MOUSE:LDB1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ldb1 (synonyms: Nli)
Protein Name(s)	LIM domain-binding protein 1 LDB-1 Carboxyl-terminal LIM domain-binding protein 2 CLIM-2 LIM domain-binding factor CLIM2 mLdb1 Nuclear LIM interactor
External Links
UniProt	P70662
EMBL	U70375 U69270 U89488 AF030333 AF024524 AB250383 BC013624
CCDS	CCDS50455.1
RefSeq	NP_001106879.1 NP_034827.1
UniGene	Mm.327442
PDB	1J2O 1M3V 1RUT 2JTN 2L6Y 2L6Z 2LXD 4JCJ
PDBsum	1J2O 1M3V 1RUT 2JTN 2L6Y 2L6Z 2LXD 4JCJ
ProteinModelPortal	P70662
SMR	P70662
BioGrid	201125
IntAct	P70662
MINT	MINT-2779250
PhosphoSite	P70662
MaxQB	P70662
PaxDb	P70662
PRIDE	P70662
DNASU	16825
Ensembl	ENSMUST00000026252 ENSMUST00000056931 ENSMUST00000137771 ENSMUST00000156585 ENSMUST00000185355
GeneID	16825
KEGG	mmu:16825
UCSC	uc008hrz.1 uc008hsa.1
CTD	8861
MGI	MGI:894762
eggNOG	NOG282114
GeneTree	ENSGT00390000005639
HOGENOM	HOG000030908
HOVERGEN	HBG000135
InParanoid	P70662
KO	K15617
OMA	GSNSPWN
PhylomeDB	P70662
TreeFam	TF319923
ChiTaRS	Ldb1
EvolutionaryTrace	P70662
NextBio	290724
PRO	PR:P70662
Proteomes	UP000000589
Bgee	P70662
CleanEx	MM_LDB1
ExpressionAtlas	P70662
Genevestigator	P70662
GO	GO:0000790 GO:0005634 GO:0043234 GO:0005667 GO:0003682 GO:0001158 GO:0019899 GO:0030274 GO:0042803 GO:0043621 GO:0003712 GO:0000989 GO:0009948 GO:0022607 GO:0021702 GO:0021549 GO:0010669 GO:0001702 GO:0001942 GO:0060322 GO:0043973 GO:0045647 GO:0045892 GO:0030182 GO:0045785 GO:0046985 GO:0045944 GO:0060319 GO:0032784 GO:0035019 GO:0006366 GO:0000972 GO:0016055
InterPro	IPR030167 IPR029005 IPR002691
PANTHER	PTHR10378 PTHR10378:SF7
Pfam	PF01803

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001105	RNA polymerase II transcription coactivator activity	PMID:20570862^[1]	ECO:0000315			F		Figure 6: Ldb1-/- cells differentiated more slowly than wild type cells, no detectable globin transcription was observed for the Ldb1 null ES cell	complete
	GO:0007097	nuclear migration	PMID:20570862^[1]	ECO:0000269			P		Figure 5A: According to immuno FISH studies, Ldb1 is necessary for the localization of the β-globin locus away from the nuclear periphery during differentiation NOTE: A more specific GO term name, could be used such as: β-globin locus intranuclear migration	complete
	GO:0034398	telomere tethering at nuclear periphery	PMID:20570862^[1]	ECO:0000269			P		Figure 5: It is not the most approprate GO term to be used, but it is the only one i found that resembles to the result of this experiment (chromatin-chromosome organization-telomere organization). Therefore, another GO term is needed similar to the above, in order to describe that Ldb1 is required for intranuclear migration of the β-globin locus on induction	complete
	GO:0008024	positive transcription elongation factor complex b	PMID:20570862^[1]	ECO:0000269			C		Figures 1,2,3: It is not the most appropriate GO term, but it was only i found which is related a bit with the results from ChIP. It describes, that Ldb1 is important for stability of Ldb1 complex on chromatin and is required for Ser2 pol II phosphorylation at the β-globin locus. I would propose the following GO terms although they are not too specific: Ldb1 complex chromatin stability, enrichment of key transcriptional components in the β-globin locus. In general, i had difficulty in annotating Chip-based results	complete
	GO:0003712	transcription cofactor activity	PMID:20570862^[1]	ECO:0000315			F		Figure 6: no detectable globin transcription was observed for the Ldb1 null ES cells. I was not sure if a more specific child term (like the one i have already found and i mention below) was needed, or this one. Moreover, in terms of differentiation, through go terms inferred from electronic annotation(IEA), this protein is a negative regulator of erythroid differentiation, but it is not an epxerimental evidence in this paper. Only the role of the Lbd1 in β-globin gene expression was studies,so i had difficulty in finding other GO terms.	complete
involved_in	GO:0051893	regulation of focal adhesion assembly	PMID:19675209^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043549	regulation of kinase activity	PMID:19675209^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	PMID:19675209^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	PMID:19675209^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046985	positive regulation of hemoglobin biosynthetic process	PMID:20570862^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20570862^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043973	histone H3-K4 acetylation	PMID:20570862^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032784	regulation of DNA-templated transcription, elongation	PMID:20570862^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	PMID:20570862^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060322	head development	PMID:15857913^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9D032	P		Seeded From UniProt	complete
involved_in	GO:0045647	negative regulation of erythrocyte differentiation	PMID:9391090^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:9391090^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22091	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:9391090^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P25801	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:15857913^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:9315627^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:9468533^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030274	LIM domain binding	PMID:9468533^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P29674	F		Seeded From UniProt	complete
enables	GO:0030274	LIM domain binding	PMID:9468533^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63006	F		Seeded From UniProt	complete
enables	GO:0030274	LIM domain binding	PMID:9315627^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030274	LIM domain binding	PMID:8876198^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:8876198^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11882901^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9WTV7	F		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:15857913^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9391090^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8876198^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0003677	DNA binding	PMID:9391090^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013764 MGI:MGI:894670 MGI:MGI:894762 PANTHER:PTN001623859 UniProtKB:Q86U70	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001623859 UniProtKB:Q86U70	P		Seeded From UniProt	complete
enables	GO:0030274	LIM domain binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:894762 PANTHER:PTN000822352 UniProtKB:Q86U70 WB:WBGene00002261 ZFIN:ZDB-GENE-990415-138	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001623859 TAIR:locus:2029137	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:894670 PANTHER:PTN001623859 UniProtKB:Q86U70	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013764 MGI:MGI:894762 PANTHER:PTN001623859 RGD:1310359 UniProtKB:O43679	C		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001623859 UniProtKB:Q86U70	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001623859 UniProtKB:F2Z5G6	P		Seeded From UniProt	complete
part_of	GO:1990907	beta-catenin-TCF complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86U70	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048382	mesendoderm development	PMID:26494787^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2656539,MGI:MGI:5698524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9192866^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102673 MGI:MGI:107374	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19323994^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1919725	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18184866^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95662 MGI:MGI:98480 MGI:MGI:98510	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17991461^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109360	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9192866^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86U70	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86U70	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045785	positive regulation of cell adhesion	PMID:17991461^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109360	P	regulates_o_occurs_in:(EMAPA:17162) regulates_o_has_participant:(CL:0000066)	Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:19323994^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P70662	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:19323994^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035019	somatic stem cell population maintenance	PMID:17991461^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109360	P	occurs_in:(EMAPA:35246)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19323994^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030274	LIM domain binding	PMID:9192866^[11]	ECO:0001242	phage display evidence used in manual assertion	UniProtKB:P50481 UniProtKB:P61372	F		Seeded From UniProt	complete
enables	GO:0030274	LIM domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86U70	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022607	cellular component assembly	PMID:17991461^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109360	P	occurs_in:(EMAPA:17162) occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021702	cerebellar Purkinje cell differentiation	PMID:17664423^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3719683	P	occurs_in:(EMAPA:17787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021549	cerebellum development	PMID:17664423^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3719683	P	results_in_development_of:(EMAPA:17787)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86U70	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016055	Wnt signaling pathway	PMID:12490556^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010669	epithelial structure maintenance	PMID:17991461^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:894670	P	occurs_in:(EMAPA:17162)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009948	anterior/posterior axis specification	PMID:12490556^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449177	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:26494787^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86U70	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19011221^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310359	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:19011221^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18550854^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000764) has_participant:(MGI:MGI:1342771)\|occurs_in(CL:0000764) has_participant:(MGI:MGI:95880)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001942	hair follicle development	PMID:17991461^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109360	P	results_in_development_of:(EMAPA:35246)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001702	gastrulation with mouth forming second	PMID:12490556^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449177	P		Seeded From UniProt	complete
enables	GO:0001158	enhancer sequence-specific DNA binding	PMID:19323994^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86U70	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86U70	C		Seeded From UniProt	complete
part_of	GO:1990907	beta-catenin-TCF complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86U70 ensembl:ENSP00000392466	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86U70 ensembl:ENSP00000392466	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86U70 ensembl:ENSP00000392466	P		Seeded From UniProt	complete
enables	GO:0030274	LIM domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86U70 ensembl:ENSP00000392466	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86U70 ensembl:ENSP00000392466	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86U70 ensembl:ENSP00000392466	C		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86U70 ensembl:ENSP00000392466	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86U70 ensembl:ENSP00000392466	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVQ2 ensembl:ENSRNOP00000069575	C		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030167	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030167	C		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030167	P		Seeded From UniProt	complete
enables	GO:0030274	LIM domain binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030167	F		Seeded From UniProt	complete
involved_in	GO:0060319	primitive erythrocyte differentiation	PMID:20570862^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9010548	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Song, SH et al. (2010) Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation. Blood 116 2356-64 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Storbeck, CJ et al. (2009) The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration. Mol. Biol. Cell 20 4174-82 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Nishioka, N et al. (2005) Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex. Development 132 2535-46 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Visvader, JE et al. (1997) The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc. Natl. Acad. Sci. U.S.A. 94 13707-12 PubMed GONUTS page
↑ ^5.0 ^5.1 Jurata, LW & Gill, GN (1997) Functional analysis of the nuclear LIM domain interactor NLI. Mol. Cell. Biol. 17 5688-98 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Breen, JJ et al. (1998) Interactions between LIM domains and the LIM domain-binding protein Ldb1. J. Biol. Chem. 273 4712-7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Jurata, LW et al. (1996) Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. Proc. Natl. Acad. Sci. U.S.A. 93 11693-8 PubMed GONUTS page
↑ Ostendorff, HP et al. (2002) Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature 416 99-103 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 Costello, I et al. (2015) Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 29 2108-22 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Bach, I et al. (1997) A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes Dev. 11 1370-80 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Joshi, K et al. (2009) LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron 61 839-51 PubMed GONUTS page
↑ Landry, JR et al. (2008) Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. Blood 111 3005-14 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Xu, X et al. (2007) Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells. Dev. Biol. 312 484-500 PubMed GONUTS page
↑ ^15.0 ^15.1 Zhao, Y et al. (2007) LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum. Proc. Natl. Acad. Sci. U.S.A. 104 13182-6 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Mukhopadhyay, M et al. (2003) Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development 130 495-505 PubMed GONUTS page
↑ ^17.0 ^17.1 Tripic, T et al. (2009) SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood 113 2191-201 PubMed GONUTS page
↑ Kassouf, MT et al. (2008) Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis. Blood 112 1056-67 PubMed GONUTS page

[PMID:20570862-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Song, SH et al. (2010) Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation. Blood 116 2356-64 PubMed GONUTS page

[PMID:19675209-2] 2.0 ^2.1 ^2.2 ^2.3 Storbeck, CJ et al. (2009) The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration. Mol. Biol. Cell 20 4174-82 PubMed GONUTS page

[PMID:15857913-3] 3.0 ^3.1 ^3.2 Nishioka, N et al. (2005) Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex. Development 132 2535-46 PubMed GONUTS page

[PMID:9391090-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Visvader, JE et al. (1997) The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc. Natl. Acad. Sci. U.S.A. 94 13707-12 PubMed GONUTS page

[PMID:9315627-5] 5.0 ^5.1 Jurata, LW & Gill, GN (1997) Functional analysis of the nuclear LIM domain interactor NLI. Mol. Cell. Biol. 17 5688-98 PubMed GONUTS page

[PMID:9468533-6] 6.0 ^6.1 ^6.2 Breen, JJ et al. (1998) Interactions between LIM domains and the LIM domain-binding protein Ldb1. J. Biol. Chem. 273 4712-7 PubMed GONUTS page

[PMID:8876198-7] 7.0 ^7.1 ^7.2 Jurata, LW et al. (1996) Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. Proc. Natl. Acad. Sci. U.S.A. 93 11693-8 PubMed GONUTS page

[PMID:11882901-8] Ostendorff, HP et al. (2002) Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature 416 99-103 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26494787-10] 10.0 ^10.1 Costello, I et al. (2015) Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 29 2108-22 PubMed GONUTS page

[PMID:9192866-11] 11.0 ^11.1 ^11.2 Bach, I et al. (1997) A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes Dev. 11 1370-80 PubMed GONUTS page

[PMID:19323994-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Joshi, K et al. (2009) LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron 61 839-51 PubMed GONUTS page

[PMID:18184866-13] Landry, JR et al. (2008) Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. Blood 111 3005-14 PubMed GONUTS page

[PMID:17991461-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Xu, X et al. (2007) Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells. Dev. Biol. 312 484-500 PubMed GONUTS page

[PMID:17664423-15] 15.0 ^15.1 Zhao, Y et al. (2007) LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum. Proc. Natl. Acad. Sci. U.S.A. 104 13182-6 PubMed GONUTS page

[PMID:12490556-16] 16.0 ^16.1 ^16.2 Mukhopadhyay, M et al. (2003) Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development 130 495-505 PubMed GONUTS page

[PMID:19011221-17] 17.0 ^17.1 Tripic, T et al. (2009) SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood 113 2191-201 PubMed GONUTS page

[PMID:18550854-18] Kassouf, MT et al. (2008) Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis. Blood 112 1056-67 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

MOUSE:LDB1

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

l

m

n

o

p

r

s

t

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools