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PMID:11248802

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Citation

Ayabe, T, Satchell, DP, Wilson, CL, Parks, WC, Selsted, ME and Ouellette, AJ (2000) Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat. Immunol. 1:113-8

Abstract

Paneth cells in mouse small intestinal crypts secrete granules rich in microbicidal peptides when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs within minutes and alpha-defensins, or cryptdins, account for 70% of the released bactericidal peptide activity. Gram-negative bacteria, Gram-positive bacteria, lipopolysaccharide, lipoteichoic acid, lipid A and muramyl dipeptide elicit cryptdin secretion. Live fungi and protozoa, however, do not stimulate degranulation. Thus intestinal Paneth cells contribute to innate immunity by sensing bacteria and bacterial antigens, and discharge microbicidal peptides at effective concentrations accordingly.

Links

PubMed Online version:10.1038/77783

Keywords

Animals; Escherichia coli/immunology; Intestine, Small/immunology; Intestine, Small/metabolism; Lipid A/immunology; Lipopolysaccharides/immunology; Matrix Metalloproteinase 7/genetics; Matrix Metalloproteinase 7/physiology; Mice; Mice, Knockout; Paneth Cells/drug effects; Paneth Cells/immunology; Paneth Cells/metabolism; Paneth Cells/microbiology; Protein Precursors/immunology; Salmonella typhimurium/immunology; Staphylococcus aureus/immunology; Teichoic Acids/immunology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:DEFA1

located_in

GO:0005615: extracellular space

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:DEFA1

acts_upstream_of_or_within

GO:0009410: response to xenobiotic stimulus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:DEFA2

located_in

GO:0005615: extracellular space

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:DEFA2

acts_upstream_of_or_within

GO:0009410: response to xenobiotic stimulus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:DEFA2

acts_upstream_of_or_within

GO:0050830: defense response to Gram-positive bacterium

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94883
MGI:MGI:99582

P

Seeded From UniProt

complete

MOUSE:DEFA2

acts_upstream_of_or_within

GO:0050829: defense response to Gram-negative bacterium

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94883
MGI:MGI:99582

P

Seeded From UniProt

complete

MOUSE:DEFA2

acts_upstream_of_or_within

GO:0071222: cellular response to lipopolysaccharide

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94883
MGI:MGI:99582

P

Seeded From UniProt

complete

MOUSE:DEFA3

located_in

GO:0005615: extracellular space

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:DEFA3

acts_upstream_of_or_within

GO:0009410: response to xenobiotic stimulus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:DEFA3

acts_upstream_of_or_within

GO:0050830: defense response to Gram-positive bacterium

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:99582

P

Seeded From UniProt

complete

MOUSE:DEFA3

acts_upstream_of_or_within

GO:0050829: defense response to Gram-negative bacterium

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:99582

P

Seeded From UniProt

complete

MOUSE:DEFA3

acts_upstream_of_or_within

GO:0071222: cellular response to lipopolysaccharide

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:99582

P

Seeded From UniProt

complete

MOUSE:DEFA6

located_in

GO:0005615: extracellular space

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:DEFA6

acts_upstream_of_or_within

GO:0009410: response to xenobiotic stimulus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:DEFA6

acts_upstream_of_or_within

GO:0050830: defense response to Gram-positive bacterium

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883

P

Seeded From UniProt

complete

MOUSE:DEFA6

acts_upstream_of_or_within

GO:0050829: defense response to Gram-negative bacterium

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883

P

Seeded From UniProt

complete

MOUSE:DEFA6

acts_upstream_of_or_within

GO:0071222: cellular response to lipopolysaccharide

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883

P

Seeded From UniProt

complete

MOUSE:MMP7

acts_upstream_of_or_within

GO:0009410: response to xenobiotic stimulus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:DEFA1

acts_upstream_of_or_within

GO:0071222: cellular response to lipopolysaccharide

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94882
MGI:MGI:94883
MGI:MGI:99582

P

Seeded From UniProt

complete

MOUSE:DEFA1

acts_upstream_of_or_within

GO:0042493: response to drug

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:DEFA1

part_of

GO:0005615: extracellular space

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:DEFA1

acts_upstream_of_or_within

GO:0050830: defense response to Gram-positive bacterium

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94882
MGI:MGI:94883
MGI:MGI:99582

P

Seeded From UniProt

complete

MOUSE:MMP7

acts_upstream_of_or_within

GO:0002779: antibacterial peptide secretion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:MMP7

acts_upstream_of_or_within

GO:0042742: defense response to bacterium

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:MMP7

acts_upstream_of_or_within

GO:0042493: response to drug

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:MMP7

acts_upstream_of_or_within

GO:0050829: defense response to Gram-negative bacterium

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:MMP7

acts_upstream_of_or_within

GO:0050830: defense response to Gram-positive bacterium

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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