MOUSE:NLRC4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nlrc4 (synonyms: Card12, Ipaf)
Protein Name(s)	NLR family CARD domain-containing protein 4 Caspase recruitment domain-containing protein 12 Ice protease-activating factor Ipaf
External Links
UniProt	Q3UP24
EMBL	AK143864 AK171624 CT033749
CCDS	CCDS37692.1
RefSeq	NP_001028539.1 XP_006524408.1 XP_006524409.1
UniGene	Mm.311884
PDB	3JBL 4KXF 5AJ2
PDBsum	3JBL 4KXF 5AJ2
ProteinModelPortal	Q3UP24
SMR	Q3UP24
STRING	10090.ENSMUSP00000059637
iPTMnet	Q3UP24
MaxQB	Q3UP24
PaxDb	Q3UP24
Ensembl	ENSMUST00000052124
GeneID	268973
KEGG	mmu:268973
UCSC	uc008doc.1
CTD	58484
MGI	MGI:3036243
eggNOG	ENOG410IHIG ENOG410YI2E
GeneTree	ENSGT00500000044782
HOGENOM	HOG000059630
HOVERGEN	HBG050790
InParanoid	Q3UP24
KO	K12805
OMA	DLFVWNV
OrthoDB	EOG73BVBV
PhylomeDB	Q3UP24
TreeFam	TF336864
NextBio	392615
PRO	PR:Q3UP24
Proteomes	UP000000589
Bgee	Q3UP24
GO	GO:0005829 GO:0072557 GO:0005634 GO:0005876 GO:0005524 GO:0004869 GO:0042802 GO:0042803 GO:0004842 GO:0006919 GO:0002218 GO:0042742 GO:0016045 GO:0006954 GO:1990001 GO:0045087 GO:0050702 GO:0090307 GO:0043066 GO:0043065 GO:0051092 GO:0051260 GO:0016567 GO:0070269 GO:0042981 GO:0043281 GO:0043523 GO:0009966
Gene3D	1.10.533.10 3.80.10.10
InterPro	IPR001315 IPR011029 IPR032675 IPR007111 IPR027417
Pfam	PF00619
SUPFAM	SSF47986 SSF52540
PROSITE	PS50209 PS50837

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0050702	interleukin-1 beta secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPP4	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPP4	F	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPP4	P	Seeded From UniProt	complete
involved_in	GO:0016045	detection of bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPP4	P	Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPP4	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPP4	F	Seeded From UniProt	complete
part_of	GO:0072557	IPAF inflammasome complex	PMID:22885697^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0072557	IPAF inflammasome complex	PMID:21874021^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0070269	pyroptosis	PMID:16648852^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070269	pyroptosis	PMID:22484733^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070269	pyroptosis	PMID:16648853^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070269	pyroptosis	PMID:22885697^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070269	pyroptosis	PMID:21874021^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:21874021^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	PMID:16648852^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	PMID:22484733^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	PMID:16648853^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:22484733^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:16648852^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:16648853^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:22885697^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:21874021^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016045	detection of bacterium	PMID:22885697^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:22484733^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:16648852^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:16648853^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:22885697^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21874021^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22885697^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:16648852^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3036243 PANTHER:PTN000005175 UniProtKB:Q9NPP4	P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3036243 PANTHER:PTN000005175 UniProtKB:Q9NPP4	P	Seeded From UniProt	complete
involved_in	GO:0016045	detection of bacterium	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3036243 PANTHER:PTN000005175 UniProtKB:Q9NPP4	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPP4	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050702	interleukin-1 beta secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPP4	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:15190255^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3046934	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPP4	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:15190255^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3046934	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPP4	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPP4	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042742	defense response to bacterium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPP4	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016045	detection of bacterium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPP4	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006954	inflammatory response	PMID:15190255^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3046934	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPP4	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPP4	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26585513^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q3UP24	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26449475^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q3UP24	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26449474^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q3UP24	F	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPP4 ensembl:ENSP00000385428	P	Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPP4 ensembl:ENSP00000385428	P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPP4 ensembl:ENSP00000385428	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPP4 ensembl:ENSP00000385428	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPP4 ensembl:ENSP00000385428	F	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPP4 ensembl:ENSP00000385428	P	Seeded From UniProt	complete
involved_in	GO:0016045	detection of bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPP4 ensembl:ENSP00000385428	P	Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPP4 ensembl:ENSP00000385428	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPP4 ensembl:ENSP00000385428	F	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001315	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-844613	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Qu, Y et al. (2012) Phosphorylation of NLRC4 is critical for inflammasome activation. Nature 490 539-42 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kofoed, EM & Vance, RE (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477 592-5 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Franchi, L et al. (2006) Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat. Immunol. 7 576-82 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Franchi, L et al. (2012) NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat. Immunol. 13 449-56 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Miao, EA et al. (2006) Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat. Immunol. 7 569-75 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Mariathasan, S et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430 213-8 PubMed GONUTS page
↑ Diebolder, CA et al. (2015) Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation. Structure 23 2349-2357 PubMed GONUTS page
↑ Hu, Z et al. (2015) Structural and biochemical basis for induced self-propagation of NLRC4. Science 350 399-404 PubMed GONUTS page
↑ Zhang, L et al. (2015) Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Science 350 404-9 PubMed GONUTS page

[PMID:22885697-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Qu, Y et al. (2012) Phosphorylation of NLRC4 is critical for inflammasome activation. Nature 490 539-42 PubMed GONUTS page

[PMID:21874021-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kofoed, EM & Vance, RE (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477 592-5 PubMed GONUTS page

[PMID:16648852-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Franchi, L et al. (2006) Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat. Immunol. 7 576-82 PubMed GONUTS page

[PMID:22484733-4] 4.0 ^4.1 ^4.2 ^4.3 Franchi, L et al. (2012) NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat. Immunol. 13 449-56 PubMed GONUTS page

[PMID:16648853-5] 5.0 ^5.1 ^5.2 ^5.3 Miao, EA et al. (2006) Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat. Immunol. 7 569-75 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15190255-7] 7.0 ^7.1 ^7.2 Mariathasan, S et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430 213-8 PubMed GONUTS page

[PMID:26585513-8] Diebolder, CA et al. (2015) Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation. Structure 23 2349-2357 PubMed GONUTS page

[PMID:26449475-9] Hu, Z et al. (2015) Structural and biochemical basis for induced self-propagation of NLRC4. Science 350 399-404 PubMed GONUTS page

[PMID:26449474-10] Zhang, L et al. (2015) Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Science 350 404-9 PubMed GONUTS page

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MOUSE:NLRC4

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References

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