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MOUSE:IRF6

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Irf6
Protein Name(s) Interferon regulatory factor 6

IRF-6

External Links
UniProt P97431
EMBL U73029
AK143299
AK143954
AL365322
CH466555
BC008515
CCDS CCDS15632.1
RefSeq NP_058547.2
XP_006497325.1
XP_006497326.1
UniGene Mm.273695
ProteinModelPortal P97431
SMR P97431
STRING 10090.ENSMUSP00000075839
PhosphoSite P97431
MaxQB P97431
PaxDb P97431
PRIDE P97431
Ensembl ENSMUST00000076521
GeneID 54139
KEGG mmu:54139
UCSC uc007edy.1
CTD 3664
MGI MGI:1859211
eggNOG NOG45968
GeneTree ENSGT00760000119093
HOGENOM HOG000037433
HOVERGEN HBG105715
InParanoid P97431
KO K10154
OMA HEEENTI
OrthoDB EOG7CCBR1
TreeFam TF328512
Reactome REACT_198660
NextBio 310957
PRO PR:P97431
Proteomes UP000000589
Bgee P97431
CleanEx MM_IRF6
Genevestigator P97431
GO GO:0005737
GO:0070062
GO:0005634
GO:0003677
GO:0000975
GO:0003700
GO:0007050
GO:0048468
GO:0030216
GO:0043616
GO:0060644
GO:0008285
GO:0045893
GO:0043588
GO:0006351
Gene3D 1.10.10.10
2.60.200.10
InterPro IPR019817
IPR001346
IPR019471
IPR017855
IPR008984
IPR011991
Pfam PF00605
PF10401
PRINTS PR00267
SMART SM00348
SUPFAM SSF49879
PROSITE PS00601
PS51507

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:1905437

positive regulation of histone H3-K4 trimethylation

PMID:26691508[1]

ECO:0000314

P

Fig. 2 (top panel) shows that in mice, levels of H3K4 trimethylation associated with the Irf6 promoter increase during reprogramming.

complete
CACAO 13393

involved_in

GO:0060644

mammary gland epithelial cell differentiation

PMID:18212048[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:19036739[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O14896

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:19036739[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:19036739[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1096873
MGI:MGI:1859179
MGI:MGI:96395
MGI:MGI:96590
PANTHER:PTN000942746
RGD:2920
UniProtKB:O14896
UniProtKB:P10914
UniProtKB:P14316
UniProtKB:Q02556
UniProtKB:Q13568
UniProtKB:Q14653
UniProtKB:Q15306
UniProtKB:Q92985
ZFIN:ZDB-GENE-041114-13
ZFIN:ZDB-GENE-070912-330

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1096873
MGI:MGI:1350924
MGI:MGI:1859179
MGI:MGI:1859212
MGI:MGI:96395
MGI:MGI:96590
PANTHER:PTN000942747
UniProtKB:P10914
UniProtKB:P14316
UniProtKB:Q02556
UniProtKB:Q92985
ZFIN:ZDB-GENE-040718-367
ZFIN:ZDB-GENE-070912-330

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1859212
PANTHER:PTN000942746
UniProtKB:P10914
UniProtKB:P14316
UniProtKB:Q02556
UniProtKB:Q14653
UniProtKB:Q15306
UniProtKB:Q92985
ZFIN:ZDB-GENE-070912-330

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048468

cell development

PMID:17041603[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3693324

P

  • occurs_in:(EMAPA:17525)
  • occurs_in:(CL:0000312)|occurs_in:(EMAPA:17525)
  • occurs_in:(CL:0000646)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14896

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043616

keratinocyte proliferation

PMID:17041603[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1891831

P

  • occurs_in:(EMAPA:17525)
  • acts_on_population_of:(CL:0000312)|occurs_in(EMAPA:17525)
  • acts_on_population_of:(CL:0000646)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043616

keratinocyte proliferation

PMID:17041603[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3693324

P

occurs_in:(EMAPA:17525)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043616

keratinocyte proliferation

PMID:17041601[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3522096

P

  • occurs_in:(EMAPA:17525)
  • acts_on_population_of:(CL:0000312)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043588

skin development

PMID:17041603[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1891831

P

results_in_development_of:(EMAPA:17525)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043588

skin development

PMID:17041603[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3693324

P

results_in_development_of:(EMAPA:17525)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043588

skin development

PMID:17041601[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3522096

P

results_in_development_of:(EMAPA:17525)

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14896

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030216

keratinocyte differentiation

PMID:17041603[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3693324

P

  • occurs_in:(EMAPA:17525)
  • results_in_acquisition_of_features_of:(CL:0000312)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030216

keratinocyte differentiation

PMID:17041601[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3522096

P

  • occurs_in:(EMAPA:17525)
  • results_in_acquisition_of_features_of:(CL:0000312)

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14896

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:17041603[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1891831

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14896

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007050

cell cycle arrest

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14896

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14896

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14896

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14896

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G0Z349
ensembl:ENSP00000355988

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G0Z349
ensembl:ENSP00000355988

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G0Z349
ensembl:ENSP00000355988

C

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14896
ensembl:ENSP00000355988

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14896
ensembl:ENSP00000355988

F

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14896
ensembl:ENSP00000355988

C

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14896
ensembl:ENSP00000355988

P

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14896
ensembl:ENSP00000355988

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14896
ensembl:ENSP00000355988

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14896
ensembl:ENSP00000355988

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14896
ensembl:ENSP00000355988

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019471
InterPro:IPR019817

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019471
InterPro:IPR019817

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001346

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page
  2. ↑ Bailey, CM et al. (2008) Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner. Mol. Cell. Biol. 28 2235-43 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Little, HJ et al. (2009) Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6. Hum. Mol. Genet. 18 535-45 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Richardson, RJ et al. (2006) Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat. Genet. 38 1329-34 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Ingraham, CR et al. (2006) Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6). Nat. Genet. 38 1335-40 PubMed GONUTS page
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