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MOUSE:KEAP1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Keap1 (synonyms: Inrf2, Kiaa0132) | |
| Protein Name(s) | Kelch-like ECH-associated protein 1
Cytosolic inhibitor of Nrf2 INrf2 | |
| External Links | ||
| UniProt | Q9Z2X8 | |
| EMBL | AB020063 AF454353 AK129061 AK046178 AK076234 AK150437 AK150485 AK152142 AK154430 AK155507 AK159858 BC055732 | |
| CCDS | CCDS22897.1 | |
| RefSeq | NP_001103775.1 NP_001103776.1 NP_001103777.1 NP_057888.1 | |
| UniGene | Mm.248266 | |
| PDB | 1X2J 1X2R 2DYH 2Z32 3ADE 3WDZ 3WN7 | |
| PDBsum | 1X2J 1X2R 2DYH 2Z32 3ADE 3WDZ 3WN7 | |
| ProteinModelPortal | Q9Z2X8 | |
| SMR | Q9Z2X8 | |
| BioGrid | 206135 | |
| DIP | DIP-49698N | |
| IntAct | Q9Z2X8 | |
| MINT | MINT-4111966 | |
| STRING | 10090.ENSMUSP00000062467 | |
| PhosphoSite | Q9Z2X8 | |
| MaxQB | Q9Z2X8 | |
| PaxDb | Q9Z2X8 | |
| PRIDE | Q9Z2X8 | |
| Ensembl | ENSMUST00000049567 ENSMUST00000164812 | |
| GeneID | 50868 | |
| KEGG | mmu:50868 | |
| UCSC | uc009oko.2 | |
| CTD | 9817 | |
| MGI | MGI:1858732 | |
| eggNOG | NOG255039 | |
| GeneTree | ENSGT00760000118931 | |
| HOGENOM | HOG000230814 | |
| HOVERGEN | HBG014286 | |
| InParanoid | Q9Z2X8 | |
| KO | K10456 | |
| OMA | ERYEPEG | |
| OrthoDB | EOG76739M | |
| PhylomeDB | Q9Z2X8 | |
| TreeFam | TF329218 | |
| Reactome | REACT_199115 | |
| UniPathway | UPA00143 | |
| EvolutionaryTrace | Q9Z2X8 | |
| NextBio | 307831 | |
| PRO | PR:Q9Z2X8 | |
| Proteomes | UP000000589 | |
| Bgee | Q9Z2X8 | |
| CleanEx | MM_KEAP1 | |
| ExpressionAtlas | Q9Z2X8 | |
| Genevestigator | Q9Z2X8 | |
| GO | GO:0031463 GO:0005737 GO:0005783 GO:0005815 GO:0030496 GO:0005634 GO:0071353 GO:0001701 GO:0010499 GO:0016567 GO:0045604 GO:0006355 GO:0006351 | |
| Gene3D | 2.130.10.80 | |
| InterPro | IPR011705 IPR000210 IPR011333 IPR013069 IPR015916 IPR017096 IPR006652 | |
| Pfam | PF07707 PF00651 PF01344 | |
| PIRSF | PIRSF037037 | |
| SMART | SM00875 SM00225 SM00612 | |
| SUPFAM | SSF54695 | |
| PROSITE | PS50097 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005884 |
actin filament |
ECO:0000314 |
C |
Figure 1 |
complete | |||||
| GO:0005739 |
mitochondrion |
ECO:0000314 |
C |
Fig. 6A |
complete | |||||
| GO:0030972 |
cleavage of cytosolic proteins involved in apoptosis |
ECO:0000314 |
P |
Fig. 8D |
complete | |||||
| GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000314 |
P |
Fig. 8C |
complete | |||||
| GO:0001836 |
release of cytochrome c from mitochondria |
ECO:0000314 |
P |
Fig. 8B |
complete | |||||
| GO:0016567 |
protein ubiquitination |
ECO:0000314 |
P |
Fig. 3BC |
complete | |||||
| GO:0045732 |
positive regulation of protein catabolic process |
ECO:0000314 |
P |
Fig. 1 and Fig. 8A |
complete | |||||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0097718 |
disordered domain specific binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005884 |
actin filament |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031463 |
Cul3-RING ubiquitin ligase complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010499 |
proteasomal ubiquitin-independent protein catabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042994 |
cytoplasmic sequestering of transcription factor |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000697162 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000697162 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071353 |
cellular response to interleukin-4 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051259 |
protein complex oligomerization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621619 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045604 |
regulation of epidermal cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2681416 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042994 |
cytoplasmic sequestering of transcription factor |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621619 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031463 |
Cul3-RING ubiquitin ligase complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030496 |
midbody |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016567 |
protein ubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010629 |
negative regulation of gene expression |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621619 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010499 |
proteasomal ubiquitin-independent protein catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2681416 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621619 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005913 |
cell-cell adherens junction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621619 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000353 |
physical interaction evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621619 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621619 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001701 |
in utero embryonic development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2681416 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031463 |
Cul3-RING ubiquitin ligase complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14145 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030496 |
midbody |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14145 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14145 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010499 |
proteasomal ubiquitin-independent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14145 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14145 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14145 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14145 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14145 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14145 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A024R7C0 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A024R7C0 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A024R7C0 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031463 |
Cul3-RING ubiquitin ligase complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kang, MI et al. (2004) Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Proc. Natl. Acad. Sci. U.S.A. 101 2046-51 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Niture, SK & Jaiswal, AK (2011) Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J. Biol. Chem. 286 44542-56 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Tong, KI et al. (2006) Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol. Cell. Biol. 26 2887-900 PubMed GONUTS page
- ↑ 4.0 4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Chu, CC & Paul, WE (1998) Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol. Immunol. 35 487-502 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Motohashi, H et al. (2004) Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Proc. Natl. Acad. Sci. U.S.A. 101 6379-84 PubMed GONUTS page
- ↑ 7.0 7.1 Cullinan, SB et al. (2003) Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 23 7198-209 PubMed GONUTS page
- ↑ Ogura, T et al. (2010) Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains. Proc. Natl. Acad. Sci. U.S.A. 107 2842-7 PubMed GONUTS page
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- GO:0045732 ! positive regulation of protein catabolic process
- GO:0010499 ! proteasomal ubiquitin-independent protein catabolic process
- GO:0032991 ! protein-containing complex
- GO:0051259 ! protein complex oligomerization
- GO:0042803 ! protein homodimerization activity
- GO:0016567 ! protein ubiquitination
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