MOUSE:MD2L1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mad2l1 (synonyms: Mad2a)
Protein Name(s)	Mitotic spindle assembly checkpoint protein MAD2A Mitotic arrest deficient 2-like protein 1 MAD2-like protein 1
External Links
UniProt	Q9Z1B5
EMBL	U83902 AF261919 AK082934
CCDS	CCDS20210.1
RefSeq	NP_062372.2 XP_006506469.1
UniGene	Mm.489653
ProteinModelPortal	Q9Z1B5
SMR	Q9Z1B5
BioGrid	207818
IntAct	Q9Z1B5
MINT	MINT-123716
PhosphoSite	Q9Z1B5
MaxQB	Q9Z1B5
PaxDb	Q9Z1B5
PRIDE	Q9Z1B5
Ensembl	ENSMUST00000101343 ENSMUST00000116605
GeneID	56150
KEGG	mmu:56150
UCSC	uc009cen.1
CTD	4085
MGI	MGI:1860374
eggNOG	NOG263853
GeneTree	ENSGT00390000007908
HOGENOM	HOG000199586
HOVERGEN	HBG105691
InParanoid	Q9Z1B5
KO	K02537
OMA	SIHKVNS
OrthoDB	EOG7288SG
PhylomeDB	Q9Z1B5
TreeFam	TF101084
Reactome	REACT_198961 REACT_207679 REACT_222875 REACT_248037 REACT_256672 REACT_256756 REACT_263475
NextBio	311932
PRO	PR:Q9Z1B5
Proteomes	UP000000589
Bgee	Q9Z1B5
ExpressionAtlas	Q9Z1B5
Genevestigator	Q9Z1B5
GO	GO:0000775 GO:0000777 GO:0005829 GO:0000776 GO:0072686 GO:0005643 GO:0005634 GO:0048471 GO:0000922 GO:0000070 GO:0007094 GO:0043066 GO:0060564 GO:0045841 GO:0042177 GO:0090267
Gene3D	3.30.900.10
InterPro	IPR003511 IPR027097
PANTHER	PTHR11842:SF11
Pfam	PF02301
SUPFAM	SSF56019
PROSITE	PS50815

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0051301	cell division	PMID:20173739^[1]	ECO:0000314			P		Noted in Fig.1 B and C	complete
involved_in	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	PMID:20870947^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63167	C		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13257	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13257	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:20870947^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13257	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13257	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13257	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904667	negative regulation of ubiquitin protein ligase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	P		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	P		Seeded From UniProt	complete
part_of	GO:0044615	nuclear pore nuclear basket	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007094	mitotic spindle assembly checkpoint	PMID:11201745^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178781	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007094	mitotic spindle assembly checkpoint	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007094	mitotic spindle assembly checkpoint	PMID:10892650^[4]	ECO:0000247	sequence alignment evidence used in manual assertion	EMBL:U14132	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007093	mitotic cell cycle checkpoint	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17504913^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:17325031^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	C		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	PMID:17504913^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	PMID:10964468^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:19376971^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16036)	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:19075002^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:17504913^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:10964468^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	C		Seeded From UniProt	complete
colocalizes_with	GO:0000776	kinetochore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13257	C		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	PMID:12355205^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000070	mitotic sister chromatid segregation	PMID:10892650^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178781	P		Seeded From UniProt	complete
involved_in	GO:1904667	negative regulation of ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	P		Seeded From UniProt	complete
involved_in	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	P		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	C		Seeded From UniProt	complete
involved_in	GO:0051660	establishment of centrosome localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	C		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	P		Seeded From UniProt	complete
part_of	GO:0044615	nuclear pore nuclear basket	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	F		Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	F		Seeded From UniProt	complete
involved_in	GO:0007094	mitotic spindle assembly checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	P		Seeded From UniProt	complete
involved_in	GO:0007093	mitotic cell cycle checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	C		Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13257 ensembl:ENSP00000296509	P		Seeded From UniProt	complete
involved_in	GO:0007094	mitotic spindle assembly checkpoint	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027097	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	PMID:12147697^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137	C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0995	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0149	C		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0448	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sotillo, R et al. (2010) Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature 464 436-40 PubMed GONUTS page
↑ ^2.0 ^2.1 Nakaya, T et al. (2010) Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. J. Immunol. 185 5180-7 PubMed GONUTS page
↑ Michel, LS et al. (2001) MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409 355-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Dobles, M et al. (2000) Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 101 635-45 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Zhang, D et al. (2007) Cytoplasmic dynein participates in meiotic checkpoint inactivation in mouse oocytes by transporting cytoplasmic mitotic arrest-deficient (Mad) proteins from kinetochores to spindle poles. Reproduction 133 685-95 PubMed GONUTS page
↑ Li, M et al. (2007) Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos. Mol. Cell. Biol. 27 3481-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Kallio, M et al. (2000) Differences in spindle association of the mitotic checkpoint protein Mad2 in mammalian spermatogenesis and oogenesis. Dev. Biol. 225 112-23 PubMed GONUTS page
↑ Zheng, P & Dean, J (2009) Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Proc. Natl. Acad. Sci. U.S.A. 106 7473-8 PubMed GONUTS page
↑ Cowley, DO et al. (2009) Aurora-A kinase is essential for bipolar spindle formation and early development. Mol. Cell. Biol. 29 1059-71 PubMed GONUTS page
↑ Hodges, CA & Hunt, PA (2002) Simultaneous analysis of chromosomes and chromosome-associated proteins in mammalian oocytes and embryos. Chromosoma 111 165-9 PubMed GONUTS page
↑ Bahar, R et al. (2002) Growth retardation, polyploidy, and multinucleation induced by Clast3, a novel cell cycle-regulated protein. J. Biol. Chem. 277 40012-9 PubMed GONUTS page

[PMID:20173739-1] Sotillo, R et al. (2010) Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature 464 436-40 PubMed GONUTS page

[PMID:20870947-2] 2.0 ^2.1 Nakaya, T et al. (2010) Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. J. Immunol. 185 5180-7 PubMed GONUTS page

[PMID:11201745-3] Michel, LS et al. (2001) MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409 355-9 PubMed GONUTS page

[PMID:10892650-4] 4.0 ^4.1 Dobles, M et al. (2000) Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 101 635-45 PubMed GONUTS page

[PMID:17504913-5] 5.0 ^5.1 ^5.2 Zhang, D et al. (2007) Cytoplasmic dynein participates in meiotic checkpoint inactivation in mouse oocytes by transporting cytoplasmic mitotic arrest-deficient (Mad) proteins from kinetochores to spindle poles. Reproduction 133 685-95 PubMed GONUTS page

[PMID:17325031-6] Li, M et al. (2007) Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos. Mol. Cell. Biol. 27 3481-8 PubMed GONUTS page

[PMID:10964468-7] 7.0 ^7.1 Kallio, M et al. (2000) Differences in spindle association of the mitotic checkpoint protein Mad2 in mammalian spermatogenesis and oogenesis. Dev. Biol. 225 112-23 PubMed GONUTS page

[PMID:19376971-8] Zheng, P & Dean, J (2009) Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Proc. Natl. Acad. Sci. U.S.A. 106 7473-8 PubMed GONUTS page

[PMID:19075002-9] Cowley, DO et al. (2009) Aurora-A kinase is essential for bipolar spindle formation and early development. Mol. Cell. Biol. 29 1059-71 PubMed GONUTS page

[PMID:12355205-10] Hodges, CA & Hunt, PA (2002) Simultaneous analysis of chromosomes and chromosome-associated proteins in mammalian oocytes and embryos. Chromosoma 111 165-9 PubMed GONUTS page

[PMID:12147697-11] Bahar, R et al. (2002) Growth retardation, polyploidy, and multinucleation induced by Clast3, a novel cell cycle-regulated protein. J. Biol. Chem. 277 40012-9 PubMed GONUTS page

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MOUSE:MD2L1

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