MOUSE:IGF1R

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Igf1r
Protein Name(s)	Insulin-like growth factor 1 receptor Insulin-like growth factor I receptor IGF-I receptor Insulin-like growth factor 1 receptor alpha chain Insulin-like growth factor 1 receptor beta chain
External Links
UniProt	Q60751
EMBL	AF056187 U00182 M33422
PIR	A48805 JH0113
RefSeq	NP_034643.2
UniGene	Mm.275742
ProteinModelPortal	Q60751
SMR	Q60751
BioGrid	200548
IntAct	Q60751
MINT	MINT-219894
BindingDB	Q60751
ChEMBL	CHEMBL5381
PhosphoSite	Q60751
MaxQB	Q60751
PaxDb	Q60751
PRIDE	Q60751
GeneID	16001
KEGG	mmu:16001
CTD	3480
MGI	MGI:96433
eggNOG	COG0515
HOGENOM	HOG000038045
HOVERGEN	HBG006134
InParanoid	Q60751
KO	K05087
PhylomeDB	Q60751
BRENDA	2.7.10.1
Reactome	REACT_188215 REACT_188219 REACT_188220
ChiTaRS	Igf1r
NextBio	288790
PRO	PR:Q60751
Proteomes	UP000000589
Bgee	Q60751
CleanEx	MM_IGF1R
ExpressionAtlas	Q60751
Genevestigator	Q60751
GO	GO:0005901 GO:0016021 GO:0043231 GO:0043005 GO:0005886 GO:0043235 GO:0005524 GO:0043559 GO:0043560 GO:0005520 GO:0005010 GO:0043548 GO:0004713 GO:0007409 GO:0007420 GO:0008544 GO:0030010 GO:0031017 GO:0006955 GO:0051389 GO:0048009 GO:0030238 GO:0030879 GO:0043409 GO:0010656 GO:0051898 GO:0043433 GO:0009887 GO:0038083 GO:0048015 GO:0030335 GO:0032467 GO:0045740 GO:0043410 GO:0045840 GO:0051897 GO:0090031 GO:0060740 GO:0046777 GO:0051291 GO:0006468 GO:0051262 GO:0046328 GO:0033197
Gene3D	2.60.40.10 3.80.20.20
InterPro	IPR003961 IPR006211 IPR006212 IPR009030 IPR013783 IPR011009 IPR000719 IPR017441 IPR000494 IPR001245 IPR008266 IPR020635 IPR016246 IPR002011
Pfam	PF00041 PF00757 PF07714 PF01030
PIRSF	PIRSF000620
PRINTS	PR00109
SMART	SM00060 SM00261 SM00219
SUPFAM	SSF49265 SSF56112 SSF57184
PROSITE	PS50853 PS00107 PS50011 PS00109 PS00239

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030325	adrenal gland development	PMID:23300479^[1]	ECO:0000316		UniProtKB:P15208	P		Figure 6 shows that mice with an absence of INSR and IGF1R, through knockout, presented with adrenal agenesis.	complete CACAO 6584
	GO:0048639	positive regulation of developmental growth	PMID:23300479^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Figure 1 shows that mice with the absence of Insulin-like growth factor 1 receptor, due to gene knockout, experienced growth retardation.	complete CACAO 6585
Contributes to	GO:0008584	male gonad development	PMID:23300479^[1]	ECO:0000315			P		Figures 1 and 2 show that mice without IGF1R, due to gene knockout, experienced male to female sex reversal and disrupted testicular development.	complete CACAO 6586
	GO:0001892	embryonic placenta development	PMID:23300479^[1]	ECO:0000315			P		Figure 3 shows that mice without IGF1R, due to gene knockout, experienced delayed ovarian differentiation.	complete CACAO 6587
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:23300479^[1]	ECO:0000316		UniProtKB:P15208	P		Fig 6 shows that IGF1R and INSR positively regulate SF1 expression through gene interaction.	complete CACAO 6697
	GO:0051446	positive regulation of meiotic cell cycle	PMID:23300479^[1]	ECO:0000316		UniProtKB:P15208	P		FIg 4 shows that IGF1R and INSR positively regulate the meiotic cell cycle. When IGF1R and INSR are absent, the speed of cells entering into meiosis is delayed.	complete CACAO 6704
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:26910308^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005520	insulin-like growth factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05688	F		Seeded From UniProt	complete
enables	GO:0005520	insulin-like growth factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:I3PGL2	F		Seeded From UniProt	complete
enables	GO:0005520	insulin-like growth factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G1K218	F		Seeded From UniProt	complete
involved_in	GO:0051446	positive regulation of meiotic cell cycle	PMID:23300479^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P15208	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:23300479^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P15208	P		Seeded From UniProt	complete
involved_in	GO:0030325	adrenal gland development	PMID:23300479^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P15208	P		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
involved_in	GO:0048009	insulin-like growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0005520	insulin-like growth factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0005010	insulin-like growth factor-activated receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96433 PANTHER:PTN000699676 RGD:2869	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96433 PANTHER:PTN000699611 UniProtKB:P06213	P		Seeded From UniProt	complete
involved_in	GO:0048856	anatomical structure development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346037 MGI:MGI:96433 MGI:MGI:96575 PANTHER:PTN002521379 RGD:2869 RGD:2917 UniProtKB:P06213 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-020503-3 ZFIN:ZDB-GENE-020503-4	P		Seeded From UniProt	complete
involved_in	GO:0048009	insulin-like growth factor receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814784 RGD:2869 UniProtKB:P08069 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2	P		Seeded From UniProt	complete
involved_in	GO:0046328	regulation of JNK cascade	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814784 UniProtKB:P08069	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 RGD:2869 RGD:2917 UniProtKB:P06213 UniProtKB:P08069	F		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96433 PANTHER:PTN000699611 UniProtKB:P06213	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283499 MGI:MGI:96433 PANTHER:PTN000699611 RGD:2869 RGD:2917 UniProtKB:P06213	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002400529 RGD:2869	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 RGD:2869 WB:WBGene00000898	C		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283499 PANTHER:PTN000699611 RGD:2869	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005899	insulin receptor complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 UniProtKB:P06213	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005009	insulin-activated receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 RGD:2917 UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990314	cellular response to insulin-like growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904646	cellular response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904385	cellular response to angiotensin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904193	negative regulation of cholangiocyte apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903944	negative regulation of hepatocyte apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902065	response to L-glutamate	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097242	amyloid-beta clearance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097062	dendritic spine maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090031	positive regulation of steroid hormone biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071333	cellular response to glucose stimulus	PMID:21677284^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386329	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060740	prostate gland epithelium morphogenesis	PMID:18451178^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386328	P	has_participant:(EMAPA:32290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051898	negative regulation of protein kinase B signaling	PMID:18451178^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386328	P	regulates_o_occurs_in:(EMAPA:35710)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	PMID:18451178^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386328	P	regulates_o_occurs_in:(EMAPA:29836)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051389	inactivation of MAPKK activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051291	protein heterooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051262	protein tetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051054	positive regulation of DNA metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048680	positive regulation of axon regeneration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048015	phosphatidylinositol-mediated signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048009	insulin-like growth factor receptor signaling pathway	PMID:12771153^[6]	ECO:0000305	curator inference used in manual assertion	GO:0005520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048009	insulin-like growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046328	regulation of JNK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045840	positive regulation of mitotic nuclear division	PMID:23906066^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17528) regulates_o_occurs_in:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045471	response to ethanol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044849	estrous cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	F		Seeded From UniProt	complete
enables	GO:0043559	insulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:23906066^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	PMID:18451178^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386328	P	regulates_o_occurs_in:(EMAPA:29836)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043409	negative regulation of MAPK cascade	PMID:18451178^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386328	P	regulates_o_occurs_in:(EMAPA:35710)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043243	positive regulation of protein complex disassembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:10100151^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:19545541^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
part_of	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033690	positive regulation of osteoblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032869	cellular response to insulin stimulus	PMID:21677284^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386329	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032467	positive regulation of cytokinesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
enables	GO:0031994	insulin-like growth factor I binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031017	exocrine pancreas development	PMID:12101187^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926486	P	results_in_development_of:(EMAPA:18816)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030879	mammary gland development	PMID:17662267^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926486	P	results_in_development_of:(EMAPA:17760)	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	PMID:23695157^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32716)	Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030238	male sex determination	PMID:14628051^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926486	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030010	establishment of cell polarity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021549	cerebellum development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:7931420^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17787)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010656	negative regulation of muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:12101187^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926486	P	has_participant:(EMAPA:18816)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008544	epidermis development	PMID:23906066^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008286	insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:12904469^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926486	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006955	immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:18216249^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:23695157^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32716)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18451178^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:29836)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	C		Seeded From UniProt	complete
enables	GO:0005520	insulin-like growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0005010	insulin-like growth factor-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0005010	insulin-like growth factor-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	F		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2869	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR016246	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR016246 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR016246	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR006211	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	C		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	P		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Pitetti, JL et al. (2013) Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. PLoS Genet. 9 e1003160 PubMed GONUTS page
↑ Viana-Huete, V et al. (2016) Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity. Endocrinology 157 1495-511 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Abbas, A et al. (2011) The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes 60 2169-78 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Sutherland, BW et al. (2008) Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium. Cancer Res. 68 3495-504 PubMed GONUTS page
↑ Giovannone, B et al. (2003) Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J. Biol. Chem. 278 31564-73 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Günschmann, C et al. (2013) Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev. Cell 26 176-87 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ Martineau, LC et al. (1999) Age-associated alterations in cardiac and skeletal muscle glucose transporters, insulin and IGF-1 receptors, and PI3-kinase protein contents in the C57BL/6 mouse. Mech. Ageing Dev. 106 217-32 PubMed GONUTS page
↑ Andersson, S et al. (2009) Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor. Biochem. Biophys. Res. Commun. 387 36-41 PubMed GONUTS page
↑ ^11.0 ^11.1 Kido, Y et al. (2002) Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J. Biol. Chem. 277 36740-7 PubMed GONUTS page
↑ Heckman, BM et al. (2007) Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev. Biol. 309 137-49 PubMed GONUTS page
↑ ^13.0 ^13.1 Al-Qusairi, L et al. (2013) Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways. FASEB J. 27 3384-94 PubMed GONUTS page
↑ Nef, S et al. (2003) Testis determination requires insulin receptor family function in mice. Nature 426 291-5 PubMed GONUTS page
↑ Vig, PJ et al. (1994) Decreased insulin-like growth factor I-mediated protein tyrosine phosphorylation in human olivopontocerebellar atrophy and lurcher mutant mouse. J. Neurol. Sci. 124 38-44 PubMed GONUTS page
↑ Schubert, M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J. Neurosci. 23 7084-92 PubMed GONUTS page
↑ Gatchel, JR et al. (2008) The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7. Proc. Natl. Acad. Sci. U.S.A. 105 1291-6 PubMed GONUTS page

[PMID:23300479-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Pitetti, JL et al. (2013) Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. PLoS Genet. 9 e1003160 PubMed GONUTS page

[PMID:26910308-2] Viana-Huete, V et al. (2016) Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity. Endocrinology 157 1495-511 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21677284-4] 4.0 ^4.1 Abbas, A et al. (2011) The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes 60 2169-78 PubMed GONUTS page

[PMID:18451178-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Sutherland, BW et al. (2008) Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium. Cancer Res. 68 3495-504 PubMed GONUTS page

[PMID:12771153-6] Giovannone, B et al. (2003) Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J. Biol. Chem. 278 31564-73 PubMed GONUTS page

[PMID:23906066-7] 7.0 ^7.1 ^7.2 Günschmann, C et al. (2013) Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev. Cell 26 176-87 PubMed GONUTS page

[PMID:23382219-8] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

[PMID:10100151-9] Martineau, LC et al. (1999) Age-associated alterations in cardiac and skeletal muscle glucose transporters, insulin and IGF-1 receptors, and PI3-kinase protein contents in the C57BL/6 mouse. Mech. Ageing Dev. 106 217-32 PubMed GONUTS page

[PMID:19545541-10] Andersson, S et al. (2009) Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor. Biochem. Biophys. Res. Commun. 387 36-41 PubMed GONUTS page

[PMID:12101187-11] 11.0 ^11.1 Kido, Y et al. (2002) Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J. Biol. Chem. 277 36740-7 PubMed GONUTS page

[PMID:17662267-12] Heckman, BM et al. (2007) Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev. Biol. 309 137-49 PubMed GONUTS page

[PMID:23695157-13] 13.0 ^13.1 Al-Qusairi, L et al. (2013) Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways. FASEB J. 27 3384-94 PubMed GONUTS page

[PMID:14628051-14] Nef, S et al. (2003) Testis determination requires insulin receptor family function in mice. Nature 426 291-5 PubMed GONUTS page

[PMID:7931420-15] Vig, PJ et al. (1994) Decreased insulin-like growth factor I-mediated protein tyrosine phosphorylation in human olivopontocerebellar atrophy and lurcher mutant mouse. J. Neurol. Sci. 124 38-44 PubMed GONUTS page

[PMID:12904469-16] Schubert, M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J. Neurosci. 23 7084-92 PubMed GONUTS page

[PMID:18216249-17] Gatchel, JR et al. (2008) The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7. Proc. Natl. Acad. Sci. U.S.A. 105 1291-6 PubMed GONUTS page

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MOUSE:IGF1R

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