MOUSE:NTRK1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ntrk1
Protein Name(s)	High affinity nerve growth factor receptor Neurotrophic tyrosine kinase receptor type 1
External Links
UniProt	Q3UFB7
EMBL	AK081588 AK148691
CCDS	CCDS50947.1
RefSeq	NP_001028296.1
UniGene	Mm.80682
ProteinModelPortal	Q3UFB7
SMR	Q3UFB7
BioGrid	201868
DIP	DIP-60900N
IntAct	Q3UFB7
STRING	10090.ENSMUSP00000029712
PhosphoSite	Q3UFB7
PaxDb	Q3UFB7
PRIDE	Q3UFB7
Ensembl	ENSMUST00000029712
GeneID	18211
KEGG	mmu:18211
UCSC	uc008psw.1
CTD	4914
MGI	MGI:97383
eggNOG	COG0515
GeneTree	ENSGT00760000118818
HOGENOM	HOG000264255
HOVERGEN	HBG056735
InParanoid	Q3UFB7
KO	K03176
OMA	KNVTCWA
OrthoDB	EOG7GTT32
PhylomeDB	Q3UFB7
TreeFam	TF106465
Reactome	REACT_202778 REACT_205300 REACT_209347 REACT_212952 REACT_213333 REACT_234035 REACT_239722 REACT_252757 REACT_262560 REACT_263607
NextBio	293598
PRO	PR:Q3UFB7
Proteomes	UP000000589
Bgee	Q3UFB7
CleanEx	MM_NTRK1
Genevestigator	Q3UFB7
GO	GO:0030424 GO:0009986 GO:0005737 GO:0031410 GO:0030425 GO:0005769 GO:0031901 GO:0005887 GO:0005770 GO:0031902 GO:0043025 GO:0005886 GO:0043234 GO:0043235 GO:0005524 GO:0048406 GO:0010465 GO:0042803 GO:0004713 GO:0004714 GO:0007568 GO:0007411 GO:0060385 GO:0030183 GO:0071363 GO:1990090 GO:0071316 GO:0007623 GO:0050966 GO:0050965 GO:0010623 GO:0007611 GO:0042490 GO:0008285 GO:0043524 GO:0038180 GO:0007399 GO:0048011 GO:0021553 GO:0018108 GO:0045766 GO:0070374 GO:0010976 GO:0051092 GO:0043068 GO:0032320 GO:0046579 GO:0051968 GO:0046777 GO:0006468 GO:0014823 GO:0048678 GO:0042493 GO:0051602 GO:0045471 GO:0051599 GO:0031667 GO:0009314 GO:0060009 GO:0048485
Gene3D	2.60.40.10
InterPro	IPR007110 IPR013783 IPR003599 IPR011009 IPR001611 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635 IPR020461 IPR020777 IPR002011
Pfam	PF13855 PF07714
PRINTS	PR01939 PR01940 PR00109
SMART	SM00409 SM00219
SUPFAM	SSF56112
PROSITE	PS50835 PS00107 PS50011 PS00109 PS00239

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0009986	cell surface	PMID:3815101^[1]	ECO:0000314			C		Figure 1A. Western blotting displays that NTRK1 (TrkA) was present on cell surfaces.	complete CACAO 9324
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35739	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
involved_in	GO:0060385	axonogenesis involved in innervation	PMID:8815902^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
involved_in	GO:0048485	sympathetic nervous system development	PMID:8815902^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048406	nerve growth factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	F		Seeded From UniProt	complete
involved_in	GO:0048011	neurotrophin TRK receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
involved_in	GO:0046579	positive regulation of Ras protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:8815902^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35739	C		Seeded From UniProt	complete
involved_in	GO:0043068	positive regulation of programmed cell death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35739	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	F		Seeded From UniProt	complete
involved_in	GO:0038180	nerve growth factor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35739	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
involved_in	GO:0010623	programmed cell death involved in cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35739	P		Seeded From UniProt	complete
enables	GO:0010465	nerve growth factor receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:23785138^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35739	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35739	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35739	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04629	F		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97383 PANTHER:PTN001230900 RGD:3213 RGD:620144 UniProtKB:P04629	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002400475 UniProtKB:P04629	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002400475 RGD:3213 UniProtKB:Q16288	P		Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002400475 RGD:3213 UniProtKB:Q16288	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
enables	GO:0043121	neurotrophin binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97384 PANTHER:PTN001230900 RGD:3213 UniProtKB:Q16620	F		Seeded From UniProt	complete
involved_in	GO:0038180	nerve growth factor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97383 PANTHER:PTN000699860 RGD:620144 UniProtKB:P04629	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97383 PANTHER:PTN001230900 RGD:3213 RGD:620144	C		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002400475 RGD:3213	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97384 MGI:MGI:97385 PANTHER:PTN002400475 RGD:3213 RGD:3214 UniProtKB:Q91987	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97383 MGI:MGI:97384 MGI:MGI:97385 PANTHER:PTN002400475 RGD:3213 RGD:3214 RGD:620144 UniProtKB:P04629 UniProtKB:Q91987 ZFIN:ZDB-GENE-010126-3	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005030	neurotrophin receptor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001230900 RGD:3213 UniProtKB:Q16288	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990090	cellular response to nerve growth factor stimulus	PMID:24760869^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071363	cellular response to growth factor stimulus	PMID:19029245^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35739	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071316	cellular response to nicotine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061368	behavioral response to formalin induced pain	PMID:24760869^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060384	innervation	PMID:24760869^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060009	Sertoli cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051965	positive regulation of synapse assembly	PMID:24613359^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051602	response to electrical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048666	neuron development	PMID:27655914^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629-2	P		Seeded From UniProt	complete
enables	GO:0048406	nerve growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	F		Seeded From UniProt	complete
enables	GO:0048406	nerve growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048011	neurotrophin TRK receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	PMID:19029245^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35739	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046579	positive regulation of Ras protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043547	positive regulation of GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:11731452^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P	occurs_in:(EMAPA:18441) regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043068	positive regulation of programmed cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042490	mechanoreceptor differentiation	PMID:15376326^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888374	P	occurs_in:(EMAPA:19141) results_in_acquisition_of_features_of:(CL:0000199)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038180	nerve growth factor signaling pathway	PMID:24270184^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1345961 MGI:MGI:97321	P	occurs_in:(CL:0011103)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038180	nerve growth factor signaling pathway	PMID:7854358^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038180	nerve growth factor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038180	nerve growth factor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:27655914^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629-2	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038083	peptidyl-tyrosine autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035094	response to nicotine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031667	response to nutrient levels	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	PMID:27655914^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629-2	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:24270184^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0011103)	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030183	B cell differentiation	PMID:15459109^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3505767	P	results_in_acquisition_of_features_of:(CL:0000236)	Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019233	sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014823	response to activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010623	programmed cell death involved in cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
enables	GO:0010465	nerve growth factor receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:24760869^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19029245^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35739	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007399	nervous system development	PMID:12810599^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:11877420^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:27655914^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629-2	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:24760869^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:24760869^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:24270184^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0011103)	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11551509^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16666) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10207144^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16797) part_of:(CL:0000117)	Seeded From UniProt	complete
enables	GO:0005166	neurotrophin p75 receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	F		Seeded From UniProt	complete
enables	GO:0005004	GPI-linked ephrin receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:27655914^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629-2	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:19029245^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35739	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04629	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620144	P		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005004	P		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005004	P		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	P		Seeded From UniProt	complete
enables	GO:0048406	nerve growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	F		Seeded From UniProt	complete
involved_in	GO:0048011	neurotrophin TRK receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	P		Seeded From UniProt	complete
involved_in	GO:0046579	positive regulation of Ras protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	F		Seeded From UniProt	complete
involved_in	GO:0038180	nerve growth factor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	P		Seeded From UniProt	complete
enables	GO:0010465	nerve growth factor receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04629 ensembl:ENSP00000431418	F		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0071316	cellular response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0060009	Sertoli cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	C		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0051599	response to hydrostatic pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0048678	response to axon injury	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
enables	GO:0048406	nerve growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0043068	positive regulation of programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0038180	nerve growth factor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	C		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	C		Seeded From UniProt	complete
involved_in	GO:0021553	olfactory nerve development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	F		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0010623	programmed cell death involved in cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	C		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	C		Seeded From UniProt	complete
enables	GO:0005166	neurotrophin p75 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	F		Seeded From UniProt	complete
enables	GO:0005004	GPI-linked ephrin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35739 ensembl:ENSRNOP00000018961	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR020461 InterPro:IPR020777	F		Seeded From UniProt	complete
enables	GO:0005030	neurotrophin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020461	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR002011 InterPro:IPR017441 InterPro:IPR020777	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020461 InterPro:IPR020777	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR002011 InterPro:IPR008266 InterPro:IPR020461 InterPro:IPR020635 InterPro:IPR020777	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR020461 InterPro:IPR020777	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-198275 Reactome:R-MMU-198263	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0055038	recycling endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0231	C		Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0151	C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Fung, SJ et al. (1987) Differential labeling of the vestibular complex following unilateral injections of horseradish peroxidase into the cat and rat locus coeruleus. Brain Res. 401 347-52 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Fagan, AM et al. (1996) TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo. J. Neurosci. 16 6208-18 PubMed GONUTS page
↑ Baeza-Raja, B et al. (2013) p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J. Neurosci. 33 10221-34 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Yu, T et al. (2014) In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA. J. Neurosci. 34 6098-106 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Van Kanegan, MJ & Strack, S (2009) The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Mol. Cell. Biol. 29 662-74 PubMed GONUTS page
↑ Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Zhang, D et al. (2016) The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A. J. Biol. Chem. 291 23895-23905 PubMed GONUTS page
↑ Middleton, G & Davies, AM (2001) Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo. Development 128 4715-28 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ Sedý, J et al. (2004) Pacinian corpuscle development involves multiple Trk signaling pathways. Dev. Dyn. 231 551-63 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Suo, D et al. (2014) Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nat. Neurosci. 17 36-45 PubMed GONUTS page
↑ Chen, F et al. (1994) Cloning of a novel orphan receptor (GCNF) expressed during germ cell development. Mol. Endocrinol. 8 1434-44 PubMed GONUTS page
↑ Coppola, V et al. (2004) Ablation of TrkA function in the immune system causes B cell abnormalities. Development 131 5185-95 PubMed GONUTS page
↑ Ma, L et al. (2003) Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. Development 130 3525-34 PubMed GONUTS page
↑ Tarr, PE et al. (2002) Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. J. Biol. Chem. 277 16798-804 PubMed GONUTS page
↑ Dong, X et al. (2001) A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 106 619-32 PubMed GONUTS page
↑ Huang, EJ et al. (1999) Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC. Development 126 2191-203 PubMed GONUTS page

[PMID:3815101-1] Fung, SJ et al. (1987) Differential labeling of the vestibular complex following unilateral injections of horseradish peroxidase into the cat and rat locus coeruleus. Brain Res. 401 347-52 PubMed GONUTS page

[PMID:8815902-2] 2.0 ^2.1 ^2.2 Fagan, AM et al. (1996) TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo. J. Neurosci. 16 6208-18 PubMed GONUTS page

[PMID:23785138-3] Baeza-Raja, B et al. (2013) p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J. Neurosci. 33 10221-34 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24760869-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Yu, T et al. (2014) In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA. J. Neurosci. 34 6098-106 PubMed GONUTS page

[PMID:19029245-6] 6.0 ^6.1 ^6.2 ^6.3 Van Kanegan, MJ & Strack, S (2009) The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Mol. Cell. Biol. 29 662-74 PubMed GONUTS page

[PMID:24613359-7] Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page

[PMID:27655914-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Zhang, D et al. (2016) The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A. J. Biol. Chem. 291 23895-23905 PubMed GONUTS page

[PMID:11731452-9] Middleton, G & Davies, AM (2001) Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo. Development 128 4715-28 PubMed GONUTS page

[PMID:23382219-10] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

[PMID:15376326-11] Sedý, J et al. (2004) Pacinian corpuscle development involves multiple Trk signaling pathways. Dev. Dyn. 231 551-63 PubMed GONUTS page

[PMID:24270184-12] 12.0 ^12.1 ^12.2 Suo, D et al. (2014) Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nat. Neurosci. 17 36-45 PubMed GONUTS page

[PMID:7854358-13] Chen, F et al. (1994) Cloning of a novel orphan receptor (GCNF) expressed during germ cell development. Mol. Endocrinol. 8 1434-44 PubMed GONUTS page

[PMID:15459109-14] Coppola, V et al. (2004) Ablation of TrkA function in the immune system causes B cell abnormalities. Development 131 5185-95 PubMed GONUTS page

[PMID:12810599-15] Ma, L et al. (2003) Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. Development 130 3525-34 PubMed GONUTS page

[PMID:11877420-16] Tarr, PE et al. (2002) Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. J. Biol. Chem. 277 16798-804 PubMed GONUTS page

[PMID:11551509-17] Dong, X et al. (2001) A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 106 619-32 PubMed GONUTS page

[PMID:10207144-18] Huang, EJ et al. (1999) Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC. Development 126 2191-203 PubMed GONUTS page

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