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MOUSE:P73
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Tp73 | |
Protein Name(s) | Tumor protein p73 (ECO:0000250 with UniProtKB:O15350)
p53-like transcription factor (ECO:0000250 with UniProtKB:O15350) p53-related protein (ECO:0000250 with UniProtKB:O15350) | |
External Links | ||
UniProt | Q9JJP2 | |
EMBL | Y19234 Y19235 AK017412 AK139633 AL806525 AL806525 AL806525 CH466594 BC066045 AF138873 | |
CCDS | CCDS51396.1 CCDS51397.1 | |
RefSeq | NP_001119802.1 NP_001119803.1 NP_035772.2 | |
UniGene | Mm.78015 | |
ProteinModelPortal | Q9JJP2 | |
SMR | Q9JJP2 | |
BioGrid | 204326 | |
DIP | DIP-41942N | |
IntAct | Q9JJP2 | |
MINT | MINT-3388880 | |
PhosphoSite | Q9JJP2 | |
PRIDE | Q9JJP2 | |
Ensembl | ENSMUST00000097762 ENSMUST00000105643 ENSMUST00000133533 | |
GeneID | 22062 | |
KEGG | mmu:22062 | |
UCSC | uc008wbg.2 uc008wbh.2 uc012dqi.1 | |
CTD | 22062 | |
MGI | MGI:1336991 | |
eggNOG | NOG80479 | |
GeneTree | ENSGT00390000015092 | |
InParanoid | Q9JJP2 | |
KO | K10148 | |
OrthoDB | EOG7JQBNW | |
PhylomeDB | Q9JJP2 | |
TreeFam | TF106101 | |
NextBio | 301868 | |
PRO | PR:Q9JJP2 | |
Proteomes | UP000000589 | |
Bgee | Q9JJP2 | |
ExpressionAtlas | Q9JJP2 | |
Genevestigator | Q9JJP2 | |
GO | GO:0000785 GO:0005829 GO:0005634 GO:0005667 GO:0003682 GO:0003684 GO:0003677 GO:0003690 GO:0046872 GO:0002039 GO:0043565 GO:0003700 GO:0044212 GO:0007050 GO:0006974 GO:0034644 GO:0033326 GO:0048546 GO:0006978 GO:0030900 GO:0021766 GO:0006954 GO:0042771 GO:0031571 GO:0060044 GO:0043508 GO:0043524 GO:0000122 GO:0048666 GO:2001235 GO:0045793 GO:1902167 GO:0045944 GO:0045893 GO:0009791 GO:0051262 GO:0010468 GO:0007346 GO:0043523 GO:0001836 GO:0010332 GO:0010165 GO:0006351 | |
Gene3D | 1.10.150.50 2.60.40.720 4.10.170.10 | |
InterPro | IPR008967 IPR012346 IPR011615 IPR010991 IPR002117 IPR001660 IPR013761 IPR011510 | |
PANTHER | PTHR11447 | |
Pfam | PF00870 PF07710 PF07647 | |
PRINTS | PR00386 | |
SMART | SM00454 | |
SUPFAM | SSF47719 SSF47769 SSF49417 | |
PROSITE | PS00348 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0006281 |
DNA repair |
ECO:0000315 |
P |
Figure 4a. Loss of p73 results in increased DNA damage. |
complete | |||||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000333) |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042771 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859911 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043523 |
regulation of neuron apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98834 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043508 |
negative regulation of JUN kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1307083 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0042771 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0033326 |
cerebrospinal fluid secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859911 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0030900 |
forebrain development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859911 |
P |
results_in_development_of:(EMAPA:17544) |
Seeded From UniProt |
complete | |
part_of |
GO:0030054 |
cell junction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0021766 |
hippocampus development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859911 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010468 |
regulation of gene expression |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0009791 |
post-embryonic development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859911 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0009791 |
post-embryonic development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859911 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007346 |
regulation of mitotic cell cycle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007050 |
cell cycle arrest |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006954 |
inflammatory response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859911 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1307083 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1307083 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0002039 |
p53 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0002039 |
p53 binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001836 |
release of cytochrome c from mitochondria |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0000785 |
chromatin |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1307083 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0000187 |
activation of MAPK activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1307083 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:2001235 |
positive regulation of apoptotic signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902167 |
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2442925 |
P |
regulates_o_occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | |
enables |
GO:0097371 |
MDM2/MDM4 family protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071158 |
positive regulation of cell cycle arrest |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060044 |
negative regulation of cardiac muscle cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0048714 |
positive regulation of oligodendrocyte differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1307083 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048666 |
neuron development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859911 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048546 |
digestive tract morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859911 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045793 |
positive regulation of cell size |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859911 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045793 |
positive regulation of cell size |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859911 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045665 |
negative regulation of neuron differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1307083 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1307083 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859911 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859911 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR002117 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007050 |
cell cycle arrest |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051262 |
protein tetramerization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Zaika, E et al. (2011) p73 protein regulates DNA damage repair. FASEB J. 25 4406-14 PubMed GONUTS page
- ↑ Hudson, CD et al. (2008) Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription. Cell Death Differ. 15 1266-78 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Pozniak, CD et al. (2000) An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science 289 304-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Pozniak, CD et al. (2002) p73 is required for survival and maintenance of CNS neurons. J. Neurosci. 22 9800-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Lee, AF et al. (2004) Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J. Neurosci. 24 9174-84 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Yang, A et al. (2000) p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404 99-103 PubMed GONUTS page
- ↑ 7.0 7.1 Meyer, G et al. (2004) Developmental roles of p73 in Cajal-Retzius cells and cortical patterning. J. Neurosci. 24 9878-87 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Ebelt, H et al. (2008) Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice. J. Mol. Cell. Cardiol. 45 411-9 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 Tomasini, R et al. (2005) TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity. Oncogene 24 8093-104 PubMed GONUTS page
- ↑ Maisse, C et al. (2003) p73 and p63 protein stability: the way to regulate function? Biochem. Pharmacol. 66 1555-61 PubMed GONUTS page
- ↑ 11.0 11.1 Rossi, M et al. (2005) The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J. 24 836-48 PubMed GONUTS page
- ↑ Kulesz-Martin, M et al. (2005) Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles. J. Investig. Dermatol. Symp. Proc. 10 142-52 PubMed GONUTS page
- ↑ Ishii, H et al. (2005) Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proc. Natl. Acad. Sci. U.S.A. 102 9655-60 PubMed GONUTS page
c
d
- GO:0048546 ! digestive tract morphogenesis
- GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0001228 ! DNA-binding transcription activator activity, RNA polymerase II-specific
- GO:0003700 ! DNA-binding transcription factor activity
- GO:0003677 ! DNA binding
- GO:0006974 ! DNA damage response
- GO:0006281 ! DNA repair
i
m
n
- GO:0043524 ! negative regulation of neuron apoptotic process
- GO:0060044 ! negative regulation of cardiac muscle cell proliferation
- GO:0043508 ! negative regulation of JUN kinase activity
- GO:0045665 ! negative regulation of neuron differentiation
- GO:0008285 ! negative regulation of cell population proliferation
- GO:0048666 ! neuron development
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
p
- GO:0002039 ! p53 binding
- GO:0071158 ! positive regulation of cell cycle arrest
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0043065 ! positive regulation of apoptotic process
- GO:1902167 ! positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- GO:2001235 ! positive regulation of apoptotic signaling pathway
- GO:0048714 ! positive regulation of oligodendrocyte differentiation
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0045793 ! positive regulation of cell size
- GO:0009791 ! post-embryonic development
- GO:0019901 ! protein kinase binding
- GO:0051262 ! protein tetramerization
r
- GO:0043523 ! regulation of neuron apoptotic process
- GO:0010468 ! regulation of gene expression
- GO:0006355 ! regulation of DNA-templated transcription
- GO:0007346 ! regulation of mitotic cell cycle
- GO:0001836 ! release of cytochrome c from mitochondria
- GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding
- Rodentia
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