MOUSE:LMNA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Lmna (synonyms: Lmn1)
Protein Name(s)	Prelamin-A/C Lamin-A/C
External Links
UniProt	P48678
EMBL	D49733 D49733 D49733 X14170 D14850 DQ832702 DQ832703 AK004619 AK147150 AK149998 AK150391 AK150501 AK150624 AK152539 AK152646 AK152846 AK161221 AK167858 CH466547 BC015302 BC094020 D13181
CCDS	CCDS38482.1 CCDS38483.1 CCDS50951.1
PIR	I53414 S04333 S18324 S28182
RefSeq	NP_001002011.2 NP_001104572.1 NP_062263.1 XP_006501136.1
UniGene	Mm.243014 Mm.471227
PDB	1UFG
PDBsum	1UFG
ProteinModelPortal	P48678
SMR	P48678
BioGrid	201176
IntAct	P48678
MINT	MINT-1868521
STRING	10090.ENSMUSP00000029699
PhosphoSite	P48678
REPRODUCTION-2DPAGE	IPI00400300 IPI00620256
MaxQB	P48678
PaxDb	P48678
PRIDE	P48678
Ensembl	ENSMUST00000029699 ENSMUST00000036252 ENSMUST00000120377
GeneID	16905
KEGG	mmu:16905
UCSC	uc008pvj.2 uc008pvk.2
CTD	4000
MGI	MGI:96794
eggNOG	NOG325506
GeneTree	ENSGT00760000118905
HOVERGEN	HBG013015
InParanoid	P48678
KO	K12641
OMA	HCSGSGD
OrthoDB	EOG7MD4PW
PhylomeDB	P48678
TreeFam	TF101181
Reactome	REACT_106572 REACT_198626 REACT_208718 REACT_209025 REACT_210180 REACT_221677 REACT_75800
ChiTaRS	Lmna
EvolutionaryTrace	P48678
NextBio	290934
PRO	PR:P48678
Proteomes	UP000000589
Bgee	P48678
CleanEx	MM_LMNA
ExpressionAtlas	P48678
Genevestigator	P48678
GO	GO:0005638 GO:0005635 GO:0005654 GO:0005634 GO:0048471 GO:0005198 GO:0071456 GO:0030010 GO:0030951 GO:0007517 GO:2001237 GO:0090201 GO:0006998 GO:0006997 GO:0090343 GO:0034504 GO:0030334 GO:1900180 GO:0035105 GO:0055015
Gene3D	2.60.40.1260
InterPro	IPR001664 IPR018039 IPR001322
PANTHER	PTHR23239
Pfam	PF00038 PF00932
SUPFAM	SSF74853
PROSITE	PS00226

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005783	endoplasmic reticulum	PMID 10021336	ECO:0000314			C		Immunohistochemical staining shows location of lamin alpha to follow distribution of ER - figure 6c	Missing: reference
part_of	GO:0005634	nucleus	PMID:26436652^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	PMID:26436652^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090343	positive regulation of cell aging	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02545	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02545	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02545-1	C		Seeded From UniProt	complete
involved_in	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	PMID:17631533^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	PMID:17631533^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	PMID:17631533^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007517	muscle organ development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02545-2	P		Seeded From UniProt	complete
involved_in	GO:0007517	muscle organ development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02545-1	P		Seeded From UniProt	complete
involved_in	GO:0090343	positive regulation of cell aging	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02545	P		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	PMID:21498514^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:18606848^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:21151901^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904178	negative regulation of adipose tissue development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620456	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900180	regulation of protein localization to nucleus	PMID:22349700^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900114	positive regulation of histone H3-K9 trimethylation	PMID:23695662^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090343	positive regulation of cell aging	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02545	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090201	negative regulation of release of cytochrome c from mitochondria	PMID:21151901^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072201	negative regulation of mesenchymal cell proliferation	PMID:22886301^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055015	ventricular cardiac muscle cell development	PMID:14755333^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177930	P	occurs_in:(EMAPA:17339) results_in_development_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02545	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620456	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02545	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034613	cellular protein localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02545	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034504	protein localization to nucleus	PMID:16339967^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177930	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032204	regulation of telomere maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02545	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:17164264^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:11092755^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031647	regulation of protein stability	PMID:23695662^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620456	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:22886301^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02545	P		Seeded From UniProt	complete
enables	GO:0008157	protein phosphatase 1 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620456	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007517	muscle organ development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02545	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006998	nuclear envelope organization	PMID:15608054^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890508	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006998	nuclear envelope organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02545	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006997	nucleus organization	PMID:16511604^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890508	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006997	nucleus organization	PMID:14755333^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177930	P	occurs_in:(EMAPA:17339) occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006606	protein import into nucleus	PMID:14755333^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177930	P	occurs_in:(EMAPA:17339) occurs_in:(CL:0000746) has_participant:(MGI:MGI:107606)	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02545	C		Seeded From UniProt	complete
part_of	GO:0005638	lamin filament	PMID:8032679^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:23686339^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:20457914^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02545	C		Seeded From UniProt	complete
colocalizes_with	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02545	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26657864^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22886301^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19915186^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16731532^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11739632^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18809582^[22]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02545	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02545	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620456	C		Seeded From UniProt	complete
involved_in	GO:0090343	positive regulation of cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02545 ensembl:ENSP00000357283	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02545 ensembl:ENSP00000357283	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02545 ensembl:ENSP00000357283	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02545 ensembl:ENSP00000357283	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02545 ensembl:ENSP00000357283	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02545 ensembl:ENSP00000357283	C		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001664	F		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001664	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18664494^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-8868356	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	Reactome:R-MMU-912355	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0403	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
part_of	GO:0005652	nuclear lamina	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0180	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0178	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Huang, ZP et al. (2015) Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J. Clin. Invest. 125 4122-34 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Lee, JS et al. (2007) Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys. J. 93 2542-52 PubMed GONUTS page
↑ Ahmady, E et al. (2011) Identification of a novel muscle A-type lamin-interacting protein (MLIP). J. Biol. Chem. 286 19702-13 PubMed GONUTS page
↑ Zhang, YQ & Sarge, KD (2008) Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies. J. Cell Biol. 182 35-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Lu, D et al. (2010) LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice. PLoS ONE 5 e15167 PubMed GONUTS page
↑ Borrego-Pinto, J et al. (2012) Samp1 is a component of TAN lines and is required for nuclear movement. J. Cell. Sci. 125 1099-105 PubMed GONUTS page
↑ ^7.0 ^7.1 Liu, B et al. (2013) Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. Nat Commun 4 1868 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Liu, Y et al. (2012) Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J. Clin. Invest. 122 3101-13 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Nikolova, V et al. (2004) Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice. J. Clin. Invest. 113 357-69 PubMed GONUTS page
↑ Brachner, A et al. (2005) LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins. J. Cell. Sci. 118 5797-810 PubMed GONUTS page
↑ Heydemann, A et al. (2007) Nuclear sequestration of delta-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes. Hum. Mol. Genet. 16 355-63 PubMed GONUTS page
↑ Hilditch-Maguire, P et al. (2000) Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles. Hum. Mol. Genet. 9 2789-97 PubMed GONUTS page
↑ Fong, LG et al. (2004) Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 101 18111-6 PubMed GONUTS page
↑ Fong, LG et al. (2006) Prelamin A and lamin A appear to be dispensable in the nuclear lamina. J. Clin. Invest. 116 743-52 PubMed GONUTS page
↑ Furukawa, K et al. (1994) cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association. Chromosome Res. 2 99-113 PubMed GONUTS page
↑ Ibrahim, MX et al. (2013) Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria. Science 340 1330-3 PubMed GONUTS page
↑ Kim, CE et al. (2010) A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proc. Natl. Acad. Sci. U.S.A. 107 9861-6 PubMed GONUTS page
↑ Lagarrigue, S et al. (2016) CDK4 is an essential insulin effector in adipocytes. J. Clin. Invest. 126 335-48 PubMed GONUTS page
↑ Yamada, M et al. (2010) Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development. Hum. Mol. Genet. 19 480-93 PubMed GONUTS page
↑ Dai, FF et al. (2006) The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion. J. Biol. Chem. 281 21942-53 PubMed GONUTS page
↑ Muralikrishna, B et al. (2001) Distinct changes in intranuclear lamin A/C organization during myoblast differentiation. J. Cell. Sci. 114 4001-11 PubMed GONUTS page
↑ Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page
↑ Ojeh, N et al. (2008) The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. J. Cell. Sci. 121 2705-17 PubMed GONUTS page

[PMID:26436652-1] 1.0 ^1.1 Huang, ZP et al. (2015) Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J. Clin. Invest. 125 4122-34 PubMed GONUTS page

[PMID:17631533-2] 2.0 ^2.1 ^2.2 Lee, JS et al. (2007) Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys. J. 93 2542-52 PubMed GONUTS page

[PMID:21498514-3] Ahmady, E et al. (2011) Identification of a novel muscle A-type lamin-interacting protein (MLIP). J. Biol. Chem. 286 19702-13 PubMed GONUTS page

[PMID:18606848-4] Zhang, YQ & Sarge, KD (2008) Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies. J. Cell Biol. 182 35-9 PubMed GONUTS page

[PMID:21151901-5] 5.0 ^5.1 Lu, D et al. (2010) LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice. PLoS ONE 5 e15167 PubMed GONUTS page

[PMID:22349700-6] Borrego-Pinto, J et al. (2012) Samp1 is a component of TAN lines and is required for nuclear movement. J. Cell. Sci. 125 1099-105 PubMed GONUTS page

[PMID:23695662-7] 7.0 ^7.1 Liu, B et al. (2013) Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. Nat Commun 4 1868 PubMed GONUTS page

[PMID:22886301-8] 8.0 ^8.1 ^8.2 Liu, Y et al. (2012) Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J. Clin. Invest. 122 3101-13 PubMed GONUTS page

[PMID:14755333-9] 9.0 ^9.1 ^9.2 Nikolova, V et al. (2004) Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice. J. Clin. Invest. 113 357-69 PubMed GONUTS page

[PMID:16339967-10] Brachner, A et al. (2005) LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins. J. Cell. Sci. 118 5797-810 PubMed GONUTS page

[PMID:17164264-11] Heydemann, A et al. (2007) Nuclear sequestration of delta-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes. Hum. Mol. Genet. 16 355-63 PubMed GONUTS page

[PMID:11092755-12] Hilditch-Maguire, P et al. (2000) Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles. Hum. Mol. Genet. 9 2789-97 PubMed GONUTS page

[PMID:15608054-13] Fong, LG et al. (2004) Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 101 18111-6 PubMed GONUTS page

[PMID:16511604-14] Fong, LG et al. (2006) Prelamin A and lamin A appear to be dispensable in the nuclear lamina. J. Clin. Invest. 116 743-52 PubMed GONUTS page

[PMID:8032679-15] Furukawa, K et al. (1994) cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association. Chromosome Res. 2 99-113 PubMed GONUTS page

[PMID:23686339-16] Ibrahim, MX et al. (2013) Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria. Science 340 1330-3 PubMed GONUTS page

[PMID:20457914-17] Kim, CE et al. (2010) A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proc. Natl. Acad. Sci. U.S.A. 107 9861-6 PubMed GONUTS page

[PMID:26657864-18] Lagarrigue, S et al. (2016) CDK4 is an essential insulin effector in adipocytes. J. Clin. Invest. 126 335-48 PubMed GONUTS page

[PMID:19915186-19] Yamada, M et al. (2010) Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development. Hum. Mol. Genet. 19 480-93 PubMed GONUTS page

[PMID:16731532-20] Dai, FF et al. (2006) The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion. J. Biol. Chem. 281 21942-53 PubMed GONUTS page

[PMID:11739632-21] Muralikrishna, B et al. (2001) Distinct changes in intranuclear lamin A/C organization during myoblast differentiation. J. Cell. Sci. 114 4001-11 PubMed GONUTS page

[PMID:18809582-22] Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page

[PMID:18664494-23] Ojeh, N et al. (2008) The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. J. Cell. Sci. 121 2705-17 PubMed GONUTS page

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MOUSE:LMNA

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