MOUSE:LRP8

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Lrp8 (synonyms: Apoer2)
Protein Name(s)	Low-density lipoprotein receptor-related protein 8 LRP-8 Apolipoprotein E receptor 2
External Links
UniProt	Q924X6
EMBL	D85463 AJ312058
CCDS	CCDS51255.1
PIR	JE0237
UniGene	Mm.442134
ProteinModelPortal	Q924X6
SMR	Q924X6
DIP	DIP-33284N
IntAct	Q924X6
MINT	MINT-111626
TCDB	9.B.87.2.1
PhosphoSite	Q924X6
MaxQB	Q924X6
PaxDb	Q924X6
PRIDE	Q924X6
Ensembl	ENSMUST00000143601
MGI	MGI:1340044
eggNOG	NOG255913
GeneTree	ENSGT00760000118968
HOGENOM	HOG000115656
HOVERGEN	HBG006250
InParanoid	Q924X6
OMA	YWCDLFY
OrthoDB	EOG7NGQ9P
PhylomeDB	Q924X6
Reactome	REACT_198569 REACT_250548
NextBio	13887235
PRO	PR:Q924X6
Proteomes	UP000000589
Bgee	Q924X6
ExpressionAtlas	Q924X6
Genevestigator	Q924X6
GO	GO:0005615 GO:0016021 GO:0005886 GO:0043235 GO:0034185 GO:0005509 GO:0048306 GO:0001948 GO:0005041 GO:0038025 GO:0021541 GO:0006897 GO:0021766 GO:0021819 GO:0000122 GO:0032793 GO:1900006 GO:0061003 GO:0050731 GO:0045860 GO:0061098 GO:0006898 GO:0038026 GO:0050804 GO:0021517
Gene3D	2.120.10.30 4.10.400.10
InterPro	IPR011042 IPR000742 IPR001881 IPR013032 IPR000152 IPR018097 IPR023415 IPR000033 IPR002172
Pfam	PF07645 PF00057 PF00058
PRINTS	PR00261
SMART	SM00181 SM00179 SM00192 SM00135
SUPFAM	SSF57424
PROSITE	PS00010 PS01186 PS50026 PS01187 PS01209 PS50068 PS51120

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0021541	ammon gyrus development	PMID:18778775^[1]	ECO:0000315			P		Figure 1 shows abnormal hippocampal cytoarchitecture of stratum pyramidale of CA1 region. Ammon gyrus definition includes the the CA1 and CA3 regions. There was abnormal structure in the caudal coronal (figure 1B) and sagittal section (figure 1D). The infra stratum pyramidale of knockout Lrp8 is closer to the fissure compared to wild type mice.	complete CACAO 2136
	GO:0038025	reelin receptor activity	PMID:18778775^[1]	ECO:0000315			F		Reelin signal was measured in Lrp8 knockout mice by measuring Dab1 expression to examine neuron’s ability to transmit Reelin signal across plasma membrane. Quantitative immunofluorescence microscopy was used to determine levels of Dab1 expression. If neurons respond to Reelin, Dab1 expression is decreased whereas neurons that do not respond to Reelin, Dab1 expression is increased. Therefore knockout mice showed higher expression of Dab1 than wild type (five times)when mice reached maturity, meaning knockout mice did not respond to Reelin signaling. (supplemental figure 2)	complete CACAO 2137
	GO:0048813	dendrite morphogenesis	PMID:18778775^[1]	ECO:0000315			P		Supplemental figure 3B: significant difference in primary and secondary dendritic branch length at early development of 4 DIV knockout Lrp8 mice. Also figure 2C shows shorter dendrites in knockout than wild type.	complete CACAO 2138
	GO:0007268	synaptic transmission	PMID:18778775^[1]	ECO:0000315			P		population excitatory postsynaptic potential (pEPSP) was measured in Lrp8 knockout mice, one amplitude peak was seen in mid distal apical dendrite region of pyramidal cells in stratum pyramidale of wild type mice (figure 3A)whereas figure 3B traces 2-4 shows Lrp8 knockout mice showed two distinct peaks.	complete CACAO 2139
	GO:0061003	positive regulation of dendritic spine morphogenesis	PMID:21852430^[2]	ECO:0000315			P		Figure 5: Knock out ApoER2 showed decrease in dendrite spine density compared to wild type injected with reelin, therefore ApoER2 as a receptor for reelin is also needed for dendrite spine formation.	complete CACAO 2376
involved_in	GO:0042981	regulation of apoptotic process	PMID:29336888^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045088	regulation of innate immune response	PMID:29336888^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061003	positive regulation of dendritic spine morphogenesis	PMID:21852430^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:18778775^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	PMID:18778775^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0038025	reelin receptor activity	PMID:18778775^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0021541	ammon gyrus development	PMID:18778775^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900006	positive regulation of dendrite development	PMID:18778775^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P98156	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:21852430^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061003	positive regulation of dendritic spine morphogenesis	PMID:21852430^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:18778775^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:21852430^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:10571240^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q60841	F		Seeded From UniProt	complete
involved_in	GO:0038026	reelin-mediated signaling pathway	PMID:18778775^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038026	reelin-mediated signaling pathway	PMID:21852430^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0038025	reelin receptor activity	PMID:18778775^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	PMID:10571240^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032793	positive regulation of CREB transcription factor activity	PMID:21852430^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021541	ammon gyrus development	PMID:18778775^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15950758^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18778775^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021517	ventral spinal cord development	PMID:20711475^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14114	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:16227578^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8VCC9	F	occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045860	positive regulation of protein kinase activity	PMID:12526740^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103022 MGI:MGI:98935	P	regulates_o_occurs_in:(EMAPA:17544) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14114	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305729	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305729	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305729	C		Seeded From UniProt	complete
enables	GO:0030229	very-low-density lipoprotein particle receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14114	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021819	layer formation in cerebral cortex	PMID:17330141^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109520	P	has_participant:(EMAPA:35588)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021766	hippocampus development	PMID:17330141^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109520	P	results_in_development_of:(EMAPA:32845)	Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305729	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305729	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305729	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:16227578^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008035	high-density lipoprotein particle binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305729	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006897	endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14114	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14114	C		Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305729	C		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:16227578^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12023	F	occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001881 InterPro:IPR018097	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11294845^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005041	low-density lipoprotein particle receptor activity	PMID:9685741^[12] PMID:11294845^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Fish, KN & Krucker, T (2008) Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse. Neurobiol. Dis. 32 391-401 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Rogers, JT et al. (2011) Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density. Learn. Mem. 18 558-64 PubMed GONUTS page
↑ ^3.0 ^3.1 Tavazoie, MF et al. (2018) LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Cell 172 825-840.e18 PubMed GONUTS page
↑ ^4.0 ^4.1 D'Arcangelo, G et al. (1999) Reelin is a ligand for lipoprotein receptors. Neuron 24 471-9 PubMed GONUTS page
↑ Hoe, HS & Rebeck, GW (2005) Regulation of ApoE receptor proteolysis by ligand binding. Brain Res. Mol. Brain Res. 137 31-9 PubMed GONUTS page
↑ Palmesino, E et al. (2010) Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 8 e1000446 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Hoe, HS et al. (2005) F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein. Mol. Cell. Biol. 25 9259-68 PubMed GONUTS page
↑ Bock, HH & Herz, J (2003) Reelin activates SRC family tyrosine kinases in neurons. Curr. Biol. 13 18-26 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ ^10.0 ^10.1 Zhang, G et al. (2007) The Pafah1b complex interacts with the reelin receptor VLDLR. PLoS ONE 2 e252 PubMed GONUTS page
↑ ^11.0 ^11.1 Brandes, C et al. (2001) Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha 2-macroglobulin. J. Biol. Chem. 276 22160-9 PubMed GONUTS page
↑ Kim, HJ et al. (1998) Evolution of the apolipoprotein E receptor 2 gene by exon loss. J. Biochem. 124 451-6 PubMed GONUTS page

[PMID:18778775-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Fish, KN & Krucker, T (2008) Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse. Neurobiol. Dis. 32 391-401 PubMed GONUTS page

[PMID:21852430-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Rogers, JT et al. (2011) Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density. Learn. Mem. 18 558-64 PubMed GONUTS page

[PMID:29336888-3] 3.0 ^3.1 Tavazoie, MF et al. (2018) LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Cell 172 825-840.e18 PubMed GONUTS page

[PMID:10571240-4] 4.0 ^4.1 D'Arcangelo, G et al. (1999) Reelin is a ligand for lipoprotein receptors. Neuron 24 471-9 PubMed GONUTS page

[PMID:15950758-5] Hoe, HS & Rebeck, GW (2005) Regulation of ApoE receptor proteolysis by ligand binding. Brain Res. Mol. Brain Res. 137 31-9 PubMed GONUTS page

[PMID:20711475-6] Palmesino, E et al. (2010) Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 8 e1000446 PubMed GONUTS page

[PMID:16227578-7] 7.0 ^7.1 ^7.2 Hoe, HS et al. (2005) F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein. Mol. Cell. Biol. 25 9259-68 PubMed GONUTS page

[PMID:12526740-8] Bock, HH & Herz, J (2003) Reelin activates SRC family tyrosine kinases in neurons. Curr. Biol. 13 18-26 PubMed GONUTS page

[PMID:23382219-9] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

[PMID:17330141-10] 10.0 ^10.1 Zhang, G et al. (2007) The Pafah1b complex interacts with the reelin receptor VLDLR. PLoS ONE 2 e252 PubMed GONUTS page

[PMID:11294845-11] 11.0 ^11.1 Brandes, C et al. (2001) Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha 2-macroglobulin. J. Biol. Chem. 276 22160-9 PubMed GONUTS page

[PMID:9685741-12] Kim, HJ et al. (1998) Evolution of the apolipoprotein E receptor 2 gene by exon loss. J. Biochem. 124 451-6 PubMed GONUTS page

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MOUSE:LRP8

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