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PMID:9685741
| Citation |
Kim, HJ, Kim, DH, Magoori, K, Saeki, S and Yamamoto, TT (1998) Evolution of the apolipoprotein E receptor 2 gene by exon loss. J. Biochem. 124:451-6 |
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| Abstract |
The apolipoprotein E receptor 2 (apoER2) gene consists of a mosaic of exons, which may have been assembled by "exon shuffling." Analysis of apoER2 transcripts in several species reveals a lost repeat in the ligand-binding domain of primate apoER2. A pseudo-exon found in the primate apoER2 genes corresponds to the lost repeat but contains a crucial deletion that leads to a translational frameshift. The pseudo-exon sequence in primary transcripts of the human apoER2 gene is shown to be abolished by exon skipping due to two nucleotide substitutions at the 5'-splice donor adjacent to the pseudo-exon. These data suggest the occurrence of exon loss in the evolution of the primate apoER2 gene. |
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| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Callithrix; DNA; Evolution, Molecular; Exons/genetics; Gene Deletion; Genetic Variation; Humans; LDL-Receptor Related Proteins; Ligands; Mice; Molecular Sequence Data; Receptors, Lipoprotein/genetics; Repetitive Sequences, Nucleic Acid; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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