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MOUSE:LTBP1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ltbp1
Protein Name(s) Latent-transforming growth factor beta-binding protein 1

LTBP-1 Transforming growth factor beta-1-binding protein 1 TGF-beta1-BP-1

External Links
UniProt Q8CG19
EMBL AF346465
AF346434
AF346435
AF346436
AF346437
AF346438
AF346439
AF346440
AF346441
AF346442
AF346443
AF346444
AF346445
AF346446
AF346447
AF346448
AF346449
AF346450
AF346451
AF346452
AF346453
AF346454
AF346455
AF346456
AF346457
AF346458
AF346459
AF346460
AF346461
AF346462
AF346463
AF346464
AF346465
AF346438
AF346439
AF346440
AF346441
AF346442
AF346443
AF346444
AF346445
AF346446
AF346447
AF346448
AF346449
AF346450
AF346451
AF346452
AF346453
AF346454
AF346455
AF346456
AF346457
AF346458
AF346459
AF346460
AF346461
AF346462
AF346463
AF346464
AY143161
AF022889
CT033758
AC118018
AC126550
AC154178
AC154491
CT033758
AC118018
AC154491
CT033758
AC118018
AC154491
BC094612
AK050380
AK080024
CCDS CCDS28973.1
CCDS37694.1
RefSeq NP_064303.2
NP_996841.1
XP_006524418.1
UniGene Mm.269747
ProteinModelPortal Q8CG19
SMR Q8CG19
BioGrid 234589
IntAct Q8CG19
MINT MINT-1751360
PhosphoSite Q8CG19
MaxQB Q8CG19
PaxDb Q8CG19
PRIDE Q8CG19
Ensembl ENSMUST00000001927
ENSMUST00000112514
ENSMUST00000112516
GeneID 268977
KEGG mmu:268977
UCSC uc008dom.2
uc008doo.2
CTD 4052
MGI MGI:109151
eggNOG NOG318792
GeneTree ENSGT00760000118806
InParanoid Q8CG19
KO K08023
OMA TQLGRCF
OrthoDB EOG7FR7FP
PhylomeDB Q8CG19
TreeFam TF317514
Reactome REACT_198998
ChiTaRS Ltbp1
NextBio 392619
PRO PR:Q8CG19
Proteomes UP000000589
Bgee Q8CG19
ExpressionAtlas Q8CG19
Genevestigator Q8CG19
GO GO:0005578
GO:0005509
GO:0007179
Gene3D 3.90.290.10
InterPro IPR000742
IPR001881
IPR013032
IPR000152
IPR018097
IPR009030
IPR017878
Pfam PF07645
PF00683
SMART SM00181
SM00179
SUPFAM SSF57184
SSF57581
PROSITE PS00010
PS00022
PS01186
PS50026
PS01187
PS51364

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28071719[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0000006)

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:28071719[1]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0000006)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:22159717[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0002048)|part_of:(UBERON:0001155)

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:22159717[2]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0002048)|occurs_in:(UBERON:0001155)

Seeded From UniProt

complete

involved_in

GO:1901388

regulation of transforming growth factor beta activation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q14766

P

Seeded From UniProt

complete

involved_in

GO:0035583

sequestering of TGFbeta in extracellular matrix

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q14766

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:24006456[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

produced_by:(CL:0002548)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901388

regulation of transforming growth factor beta activation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14766

P

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14766

C

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68379

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060976

coronary vasculature development

PMID:25807483[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050436

microfibril binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14766

F

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14766

F

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68379

C

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68379

C

Seeded From UniProt

complete

part_of

GO:0038045

large latent transforming growth factor-beta complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68379

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035904

aorta development

PMID:25807483[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035583

sequestering of TGFbeta in extracellular matrix

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14766

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14766

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032967

positive regulation of collagen biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68379

P

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:9008713[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14766

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68379

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68379

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68379

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003281

ventricular septum development

PMID:25807483[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0001527

microfibril

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14766

C

Seeded From UniProt

complete

involved_in

GO:1901388

regulation of transforming growth factor beta activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14766
ensembl:ENSP00000386043

P

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14766
ensembl:ENSP00000386043

C

Seeded From UniProt

complete

enables

GO:0050436

microfibril binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14766
ensembl:ENSP00000386043

F

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14766
ensembl:ENSP00000386043

F

Seeded From UniProt

complete

involved_in

GO:0035583

sequestering of TGFbeta in extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14766
ensembl:ENSP00000386043

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14766
ensembl:ENSP00000386043

C

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14766
ensembl:ENSP00000386043

C

Seeded From UniProt

complete

part_of

GO:0001527

microfibril

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14766
ensembl:ENSP00000386043

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001881
InterPro:IPR018097

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:7730318[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0019838

growth factor binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0340

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
  2. ↑ 2.0 2.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
  3. ↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Li, Y et al. (2015) Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature 521 520-4 PubMed GONUTS page
  5. ↑ Nakajima, Y et al. (1997) Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart. J. Cell Biol. 136 193-204 PubMed GONUTS page
  6. ↑ Yin, W et al. (1995) Isolation of a novel latent transforming growth factor-beta binding protein gene (LTBP-3). J. Biol. Chem. 270 10147-60 PubMed GONUTS page
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