MOUSE:LHX6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Lhx6 (synonyms: Lhx6.1)
Protein Name(s)	LIM/homeobox protein Lhx6 LIM homeobox protein 6 LIM/homeobox protein Lhx6.1
External Links
UniProt	Q9R1R0
EMBL	AJ000337 AB031040 AB031039 AL773525 BC065077
CCDS	CCDS38111.1 CCDS38113.1
RefSeq	NP_001076595.1 NP_001076596.1 NP_032526.2 XP_006497807.1
UniGene	Mm.12881
ProteinModelPortal	Q9R1R0
SMR	Q9R1R0
PRIDE	Q9R1R0
Ensembl	ENSMUST00000112961 ENSMUST00000112963 ENSMUST00000112966 ENSMUST00000148852
GeneID	16874
KEGG	mmu:16874
UCSC	uc008jld.1
CTD	26468
MGI	MGI:1306803
eggNOG	NOG264882
GeneTree	ENSGT00760000118921
HOGENOM	HOG000038965
HOVERGEN	HBG006261
InParanoid	Q9R1R0
KO	K09375
OrthoDB	EOG744T9J
ChiTaRS	Lhx6
NextBio	290850
PRO	PR:Q9R1R0
Proteomes	UP000000589
Bgee	Q9R1R0
ExpressionAtlas	Q9R1R0
Genevestigator	Q9R1R0
GO	GO:0005634 GO:0043565 GO:0003700 GO:0008270 GO:0048469 GO:0021853 GO:0021895 GO:0021799 GO:0021800 GO:0021884 GO:0021877 GO:0006351
Gene3D	1.10.10.60 2.10.110.10
InterPro	IPR017970 IPR001356 IPR009057 IPR001781
Pfam	PF00046 PF00412
SMART	SM00389 SM00132
SUPFAM	SSF46689
PROSITE	PS00027 PS50071 PS00478 PS50023

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0003700	DNA-binding transcription factor activity	PMID:10393337^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267978 MGI:MGI:102673 MGI:MGI:1100513 MGI:MGI:1888519 MGI:MGI:96785 PANTHER:PTN000654232 UniProtKB:Q969G2 UniProtKB:Q9UBR4 WB:WBGene00000438 WB:WBGene00002988 WB:WBGene00003167 WB:WBGene00006654	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002023 FB:FBgn0267978 MGI:MGI:101776 MGI:MGI:102673 MGI:MGI:107792 MGI:MGI:1096343 MGI:MGI:1100513 MGI:MGI:1306803 MGI:MGI:1888519 MGI:MGI:96785 MGI:MGI:99783 PANTHER:PTN000654232 RGD:71076 UniProtKB:P53411 UniProtKB:Q90881 WB:WBGene00000438 WB:WBGene00002988 WB:WBGene00003000 WB:WBGene00003167 WB:WBGene00006654 ZFIN:ZDB-GENE-050114-2 ZFIN:ZDB-GENE-050114-3 ZFIN:ZDB-GENE-050417-210 ZFIN:ZDB-GENE-051220-1 ZFIN:ZDB-GENE-060728-1 ZFIN:ZDB-GENE-980526-131	P		Seeded From UniProt	complete
involved_in	GO:0021884	forebrain neuron development	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096343 MGI:MGI:1306803 PANTHER:PTN000654603	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267978 MGI:MGI:1096343 MGI:MGI:1100513 MGI:MGI:1306803 MGI:MGI:96785 MGI:MGI:99783 PANTHER:PTN000654232 RGD:71074 UniProtKB:O60663 UniProtKB:O97581 UniProtKB:P53411 UniProtKB:Q9UPM6 WB:WBGene00000438 WB:WBGene00002987 WB:WBGene00002988 WB:WBGene00003167	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1100513 MGI:MGI:1888519 MGI:MGI:96785 PANTHER:PTN000654232 UniProtKB:Q9UBR4	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267978 MGI:MGI:1100513 MGI:MGI:1888519 MGI:MGI:96785 PANTHER:PTN000654232 WB:WBGene00000438 WB:WBGene00002987 WB:WBGene00006654	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048469	cell maturation	PMID:17376969^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3702518	P	occurs_in:(EMAPA:17544) results_in_maturation_of:(CL:0000617)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021895	cerebral cortex neuron differentiation	PMID:18339674^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108067	P	occurs_in:(EMAPA:17544) results_in_acquisition_of_features_of:(CL:0000498)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021884	forebrain neuron development	PMID:15217369^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096343	P	occurs_in:(EMAPA:16895) results_in_development_of:(CL:0000108)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021877	forebrain neuron fate commitment	PMID:18339674^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108067	P	occurs_in:(EMAPA:17544) results_in_commitment_to:(CL:0000498)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021853	cerebral cortex GABAergic interneuron migration	PMID:17376969^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3702518	P	occurs_in:(EMAPA:17544) results_in_movement_of:(CL:0000617)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021800	cerebral cortex tangential migration	PMID:17376969^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3702518	P	occurs_in:(EMAPA:17544) results_in_movement_of:(CL:0000617)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021799	cerebral cortex radially oriented cell migration	PMID:17376969^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3702518	P	occurs_in:(EMAPA:17544) results_in_movement_of:(CL:0000617)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17376969^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544)\|part_of:(EMAPA:17544)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UPM6	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kimura, N et al. (1999) A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. J. Biochem. 126 180-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Liodis, P et al. (2007) Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J. Neurosci. 27 3078-89 PubMed GONUTS page
↑ ^4.0 ^4.1 Du, T et al. (2008) NKX2.1 specifies cortical interneuron fate by activating Lhx6. Development 135 1559-67 PubMed GONUTS page
↑ Mori, T et al. (2004) The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons. Eur. J. Neurosci. 19 3129-41 PubMed GONUTS page

[PMID:10393337-1] Kimura, N et al. (1999) A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. J. Biochem. 126 180-7 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17376969-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Liodis, P et al. (2007) Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J. Neurosci. 27 3078-89 PubMed GONUTS page

[PMID:18339674-4] 4.0 ^4.1 Du, T et al. (2008) NKX2.1 specifies cortical interneuron fate by activating Lhx6. Development 135 1559-67 PubMed GONUTS page

[PMID:15217369-5] Mori, T et al. (2004) The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons. Eur. J. Neurosci. 19 3129-41 PubMed GONUTS page

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MOUSE:LHX6

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