2rl1 (synonyms: Gpcr11, Gpr11, Par2) | |
Protein Name(s) | Proteinase-activated receptor 2
PAR-2 Coagulation factor II receptor-like 1 G-protein coupled receptor 11 Thrombin receptor-like 1 | |
External Links | ||
UniProt | P55086 | |
EMBL | Z48043 | |
CCDS | CCDS26700.1 | |
PIR | I48705 | |
RefSeq | NP_032000.3 | |
UniGene | Mm.1614 | |
ProteinModelPortal | P55086 | |
SMR | P55086 | |
PhosphoSite | P55086 | |
PRIDE | P55086 | |
Ensembl | ENSMUST00000022185 | |
GeneID | 14063 | |
KEGG | mmu:14063 | |
UCSC | uc011zda.2 | |
CTD | 2150 | |
MGI | MGI:101910 | |
eggNOG | NOG145128 | |
HOGENOM | HOG000116291 | |
HOVERGEN | HBG105658 | |
InParanoid | P55086 | |
KO | K04234 | |
OMA | LAMYLIC | |
OrthoDB | EOG7DNNVR | |
PhylomeDB | P55086 | |
TreeFam | TF330775 | |
Reactome | REACT_207651 REACT_235286 | |
ChiTaRS | F2rl1 | |
NextBio | 285036 | |
PRO | PR:P55086 | |
Proteomes | UP000000589 | |
Bgee | P55086 | |
CleanEx | MM_F2RL1 | |
ExpressionAtlas | P55086 | |
Genevestigator | P55086 | |
GO | GO:0005769 GO:0005887 GO:0005886 GO:0031143 GO:0001965 GO:0031681 GO:0004930 GO:0032795 GO:0015057 GO:0007596 GO:0035926 GO:0090195 GO:0051607 GO:0061028 GO:0006954 GO:0045087 GO:0072643 GO:0050702 GO:0072608 GO:0050900 GO:0070661 GO:0097029 GO:0090198 GO:0046329 GO:0034140 GO:0010804 GO:0042119 GO:0030836 GO:0030335 GO:0050921 GO:0002741 GO:0007204 GO:0043311 GO:0070374 GO:0003104 GO:0043123 GO:2000778 GO:2000484 GO:0046330 GO:0002690 GO:0070963 GO:0060100 GO:0014068 GO:0050927 GO:0031274 GO:1900135 GO:0035025 GO:0032930 GO:0034137 GO:0034141 GO:0034145 GO:0045944 GO:0045909 GO:0030193 GO:0043122 GO:0046328 GO:0002286 | |
InterPro | IPR000276 IPR017452 IPR002281 IPR003912 | |
Pfam | PF00001 | |
PRINTS | PR00237 PR01428 PR01152 | |
PROSITE | PS50262 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 2A |
complete | |||||
GO:0005886 |
plasma membrane |
ECO:0000314 |
C |
Figure 2A |
complete | |||||
involved_in |
GO:2000778 |
positive regulation of interleukin-6 secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000484 |
positive regulation of interleukin-8 secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1900135 |
positive regulation of renin secretion into blood stream |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097029 |
mature conventional dendritic cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090195 |
chemokine secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072643 |
interferon-gamma secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072608 |
interleukin-10 secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070661 |
leukocyte proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050921 |
positive regulation of chemotaxis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050900 |
leukocyte migration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050702 |
interleukin-1 beta secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046328 |
regulation of JNK cascade |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097755 |
positive regulation of blood vessel diameter |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097755 |
positive regulation of blood vessel diameter |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(UBERON:0006544) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043122 |
regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042119 |
neutrophil activation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035926 |
chemokine (C-C motif) ligand 2 secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035025 |
positive regulation of Rho protein signal transduction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032930 |
positive regulation of superoxide anion generation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0031681 |
G-protein beta-subunit binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031274 |
positive regulation of pseudopodium assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0031143 |
pseudopodium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003104 |
positive regulation of glomerular filtration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002741 |
positive regulation of cytokine secretion involved in immune response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002286 |
T cell activation involved in immune response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0001965 |
G-protein alpha-subunit binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051482 |
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000660850 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035025 |
positive regulation of Rho protein signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101802 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1929509 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101802 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:2000778 |
positive regulation of interleukin-6 secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:2000484 |
positive regulation of interleukin-8 secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0097755 |
positive regulation of blood vessel diameter |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620866 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0097029 |
mature conventional dendritic cell differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0090198 |
negative regulation of chemokine secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0090195 |
chemokine secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0072608 |
interleukin-10 secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0070963 |
positive regulation of neutrophil mediated killing of gram-negative bacterium |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0061028 |
establishment of endothelial barrier |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060100 |
positive regulation of phagocytosis, engulfment |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051607 |
defense response to virus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050927 |
positive regulation of positive chemotaxis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050900 |
leukocyte migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050702 |
interleukin-1 beta secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0046330 |
positive regulation of JNK cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0046329 |
negative regulation of JNK cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0046328 |
regulation of JNK cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045217 |
cell-cell junction maintenance |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043311 |
positive regulation of eosinophil degranulation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043122 |
regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0042119 |
neutrophil activation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0035926 |
chemokine (C-C motif) ligand 2 secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0035025 |
positive regulation of Rho protein signal transduction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0034145 |
positive regulation of toll-like receptor 4 signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0034141 |
positive regulation of toll-like receptor 3 signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0034140 |
negative regulation of toll-like receptor 3 signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0034137 |
positive regulation of toll-like receptor 2 signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0032930 |
positive regulation of superoxide anion generation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030836 |
positive regulation of actin filament depolymerization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030193 |
regulation of blood coagulation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010804 |
negative regulation of tumor necrosis factor-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005769 |
early endosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0003104 |
positive regulation of glomerular filtration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620866 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0002741 |
positive regulation of cytokine secretion involved in immune response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0002690 |
positive regulation of leukocyte chemotaxis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000778 |
positive regulation of interleukin-6 secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000484 |
positive regulation of interleukin-8 secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097029 |
mature conventional dendritic cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090198 |
negative regulation of chemokine secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090195 |
chemokine secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0072608 |
interleukin-10 secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070963 |
positive regulation of neutrophil mediated killing of gram-negative bacterium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061028 |
establishment of endothelial barrier |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060100 |
positive regulation of phagocytosis, engulfment |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050927 |
positive regulation of positive chemotaxis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050900 |
leukocyte migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050702 |
interleukin-1 beta secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046330 |
positive regulation of JNK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046329 |
negative regulation of JNK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046328 |
regulation of JNK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045217 |
cell-cell junction maintenance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043311 |
positive regulation of eosinophil degranulation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043122 |
regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042119 |
neutrophil activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035926 |
chemokine (C-C motif) ligand 2 secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035025 |
positive regulation of Rho protein signal transduction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034145 |
positive regulation of toll-like receptor 4 signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034141 |
positive regulation of toll-like receptor 3 signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034140 |
negative regulation of toll-like receptor 3 signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034137 |
positive regulation of toll-like receptor 2 signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032930 |
positive regulation of superoxide anion generation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030836 |
positive regulation of actin filament depolymerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030193 |
regulation of blood coagulation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010804 |
negative regulation of tumor necrosis factor-mediated signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005769 |
early endosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002741 |
positive regulation of cytokine secretion involved in immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002690 |
positive regulation of leukocyte chemotaxis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55085 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097755 |
positive regulation of blood vessel diameter |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q63645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003104 |
positive regulation of glomerular filtration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q63645 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007596 |
blood coagulation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0015057 |
thrombin-activated receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000276 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070493 |
thrombin-activated receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0032795 |
heterotrimeric G-protein binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Joyal, JS et al. (2014) Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nat. Med. 20 1165-73 PubMed GONUTS page
- ↑ 2.0 2.1 Höcherl, K et al. (2011) Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release. Hypertension 58 611-8 PubMed GONUTS page
- ↑ 3.0 3.1 Ramelli, G et al. (2010) Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo. Immunology 129 20-7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Khoufache, K et al. (2009) Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway. J. Immunol. 182 7795-802 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 McCoy, KL et al. (2010) PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Mol. Pharmacol. 77 1005-15 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Ge, L et al. (2003) A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J. Biol. Chem. 278 34418-26 PubMed GONUTS page
- ↑ Damiano, BP et al. (1999) Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. J. Pharmacol. Exp. Ther. 288 671-8 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
e
g
i
- GO:0002376 ! immune system process
- GO:0006954 ! inflammatory response
- GO:0045087 ! innate immune response
- GO:0016021 ! integral component of membrane
- GO:0005887 ! integral component of plasma membrane
- GO:0072643 ! interferon-gamma secretion
- GO:0072608 ! interleukin-10 secretion
- GO:0050702 ! interleukin-1 beta secretion
m
n
- GO:0010804 ! negative regulation of tumor necrosis factor-mediated signaling pathway
- GO:0034140 ! negative regulation of toll-like receptor 3 signaling pathway
- GO:0046329 ! negative regulation of JNK cascade
- GO:0090198 ! negative regulation of chemokine secretion
- GO:0042119 ! neutrophil activation
- GO:0005634 ! nucleus
o
- GO:0097755 ! obsolete positive regulation of blood vessel diameter
- GO:0051482 ! obsolete positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
- GO:0014068 ! obsolete positive regulation of phosphatidylinositol 3-kinase signaling
p
- GO:0005886 ! plasma membrane
- GO:2000484 ! positive regulation of interleukin-8 secretion
- GO:1900135 ! positive regulation of renin secretion into blood stream
- GO:0070374 ! positive regulation of ERK1 and ERK2 cascade
- GO:0050921 ! positive regulation of chemotaxis
- GO:0043123 ! positive regulation of canonical NF-kappaB signal transduction
- GO:0003104 ! positive regulation of glomerular filtration
- GO:0035025 ! positive regulation of Rho protein signal transduction
- GO:0032930 ! positive regulation of superoxide anion generation
- GO:0031274 ! positive regulation of pseudopodium assembly
- GO:2000778 ! positive regulation of interleukin-6 secretion
- GO:0030335 ! positive regulation of cell migration
- GO:0046330 ! positive regulation of JNK cascade
- GO:0007204 ! positive regulation of cytosolic calcium ion concentration
- GO:0034141 ! positive regulation of toll-like receptor 3 signaling pathway
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0050927 ! positive regulation of positive chemotaxis
- GO:0043547 ! positive regulation of GTPase activity
- GO:0002690 ! positive regulation of leukocyte chemotaxis
- GO:0070963 ! positive regulation of neutrophil mediated killing of gram-negative bacterium
- GO:0043311 ! positive regulation of eosinophil degranulation
- GO:0030836 ! positive regulation of actin filament depolymerization
- GO:0034137 ! positive regulation of toll-like receptor 2 signaling pathway
- GO:0034145 ! positive regulation of toll-like receptor 4 signaling pathway
- GO:0002741 ! positive regulation of cytokine secretion involved in immune response
- GO:0060100 ! positive regulation of phagocytosis, engulfment
- GO:0031143 ! pseudopodium
r
t