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MOUSE:MMP7
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Mmp7 | |
| Protein Name(s) | Matrilysin
Matrin Matrix metalloproteinase-7 MMP-7 Pump-1 protease Uterine metalloproteinase | |
| External Links | ||
| UniProt | Q10738 | |
| EMBL | L36238 L36243 L36242 L36241 L36240 L36239 L36244 | |
| UniGene | Mm.4825 | |
| ProteinModelPortal | Q10738 | |
| SMR | Q10738 | |
| STRING | 10090.ENSMUSP00000018767 | |
| MEROPS | M10.008 | |
| PhosphoSite | Q10738 | |
| PaxDb | Q10738 | |
| PRIDE | Q10738 | |
| MGI | MGI:103189 | |
| eggNOG | KOG1565 ENOG410XQ5D | |
| HOVERGEN | HBG052484 | |
| InParanoid | Q10738 | |
| BRENDA | 3.4.24.23 | |
| Reactome | [www.reactome.org/content/detail/R-MMU-1474228 R-MMU-1474228] | |
| PRO | PR:Q10738 | |
| Proteomes | UP000000589 | |
| Bgee | Q10738 | |
| CleanEx | MM_MMP7 | |
| GO | GO:0070062 GO:0005576 GO:0005578 GO:0004222 GO:0008233 GO:0004252 GO:0008270 GO:0002780 GO:0002779 GO:0030574 GO:0042742 GO:0050829 GO:0050830 GO:0022617 GO:0006508 GO:0042127 GO:0042493 | |
| Gene3D | 3.40.390.10 | |
| InterPro | IPR028707 IPR024079 IPR001818 IPR021190 IPR021158 IPR006026 IPR002477 | |
| PANTHER | PTHR10201:SF143 | |
| Pfam | PF00413 PF01471 | |
| PRINTS | PR00138 | |
| SMART | SM00235 | |
| SUPFAM | SSF47090 | |
| PROSITE | PS00546 PS00142 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004222 |
metalloendopeptidase activity |
ECO:0000314 |
F |
Figure 7. |
complete | |||||
|
involved_in |
GO:0030574 |
collagen catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101900 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030198 |
extracellular matrix organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0033438 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97005 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0033438 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050830 |
defense response to Gram-positive bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050829 |
defense response to Gram-negative bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042742 |
defense response to bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042493 |
response to drug |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88039 |
P |
occurs_in:(EMAPA:32874) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0009986 |
cell surface |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3100 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857932 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008201 |
heparin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3100 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006508 |
proteolysis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857932 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006508 |
proteolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006508 |
proteolysis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3100 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0002780 |
antibacterial peptide biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0002779 |
antibacterial peptide secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-MMU-2533958 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030574 |
collagen catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Guynn, RW & Pieklik, JR (1975) Dependence on dose of the acute effects of ethanol on liver metabolism in vivo. J. Clin. Invest. 56 1411-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Ayabe, T et al. (2000) Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat. Immunol. 1 113-8 PubMed GONUTS page
- ↑ Wilson, CL et al. (1997) Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc. Natl. Acad. Sci. U.S.A. 94 1402-7 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Shanahan, MT et al. (2010) Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action. J. Biol. Chem. 285 7493-504 PubMed GONUTS page
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