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PMID:10393337

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Citation

Kimura, N, Ueno, M, Nakashima, K and Taga, T (1999) A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. J. Biochem. 126:180-7

Abstract

LIM-homeodomain (LHX) transcription factors play critical roles in cell fate determination during development, in particular, in CNS. The transcriptional activity of several LHX proteins is postulated to be regulated by interaction with an LIM-domain binding protein, Ldb1. We have now identified a novel LHX molecule, termed Lhx6.1, that is closely related to a recently reported Lhx6 molecule. The Lhx6.1 transcript is found in several restricted regions in the developing CNS, mostly within the embryonic forebrain. We further show that Lhx6.1 interacts with Ldb1 through tandem LIM-domains, implying transcriptional regulation of Lhx6.1 by Ldb1.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Brain/embryology; Brain/growth & development; Brain/metabolism; COS Cells/metabolism; Cloning, Molecular; DNA-Binding Proteins/metabolism; Gene Expression Regulation, Developmental; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Humans; LIM Domain Proteins; LIM-Homeodomain Proteins; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Organ Specificity; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Sequence Homology, Amino Acid; Transcription Factors; Transcription, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:LDB1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9R1R0

F

Seeded From UniProt

complete

MOUSE:LHX6

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P70662

F

Seeded From UniProt

complete

MOUSE:LHX6

enables

GO:0003700: DNA-binding transcription factor activity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

HUMAN:LHX6

enables

GO:0003700: DNA-binding transcription factor activity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete


See also

References

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