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Category:GO:0035583 ! sequestering of TGFbeta in extracellular matrix
name: sequestering of TGFbeta in extracellular matrix
namespace: biological_process
def: "Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins." [GOC:bf, GOC:BHF, GOC:signaling, PMID:12482908, PMID:20855508]
synonym: "negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta" EXACT [GOC:bf]
synonym: "negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta" EXACT [GOC:mah]
synonym: "sequestering of TGFbeta large latency complex in extracellular matrix" EXACT [PMID:12482908]
synonym: "sequestering of TGFbeta LLC in extracellular matrix" EXACT [PMID:12482908]
is_a: GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway
is_a: GO:0035581 ! sequestering of extracellular ligand from receptor
is_a: GO:0071694 ! maintenance of protein location in extracellular region
AmiGO
<GOterm>GO:0035583</GOterm>
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