MOUSE:HXA2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Hoxa2 (synonyms: Hox-1.11, Hoxa-2)
Protein Name(s)	Homeobox protein Hox-A2 Homeobox protein Hox-1.11 Hox1.11
External Links
UniProt	P31245
EMBL	M95599 M93148 M93292 BC117105 BC117107 M87801 AB039191
CCDS	CCDS20139.1
PIR	A42694 A46037
RefSeq	NP_034581.1
UniGene	Mm.131
ProteinModelPortal	P31245
SMR	P31245
BioGrid	200367
IntAct	P31245
STRING	10090.ENSMUSP00000014848
PhosphoSite	P31245
PRIDE	P31245
Ensembl	ENSMUST00000014848
GeneID	15399
KEGG	mmu:15399
UCSC	uc009bxz.1
CTD	3199
MGI	MGI:96174
eggNOG	NOG321520
GeneTree	ENSGT00760000118940
HOGENOM	HOG000063664
HOVERGEN	HBG006088
InParanoid	P31245
KO	K09302
OMA	NCGSGLN
OrthoDB	EOG73RBBF
PhylomeDB	P31245
TreeFam	TF317730
NextBio	288090
PRO	PR:P31245
Proteomes	UP000000589
Bgee	P31245
CleanEx	MM_HOXA2
ExpressionAtlas	P31245
Genevestigator	P31245
GO	GO:0005654 GO:0005634 GO:0000978 GO:0001078 GO:0043565 GO:0009952 GO:0035284 GO:0045165 GO:0001709 GO:0071300 GO:0009953 GO:0048704 GO:0048703 GO:0042474 GO:0008045 GO:0045665 GO:0045668 GO:0000122 GO:0002076 GO:0007389 GO:0045944 GO:0021568 GO:0021569 GO:0021658 GO:0007379
Gene3D	1.10.10.60
InterPro	IPR001827 IPR017970 IPR001356 IPR020479 IPR009057
Pfam	PF00046
PRINTS	PR00024
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00032 PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:15634706^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:15634706^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048704	embryonic skeletal system morphogenesis	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96174 MGI:MGI:96175 MGI:MGI:96184 MGI:MGI:96207 PANTHER:PTN002903063	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000166 FB:FBgn0004053 MGI:MGI:102851 MGI:MGI:96174 PANTHER:PTN002518688 RGD:62387 UniProtKB:P14651 UniProtKB:P14652 UniProtKB:P31249	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96174 MGI:MGI:96175 MGI:MGI:96184 MGI:MGI:96207 PANTHER:PTN002903063	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0051481 MGI:MGI:102851 MGI:MGI:96174 PANTHER:PTN002518688 RGD:62387 UniProtKB:O43364 UniProtKB:P14652	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000166 MGI:MGI:102851 MGI:MGI:96175 PANTHER:PTN002518688 RGD:62387	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102851 MGI:MGI:96174 MGI:MGI:96184 PANTHER:PTN002518688 UniProtKB:P14651	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96174 MGI:MGI:96184 PANTHER:PTN001215678	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071300	cellular response to retinoic acid	PMID:23723417^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048704	embryonic skeletal system morphogenesis	PMID:15634706^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102778	P	has_participant:(EMAPA:18585)\|has_participant:(EMAPA:18842)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048703	embryonic viscerocranium morphogenesis	PMID:16221728^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385711	P	has_participant:(EMAPA:18650)\|has_participant:(EMAPA:18024)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18787068^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045668	negative regulation of osteoblast differentiation	PMID:21324897^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	PMID:18164701^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104717 MGI:MGI:96207 MGI:MGI:97495	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	PMID:18164701^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857530	P	occurs_in:(EMAPA:17569) regulates_o_results_in_acquisition_of_features_of:(CL:0000101)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:7903601^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857626	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:7903600^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857530	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:15634706^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:102778)	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43364	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042474	middle ear morphogenesis	PMID:15634706^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102778	P	has_participant:(EMAPA:18585)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042474	middle ear morphogenesis	PMID:16221728^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385711	P	has_participant:(EMAPA:17825)\|has_participant:(EMAPA:17826)\|has_participant:(EMAPA:17827)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042474	middle ear morphogenesis	PMID:15861402^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857530	P	has_participant:(EMAPA:17826)\|has_participant:(EMAPA:17825)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035284	brain segmentation	PMID:9367425^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857626	P	has_participant:(EMAPA:16480)\|has_participant:(EMAPA:16484)\|has_participant:(EMAPA:16488)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021658	rhombomere 3 morphogenesis	PMID:10230789^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857626	P	has_participant:(EMAPA:16488)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021569	rhombomere 3 development	PMID:7508007^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96183	P	results_in_development_of:(EMAPA:16932)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021568	rhombomere 2 development	PMID:7508007^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857626	P	results_in_development_of:(EMAPA:16925)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:10230789^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96183	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:10230789^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857626	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:9367425^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857626	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008045	motor neuron axon guidance	PMID:9367425^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857626	P	occurs_in:(EMAPA:16925) occurs_in:(CL:0000100)\|occurs_in:(EMAPA:16983) occurs_in:(CL:0000100)\|occurs_in:(EMAPA:16925) occurs_in:(CL:0000100)\|occurs_in:(EMAPA:16797) occurs_in:(CL:0000100)\|occurs_in:(EMAPA:16932) occurs_in:(CL:0000100)\|occurs_in:(EMAPA:16983) occurs_in:(CL:0000100)\|occurs_in:(EMAPA:16932) occurs_in:(CL:0000100)\|occurs_in:(EMAPA:16797) occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:7903601^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857626	P	occurs_in:(EMAPA:16117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:7903600^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857530	P	occurs_in:(EMAPA:16117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007379	segment specification	PMID:9367425^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857626	P	has_participant:(EMAPA:16484)\|has_participant:(EMAPA:16488)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11209945^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16896)\|part_of:(EMAPA:17536)\|part_of:(EMAPA:17540)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10536059^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17577)\|part_of:(EMAPA:17577)\|part_of:(EMAPA:17577)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43364	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002076	osteoblast development	PMID:16751105^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2679336	P	occurs_in:(EMAPA:17213) results_in_development_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001709	cell fate determination	PMID:16221728^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385711	P	occurs_in:(EMAPA:16272)\|occurs_in:(EMAPA:16272)\|occurs_in:(EMAPA:16272)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15634706^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:102778)	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43364 ensembl:ENSP00000222718	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43364 ensembl:ENSP00000222718	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR001827 InterPro:IPR009057 InterPro:IPR020479	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001827	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001827 InterPro:IPR017970	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9010499 Reactome:R-MMU-5619429	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Kutejova, E et al. (2005) Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme. Development 132 469-78 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Maamar, H et al. (2013) linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis. Genes Dev. 27 1260-71 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Santagati, F et al. (2005) Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis. Development 132 4927-36 PubMed GONUTS page
↑ Wassef, MA et al. (2008) Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Development 135 3369-78 PubMed GONUTS page
↑ Hu, R et al. (2011) A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J. Biol. Chem. 286 12328-39 PubMed GONUTS page
↑ ^7.0 ^7.1 Yang, X et al. (2008) Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice. Dev. Biol. 314 171-88 PubMed GONUTS page
↑ ^8.0 ^8.1 Rijli, FM et al. (1993) A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene. Cell 75 1333-49 PubMed GONUTS page
↑ ^9.0 ^9.1 Gendron-Maguire, M et al. (1993) Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest. Cell 75 1317-31 PubMed GONUTS page
↑ O'Gorman, S (2005) Second branchial arch lineages of the middle ear of wild-type and Hoxa2 mutant mice. Dev. Dyn. 234 124-31 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Gavalas, A et al. (1997) Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning. Development 124 3693-702 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Davenne, M et al. (1999) Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain. Neuron 22 677-91 PubMed GONUTS page
↑ ^13.0 ^13.1 Fung, KM et al. (1994) Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice. Lab. Invest. 70 114-24 PubMed GONUTS page
↑ Wolf, LV et al. (2001) Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalon. Neuroreport 12 329-33 PubMed GONUTS page
↑ Hao, Z et al. (1999) Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord. Dev. Dyn. 216 201-17 PubMed GONUTS page
↑ Dobreva, G et al. (2006) SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell 125 971-86 PubMed GONUTS page

[PMID:15634706-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Kutejova, E et al. (2005) Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme. Development 132 469-78 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23723417-3] Maamar, H et al. (2013) linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis. Genes Dev. 27 1260-71 PubMed GONUTS page

[PMID:16221728-4] 4.0 ^4.1 ^4.2 Santagati, F et al. (2005) Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis. Development 132 4927-36 PubMed GONUTS page

[PMID:18787068-5] Wassef, MA et al. (2008) Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Development 135 3369-78 PubMed GONUTS page

[PMID:21324897-6] Hu, R et al. (2011) A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J. Biol. Chem. 286 12328-39 PubMed GONUTS page

[PMID:18164701-7] 7.0 ^7.1 Yang, X et al. (2008) Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice. Dev. Biol. 314 171-88 PubMed GONUTS page

[PMID:7903601-8] 8.0 ^8.1 Rijli, FM et al. (1993) A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene. Cell 75 1333-49 PubMed GONUTS page

[PMID:7903600-9] 9.0 ^9.1 Gendron-Maguire, M et al. (1993) Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest. Cell 75 1317-31 PubMed GONUTS page

[PMID:15861402-10] O'Gorman, S (2005) Second branchial arch lineages of the middle ear of wild-type and Hoxa2 mutant mice. Dev. Dyn. 234 124-31 PubMed GONUTS page

[PMID:9367425-11] 11.0 ^11.1 ^11.2 ^11.3 Gavalas, A et al. (1997) Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning. Development 124 3693-702 PubMed GONUTS page

[PMID:10230789-12] 12.0 ^12.1 ^12.2 Davenne, M et al. (1999) Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain. Neuron 22 677-91 PubMed GONUTS page

[PMID:7508007-13] 13.0 ^13.1 Fung, KM et al. (1994) Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice. Lab. Invest. 70 114-24 PubMed GONUTS page

[PMID:11209945-14] Wolf, LV et al. (2001) Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalon. Neuroreport 12 329-33 PubMed GONUTS page

[PMID:10536059-15] Hao, Z et al. (1999) Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord. Dev. Dyn. 216 201-17 PubMed GONUTS page

[PMID:16751105-16] Dobreva, G et al. (2006) SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell 125 971-86 PubMed GONUTS page

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MOUSE:HXA2

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References

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