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MOUSE:P73

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Tp73
Protein Name(s) Tumor protein p73 (ECO:0000250 with UniProtKB:O15350)

p53-like transcription factor (ECO:0000250 with UniProtKB:O15350) p53-related protein (ECO:0000250 with UniProtKB:O15350)

External Links
UniProt Q9JJP2
EMBL Y19234
Y19235
AK017412
AK139633
AL806525
AL806525
AL806525
CH466594
BC066045
AF138873
CCDS CCDS51396.1
CCDS51397.1
RefSeq NP_001119802.1
NP_001119803.1
NP_035772.2
UniGene Mm.78015
ProteinModelPortal Q9JJP2
SMR Q9JJP2
BioGrid 204326
DIP DIP-41942N
IntAct Q9JJP2
MINT MINT-3388880
PhosphoSite Q9JJP2
PRIDE Q9JJP2
Ensembl ENSMUST00000097762
ENSMUST00000105643
ENSMUST00000133533
GeneID 22062
KEGG mmu:22062
UCSC uc008wbg.2
uc008wbh.2
uc012dqi.1
CTD 22062
MGI MGI:1336991
eggNOG NOG80479
GeneTree ENSGT00390000015092
InParanoid Q9JJP2
KO K10148
OrthoDB EOG7JQBNW
PhylomeDB Q9JJP2
TreeFam TF106101
NextBio 301868
PRO PR:Q9JJP2
Proteomes UP000000589
Bgee Q9JJP2
ExpressionAtlas Q9JJP2
Genevestigator Q9JJP2
GO GO:0000785
GO:0005829
GO:0005634
GO:0005667
GO:0003682
GO:0003684
GO:0003677
GO:0003690
GO:0046872
GO:0002039
GO:0043565
GO:0003700
GO:0044212
GO:0007050
GO:0006974
GO:0034644
GO:0033326
GO:0048546
GO:0006978
GO:0030900
GO:0021766
GO:0006954
GO:0042771
GO:0031571
GO:0060044
GO:0043508
GO:0043524
GO:0000122
GO:0048666
GO:2001235
GO:0045793
GO:1902167
GO:0045944
GO:0045893
GO:0009791
GO:0051262
GO:0010468
GO:0007346
GO:0043523
GO:0001836
GO:0010332
GO:0010165
GO:0006351
Gene3D 1.10.150.50
2.60.40.720
4.10.170.10
InterPro IPR008967
IPR012346
IPR011615
IPR010991
IPR002117
IPR001660
IPR013761
IPR011510
PANTHER PTHR11447
Pfam PF00870
PF07710
PF07647
PRINTS PR00386
SMART SM00454
SUPFAM SSF47719
SSF47769
SSF49417
PROSITE PS00348

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006281

DNA repair

PMID:21891782[1]

ECO:0000315

P

Figure 4a. Loss of p73 results in increased DNA damage.

complete
CACAO 3917

part_of

GO:0005634

nucleus

PMID:18421303[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000333)

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O15350

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O15350

P

Seeded From UniProt

complete

involved_in

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O15350

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:10894779[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859911

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:12427836[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:10894779[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043523

regulation of neuron apoptotic process

PMID:15483136[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98834

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043508

negative regulation of JUN kinase activity

PMID:15483136[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1307083

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033326

cerebrospinal fluid secretion

PMID:10716451[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859911

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030900

forebrain development

PMID:15525772[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859911

P

results_in_development_of:(EMAPA:17544)

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021766

hippocampus development

PMID:10716451[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859911

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:18634800[8]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009791

post-embryonic development

PMID:15483136[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859911

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009791

post-embryonic development

PMID:10716451[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859911

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007346

regulation of mitotic cell cycle

PMID:18634800[8]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007050

cell cycle arrest

PMID:16044147[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

PMID:16044147[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006954

inflammatory response

PMID:10716451[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859911

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1307083

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15525772[7]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17544)
  • part_of:(CL:0000695)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15483136[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:14555234[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1307083

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:16044147[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:15678106[11]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:16363065[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0002039

p53 binding

PMID:10894779[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02340

F

Seeded From UniProt

complete

enables

GO:0002039

p53 binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001836

release of cytochrome c from mitochondria

PMID:15483136[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

F

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1307083

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000187

activation of MAPK activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1307083

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001235

positive regulation of apoptotic signaling pathway

PMID:16044147[9]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9QXE4-2

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902167

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:15983387[13]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2442925
MGI:MGI:98834

P

regulates_o_occurs_in:(CL:0000057)

Seeded From UniProt

complete

enables

GO:0097371

MDM2/MDM4 family protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071158

positive regulation of cell cycle arrest

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060044

negative regulation of cardiac muscle cell proliferation

PMID:18634800[8]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048714

positive regulation of oligodendrocyte differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1307083

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048666

neuron development

PMID:12427836[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859911

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048546

digestive tract morphogenesis

PMID:10716451[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859911

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

PMID:16044147[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

PMID:15678106[11]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045793

positive regulation of cell size

PMID:15483136[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859911

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045793

positive regulation of cell size

PMID:12427836[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859911

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045665

negative regulation of neuron differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1307083

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15350

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1307083

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:15483136[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859911

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:12427836[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859911

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002117
InterPro:IPR012346
InterPro:IPR032646

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002117
InterPro:IPR008967
InterPro:IPR012346

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002117
InterPro:IPR012346
InterPro:IPR032646

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002117
InterPro:IPR008967
InterPro:IPR012346
InterPro:IPR032646

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002117
InterPro:IPR032646

P

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032646

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011615

F

Seeded From UniProt

complete

involved_in

GO:0051262

protein tetramerization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010991
InterPro:IPR036674

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Zaika, E et al. (2011) p73 protein regulates DNA damage repair. FASEB J. 25 4406-14 PubMed GONUTS page
  2. Hudson, CD et al. (2008) Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription. Cell Death Differ. 15 1266-78 PubMed GONUTS page
  3. 3.0 3.1 3.2 Pozniak, CD et al. (2000) An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science 289 304-6 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Pozniak, CD et al. (2002) p73 is required for survival and maintenance of CNS neurons. J. Neurosci. 22 9800-9 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Lee, AF et al. (2004) Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J. Neurosci. 24 9174-84 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Yang, A et al. (2000) p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404 99-103 PubMed GONUTS page
  7. 7.0 7.1 Meyer, G et al. (2004) Developmental roles of p73 in Cajal-Retzius cells and cortical patterning. J. Neurosci. 24 9878-87 PubMed GONUTS page
  8. 8.0 8.1 8.2 Ebelt, H et al. (2008) Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice. J. Mol. Cell. Cardiol. 45 411-9 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 Tomasini, R et al. (2005) TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity. Oncogene 24 8093-104 PubMed GONUTS page
  10. Maisse, C et al. (2003) p73 and p63 protein stability: the way to regulate function? Biochem. Pharmacol. 66 1555-61 PubMed GONUTS page
  11. 11.0 11.1 Rossi, M et al. (2005) The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J. 24 836-48 PubMed GONUTS page
  12. Kulesz-Martin, M et al. (2005) Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles. J. Investig. Dermatol. Symp. Proc. 10 142-52 PubMed GONUTS page
  13. Ishii, H et al. (2005) Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proc. Natl. Acad. Sci. U.S.A. 102 9655-60 PubMed GONUTS page